Search filters

List of works by Sabine Merkelbach-Bruse

A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del)

scientific article

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer

scientific article

Analysis of chromosomal instability in focal cortical dysplasia of Taylor's balloon cell type

scientific article published on 14 May 2004

Association of platelet-derived growth factor receptor alpha mutations with gastric primary site and epithelioid or mixed cell morphology in gastrointestinal stromal tumors

scientific article published on August 2004

Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung

scientific article

Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients

scientific article

Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events

scientific article published on 31 January 2017

Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics

scientific article

Current diagnostic methods of HER-2/neu detection in breast cancer with special regard to real-time PCR.

scientific article

Deep ion sequencing of amplicon adapter ligated libraries: a novel tool in molecular diagnostics of formalin fixed and paraffin embedded tissues ⬇️

scientific article published on April 25, 2013

EGFR mutation detection in NSCLC--assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC.

scientific article

Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling

scientific article

FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro

scientific article published on 8 May 2015

HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat

scientific article published on 05 February 2016

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

scientific article published on June 2016

High-Resolution Melting Analysis as a Sensitive Prescreening Diagnostic Tool to Detect KRAS, BRAF, PIK3CA, and AKT1 Mutations in Formalin-Fixed, Paraffin-Embedded Tissues ⬇️

scientific article published on September 1, 2012

Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients

scientific article published on 10 January 2017

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients

scientific article published on July 2015

Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literature

scientific article published on 26 March 2007

Lung cancer as a paradigm for precision oncology in solid tumours

scientific article

Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumors, and malignant peripheral nerve sheath tumors

scientific article published on 29 April 2011

MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas

scientific article published on 6 April 2015

Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

scientific article

Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy

scientific article published on 14 August 2007

NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas ⬇️

scientific article published on 4 September 2015

PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies

scientific article

Pitfalls in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors

scientific article

Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate

scientific article

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

scientific article published in April 2015

Sensitive and specific detection of EML4-ALK rearrangements in non-small cell lung cancer (NSCLC) specimens by multiplex amplicon RNA massive parallel sequencing

scientific article published on 13 March 2014

The impact of sequencing on diagnosis and treatment of malignant melanoma

scientific article published on 28 January 2016

Use of the GeneReader NGS System in a clinical pathology laboratory: a comparative study

scientific article published on 11 April 2017

Utility of different massive parallel sequencing platforms for mutation profiling in clinical samples and identification of pitfalls using FFPE tissue

scientific article published on 7 September 2015

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia

scientific article

miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours

scientific article

qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL.

scientific article

Paulina is supported by:

About Paulina

Help