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List of works by Tsutomu Takeuchi

A combination of biochemical markers of cartilage and bone turnover, radiographic damage and body mass index to predict the progression of joint destruction in patients with rheumatoid arthritis treated with disease-modifying anti-rheumatic drugs

scientific article

A new bioassay for measuring the strength of IL-6/STAT3 signal inhibition by tocilizumab in patients with rheumatoid arthritis.

scientific article published on 17 October 2017

A paradigm shift in rheumatoid arthritis over the past decade.

scientific article published on September 2014

A phase 3 randomized, double-blind, multicenter comparative study evaluating the effect of etanercept versus methotrexate on radiographic outcomes, disease activity, and safety in Japanese subjects with active rheumatoid arthritis

scientific article published on 26 September 2012

A unique case of polymyositis with anti-signal recognition particle antibody complicated by subacute interstitial lung disease and subluxing arthropathy, resembling anti-synthetase syndrome

scientific article published on 16 February 2016

ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis.

scientific article

ASP5094, a humanized monoclonal antibody against integrin alpha-9, did not show efficacy in patients with rheumatoid arthritis refractory to methotrexate: results from a phase 2a, randomized, double-blind, placebo-controlled trial

scientific article published on 21 October 2020

Abatacept in combination with methotrexate in Japanese biologic-naive patients with active rheumatoid arthritis: a randomised placebo-controlled phase IV study

scientific article published on 04 December 2018

Acute kidney injury due to renal sarcoidosis during etanercept therapy: a case report and literature review.

scientific article published on May 2015

Adalimumab discontinuation in patients with early rheumatoid arthritis who were initially treated with methotrexate alone or in combination with adalimumab: 1 year outcomes of the HOPEFUL-2 study.

scientific article published on 18 February 2016

Adalimumab, a human anti-TNF monoclonal antibody, outcome study for the prevention of joint damage in Japanese patients with early rheumatoid arthritis: the HOPEFUL 1 study

scientific article

Addendum to "Treatment of rheumatoid arthritis with biological agents - as a typical and common immune-mediated inflammatory disease".

scientific article published in January 2018

Addition of another disease-modifying anti-rheumatic drug to methotrexate reduces the flare rate within 2 years after infliximab discontinuation in patients with rheumatoid arthritis: an open, randomized, controlled trial

scientific article published on 5 November 2013

Adolescent PR3-ANCA-positive hypertrophic pachymeningitis: A case report and review of the literature

scientific article published in April 2018

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.

scientific article published on 21 May 2016

Amebiasis in Acquired Immunodeficiency Syndrome

scientific article published on 01 July 2001

American College of Rheumatology/European League Against Rheumatism remission criteria for rheumatoid arthritis maintain reliable performance when evaluated in 44 joints

scientific article published on 15 June 2013

Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen

scientific article published on 01 January 1989

Anti-TNF Biological Agents in Rheumatoid Arthritis and Other Inflammatory Diseases

scholarly article by Tsutomu Takeuchi et al published 2005 in Allergology International

Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population

scientific article published on 18 April 2015

Anti-signal recognition particle antibody in patients without inflammatory myopathy: a survey of 6180 patients with connective tissue diseases

scientific article published on 31 August 2015

Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells

scientific article published on 07 February 2020

Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case-control study

scientific article published on 12 April 2016

Association of erythrocyte methotrexate-polyglutamate levels with the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a 76-week prospective study

scientific article published on 03 January 2017

Baricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease-Modifying Antirheumatic Drug Treatment

scientific article published on 09 October 2016

Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

scientific article

Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy

scientific article published on 13 December 2013

Bendamustine increases interleukin-10 secretion from B cells via p38 MAP kinase activation.

scientific article published on 5 August 2016

Biologic-free remission of established rheumatoid arthritis after discontinuation of abatacept: a prospective, multicentre, observational study in Japan.

scientific article

Biomarkers as a treatment guide in rheumatoid arthritis

scholarly article by Tsutomu Takeuchi published January 2018 in Clinical Immunology

Brief Report: Leucine-Rich α2-Glycoprotein as a Potential Biomarker for Joint Inflammation During Anti-Interleukin-6 Biologic Therapy in Rheumatoid Arthritis

scientific article published on 01 May 2015

CC-chemokine ligand 18 is a useful biomarker associated with disease activity in IgG4-related disease

scientific article published on 13 October 2017

CCA [N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium salt], a newly developed immunomodulating drug, suppresses T-cell activation by acting on macrophages

scientific article published in April 1989

CD11 molecule defines two types of suppressor cells within the T8+ population

scientific article published on 01 February 1988

CD14brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis.

scientific article published on 10 February 2017

CD247 variants and single-nucleotide polymorphisms observed in systemic lupus erythematosus patients.

scientific article published on 22 March 2013

CD3 ζ defects in systemic lupus erythematosus.

scientific article published on April 2012

COVID-19 infection in patients with systemic lupus erythematosus: Data from the Asia Pacific Lupus Collaboration

scientific article published on 25 August 2020

Cellular mechanism of DNA-specific antibody synthesis by lymphocytes from systemic lupus erythematosus patients

scientific article published on 01 July 1984

Cellular regulation of anti-nRNP antibody synthesis is different from that of anti-DNA antibody synthesis in patients with systemic lupus erythematosus

scientific article published on 01 January 1988

Clinical Manifestations and Prognosis of Wegener''s Granulomatosis

scientific article published on 01 August 1995

Clinical and radiological features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study

scientific article published on 15 May 2008

Clinical and radiological features of acute-onset diffuse interstitial lung diseases in patients with rheumatoid arthritis receiving treatment with biological agents: importance of Pneumocystis pneumonia in Japan revealed by a multicenter study

scientific article published on 15 February 2011

Clinical benefit of 1-year certolizumab pegol (CZP) add-on therapy to methotrexate treatment in patients with early rheumatoid arthritis was observed following CZP discontinuation: 2-year results of the C-OPERA study, a phase III randomised trial

scientific article published on 2 February 2017

Clinical characteristics and survival of Japanese patients with connective tissue disease and pulmonary arterial hypertension: a single-centre cohort

article

Clinical efficacy, radiographic progression, and safety through 156 weeks of therapy with subcutaneous golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis despite prior methotrexate therapy: final results

scientific article published on 16 October 2015

Clinical practice guideline for Sjögren's syndrome 2017.

scientific article published on 7 February 2018

Clinical significance of cartilage biomarkers for monitoring structural joint damage in rheumatoid arthritis patients treated with anti-TNF therapy

scientific article

Clinicopathologic investigation of methotrexate-induced lymphoproliferative disorders, with a focus on regression.

scientific article published on 7 September 2017

Clinicopathological analyses in patients with other iatrogenic immunodeficiency-associated lymphoproliferative diseases and rheumatoid arthritis.

scientific article published on 25 November 2011

Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study).

scientific article published on 05 January 2016

Comparison of performance of the 2016 ACR-EULAR classification criteria for primary Sjögren's syndrome with other sets of criteria in Japanese patients.

scientific article

Comparison of the Clinical Characteristics of Pneumocystis Pneumonia between Patients with Rheumatoid Arthritis Being Treated with Biologics and Those Being Treated without Biologics

scientific article published on 12 July 2017

Continuation of Methotrexate Resulted in Better Clinical and Radiographic Outcomes Than Discontinuation upon Starting Etanercept in Patients with Rheumatoid Arthritis: 52-week Results from the JESMR Study

scientific article published on 15 May 2011

Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study).

scientific article published on 21 March 2016

Critical role of CD4(+)CD25(+) regulatory T cells in preventing murine autoantibody-mediated thrombocytopenia

scientific article

Crohn's Disease in which the Patient Developed Aortitis during Treatment with Adalimumab.

scientific article published on 15 July 2015

DNA-daunorubicin complexes specifically suppress in vitro spontaneous anti-DNA antibody production in lymphocytes of patients with systemic lupus erythematosus

scientific article published on 01 October 1986

De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: successful treatment with autologous peripheral blood stem cell transplantation

scientific article

Decreased mRNA Expression of Two FOXP3 Isoforms in Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus ⬇️

scientific article published on 01 January 2011

Defective expression and tyrosine phosphorylation of the T cell receptor zeta chain in peripheral blood T cells from systemic lupus erythematosus patients

scientific article published in July 2002

Defects of Autologous Mixed Lymphocyte Reaction-Activated Immunoregulatory T Cells in Patients with Systemic Lupus Erythematosus

scientific article published on 01 October 1987

Determinants of Patient's Global Assessment of Disease Activity and Physician's Global Assessment of Disease Activity in patients with rheumatoid arthritis: A post hoc analysis of overall and Japanese results from phase 3 clinical trials

scientific article published on 26 December 2017

Development of the Asia Pacific Lupus Collaboration cohort

article

Diagnostic significance of serum soluble transferrin receptors in various anemic diseases: the first multi-institutional joint study in Japan

scientific article published on 01 January 2002

Direct Demonstration of Immunoregulatory T-Cell Defects in Patients with Systemic Lupus Erythematosus

scientific article published on 01 April 1986

Discontinuation of etanercept after achievement of sustained remission in patients with rheumatoid arthritis who initially had moderate disease activity-results from the ENCOURAGE study, a prospective, international, multicenter randomized study

scientific article published on 23 December 2015

Discordance in Global Assessments Between Patient and Estimator in Patients with Newly Diagnosed Rheumatoid Arthritis: Associations with Progressive Joint Destruction and Functional Impairment

scientific article published on 01 May 2014

Distinct arthropathies of the hands in patients with anti-aminoacyl tRNA synthetase antibodies: usefulness of autoantibody profiles in classifying patients

scientific article published in June 2014

Distinct features distinguishing IgG4-related disease from multicentric Castleman's disease.

scientific article published on 18 July 2017

Distinct patterns of lymphocyte count transition in lymphoproliferative disorder in patients with rheumatoid arthritis treated with methotrexate

scientific article

Dose reduction of baricitinib in patients with rheumatoid arthritis achieving sustained disease control: results of a prospective study

scientific article published on 07 September 2018

Down-regulation of Fas-ligand mRNA in Sjögren's syndrome patients with enlarged exocrine glands

scientific article published in November 2007

Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study

scientific article published on 01 January 2014

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update ⬇️

scientific article published on 6 March 2017

Early achievement of complete renal response predicts good long-term renal outcome and low systemic damage in newly diagnosed lupus nephritis class III or IV.

scientific article published on 24 June 2015

Economic impact of adalimumab treatment in Japanese patients with rheumatoid arthritis from the adalimumab non-interventional trial for up-verified effects and utility (ANOUVEAU) study

scientific article published on 13 July 2017

Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose-response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate

scientific article

Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells

scientific article

Effect of interleukin-6 receptor inhibitor, tocilizumab, in preventing joint destruction in patients with rheumatoid arthritis showing inadequate response to TNF inhibitors.

scientific article published on 5 November 2013

Effectiveness and safety of initiating adalimumab plus ≥12 mg/week methotrexate with adjustable dosing in biologic-naïve patients with early rheumatoid arthritis: HAWK study postmarketing surveillance in Japan

scientific article published on 11 September 2018

Effectiveness and safety of tocilizumab in achieving clinical and functional remission, and sustaining efficacy in biologics-naive patients with rheumatoid arthritis: The FIRST Bio study.

scientific article published on 14 July 2016

Effectiveness and safety of tocilizumab: postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan

scientific article published in November 2013

Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlled

scientific article published on 29 April 2019

Efficacy and safety of abatacept in routine care of patients with rheumatoid arthritis: Orencia®as Biological Intensive Treatment for RA (ORBIT) study

scientific article published on 18 July 2014

Efficacy and safety of baricitinib in Japanese patients with rheumatoid arthritis: Subgroup analyses of four multinational phase 3 randomized trials

scientific article

Efficacy and safety of certolizumab pegol plus methotrexate in Japanese rheumatoid arthritis patients with an inadequate response to methotrexate: the J-RAPID randomized, placebo-controlled trial.

scientific article published on 9 December 2013

Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: the HIKARI randomized, placebo-controlled trial

scientific article

Efficacy and safety of cyclosporine A in patients with refractory systemic lupus erythematosus in a daily clinical practice

scientific article published on 01 December 2009

Efficacy and safety of mavrilimumab in Japanese subjects with rheumatoid arthritis: Findings from a Phase IIa study

scientific article published on 11 April 2014

Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial

scientific article

Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)

scientific article published on 26 July 2019

Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan

scientific article published on 26 July 2019

Efficacy and safety of sirukumab in Japanese patients with active rheumatoid arthritis who were refractory or intolerant to anti-tumor necrosis factor therapy: Subgroup analysis of a randomized, double-blind, multicenter, phase 3 study (SIRROUND-T).

scientific article published on 13 March 2018

Efficacy and safety of sirukumab in Japanese patients with moderate to severe rheumatoid arthritis inadequately controlled by disease modifying anti-rheumatic drugs: Subgroup analysis of a phase 3 study.

scientific article

Efficacy and safety of tabalumab plus standard of care in Japanese patients with active systemic lupus erythematosus: Subgroup analyses of the ILLUMINATE-1 study

scientific article published on 29 July 2016

Efficacy and safety of the oral Janus kinase inhibitor peficitinib (ASP015K) monotherapy in patients with moderate to severe rheumatoid arthritis in Japan: a 12-week, randomised, double-blind, placebo-controlled phase IIb study

scientific article

Efficacy and safety of tofacitinib as monotherapy in Japanese patients with active rheumatoid arthritis: a 12-week, randomized, phase 2 study

scientific article published on July 2015

Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study).

scientific article

Efficacy of denosumab combined with bDMARDs on radiographic progression in rheumatoid arthritis

scientific article

Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis

scientific article

Efficacy, safety, pharmacokinetics and immunogenicity of abatacept administered subcutaneously or intravenously in Japanese patients with rheumatoid arthritis and inadequate response to methotrexate: a Phase II/III, randomized study

article

Elevated Serum Krebs von den Lungen-6 in Early Disease Predicts Subsequent Deterioration of Pulmonary Function in Patients with Systemic Sclerosis and Interstitial Lung Disease

scientific article published in August 2016

Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease

scientific article published on 13 July 2016

Enlargement of thymoma triggers overlapping autoimmune diseases

scientific article published on 27 April 2016

Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC).

scientific article published on 9 November 2017

Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis.

scientific article published on 4 March 2015

Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjogren's syndrome

scientific article published on 01 January 1993

Factors Predicting the Therapeutic Response to Methotrexate in Japanese Patients with Rheumatoid Arthritis: A Hospital-Based Cohort Study

scientific article published on 01 January 2018

Factors associated with successful discontinuation of certolizumab pegol in early rheumatoid arthritis

scientific article published on 19 January 2020

Fcγ receptor 3B polymorphism is associated with hypersensitivity reactions to adalimumab in Japanese patients with rheumatoid arthritis

scientific article

Fcγ receptor IIIb polymorphism and use of glucocorticoids at baseline are associated with infusion reactions to infliximab in patients with rheumatoid arthritis ⬇️

scientific article published on October 27, 2010

Flow Cytometric Analysis of Surface Antigens on Human Conjunctival Epithelial Cells

article

Follicular helper T cells in the pathogenesis of IgG4-related disease.

scientific article

Functional Differences of Anti-T-Cell Antibody in Patients with Systemic Lupus Erythematosus and Ulcerative Colitis

scientific article published on 01 December 1983

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

scientific article published on 8 November 2017

Glomerulomegaly in lupus nephritis: a prognostic marker for renal outcomes

scientific article published on 14 July 2015

Granulomatous amoebic encephalitis caused by Acanthamoeba in a patient with systemic lupus erythematosus

scientific article published in January 1998

High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the

scientific article published on 2 September 2017

IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse

scientific article published in Scientific Reports

Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1

scientific article published on 18 November 2019

Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study

scientific article published on 19 July 2016

Identification of definitive serum biomarkers associated with disease activity in primary Sjögren's syndrome

scientific article published on 14 May 2016

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndrome

scientific article published on 22 June 2020

IgG4-Related Disease: Beyond Glucocorticoids.

scientific article published on 15 March 2018

IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialadenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation

scientific article published on 05 May 2010

IgG4-related disease involving vital organs diagnosed with lip biopsy: A case report and literature review

scientific article published on June 2016

IgG4-related fibrosing mediastinitis diagnosed with computed tomography-guided percutaneous needle biopsy: Two case reports and a review of the literature

scientific article published on 01 June 2018

Imatinib mesylate inhibits proliferation of rheumatoid synovial fibroblast-like cells and phosphorylation of Gab adapter proteins activated by platelet-derived growth factor

scientific article

Immunogenicity of Biologics in Chronic Inflammatory Diseases: A Systematic Review

scientific article

Immunological characteristics of patients with vernal keratoconjunctivitis

scientific article published on 01 May 2002

Impact of Adalimumab on Work Productivity and Activity Impairment in Japanese Patients with Rheumatoid Arthritis: Large-Scale, Prospective, Single-Cohort ANOUVEAU Study.

scientific article published on 31 January 2017

Impact of subclinical synovitis in ankles and feet detected by ultrasonography in patients with rheumatoid arthritis

scientific article published on 18 October 2018

Importance of Obtaining Remission for Work Productivity and Activity of Patients with Rheumatoid Arthritis

scientific article published on 15 May 2017

In Vitro Immune Response of SLE Lymphocytes

article

In vitro anti-DNA antibody synthesis by peripheral blood lymphocytes in patients with systemic lupus erythematosus

scientific article published on 01 November 1981

Incidence and risk factors for serious infection in patients with rheumatoid arthritis treated with tumor necrosis factor inhibitors: a report from the Registry of Japanese Rheumatoid Arthritis Patients for Longterm Safety

scientific article published on 15 April 2011

Increased proportion of a CD38highIgD+ B cell subset in peripheral blood is associated with clinical and immunological features in patients with primary Sjögren's syndrome.

scientific article published on 20 October 2017

Inflammatory tenosynovitis and enthesitis induced by immune checkpoint inhibitor treatment.

scientific article published on 17 February 2018

Infliximab and etanercept have distinct actions but similar effects on cytokine profiles in rheumatoid arthritis

scientific article published on 18 June 2015

Inhibition of plasma IL-6 in addition to maintenance of an efficacious trough level of infliximab associated with clinical remission in patients with rheumatoid arthritis: analysis of the RISING Study ⬇️

scientific article published on May 5, 2012

Initial presentation determines clinical entity in patients with anti-centromere antibody positivity

scientific article published on 14 November 2018

Integrin VLA-5 Negative Primary Plasma Cell Leukemia

scientific article published on 01 July 1993

Interferon α-targeted therapy.

scientific article published on January 2013

Interleukin-4 contributes to the shift of balance of IgG subclasses toward IgG4 in IgG4-related disease

scientific article published on 31 May 2018

Interleukin-6 in idiopathic multicentric Castleman's disease after long-term tocilizumab

scientific article published in September 2017

Intravenous epoprostenol treatment of patients with connective tissue disease and pulmonary arterial hypertension at a single center

scientific article published on 29 January 2013

Intriguing Findings of the Muscle on Magnetic Resonance Imaging in Polyarteritis Nodosa

scientific article published on November 2016

Investigating sirukumab for rheumatoid arthritis: 2-year results from the phase III SIRROUND-D study

scientific article published on 16 November 2018

Involvement of αEβ7 (CD103) in the pathogenesis of autoimmune diseases

scientific article published in January 2014

Is type 2 diabetes mellitus an inverse risk factor for the development of rheumatoid arthritis?

scientific article published on 08 September 2020

Lacrimation and Salivation are Not Related to Lymphocytic Infiltration in Lacrimal and Salivary Glands in MRL lpr/lpr Mice ⬇️

scientific article published on 01 January 1998

Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term non-steroidal anti-inflammatory drug (NSAID) therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial ⬇️

scientific article published on March 3, 2012

Leflunomide-induced interstitial lung disease: prevalence and risk factors in Japanese patients with rheumatoid arthritis

scientific article published on 25 March 2009

Long-term efficacy and safety of certolizumab pegol in Japanese rheumatoid arthritis patients who could not receive methotrexate: 52-week results from an open-label extension of the HIKARI study

scientific article

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study.

scientific article

Long-term safety and efficacy of treatment with subcutaneous abatacept in Japanese patients with rheumatoid arthritis who are methotrexate inadequate responders

scientific article published on 01 September 2015

Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis

scientific article published on 16 June 2020

Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study.

scientific article published on 14 March 2017

Manifestations mimicking relapsing polychondritis in a patient with microscopic polyangiitis

scientific article published in April 2005

Messenger ribonucleic acid expression profile in peripheral blood cells from RA patients following treatment with an anti-TNF-alpha monoclonal antibody, infliximab

scientific article

Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis

scientific article published on 15 June 2016

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye

scientific article

Mitogenic Responses to Lipopolysaccharide by B Lymphocytes from Patients with Systemic Lupus Erythematosus

article

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

scientific article published on 18 May 2017

Mutations in T cell Receptor ζ Chain mRNA of Peripheral T cells from Systemic Lupus Erythematosus Patients ⬇️

scientific article published on October 1, 1998

No increased mortality in patients with rheumatoid arthritis treated with biologics: results from the biologics register of six rheumatology institutes in Japan

scientific article published on 17 October 2012

Notable difference between the development of vertebral fracture and osteonecrosis of the femoral head in patients treated with high-dose glucocorticoids for systemic rheumatic diseases.

scientific article

Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease.

scientific article published in September 2015

Obstacles to the implementation of the treat-to-target strategy for rheumatoid arthritis in clinical practice in Japan

scientific article published on 20 June 2014

Osteolytic change of distal interphalangeal joints and sacroiliac joints in subluxing arthropathy associated with anti-Jo-1 antibody

scientific article

Overview of lupus nephritis management guidelines and perspective from Asia.

scientific article published on 31 October 2013

Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response.

scientific article

Persistent fever and destructive arthritis caused by dialysis-related amyloidosis: A case report.

scientific article published in January 2018

Pharmacokinetics, efficacy and safety profiles of etanercept monotherapy in Japanese patients with rheumatoid arthritis: review of seven clinical trials

scientific article

Phase II dose-response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate.

scientific article published on 9 June 2012

Phase III, multicenter, open-label, long-term study of the safety of abatacept in Japanese patients with rheumatoid arthritis and an inadequate response to conventional or biologic disease-modifying antirheumatic drugs

scientific article

Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab: a retrospective review and case-control study of 21 patients.

scientific article published on March 2009

Polarization diversity of human CD4+ stem cell memory T cells

scientific article published on 27 April 2015

Polychondritis presenting with oculomotor and abducens nerve palsies as the initial manifestation

scientific article published on 02 June 2014

Polymyositis with elevated serum IgG4 levels and abundant IgG4+ plasma cell infiltration: A case report and literature review

scientific article published in December 2017

Poor renal outcomes in patients with anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis and normal renal function at diagnosis

scientific article published on 7 January 2016

Post-marketing surveillance of the safety and effectiveness of tacrolimus in 3,267 Japanese patients with rheumatoid arthritis

scientific article published in January 2014

Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results

scientific article published on 19 July 2017

Pre-treatment interleukin-6 levels strongly affect bone erosion progression and repair detected by magnetic resonance imaging in rheumatoid arthritis patients

scientific article published on 8 March 2017

Prediction of clinical response after 1 year of infliximab therapy in rheumatoid arthritis based on disease activity at 3 months: posthoc analysis of the RISING study

scientific article published on 15 February 2015

Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transcriptome analysis of white blood cells

scientific article published on 3 July 2009

Predictors of Favorable Responses to Immunosuppressive Treatment in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease.

scientific article

Predictors of new bone erosion in rheumatoid arthritis patients receiving conventional synthetic disease-modifying antirheumatic drugs: Analysis of data from the DRIVE and DESIRABLE studies

scientific article published on 09 January 2020

Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study ⬇️

scholarly article by Yoshiya Tanaka et al published 28 December 2012 in Modern Rheumatology

Primary and secondary surveys on epidemiology of Sjögren's syndrome in Japan

scientific article published on 5 November 2013

Primary natural killer cell lymphoma of the lacrimal sac.

scientific article published in October 2001

Proteinuria selectivity index as a prognostic biomarker in lupus nephritis.

scientific article

Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.

scientific article published on 28 August 2014

Pulmonary Cryptococcosis Developed from a Nodule after Treatment with Infliximab for Arthritis Associated with Ulcerative Colitis

scientific article published in April 2017

Pulmonary Vein Vasculitis Presenting as Multiple Pulmonary Nodules in a Patient with Systemic Lupus Erythematosus

scientific article published on 01 March 2019

Quantitative analysis of lacrimal gland function, apoptotic figures, Fas and Fas ligand expression of lacrimal glands in dry eye patients.

scientific article

RANKL: A therapeutic target for bone destruction in rheumatoid arthritis

scientific article published on 7 September 2017

Randomised clinical trial: esomeprazole for the prevention of nonsteroidal anti‐inflammatory drug‐related peptic ulcers in Japanese patients ⬇️

scientific article published on May 16, 2012

Rapid Proliferation of a Different Clone Early after Autologous Peripheral Blood Stem Cell Transplantation for Non-Hodgkin’s Lymphoma

scientific article published on 01 October 2002

Recovery of clinical but not radiographic outcomes by the delayed addition of adalimumab to methotrexate-treated Japanese patients with early rheumatoid arthritis: 52-week results of the HOPEFUL-1 trial.

scientific article published on 17 January 2014

Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus ⬇️

scientific article published on September 6, 2010

Reduction of plasma IL-6 but not TNF-α by methotrexate in patients with early rheumatoid arthritis: a potential biomarker for radiographic progression

scientific article published on 11 June 2013

Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome

scientific article published on 21 October 2011

Remission induction by Raising the dose of Remicade in RA (RRRR) study: Rationale and study protocol for a randomized controlled trial comparing for sustained clinical remission after discontinuation of infliximab in patients with rheumatoid arthrit

scientific article

Resolution of elevated circulating regulatory T cells by corticosteroids in patients with IgG4-related dacryoadenitis and sialoadenitis

scientific article published on 19 September 2015

Respiratory syncytial virus-induced interleukin-4 production by human conjunctival epithelial cells contributes to allergy: preliminary study

scientific article published in June 1998

Response to e-letter: 'Tocilizumab in patients with adult-onset Still's disease refractory to glucocorticoid treatment' by Lee

scientific article published on 10 November 2018

Response to: 'Denosumab, cortical bone and bone erosion in rheumatoid arthritis' by Rossini et al.

scientific article published on 23 August 2016

Response to: ‘When is it not ethical to withhold treatment for rheumatoid arthritis?’ by Dr Yusuf Yazici

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Restoration of Decreased T Helper 1 and CD8+ T Cell Subsets Is Associated With Regression of Lymphoproliferative Disorders Developed During Methotrexate Treatment

scientific article published on 4 April 2018

Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study

scientific article published on 01 January 2014

Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year outcome of joint destruction (RECONFIRM-2J).

scientific article published on 21 May 2008

Revolutionary Change in Rheumatoid Arthritis Managementwith Biological Therapy ⬇️

scientific article published on January 1, 2011

Risk factors for abnormal hepatic enzyme elevation by methotrexate treatment in patients with rheumatoid arthritis: A hospital based-cohort study.

scientific article published on 18 December 2017

Risk factors for the recurrence of interstitial lung disease in patients with polymyositis and dermatomyositis: a retrospective cohort study.

scientific article published on 3 October 2017

Safety and effectiveness of 6 months' etanercept monotherapy and combination therapy in Japanese patients with rheumatoid arthritis: effect of concomitant disease-modifying antirheumatic drugs

scientific article published in August 2013

Safety and effectiveness of abatacept in Japanese non-elderly and elderly patients with rheumatoid arthritis in an all-cases post-marketing surveillance

scientific article published on 25 October 2018

Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of 7740 patients

scientific article published on 6 November 2013

Safety and effectiveness of peficitinib (ASP015K) in patients with rheumatoid arthritis: interim data (22.7 months mean peficitinib treatment) from a long-term, open-label extension study in Japan, Korea, and Taiwan

scientific article published on 12 March 2020

Safety and effectiveness of tacrolimus add-on therapy for rheumatoid arthritis patients without an adequate response to biological disease-modifying anti-rheumatic drugs (DMARDs): Post-marketing surveillance in Japan

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Safety and efficacy of CT-P13 in Japanese patients with rheumatoid arthritis in an extension phase or after switching from infliximab.

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Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs.

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Safety of Biologic Agents in Elderly Patients with Rheumatoid Arthritis

scientific article published on 01 September 2016

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis.

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Secukinumab after anti-tumour necrosis factor-α therapy: a phase III study in active rheumatoid arthritis.

scientific article published on 20 February 2018

Sensitivity and specificity of 2010 rheumatoid arthritis classification criteria

scientific article published on 3 February 2011

Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.

scientific article published on 14 December 2015

Severe degenerative change of multiple organs mediated by chronic active Epstein-Barr virus infection with infected T-cell expansion

scientific article published on 23 April 2008

Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis

scientific article published on 30 December 2019

Simplified Disease Activity Index remission at month 6 is an independent predictor of functional and structural remissions at month 12 during abatacept treatment in patients with rheumatoid arthritis: A multi-center, prospective cohort study in Japa

scientific article published on 16 November 2016

Single center prospective study of tacrolimus efficacy and safety in the treatment of various manifestations in systemic lupus erythematosus

scientific article published on 19 February 2010

Single center prospective study of tacrolimus efficacy and safety in treatment of rheumatoid arthritis

scientific article published on 7 January 2009

Sirukumab for rheumatoid arthritis: the phase III SIRROUND-D study

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Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patients.

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Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis

scientific article published on 13 January 2018

Spontaneous production of antibodies to deoxyribonucleic acids in patients with systemic lupus erythematosus

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Successful resumption of tocilizumab for rheumatoid arthritis after resection of a pulmonary Mycobacterium avium complex lesion: a case report

scientific article published on 23 October 2015

Successful treatment of adult-onset Still’s disease with tocilizumab monotherapy: two case reports and literature review ⬇️

scientific article published on 04 January 2012

Successful treatment of embryo implantation failure in patients with the Sjögren syndrome with low-dose prednisolone

scientific article published in March 2001

Suppression of in Vitro Production of Anti-U1-Ribonucleoprotein Antibody by Monoclonal Anti-Idiotypic Antibody to Anti-U1-Ribonucleoprotein Antibody

scientific article published on 01 December 1988

Suppression of infliximab antibody levels by azathioprine in patients with rheumatoid arthritis.

scientific article published in February 2017

Suppression of rheumatoid factor synthesis by antiidiotypic antibody in rheumatoid arthritis patients with cross-reactive idiotypes

scientific article published in August 1985

Suppressor t cell function in patients with rheumatoid arthritis complicated by vasculitis

scientific article published on 01 July 1984

Sustainable Efficacy of Switching From Intravenous to Subcutaneous Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis

scientific article published on April 2015

Systemic lupus erythematosus with necrotizing vasculitis and upregulated expression of VLA-4 antigen

scientific article published on 01 May 1995

T cell abnormalities in systemic lupus erythematosus.

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TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus

scientific article published in July 1998

TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients.

scientific article published on 5 September 2006

Targeted antibody therapy and relevant novel biomarkers for precision medicine for rheumatoid arthritis.

scientific article published on 24 October 2017

Ten-year observation of patients with primary Sjögren's syndrome: Initial presenting characteristics and the associated outcomes

scientific article published on 26 December 2018

Tendonitis on the Fingers in Behçet's Disease

scientific article published on 30 March 2018

The 2H4 molecule but not the T3-receptor complex is involved in suppressor inducer signals in the AMLR system

scientific article published on 01 June 1987

The Japanese experience with biologic therapies for rheumatoid arthritis.

scientific article published on 28 September 2010

The effect of tocilizumab on preventing relapses in adult-onset Still's disease: A retrospective, single-center study

scientific article published on 17 November 2014

The efficacy and safety of subcutaneous clazakizumab in patients with moderate-to-severe rheumatoid arthritis and an inadequate response to methotrexate: results from a multinational, phase IIb, randomized, double-blind, placebo/active-controlled, d

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The multicenter study of a new assay for simultaneous detection of multiple anti-aminoacyl-tRNA synthetases in myositis and interstitial pneumonia

scientific article published on 14 January 2014

The presence of anti-protein A antibodies in patients with rheumatoid arthritis

scientific article published in May 1991

Therapy of inflammatory immune diseases. 3) Anti-TNF therapy for articular rheumatism

scientific article published on 01 September 2006

Time lag between the initiation of adalimumab after methotrexate correlates with the efficacy of adalimumab in rheumatoid arthritis patients.

scientific article published on 27 December 2015

Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the S

scientific article published on 31 May 2018

Tocilizumab in patients with adult-onset still's disease refractory to glucocorticoid treatment: a randomised, double-blind, placebo-controlled phase III trial

scientific article published on 02 October 2018

Tocilizumab is clinically, functionally, and radiographically effective and safe either with or without low-dose methotrexate in active rheumatoid arthritis patients with inadequate responses to DMARDs and/or TNF inhibitors: a single-center retrospe

scientific article published in April 2014

Tocilizumab is effective against polymyalgia rheumatica: experience in 13 intractable cases.

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Tofacitinib, an oral Janus kinase inhibitor, as monotherapy or with background methotrexate, in Japanese patients with rheumatoid arthritis: an open-label, long-term extension study

scientific article published on 28 January 2016

Tolerability and efficacy of abatacept in Japanese patients with rheumatoid arthritis: a phase I study ⬇️

scholarly article by Tsukasa Matsubara et al published 26 July 2012 in Modern Rheumatology

Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies

scientific article published on 15 July 2016

Translating IL-6 biology into effective treatments

scientific article published on 23 April 2020

Treating Rheumatoid Arthritis to Target: multinational recommendations assessment questionnaire

scientific article published on 29 July 2011

Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force ⬇️

scientific article published on 12 May 2015

Treatment of Inflammatory Immunologic Disease 3. Anti-TNF Therapy in Rheumatoid Arthritis

scientific article published on 15 August 2007

Treatment of rheumatoid arthritis with biological agents - as a typical and common immune-mediated inflammatory disease.

scientific article published in January 2017

Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial

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Trend of patient characteristics and its impact on the response to adalimumab in patients with rheumatoid arthritis: post hoc time-course analysis of an all-case PMS in Japan

scientific article published on 13 January 2015

Up-regulation of αEβ7, a novel integrin adhesion molecule, on T cells from systemic lupus erythematosus patients with specific epithelial involvement ⬇️

scientific article published on August 1, 1998

Utility of Dose Frequency Adjustment in Tocilizumab Administration for Rheumatoid Arthritis

scientific article published on 15 March 2017

Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients

scientific article published on 28 December 2012

Value of labial salivary gland histopathology for diagnosis of Sjögren's syndrome in patients with anti-centromere antibody positivity

scientific article published on 20 July 2020

What is the future of CCR5 antagonists in rheumatoid arthritis?

scientific article published on 30 March 2012

[Recent progress in the medical treatment of rheumatoid arthritis]

scientific article published on 01 March 2007

[Respiratory failure in polymyositis and dermatomyositis: differential diagnosis between pulmonary infection and interstitial pneumonitis]

scientific article published on 01 May 1998

lnterleukin-4 and IgE in Seasonal Allergic Conjunctivitis

scientific article published on 01 January 1996

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