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List of works by Dyfrig A. Hughes

'Seizure First Aid Training' for people with epilepsy who attend emergency departments, and their family and friends: study protocol for intervention development and a pilot randomised controlled trial.

scientific article published on 24 July 2015

062 Abolition of prescription co-payments in Wales: an observational study on dispensing rates

A Fully Integrated Real-Time Detection, Diagnosis, and Control of Community Diarrheal Disease Clusters and Outbreaks (the INTEGRATE Project): Protocol for an Enhanced Surveillance System

scientific article published on 26 September 2019

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE)

scientific article published on 24 December 2020

A Risk–Benefit Assessment of Prasugrel, Clopidogrel, and Genotype-Guided Therapy in Patients Undergoing Percutaneous Coronary Intervention

scientific article published on 28 March 2012

A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions.

scientific article published on 16 March 2016

A Systematic Review of Patients' Perspectives on the Subcutaneous Route of Medication Administration

scientific article

A framework for planning and critiquing medication compliance and persistence research using prospective study designs

scientific article published on February 2009

A global survey of antibiotic leftovers in the outpatient setting

scientific article published on 22 October 2007

A new taxonomy for describing and defining adherence to medications

scientific article

A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial).

scientific article published on 09 January 2014

A randomised, patient-assessor blinded, sham-controlled trial of external non-invasive peripheral nerve stimulation for chronic neuropathic pain following peripheral nerve injury (EN-PENS trial): study protocol for a randomised controlled trial.

scientific article published on 06 December 2016

A systematic review and empirical analysis of the relation between dose and duration of drug action

scientific article published on October 2009

A systematic review of cost-effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives

scientific article published on July 2010

A systematic review of economic evaluations of advanced therapy medicinal products

scientific article published on 10 March 2020

A “Bundle of Care” to Improve Anticoagulation Control in Patients Receiving Warfarin in Uganda and South Africa: Protocol for an Implementation Study

scientific article published in 2023

Abolition of prescription charges in Wales: the impact on medicines use in those who used to pay.

scientific article published on 5 October 2010

Abolition of prescription copayments in Wales: an observational study on dispensing rates.

scientific article published on 31 March 2010

Accounting for Noncompliance in Pharmacoeconomic Evaluations

scientific article published on January 1, 2001

Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis: a RCT

scientific article published on 01 April 2019

Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis

scientific article published in April 2017

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort

scientific article

Adherence of patients to long-term medication: a cross-sectional study of antihypertensive regimens in Austria.

scientific article published on 24 April 2015

Affordable orphan drugs: a role for not-for-profit organizations

scientific article published on 20 January 2017

An explanatory randomised controlled trial of a nurse-led, consultation-based intervention to support patients with adherence to taking glucose lowering medication for type 2 diabetes ⬇️

scientific article

Beyond registration--measuring the public-health potential of new treatments for malaria in Africa

scientific article

Biosimilars: evidential standards for health technology assessment.

scientific article published on March 2010

CATheter Infections in CHildren (CATCH): a randomised controlled trial and economic evaluation comparing impregnated and standard central venous catheters in children

scientific article

Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT

scientific article published on 01 May 2020

Challenges for Economic Evaluation of Health Care Strategies to Contain Antimicrobial Resistance

scientific article published on 27 September 2019

Challenges in the development and reimbursement of personalized medicine-payer and manufacturer perspectives and implications for health economics and outcomes research: a report of the ISPOR personalized medicine special interest group

scientific article published on 7 September 2012

Cisplatin plus vinorelbine or gemcitabine in patients with advanced non-small cell lung cancer: pharmacoeconomic considerations

scientific article published in July 2005

Climate influences on the cost-effectiveness of vector-based interventions against malaria in elimination scenarios

scientific article

Clinical pharmacology: special safety considerations in drug development and pharmacovigilance

scientific article published on January 2004

Community views on factors affecting medicines resource allocation: cross-sectional survey of 3080 adults in Australia

scientific article published on 19 April 2018

Comparative effectiveness of dabigatran, rivaroxaban, apixaban, and warfarin in the management of patients with nonvalvular atrial fibrillation.

scientific article published on 25 April 2013

Comparing Generic and Condition-Specific Preference-Based Measures in Epilepsy: EQ-5D-3L and NEWQOL-6D.

scientific article published on 25 May 2016

Conducting Economic Evaluations Alongside Randomised Trials: Current Methodological Issues and Novel Approaches

scientific article

Core Health Outcomes In Childhood Epilepsy (CHOICE): protocol for the selection of a core outcome set.

scientific article published on 28 November 2017

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus.

scientific article published on 25 April 2019

Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial.

scientific article published on 7 April 2009

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout

scientific article published in October 2017

Cost minimization of on-demand maintenance therapy with proton pump inhibitors in nonerosive gastroesophageal reflux disease

scientific article published on February 2005

Cost-Effectiveness Analysis of the Use of Point-of-Care C-Reactive Protein Testing to Reduce Antibiotic Prescribing in Primary Care

scholarly article by Emily A F Holmes et al published 7 December 2018 in Antibiotics (Basel, Switzerland)

Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework

scientific article published on 28 January 2019

Cost-Effectiveness of Pediatric Central Venous Catheters in the UK: A Secondary Publication from the CATCH Clinical Trial

scientific article published on 19 September 2017

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity

scientific article

Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with Juvenile Idiopathic Arthritis

scientific article published on 16 October 2018

Cost-effectiveness analysis of extended-release formulations of oxybutynin and tolterodine for the management of urge incontinence

scientific article

Cost-effectiveness of HLA-B*15:02 screening in Malaysia.

scientific article

Cost-effectiveness of biological therapy for Crohn's disease: Markov cohort analyses incorporating United Kingdom patient-level cost data

scientific article

Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden

scientific article

Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs

scientific article published on September 2012

Cost-effectiveness of pharmacogenetics-guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation.

scientific article published on 23 September 2013

Costs of medication nonadherence in patients with diabetes mellitus: a systematic review and critical analysis of the literature

scientific article

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?

scientific article published in August 2007

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses

scientific article

Decision-makers' preferences for approving new medicines in Wales: a discrete-choice experiment with assessment of external validity

scientific article

Defining rewardable innovation in drug therapy

scientific article published on 30 March 2012

Development of a database of instruments for resource-use measurement: purpose, feasibility, and design

scientific article

Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review.

scientific article published on 26 April 2017

Does electronic monitoring influence adherence to medication? Randomized controlled trial of measurement reactivity. ⬇️

scientific article

ESPACOMP Medication Adherence Reporting Guideline (EMERGE)

scientific article published on 26 June 2018

ESPACOMP Medication Adherence Reporting Guidelines (EMERGE): a reactive-Delphi study protocol

scientific article published on 10 February 2017

Early impact of COVID-19 social distancing measures on reported sexual behaviour of HIV pre-exposure prophylaxis users in Wales

scientific article published on 23 September 2020

Economic Impact of Emergency Visits due to Drug-Related Morbidity on a Brazilian Hospital

scientific article published on 25 April 2017

Economic Studies in Motor Neurone Disease: A Systematic Methodological Review

scientific article published on 14 December 2016

Economic analysis of on-demand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease

scientific article published in January 2005

Economic evaluation of a behavior-modifying intervention to enhance antiepileptic drug adherence.

scientific article published on 26 March 2015

Economic impact of poor compliance with pharmaceuticals

scientific article published on August 2002

Economics of Pharmacogenetic-Guided Treatments: Underwhelming or Overstated?

scientific article published on 13 February 2018

Estimating drug costs in economic evaluations in Ireland and the UK: an analysis of practice and research recommendations

scientific article published on January 2009

Estimation of the impact of noncompliance on pharmacokinetics: an analysis of the influence of dosing regimens

scientific article published on April 2008

Evaluation of a consultant audit and feedback programme to improve the quality of antimicrobial prescribing in acute medical admissions

scientific article

Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials

scientific article published on 01 September 2019

Feasibility, validity and reliability of the Welsh version of the EQ-5D health status questionnaire

scientific article published on 25 July 2007

Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.

scientific article published on July 2014

Folate augmentation of treatment - evaluation for depression (FolATED): protocol of a randomised controlled trial

scientific article

Follow-up of cancer in primary care versus secondary care: systematic review

scientific article published on July 2009

From NCE to NICE: the role of pharmacoeconomics

scientific article published on September 2010

Generalisability and Cost-Impact of Antibiotic-Impregnated Central Venous Catheters for Reducing Risk of Bloodstream Infection in Paediatric Intensive Care Units in England. ⬇️

scientific article

Generic and therapeutic substitutions in the UK: are they a good thing?

scientific article

Generic substitution: authors' response.

scientific article

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study

scientific article published in October 2009

Health-Economic Evaluation of Clostridium Difficile Infection (Cdi) And Epidemiology In England And Merseyside

scientific article published on 20 October 2015

Identification Of Items For A Standardised Resource-Use Measure: Review Of Current Instruments

scientific article published on 20 October 2015

Identification and assessment of adherence-enhancing interventions in studies assessing medication adherence through electronically compiled drug dosing histories: a systematic literature review and meta-analysis

scientific article

Identification of items for a standardised resource-use measure: review of current instruments.

scientific article published on 16 November 2015

Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model

scientific article published on 26 July 2018

Impact of interventions on medication adherence and blood pressure control in patients with essential hypertension: a systematic review by the ISPOR medication adherence and persistence special interest group

scientific article published on 04 July 2013

Impact of non-adherence on the safety and efficacy of uric acid-lowering therapies in the treatment of gout.

scientific article

Impact of the phased abolition of co-payments on the utilisation of selected prescription medicines in Wales.

scientific article

Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial

scientific article

Innovation at the Intersection of Clinical Trials and Real-World Data Science to Advance Patient Care

scientific article published on 16 May 2018

Is exercise effective in promoting mental well-being in older age? A systematic review.

scientific article published on August 2010

Less is More: Medicines that Require Less Frequent Administration Improve Adherence, but Are They Better?

article

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC)

scientific article published on 31 July 2018

Letter to the Editor. Phase III randomized controlled trials are essential to properly evaluate the role of radiotherapy in WHO grade II meningioma

scientific article published on 17 August 2018

Managing access to advanced therapy medicinal products: Challenges for NHS Wales

scientific article published on 03 June 2020

Mapping ALSFRS-R and ALSUI to EQ-5D in Patients with Motor Neuron Disease

scientific article published on 26 July 2018

Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi

scientific article published on 26 August 2009

Mechanism-based approach to the economic evaluation of pharmaceuticals: pharmacokinetic/pharmacodynamic/pharmacoeconomic analysis of rituximab for follicular lymphoma

scientific article published on May 2012

Medication adherence-Key considerations for clinical pharmacologists

scientific article published on 25 February 2020

Medicines concordance and game theory

scientific article published on 11 July 2008

Methods for integrating medication compliance and persistence in pharmacoeconomic evaluations

scientific article published on November 2007

Methods for the collection of resource use data within clinical trials: a systematic review of studies funded by the UK Health Technology Assessment program

scientific article

Multiple imputation of multiple multi-item scales when a full imputation model is infeasible

scientific article published on 26 January 2016

NICE and new: appraising innovation

scientific article published in the British Medical Journal

NICE recommendations: why no disinvestment recommendations to offset investment decisions?

scientific article published in the British Medical Journal

Nerve root block versus surgery (NERVES) for the treatment of radicular pain secondary to a prolapsed intervertebral disc herniation: study protocol for a multi-centre randomised controlled trial

scientific article published on 05 September 2018

New Medicines in Wales: The All Wales Medicines Strategy Group (AWMSG) Appraisal Process and Outcomes

scientific article published on 8 March 2018

New advice on switching antiepileptic drugs might be a false economy.

scientific article published on 16 December 2013

New drugs for old: disinvestment and NICE

scientific article published in the British Medical Journal

Non-compliance with antibiotic therapy for acute community infections: a global survey

scientific article

Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review

scientific article published on April 2009

Opportunity Costs of Implementing Nice Decisions in NHS Wales

Opportunity costs and local health service spending decisions: a qualitative study from Wales

scientific article

Orphan drugs revisited: author's response

article

P12.10 The ROAM / EORTC 1308 trial: Radiation versus observation following surgical resection of atypical meningioma - study update.

scientific article published on 19 April 2017

PAA4 ADVERSE DRUG REACTIONS IN ECONOMIC EVALUATIONS

PCV100 INTERVENTIONS TO IMPROVE COMPLIANCE WITH LIPID LOWERING MEDICATIONS: A SYSTEMATIC REVIEW OF THE LITERATURE

scholarly article by A Zuluaga et al published May 2010 in Value in Health

PCV21 A BENEFIT-RISK ASSESSMENT OF USING CYP2C19 GENOTYPE INFORMATION TO GUIDE ANTIPLATELET THERAPY IN PATIENTS WITH ACUTE CORONARY SYNDROME

PGI2 BIOLOGICAL AGENTS FOR THE MANAGEMENT OF CROHN'S DISEASE IN ADULTS:A SYSTEMATIC REVIEW, META-ANALYSIS AND MULTIPLE TREATMENT COMPARISON

article

PHP39 PUBLIC FUNDING OF DRUGS FOR ORPHAN DISEASES

PHP4 FACTORS INFLUENCING USER CHOICES TO VISIT EITHER GENERAL PRACTITIONERS OR COMMUNITY PHARMACISTS FOR MINOR AILMENTS—A DISCRETE CHOICE EXPERIMENT

PIN38 ASSESSING THE ASSOCIATION BETWEEN COMPLIANCE AND THERAPEUTIC FAILURE FOR ANTIRETROVIRAL DRUGS IN HIV POSITIVE PATIENTS

article

PMC21 FEASIBILITY, VALIDITY AND RELIABILITY OF THE WELSH VERSION OF THE EQ-5D HEALTH STATUS QUESTIONNAIRE

article

PMC41 METHODOLOGICAL ISSUES IN THE LITERATURE ON COSTS OF NON-COMPLIANCE IN CHRONIC DISEASES

PMH52 COSTS OF NON-COMPLIANCE WITH ANTIPSYCHOTIC MEDICATIONS AMONG PATIENTS WITH SCHIZOPHRENIA

PMS49 TRENDS IN THE PRESCRIBING OF CONVENTIONAL ANTIRHEUMATIC THERAPY AMONG CANADIANS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE COHORT STUDY

article

POS5 LITERATURE REVIEW ON THE COSTS OF NON-COMPLIANCE IN OSTEOPOROSIS

article

Parenting programme for parents of children at risk of developing conduct disorder: cost effectiveness analysis

scientific article published on 9 March 2007

Patient-Focused Drug Development Methods for Benefit-Risk Assessments: A Case Study Using a Discrete Choice Experiment for Antiepileptic Drugs

scientific article published on 25 October 2018

Patients' and healthcare professionals' views of cancer follow-up: systematic review

scientific article published on July 2009

Pharmacoeconomics

Pharmacoeconomics: principles and relevance to the activities of drug and therapeutics committees.

scientific article published on October 2009

Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery

scientific article

Pharmacogenetic tests: the need for a level playing field

scientific article published on 01 January 2013

Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

scientific article published in March 2006

Predicting "real world" effectiveness by integrating adherence with pharmacodynamic modeling

scientific article published on July 2003

Predicting adherence to medications using health psychology theories: a systematic review of 20 years of empirical research

scientific article published on December 2014

Predictors of self-reported adherence to antihypertensive medicines: a multinational, cross-sectional survey.

scientific article published on March 2015

Prof. John Urquhart

scientific article published on 2 May 2016

Profitability and Market Value of Orphan Drug Companies: A Retrospective, Propensity-Matched Case-Control Study

scientific article

Rare Disease Terminology and Definitions-A Systematic Global Review: Report of the ISPOR Rare Disease Special Interest Group

scientific article

Rare disease prevention and treatment: the need for a level playing field

scientific article published on 12 January 2018

Rationing of Drugs for Rare Diseases

Reimbursement decisions of the All Wales Medicines Strategy Group: influence of policy and clinical and economic factors.

scientific article published in September 2012

Renal transplant patients' preference for the supply and delivery of immunosuppressants in Wales: a discrete choice experiment

scientific article published on 2 October 2017

Reply

Resource-use measurement based on patient recall: issues and challenges for economic evaluation

scientific article

Review of the use of resource use instruments based on patient recall in relation to other methods of resource use estimation

scientific article published on 29 November 2013

Ring-fencing a budget for cancer drugs: is it fair?

Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods

scientific article published on 01 May 2018

Societal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia.

scientific article

Societal views on NICE, cancer drugs fund and value-based pricing criteria for prioritising medicines: a cross-sectional survey of 4118 adults in Great Britain

scientific article published on 7 September 2012

Statistical Methods for Adjusting Estimates of Treatment Effectiveness for Patient Nonadherence in the Context of Time-to-Event Outcomes and Health Technology Assessment: A Systematic Review of Methodological Papers

scientific article published on 24 October 2019

Study protocol for a randomised controlled trial of insulin delivery by continuous subcutaneous infusion compared to multiple daily injections

scientific article published on 16 April 2015

Subcutaneous Injection of Adalimumab Trial compared with Control (SCIATiC): a randomised controlled trial of adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica.

scientific article published in October 2017

Systematic review: outcomes and adverse events from randomised trials in Crohn's disease

article

Taxonomy for methods of resource use measurement

scientific article published on 20 January 2014

The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol

scientific article published on 03 January 2014

The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)

scientific article published on 07 April 2020

The New and Non-Transparent Cancer Drugs Fund

scientific article published on 01 January 2020

The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial

scientific article

The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial

scientific article published on 10 April 2021

The development of a QALY measure for epilepsy: NEWQOL-6D.

scientific article published on 12 April 2012

The difference between effectiveness and efficacy of antimalarial drugs in Kenya

scientific article published on September 2004

The impact of non-compliance on the cost-effectiveness of pharmaceuticals: a review of the literature.

scientific article

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors

scientific article published on January 2012

The problem of orphan drugs

scientific article published in the British Medical Journal

The trials and tribulations of accessing data from routine sources.

scientific article published on 16 November 2015

Trends and influences on use of antidiabetic drugs in England, 1992-2003.

scientific article

Understanding medication compliance and persistence from an economics perspective

scientific article

Using discrete choice experiments to define patient preferences for outcomes in trials

scientific article

Using routinely recorded data in a UK RCT: a comparison to standard prospective data collection methods

scientific article published in 2021

Using routinely recorded data in the UK to assess outcomes in a randomised controlled trial: The Trials of Access.

scientific article

Valuations of epilepsy-specific health states: a comparison of patients with epilepsy and the general population

scientific article published on 16 May 2014

Value Assessment and Quantitative Benefit-Risk Modelling of Biosimilar Infliximab for Crohn's Disease

scientific article published on 01 December 2019

Value-based pricing: incentive for innovation or zero net benefit?

scientific article published on 01 September 2011

We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment

scientific article published on 27 September 2023

What influences persistence with medicines? A multinational discrete choice experiment of 2549 patients

scientific article

What should patients do if they miss a dose? A systematic review of patient information leaflets and summaries of product characteristics

scientific article published on 29 September 2020

When Drugs Don??t Work

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