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List of works by Wilko Weichert

3D histopathology of human tumours by fast clearing and ultramicroscopy

scientific article published on 19 October 2020

A Novel Grading System Based on Tumor Budding and Cell Nest Size Is a Strong Predictor of Patient Outcome in Esophageal Squamous Cell Carcinoma

scientific article published on 12 May 2017

A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy

scientific article published on 02 October 2019

A machine learning model for the prediction of survival and tumor subtype in pancreatic ductal adenocarcinoma from preoperative diffusion-weighted imaging

scientific article published on 17 October 2019

A microsatellite based multiplex PCR method for the detection of chromosomal instability in gastric cancer

scientific article published in Scientific Reports

A multicenter round robin test of PD-L1 expression assessment in urothelial bladder cancer by immunohistochemistry and RT-qPCR with emphasis on prognosis prediction after radical cystectomy.

scientific article

A multicentre analytical comparison study of inter-reader and inter-assay agreement of four programmed death-ligand 1 (PD-L1) immunohistochemistry assays for scoring in triple-negative breast cancer

scientific article published on 16 September 2020

A multifactorial histopathologic score for the prediction of prognosis of resected esophageal adenocarcinomas after neoadjuvant chemotherapy

scientific article published on 27 November 2013

A new classification method for MALDI imaging mass spectrometry data acquired on formalin-fixed paraffin-embedded tissue samples

scientific article

A prognostic gene expression index in ovarian cancer - validation across different independent data sets

scientific article

A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer p

scientific article published on 03 February 2014

A stitch in time saves nine: external quality assessment rounds demonstrate improved quality of biomarker analysis in lung cancer.

scientific article

ALK-FISH borderline cases in non-small cell lung cancer: Implications for diagnostics and clinical decision making

scientific article published on 23 October 2015

Acrylamido polyvinyl alcohol microspheres for uterine artery embolization: 12-month clinical and MR imaging results

scientific article

Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis

scientific article

Acute myocardial infarction caused by coronary tumor thromboembolism: a rare primary manifestation of malignant tumor disease

scientific article published on 15 December 2005

Acute respiratory failure after aspiration of activated charcoal with recurrent deposition and release from an intrapulmonary cavern

article

Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC

scientific article published on 19 May 2020

Adjuvant versus early salvage radiotherapy: outcome of patients with prostate cancer treated with postoperative radiotherapy after radical prostatectomy

scientific article published on 11 November 2019

Adult jejunojejunal intussusception caused by metastasized pleomorphic carcinoma of the lung: report of a case

scientific article published on 01 November 2009

Advanced high-grade serous ovarian cancer: inverse association of KLK13 and KLK14 mRNA levels in tumor tissue and patients' prognosis

scientific article published on 15 March 2018

Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell-of-origin

scientific article published on 15 October 2020

An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas

scientific article

An optimised version of the secretome protein enrichment with click sugars (SPECS) method leads to enhanced coverage of the secretome.

scientific article published on 19 December 2016

Angiogenic and growth factors in gastric cancer

scientific article published on 26 November 2014

Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix

scientific article published on 12 January 2018

Applicability of a System for fully automated nucleic acid extraction from formalin-fixed paraffin-embedded sections for routine KRAS mutation testing

scientific article published in June 2012

Application of a BRAF V600E mutation-specific antibody for the diagnosis of hairy cell leukemia

scientific article published on 01 December 2012

Association of angiogenic factors with prognosis in esophageal cancer

scientific article

Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis

scientific article published in February 2008

Ataxia-telangiectasia-mutated protein kinase levels stratify patients with pancreatic adenocarcinoma into prognostic subgroups with loss being a strong indicator of poor survival

scientific article

Atypical protein kinase C zeta exhibits a proapoptotic function in ovarian cancer.

scientific article

BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma

scientific article published on 6 December 2013

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

scientific article

BarrettNET-a prospective registry for risk estimation of patients with Barrett's esophagus to progress to adenocarcinoma

scientific article published on 01 August 2019

Basket Trials: Just the End of the First Quarter

scientific article published on 13 July 2015

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

scientific article published on 28 May 2019

Biomarker testing in non-small cell lung cancer in routine care: Analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315)

scientific article published on 02 November 2020

Borderline-resectable pancreatic adenocarcinoma: Contour irregularity of the venous confluence in pre-operative computed tomography predicts histopathological infiltration

scientific article published in PLoS ONE

CCI-779 (Temsirolimus) exhibits increased anti-tumor activity in low EGFR expressing HNSCC cell lines and is effective in cells with acquired resistance to cisplatin or cetuximab

scientific article

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity

scientific article published on 22 February 2016

CD57 expression in incidental, clinically manifest, and metastatic carcinoma of the prostate

scientific article published on 22 May 2014

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy

scientific article published on 26 August 2014

CXCR4 is a potential target for diagnostic PET/CT imaging in Barrett's dysplasia and esophageal adenocarcinoma.

scientific article published on 5 December 2017

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

scientific article published on 8 February 2016

Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma

scientific article published on 03 September 2016

Cellular Dissociation Grading Based on the Parameters Tumor Budding and Cell Nest Size in Pretherapeutic Biopsy Specimens Allows for Prognostic Patient Stratification in Esophageal Squamous Cell Carcinoma Independent From Clinical Staging

scientific article published on 01 May 2019

Characterization of the tumor immune micromilieu and its interference with outcome after concurrent chemoradiation in patients with oropharyngeal carcinomas

scientific article published on 25 May 2019

Circulating Interleukin-4 Is Associated with a Systemic T Cell Response against Tumor-Associated Antigens in Treatment-Naïve Patients with Resectable Non-Small-Cell Lung Cancer

scientific article published on 24 November 2020

Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo

scientific article

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.

scientific article published on 19 December 2008

Classical pathology and mutational load of breast cancer - integration of two worlds

scientific article published on 20 July 2015

Classification and Prognostic Stratification of Bronchopulmonary Neuroendocrine Neoplasms

scientific article published on 19 August 2019

Clinical Relevance of Different Papillary Growth Patterns of Pulmonary Adenocarcinoma

scientific article

Clinical Validation of PITX2 DNA Methylation to Predict Outcome in High-Risk Breast Cancer Patients Treated with Anthracycline-Based Chemotherapy

scientific article published on 28 September 2018

Clinical and molecular characteristics of HNSCC patients with brain metastases: a retrospective study

scientific article

Clinical performance of an analytically validated assay in comparison to microarray technology to assess PITX2 DNA-methylation in breast cancer

scientific article published in Scientific Reports

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

scientific article published on 2 November 2017

Clinicopathological Profiling of Lung Carcinoids with a Ki67 Index > 20

scientific article published on 28 November 2018

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal breast cancer patients

scientific article

Colorectal mixed adenoneuroendocrine carcinomas and neuroendocrine carcinomas are genetically closely related to colorectal adenocarcinomas

scientific article published on 6 January 2017

Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor‐Targeting Miniproteins

scientific article published on November 13, 2012

Combined DCE-MRI- and FDG-PET enable histopathological grading prediction in a rat model of hepatocellular carcinoma

scientific article published on 23 January 2020

Combined Immunohistochemistry after Mass Spectrometry Imaging for Superior Spatial Information

scientific article published on 21 August 2018

Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma

scientific article published on 28 January 2020

Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma

scientific article

Comparison of definite chemoradiation therapy with carboplatin/paclitaxel or cisplatin/5-fluoruracil in patients with squamous cell carcinoma of the esophagus

Comparison of neoadjuvant chemoradiation with carboplatin/ paclitaxel or cisplatin/ 5-fluoruracil in patients with squamous cell carcinoma of the esophagus

scientific article published on 21 November 2017

Composition and Clinical Impact of the Immunologic Tumor Microenvironment in Oral Squamous Cell Carcinoma

scientific article published on 10 December 2018

Comprehensive analysis of clinico-pathological data reveals heterogeneous relations between atherosclerosis and cancer

scientific article

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'

scientific article published on 07 June 2020

Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases

scientific article published on 24 May 2016

Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

scientific article published on 11 December 2019

Correction to: MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus.

scientific article

Correction to: Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme

scientific article published on 01 March 2020

Correlation of radio- and histomorphological pattern of pulmonary adenocarcinoma

scientific article published on 26 July 2012

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma

scientific article published on 20 November 2018

Cut-resistant protective gloves in pathology--effective and cost-effective

scientific article published in March 2008

Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival

scientific article published on September 2005

DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer.

scientific article

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

scientific article published on 09 April 2019

Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin

scientific article published on 19 February 2015

Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective technique

scientific article published on 30 July 2015

Differences in carotid plaque content of macrophages, T cells and MMP-9 between patients with embolic and hemodynamic cerebral ischemia due to symptomatic carotid stenosis

scientific article published on 9 March 2010

Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

scientific article published on April 30, 2013

Differential expression of the tumor suppressor A-kinase anchor protein 12 in human diffuse and pilocytic astrocytomas is regulated by promoter methylation

scientific article published in October 2013

Discerning the Primary Carcinoma in Malignant Peritoneal and Pleural Effusions Using Imaging Mass Spectrometry - a Feasibility Study

scientific article published on 29 October 2018

Disease control and functional outcome in three modern combined organ preserving regimens for locally advanced squamous cell carcinoma of the head and neck (SCCHN)

scientific article published on September 23, 2011

Distinct immune evasion in APOBEC-enriched, HPV-negative HNSCC

scientific article published on 29 May 2020

Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma

scientific article

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

scientific article published on 01 October 2011

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer

scientific article published on August 2015

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis

scientific article

Do Canine Pancreatic Neuroendocrine Neoplasms Resemble Human Pancreatic Neuroendocrine Tumours? A Comparative Morphological and Immunohistochemical Investigation

scientific article published on 17 November 2020

Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer

scientific article published in December 2010

Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer

scientific article

EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®).

scientific article published on 28 September 2017

EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype.

scientific article published on 29 August 2013

Early and late toxicity profiles of patients receiving immediate postoperative radiotherapy versus salvage radiotherapy for prostate cancer after prostatectomy

scientific article published on 04 September 2018

Early lung cancer with lepidic pattern: adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant adenocarcinoma

scientific article published on July 2014

Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial

scientific article published on 29 January 2009

Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma

scientific article

Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer

scientific article published on 07 November 2018

Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis

scientific article published on 27 July 2016

Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis

scientific article published on 16 September 2004

Establishment of a patient-derived orthotopic osteosarcoma mouse model

scientific article published on 30 April 2015

Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue

scientific article published on 12 August 2009

Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia

scientific article published on September 2016

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

scientific article published on 24 January 2018

Expression and role of the embryonic protein SOX2 in head and neck squamous cell carcinoma

scientific article

Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab–Docetaxel Treatment

scientific article published on June 8, 2011

Expression of class I histone deacetylases indicates poor prognosis in endometrioid subtypes of ovarian and endometrial carcinomas

scientific article published on September 2008

Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma

scientific article published on May 2010

Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis

scientific article published in May 2009

Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2.

scientific article published on 23 June 2006

Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression.

scientific article published on February 2008

Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma

scientific article published on 01 August 2004

Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer

scientific article

Expression patterns of polo-like kinase 1 in human gastric cancer.

scientific article

Factors predicting prognosis and recurrence in patients with esophago-gastric adenocarcinoma and histopathological response with less than 10 % residual tumor

scientific article

Fibroblast and vascular endothelial growth factor coating of decellularized vascular grafts stimulates undesired giant cells and graft encapsulation in a rat model

scientific article

Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer

scientific article

First prospective outcome data for the second-generation multigene test Endopredict in ER-positive/HER2-negative breast cancer

scientific article published on 09 September 2020

Flat epithelial atypia is a common subtype of B3 breast lesions and is associated with noninvasive cancer but not with invasive cancer in final excision histology

scientific article published on 11 December 2009

Follicle‐stimulating hormone receptor expression in soft tissue sarcomas

scientific article published on May 9, 2013

Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas

scientific article published on June 2008

Fungi and inflammatory bowel diseases: Alterations of composition and diversity

scientific article

Genetic Profiling of Cancers of the Digestive System: Biological Insights and Clinical Implications

scientific article published on 9 February 2017

Genetic changes of non-small cell lung cancer under neoadjuvant therapy

scientific article published on 20 April 2016

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies

scientific article published on 9 December 2015

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer.

scientific article published in June 2017

Genetically Engineered Mouse Models of Liver Tumorigenesis Reveal a Wide Histological Spectrum of Neoplastic and Non-Neoplastic Liver Lesions

scientific article published on 13 August 2020

Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays

scientific article

Genotypic and phenotypic characterization of side population of gastric cancer cell lines

scientific article

Genotyping of colorectal cancer for cancer precision medicine: Results from the IPH Center for Molecular Pathology

scientific article

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

scientific article published on 24 December 2013

Google goes cancer: improving outcome prediction for cancer patients by network-based ranking of marker genes

scientific article

HDAC expression and clinical prognosis in human malignancies

scientific article published on 21 December 2008

HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFβ1 signalling in inflammation

scientific article published on 23 January 2019

Harmonization and Standardization of Panel-Based Tumor Mutational Burden (TMB) Measurement: Real-World Results and Recommendations of the QuIP Study

scientific article published on 28 February 2020

Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas

scientific article published on 8 July 2016

High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma

scientific article

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

scientific article

High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer

scientific article published on March 12, 2012

High prevalence of incidental and symptomatic venous thromboembolic events in patients with advanced pancreatic cancer under palliative chemotherapy: A retrospective cohort study

scientific article published on 22 April 2017

High-throughput diagnostic profiling of clinically actionable gene fusions in lung cancer

scientific article published on 23 September 2015

Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy

scientific article published on 16 July 2015

IMP3 expression in human ovarian cancer is associated with improved survival

scientific article published in May 2009

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

scientific article published on 26 September 2019

Identification of MALDI Imaging Proteolytic Peptides Using LC-MS/MS-Based Biomarker Discovery Data: A Proof of Concept

scientific article published on 19 December 2018

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

scientific article published on 21 April 2013

Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy

scientific article published on January 2009

Image-Based Molecular Phenotyping of Pancreatic Ductal Adenocarcinoma

scientific article published on 07 March 2020

Immunohistochemical expression of CD44 in oral squamous cell carcinoma in relation to histomorphologic parameters and clinicopathological factors.

scientific article published on 22 February 2018

Immunohistological Expression of SOX-10 in Triple-Negative Breast Cancer: A Descriptive Analysis of 113 Samples

scientific article published on 03 September 2020

Immunostaining of small-cell carcinoma: mistaken identity?

scientific article published on November 8, 2003

Impact of Tumor Localization and Molecular Subtypes on the Prognostic and Predictive Significance of p53 Expression in Gastric Cancer

scientific article published on 25 June 2020

Impact of microvessel density on lymph node metastasis and survival after curative resection of pancreatic cancer

scientific article published on 10 November 2011

Impact of neoadjuvant transarterial chemoembolization on tumor recurrence and patient survival after liver transplantation for hepatocellular carcinoma: a retrospective analysis

scientific article

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma

scientific article

Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology

scientific article published on 02 July 2020

In MALDI-Mass Spectrometry Imaging on Formalin-Fixed Paraffin-Embedded Tissue Specimen Section Thickness Significantly Influences m/z Peak Intensity

scientific article published on 01 October 2018

In Vivo PET Imaging of the Cancer Integrin αvβ6 Using 68Ga-Labeled Cyclic RGD Nonapeptides

scientific article published on 15 December 2016

In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

scientific article published on March 29, 2012

In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography

scientific article published on 09 September 2019

Incidental postmortem diagnosis of DIPNECH in a patient with previously unexplained 'asthma bronchiale'.

scientific article published on 21 May 2010

Increased intraepithelial CD3+ T-lymphocytes and high PD-L1 expression on tumor cells are associated with a favorable prognosis in esophageal squamous cell carcinoma and allow prognostic immunogenic subgrouping

scientific article

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

scientific article

Individualized medicine and demographic change as determining workload factors in pathology: quo vadis?

scientific article published on 24 October 2015

Induction of G0/G1 cell cycle arrest in ovarian carcinoma cells by the anti-inflammatory drug NS-398, but not by COX-2-specific RNA interference.

scientific article

Inflammation and PD-L1 expression in pulmonary neuroendocrine tumors

scientific article published on 11 January 2018

Influence of Different Neoadjuvant Chemotherapy Regimens on Response, Prognosis, and Complication Rate in Patients with Esophagogastric Adenocarcinoma

scientific article published on 22 May 2015

Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines

scientific article published on 08 December 2016

Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary

scientific article published on 11 March 2020

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

scientific article

Integrative analysis of multi-omics data identified EGFR and PTGS2 as key nodes in a gene regulatory network related to immune phenotypes in head and neck cancer

scientific article published on 11 March 2020

Integrative genomic and transcriptomic analysis of leiomyosarcoma.

scientific article published on 10 January 2018

Interlaboratory-concordance of PD-L1 immunohistochemistry for non-small cell lung cancer

scientific article published on 29 August 2017

Interobserver agreement of proliferation index (Ki-67) outperforms mitotic count in pulmonary carcinoids

scientific article published on 5 April 2013

Interobserver variability in the application of the novel IASLC/ATS/ERS classification for pulmonary adenocarcinomas

scientific article published on March 9, 2012

Interstitial pneumonitis with accumulation of intraalveolar macrophages, a facet amiodarone therapy

scientific article

Intrapericardial paraganglioma in a 78-year-old female patient.

scientific article published in April 2010

Introducing a novel highly prognostic grading scheme based on tumour budding and cell nest size for squamous cell carcinoma of the uterine cervix

scientific article published on 8 March 2018

Involvement of hypoxia-inducible transcription factors in polycystic kidney disease

scientific article published on March 2007

Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment

scientific article

Is preoperative chemotherapy followed by surgery the appropriate treatment for signet ring cell containing adenocarcinomas of the esophagogastric junction and stomach?

scientific article published on 14 January 2014

Isolated cardiac sarcoidosis: the crucial role of multimodal imaging with positron emission tomography/magnetic resonance imaging in diagnosis and therapy surveillance

scientific article published on 22 November 2017

Isolation and characterization of circulating tumor cells using a novel workflow combining the CellSearch® system and the CellCelector™.

scientific article published on 29 April 2016

KRAS genotyping of paraffin-embedded colorectal cancer tissue in routine diagnostics: comparison of methods and impact of histology

scientific article published on 10 December 2009

KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma

scientific article published in May 2014

Large scale in vivo micro-RNA loss of function screen identified miR-29a, miR-100 and miR-155 as modulators of radioresistance and tumor-stroma communication

scientific article published on 04 January 2019

Large scale multifactorial likelihood quantitative analysis of BRCA1 and BRCA2 variants: An ENIGMA resource to support clinical variant classification

scientific article published on 01 September 2019

Large‐scale comparative analyses of immunomarkers for diagnostic subtyping of non‐small‐cell lung cancer biopsies

scientific article published on August 8, 2012

Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice

scientific article published on 06 October 2018

Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma

scientific article

Loss of Gelsolin expression in human ovarian carcinomas.

scientific article published on February 2005

Loss of RNF43 function contributes to gastric carcinogenesis by impairing DNA damage response

scientific article published on 11 November 2020

Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma

scientific article published on 20 May 2015

Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas

scientific article published on 30 April 2014

Lymph node infiltration, parallel metastasis and treatment success in breast cancer

scientific article published on 05 August 2019

MALDI imaging mass spectrometry - From bench to bedside

scientific article published on 31 October 2016

MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

scientific article published on 10 September 2020

MTOR inhibitor-based combination therapies for pancreatic cancer

scientific article published on 2 January 2018

Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer

scientific article published on 13 October 2015

Mammary analogue secretory carcinoma of salivary glands: diagnostic pitfall with distinct immunohistochemical profile and molecular features

scientific article published on 3 October 2017

Mass Spectrometry Imaging Differentiates Chromophobe Renal Cell Carcinoma and Renal Oncocytoma with High Accuracy

scientific article published on 21 August 2020

Mass Spectrometry Imaging for Reliable and Fast Classification of Non-Small Cell Lung Cancer Subtypes

scientific article published on 21 September 2020

Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors

scientific article published in November 2006

Mature mediastinal teratoma with subtotal unidirectional pancreatic differentiation

scientific article published in May 2010

Measurement of tumor mutational burden (TMB) in routine molecular diagnostics: in silico and real-life analysis of three larger gene panels

scientific article published on 04 February 2019

Mesenchymal plasticity regulated by Prrx1 drives aggressive pancreatic cancer biology

scientific article published on 29 September 2020

Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover

scientific article published on 18 September 2008

MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma

scientific article published on 24 March 2017

MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus.

scientific article published on 25 April 2018

MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer.

scientific article

Microsatellite instability in pulmonary adenocarcinomas: a comprehensive study of 480 cases

scientific article published on 4 December 2015

Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma

scientific article published on 24 December 2008

Modeling and multiscale characterization of the quantitative imaging based fibrosis index reveals pathophysiological, transcriptome and proteomic correlates of lung fibrosis induced by fractionated irradiation

scientific article published on 11 January 2019

Molecular HPV typing as a diagnostic tool to discriminate primary from metastatic squamous cell carcinoma of the lung

scientific article published in April 2009

Molecular characterization of hepatic epithelioid hemangioendothelioma reveals alterations in various genes involved in DNA repair, epigenetic regulation, signaling pathways, and cell cycle control

scientific article published on 03 September 2019

Molecular diagnostic profiling of lung cancer specimens with a semiconductor-based massive parallel sequencing approach: feasibility, costs, and performance compared with conventional sequencing

scientific article

Molecular driver alterations and their clinical relevance in cancer of unknown primary site

scientific article published on 14 June 2016

Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer

scientific article published on 23 August 2019

Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading scheme

scientific article published on 23 November 2019

Multicentric Analytical and Inter-observer Comparability of Four Clinically Developed Programmed Death-ligand 1 Immunohistochemistry Assays in Advanced Clear-cell Renal Cell Carcinoma

scientific article published on 15 February 2020

Multicentric analytical comparability study of programmed death-ligand 1 expression on tumor-infiltrating immune cells and tumor cells in urothelial bladder cancer using four clinically developed immunohistochemistry assays

scientific article published on 02 July 2019

Multikinase inhibitors sorafenib and sunitinib as radiosensitizers in head and neck cancer cell lines

scientific article published on 21 February 2017

Multiparametric Modelling of Survival in Pancreatic Ductal Adenocarcinoma Using Clinical, Histomorphological, Genetic and Image-Derived Parameters

scientific article published on 25 April 2020

Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial

scientific article published on 12 April 2019

Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

scientific article

Mutational profiles of Brenner tumors show distinctive features uncoupling urothelial carcinomas and ovarian carcinoma with transitional cell histology.

scientific article published on 22 June 2017

Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment

scientific article

Mutations in genes encoding PI3K-AKT and MAPK signaling define anogenital papillary hidradenoma

scientific article published on 23 October 2015

NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial

scientific article published on 22 March 2016

NRG1 Fusions in KRAS Wild-type Pancreatic Cancer.

scientific article

NTRK testing: first results of the QuiP-EQA scheme and a comprehensive map of NTRK fusion variants and their diagnostic coverage by targeted RNA-based NGS assays

scientific article published on 22 April 2020

NUT carcinoma of the thorax: Case report and review of the literature

scientific article

Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells

scientific article published on 04 October 2019

Neoadjuvant image-guided helical intensity modulated radiotherapy of extremity sarcomas - a single center experience

scientific article published on 09 January 2019

Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus

Neoplastic cell percentage estimation in tissue samples for molecular oncology: recommendations from a modified Delphi study

scientific article published on 18 July 2019

New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma

scientific article published on 01 June 2020

Next-generation diagnostics for precision oncology: preanalytical considerations, technical challenges, and available technologies

scientific article published on 07 November 2020

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

scientific article (publication date: 2015)

Noncompaction myocardium in association with type Ib glycogen storage disease

scientific article published on July 31, 2012

Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

scientific article published on 08 December 2018

Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection: A monocentric retrospective analysis

scientific article published on 15 May 2016

Outcome, complications, and mortality of an intrathoracic anastomosis in esophageal cancer in patients without a preoperative selection with a risk score

scientific article published on 20 November 2014

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Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1.

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Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

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PD-1/PD-L1 expression in chromophobe renal cell carcinoma: An immunological exception?

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Pan-cancer analysis of copy number changes in programmed death-ligand 1 (PD-L1, CD274) - associations with gene expression, mutational load, and survival

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Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

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Pharmacoproteomic characterisation of human colon and rectal cancer.

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Phenotypic and genotypic characterization of carcinomas of the papilla of Vater has prognostic and putative therapeutic implications

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Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells

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Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to rapamycin treatment in vitro

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Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma

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Polo-like kinase 1 expression is a prognostic factor in human colon cancer

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Polo-like kinase 1 is overexpressed in prostate cancer and linked to higher tumor grades

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Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications

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Polymer coating of porcine decellularized and cross-linked aortic grafts

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Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma

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Post-therapeutic response evaluation by a combination of endoscopy and CT scan in esophagogastric adenocarcinoma after chemotherapy: better than its reputation

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Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma

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Preanalytics in lung cancer

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Precision oncology based on omics data: The NCT Heidelberg experience

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Prevalence of somatic mitochondrial mutations and spatial distribution of mitochondria in non-small cell lung cancer

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Profiling of cMET and HER Family Receptor Expression in Pancreatic Ductal Adenocarcinomas and Corresponding Lymph Node Metastasis to Assess Relevant Pathways for Targeted Therapies: Looking at the Soil Before Planting the Seed

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Prognostic Impact of Intra-alveolar Tumor Spread in Pulmonary Adenocarcinoma.

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Prognostic impact and clinicopathological correlations of the cribriform pattern in pulmonary adenocarcinoma

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Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: correlation of protein expression and GC/TOF-MS-based metabolomics

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Prognostic impact of PD-1 and its ligands in renal cell carcinoma

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Prognostic impact of lymph node involvement and the extent of lymphadenectomy (LAD) in adenocarcinoma of the esophagogastric junction (AEG)

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Prognostic implication of molecular subtypes and response to neoadjuvant chemotherapy in 760 gastric carcinomas: role of Epstein-Barr virus infection and high- and low-microsatellite instability

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Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma

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Prognostic significance of Dicer expression in ovarian cancer-link to global microRNA changes and oestrogen receptor expression

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Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer

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Proposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma

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Protein kinase C isoform expression in ovarian carcinoma correlates with indicators of poor prognosis

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Proteome activity landscapes of tumor cell lines determine drug responses

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Pseudo-pseudo Meigs' syndrome

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Quantifying potential confounders of panel-based tumor mutational burden (TMB) measurement

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Quantitative Determination of Estrogen Receptor, Progesterone Receptor, and HER2 mRNA in Formalin-fixed Paraffin-embedded Tissue—A New Option for Predictive Biomarker Assessment in Breast Cancer

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Quantitative analysis of diagnostic guidelines for HER2-status assessment

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R0 Versus R1 Resection Matters after Pancreaticoduodenectomy, and Less after Distal or Total Pancreatectomy for Pancreatic Cancer

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RAS mutations in benign epithelial tumors associated with BRAF inhibitor treatment of melanoma.

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RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

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ROS1 expression and translocations in non-small-cell lung cancer: clinicopathological analysis of 1478 cases

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RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab

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Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer

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Relevance of tumour-infiltrating lymphocytes, PD-1 and PD-L1 in patients with high-risk, nodal-metastasised breast cancer of the German Adjuvant Intergroup Node-positive study

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Reliable Entity Subtyping in Non-small Cell Lung Cancer by Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry on Formalin-fixed Paraffin-embedded Tissue Specimens

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Renal cell neoplasias: reversion-inducing cysteine-rich protein with Kazal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis

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Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer

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Risk stratification in luminal-type breast cancer: Comparison of Ki-67 with EndoPredict test results

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Role of TP53 mutations in triple negative and HER2-positive breast cancer treated with neoadjuvant anthracycline/taxane-based chemotherapy

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SMARCA4-deficient Sinonasal Carcinoma

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SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

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Semiconductor-based sequencing of formalin-fixed, paraffin-embedded colorectal cancer samples

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Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastric junction (AEG): The Heidelberg Imaging program in Cancer of the oesophago-gastric junction during Neoadjuvant treatment: HICON trial

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Several genotypes, one phenotype: PIK3CA/AKT1 mutation-negative hidradenoma papilliferum show genetic lesions in other components of the signalling network

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Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized C-MRSI

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Single-Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas

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Site-to-Site Reproducibility and Spatial Resolution in MALDI-MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples

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Solid neuroendocrine carcinomas of the breast: metastases or primary tumors?

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Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer

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Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20.

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Specific inhibition of AKT2 by RNA interference results in reduction of ovarian cancer cell proliferation: increased expression of AKT in advanced ovarian cancer

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Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.

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Still a hopeless case for personalized oncology? Pancreatic cancer revisited

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Subclonal evolution of pulmonary adenocarcinomas delineated by spatially distributed somatic mitochondrial mutations

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Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

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Surgery after anticoagulation in stroke patients with nonatherosclerotic internal carotid artery thrombus: a clinicopathological case series.

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Surgery of gastric cancer and esophageal cancer: Does age matter?

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Surgical treatment for epicardial metastasis of myxoid liposarcoma involving atrioventricular sulcus

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Synergistic effects of crizotinib and radiotherapy in experimental EML4-ALK fusion positive lung cancer

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Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression

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T-cell functionality testing is highly relevant to developing novel immuno-tracers monitoring T cells in the context of immunotherapies and revealed CD7 as an attractive target

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Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding

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Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma

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Targeting irradiation-induced mitogen-activated protein kinase activation in vitro and in an ex vivo model for human head and neck cancer.

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Testing NTRK testing: Wet-lab and in silico comparison of RNA-based targeted sequencing assays

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The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

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The Novel Histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification System of Lung Adenocarcinoma Is a Stage-Independent Predictor of Survival

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The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer

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Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin

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Transcriptome based individualized therapy of refractory pediatric sarcomas: feasibility, tolerability and efficacy.

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Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway

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Tumor Budding and Cell Nest Size Are Highly Prognostic in Laryngeal and Hypopharyngeal Squamous Cell Carcinoma: Further Evidence for a Unified Histopathologic Grading System for Squamous Cell Carcinomas of the Upper Aerodigestive Tract

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Tumor-associated lymphangiogenesis correlates with prognosis after resection of human hepatocellular carcinoma

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Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer

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Tumour budding activity and cell nest size determine patient outcome in oral squamous cell carcinoma: proposal for an adjusted grading system

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Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue

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Visceral leishmaniasis in a patient with AIDS: early pathological diagnosis using conventional histology, PCR and electron microscopy is the key for adequate treatment

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Well-differentiated neuroendocrine carcinoma mimicking an echinococcus cyst of the liver in CT-MRI findings with hepatocyte specific contrast material

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mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours

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