List of works - Melanie Boerries

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

scientific article published on 17 April 2017

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

scientific article

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks

article

Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes

scientific article published on 16 April 2007

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

scientific article

Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)

scientific article (publication date: 28 November 2003)

S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy

scientific article

miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion

scientific article

Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes

scientific article

Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

scientific article

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4

scientific article (publication date: 15 May 2014)

Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine

scientific article published on January 2015

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

scientific article published on 10 December 2012

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

scientific article published on June 2016

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

scientific article

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

scientific article published in February 2018

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

scientific article

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation

scientific article published on 24 January 2017

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

scientific article (publication date: 2014)

KDM4 inhibition targets breast cancer stem-like cells

scientific article

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization

scientific article published on 30 May 2013

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

scientific article published on 31 March 2014

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

scientific article

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints

scientific article published on 21 October 2013

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.

scientific article published on 20 November 2017

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.

scientific article published on 7 December 2017

miR-146a Controls Immune Response in the Melanoma Microenvironment

scientific article published on 13 November 2018

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

scientific article

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

scientific article published on 17 April 2017

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

scientific article published on 05 December 2018

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma.

scientific article published on 5 April 2018

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility

scientific journal article

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.

scientific article

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

scientific article published on 19 December 2017

Understanding the mTOR signaling pathway via mathematical modeling

scientific article published on 10 February 2017

Induction of phenotype modifying cytokines by FERMT1 mutations.

scientific article published in March 2011

MIRACUM: Medical Informatics in Research and Care in University Medicine

scientific article published on 17 July 2018

Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications

scientific article published on 10 May 2010

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

scientific article published on 12 January 2018

Specific role of RhoC in tumor invasion and metastasis

scientific article published on 16 September 2017

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

scientific article published on 5 May 2016

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study

scientific article published on 9 August 2017

Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cells

scientific article

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

scientific article published on 19 June 2018

S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling

scientific article published on 7 July 2016

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

scientific article published on 14 April 2016

Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development

scientific article

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

scientific article published in Nature Communications

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

article

HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration

scientific article published on 24 August 2016

List of works by Melanie Boerries

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

Cardiac adenoviral S100A1 gene delivery rescues failing myocardium

Molecular fingerprinting of the podocyte reveals novel gene and protein regulatory networks

Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)

S100A1 in cardiovascular health and disease: closing the gap between basic science and clinical therapy

miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion

Distinct subcellular location of the Ca2+-binding protein S100A1 differentially modulates Ca2+-cycling in ventricular rat cardiomyocytes

Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll‐like receptor 4

Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

KDM4 inhibition targets breast cancer stem-like cells

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization

Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation.

A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.

The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells.

Constitutional SAMD9L mutations cause familial myelodysplastic syndrome and transient monosomy 7.

miR-146a Controls Immune Response in the Melanoma Microenvironment

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma.

Monoallelic Mutations in the Translation Initiation Codon of KLHL24 Cause Skin Fragility

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer.

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Understanding the mTOR signaling pathway via mathematical modeling

Induction of phenotype modifying cytokines by FERMT1 mutations.

MIRACUM: Medical Informatics in Research and Care in University Medicine

Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

Specific role of RhoC in tumor invasion and metastasis

CREBBP is a target of epigenetic, but not genetic, modification in juvenile myelomonocytic leukemia.

Smoking is associated with hypermethylation of the APC 1A promoter in colorectal cancer: the ColoCare Study

Label-free detection of neuronal differentiation in cell populations using high-throughput live-cell imaging of PC12 cells

Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney

S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling

Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation

Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures

HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration