List of works by Stephen C Strom

A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine

scientific article

A functional polymorphism at the transcriptional initiation site in beta2-glycoprotein I (apolipoprotein H) associated with reduced gene expression and lower plasma levels of beta2-glycoprotein I

article

A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency

scientific article published on 02 April 2019

A novel bile acid-activated vitamin D receptor signaling in human hepatocytes

scientific article

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development

scientific article

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS.

scientific article

A whole-organ regenerative medicine approach for liver replacement

scientific article

ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes

scientific article

Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats

scientific journal article

Adenoviral-mediated correction of methylmalonyl-CoA mutase deficiency in murine fibroblasts and human hepatocytes

scientific article

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver

scientific article published on 21 January 2020

Amnion-derived pluripotent/multipotent stem cells.

scientific article published on January 2006

An optimal culture condition maintains human hepatocyte phenotype after long-term culture

scientific article published on 27 June 2006

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes

scientific article

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes

scientific article published on 15 April 2005

Association of breast cancer resistance protein/ABCG2 phenotypes and novel promoter and intron 1 single nucleotide polymorphisms

scientific article published on 7 January 2008

Barriers to the successful treatment of liver disease by hepatocyte transplantation

scientific article

Bigger may not be better when it comes to hepatocytes

scientific article published in 2005

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

scientific article

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose

scientific article

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation

scientific article

Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity

scientific article

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations

scientific article published on 01 March 2002

Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells

scientific article published on November 2007

Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene

scientific article

Development and application of purified tissue dissociation enzyme mixtures for human hepatocyte isolation

scientific article

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

scientific article published in September 2002

Differentiation and transplantation of human embryonic stem cell-derived hepatocytes

scientific article

Differentiation of amniotic epithelial cells into various liver cell types and potential therapeutic applications

scientific article

Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes

scientific article

Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures

scientific article

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes

scientific article

Effects of green tea compounds on irinotecan metabolism

scientific article published on 15 November 2006

Embryonic and induced pluripotent stem cells as a model for liver disease

scientific article published on January 2009

Ethanol stimulates bile acid formation in primary human hepatocytes

scientific article published on 15 October 2007

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats

scientific article published on 27 August 2003

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

scientific article

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

scientific article

Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures

scientific article published on 10 May 2008

Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice

scientific article

FoxO1 links hepatic insulin action to endoplasmic reticulum stress

scientific article

FoxO6 integrates insulin signaling with gluconeogenesis in the liver.

scientific article

Frequent aneuploidy among normal human hepatocytes

scientific article published on 2 November 2011

Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

scientific article

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

scientific article

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s

scientific article

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

scientific article published on 9 October 2003

Hepatic differentiation of amniotic epithelial cells

scientific article

Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis

scientific article

Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes

scientific article published on 5 November 2012

Hepatocyte growth factor signaling pathway inhibits cholesterol 7alpha-hydroxylase and bile acid synthesis in human hepatocytes

scientific article published in December 2007

Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).

scientific article published on 19 August 2009

Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease

scientific article published on 12 May 2009

Hepatocyte transplantation: New possibilities for therapy

article

Hepatocyte transplantation: clinical experience and potential for future use.

scientific article published on January 2006

Human hepatocyte transplantation

scientific article published on January 2010

Human hepatocyte transplantation: worldwide results

scientific article published on August 2006

Human pregnane X receptor activation and CYP3A4/CYP2B6 induction by 2,3-oxidosqualene:lanosterol cyclase inhibition

scientific article published on 21 January 2009

Hypothermic storage of human hepatocytes for transplantation

scientific article published on January 2014

INDUCTION OF CYP3A IN PRIMARY CULTURES OF HUMAN HEPATOCYTES BY GINKGOLIDES A AND B

article

Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth

scientific article published on 23 June 2008

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)

scientific journal article

Identification of stem cell marker-positive cells by immunofluorescence in term human amnion

scientific article published on 09 May 2007

Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice

scientific article published on 26 February 2013

Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London.

scientific article published in January 2012

In vitro and in vivo assessment of herb drug interactions

scientific article

In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging

scientific article published in January 2003

Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans

scientific article published on June 2006

Increased reprogramming of human fetal hepatocytes compared with adult hepatocytes in feeder-free conditions

scientific article published on 04 February 2013

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures

scientific article

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone

scientific article published on 12 January 2006

Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.

scientific article

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

scientific article published on 05 March 2004

Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes

scientific article

Isolated hepatocyte transplantation for Crigler-Najjar syndrome type 1.

scientific article published in January 2005

Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder.

scientific article

Isolation of Amniotic Epithelial Stem Cells

scientific article published in November 2007

Isolation of Amniotic Mesenchymal Stem Cells

scientific article published in March 2010

Isolation of amniotic epithelial stem cells.

scientific article published in January 2010

Lack of Fas antagonism by Met in human fatty liver disease

scientific article published on 19 August 2007

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals.

scientific article published in January 2009

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

scientific article

Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels

scientific article

Mapping the genetic architecture of gene expression in human liver ⬇️

scientific article

Metabolism of 17alpha-hydroxyprogesterone caproate, an agent for preventing preterm birth, by fetal hepatocytes.

scientific article

Mice with chimeric livers are an improved model for human lipoprotein metabolism

scientific article

Mice with human livers

scientific article

MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation

scientific article

Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols

scientific article

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.

scientific article published on 15 March 2018

Mouse fetal liver cells in artificial capillary beds in three-dimensional four-compartment bioreactors.

scientific article

Naive Rat Amnion-Derived Cell Transplantation Improved Left Ventricular Function and Reduced Myocardial Scar of Postinfarcted Heart

scientific article published on 01 January 2009

New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants.

scientific article

Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

scientific article

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

scientific article

Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats

scientific article published on 2 November 2004

Phenobarbital and phenytoin increased acetaminophen hepatotoxicity due to inhibition of UDP-glucuronosyltransferases in cultured human hepatocytes

scientific article published on 2 June 2005

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

scientific article published on 12 July 2007

Placental stem cell correction of murine intermediate maple syrup urine disease

scientific article published on 15 February 2013

Positive and Negative Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1) Gene Transcription by Rifampicin: Roles of Hepatocyte Nuclear Factor 4 and Pregnane X Receptor

scientific article published on 23 August 2007

Potential barriers to human hepatocyte transplantation in MUP-uPAtg(⁺/⁺)Rag2⁻/⁻γC⁻/⁻ mice

scientific article published on 30 August 2013

Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes

scientific article published on 08 April 2008

Production of hepatocyte-like cells from human amnion.

scientific article published on January 2009

Rapid and Sensitive Assessment of Human Hepatocyte Functions

scientific article published in December 2014

Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes

scientific article published in December 2002

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists

scientific article

Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor

scientific article published on 5 January 2005

Regulation of the human cathepsin E gene by the constitutive androstane receptor

scientific article

Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases

scientific article

Ritonavir and efavirenz significantly alter the metabolism of erlotinib--an observation in primary cultures of human hepatocytes that is relevant to HIV patients with cancer

scientific article published on 02 August 2013

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

scientific article

Side population cells derived from adult human liver generate hepatocyte-like cells in vitro

scientific article

Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers

scientific article published on 12 October 2010

Stem Cell Characteristics of Amniotic Epithelial Cells

scientific article published on 04 August 2005

Strategies for short-term storage of hepatocytes for repeated clinical infusions

scientific article published in January 2014

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes

scientific article published on February 2006

Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression

scientific article

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

scientific article

The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.

scientific article published on February 2016

The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients.

scientific article

The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

scientific article

The second extracellular loop dictates Occludin-mediated HCV entry

scientific article published on 6 September 2010

The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor

scientific article

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.

scientific article published on August 2013

To Be or Not to Be: Generation of Hepatocytes From Cells Outside the Liver

scientific article published on 01 March 2008

Toward cell therapy using placenta-derived cells: disease mechanisms, cell biology, preclinical studies, and regulatory aspects at the round table.

scientific article published on February 2010

Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites

scientific article published on 13 March 2007

Translation of amnion stem cells to the clinic.

scientific article published in December 2013

Transport, Metabolism, and Hepatotoxicity of Flutamide, Drug–Drug Interaction with Acetaminophen Involving Phase I and Phase II Metabolites

scientific article (publication date: October 2007)

Use and application of stem cells in toxicology

scientific article

Paulina is supported by:

About Paulina

Help