List of works - Bibek Gooptu

1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

scientific article published on 23 November 2011

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

scientific article

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

scientific article published on 8 December 2015

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

scientific article

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

scientific article

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Conformational changes and disease--serpins, prions and Alzheimer's.

scientific article published in December 1998

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

scientific article

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

scientific article published on 19 June 2015

Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis

scientific article published in 2024

Defining the mechanism of polymerization in the serpinopathies

scientific article

Familial dementia caused by polymerization of mutant neuroserpin

scientific article (publication date: 23 September 1999)

In silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformers

scientific article

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

scientific article published on 14 September 2015

Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study.

scientific article

Nucleation of alpha 1-antichymotrypsin polymerization

scientific article published in March 2003

Polymers and inflammation: disease mechanisms of the serpinopathies

scientific article published on July 2008

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

scientific article published on 25 June 2013

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

scientific article

Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency

scientific article published on 28 June 2018

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

scientific article

Structural dynamics associated with intermediate formation in an archetypal conformational disease.

scientific article

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders

scientific article published on 22 October 2014

Targeting serpins in high-throughput and structure-based drug design

scientific article

The molecular and cellular pathology of α₁-antitrypsin deficiency.

scientific article

The serpinopathies studying serpin polymerization in vivo

scientific article

The structural basis for Z α1-antitrypsin polymerization in the liver

scientific article published on 21 October 2020

Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

scientific article

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

scientific article

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.

scientific article

Update on alpha-1 antitrypsin deficiency: New therapies

scientific article published on 28 March 2016

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

scientific article published on 14 May 2009

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

scientific article published on 5 June 2018

List of works by Bibek Gooptu

1H, 15N and 13C backbone resonance assignments of the archetypal serpin α1-antitrypsin

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

Aberrant disulphide bonding contributes to the ER retention of alpha1-antitrypsin deficiency variants.

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Conformational changes and disease--serpins, prions and Alzheimer's.

Crystallographic and Cellular Characterisation of Two Mechanisms Stabilising the Native Fold of α1-Antitrypsin: Implications for Disease and Drug Design

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

Defining the mechanism of galectin-3–mediated TGF-β1 activation and its role in lung fibrosis

Defining the mechanism of polymerization in the serpinopathies

Familial dementia caused by polymerization of mutant neuroserpin

In silico assessment of potential druggable pockets on the surface of α1-antitrypsin conformers

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

Multicentre evaluation of multidisciplinary team meeting agreement on diagnosis in diffuse parenchymal lung disease: a case-cohort study.

Nucleation of alpha 1-antichymotrypsin polymerization

Polymers and inflammation: disease mechanisms of the serpinopathies

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

Real-world clinical applicability of pathogenicity predictors assessed on SERPINA1 mutations in alpha-1-antitrypsin deficiency

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

Structural dynamics associated with intermediate formation in an archetypal conformational disease.

Tacrolimus in idiopathic inflammatory myopathy-associated interstitial lung disease: defining roles and responders

Targeting serpins in high-throughput and structure-based drug design

The molecular and cellular pathology of α₁-antitrypsin deficiency.

The serpinopathies studying serpin polymerization in vivo

The structural basis for Z α1-antitrypsin polymerization in the liver

Therapeutic target-site variability in α1-antitrypsin characterized at high resolution

Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency

Three new alpha1-antitrypsin deficiency variants help to define a C-terminal region regulating conformational change and polymerization.

Update on alpha-1 antitrypsin deficiency: New therapies

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.