Search filters

List of works by Pietro Formisano

A functional allelic variant of the FGF23 gene is associated with renal phosphate leak in calcium nephrolithiasis

scientific article published on 14 March 2012

A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells.

scientific article

AP20187-mediated activation of a chimeric insulin receptor results in insulin-like actions in skeletal muscle and liver of diabetic mice.

scientific article

Abnormal glucose transport and GLUT1 cell-surface content in fibroblasts and skeletal muscle from NIDDM and obese subjects.

scientific article published on April 1997

Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro.

scientific article

Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5.

scientific article published on 24 March 2016

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor

scientific article

Alginate-hyaluronan composite hydrogels accelerate wound healing process.

scientific article published on 16 June 2015

Antiphosphotyrosine immunoprecipitation of an insulin-stimulated receptor phosphatase activity from FRTL5 cells

scientific article published on June 1991

Atypical protein kinase C dysfunction and the metabolic syndrome

scientific article

Autoantibodies to glutamic acid decarboxylase (GAD) in focal and generalized epilepsy: A study on 233 patients

scientific article

Bisphenol A environmental exposure and the detrimental effects on human metabolic health: is it necessary to revise the risk assessment in vulnerable population?

scientific article

Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis.

scientific article

Bisphenol-A impairs insulin action and up-regulates inflammatory pathways in human subcutaneous adipocytes and 3T3-L1 cells

scientific article (publication date: 2013)

Bisphenol-A plasma levels are related to inflammatory markers, visceral obesity and insulin-resistance: a cross-sectional study on adult male population

scientific article published on 29 May 2015

Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake

scientific article

Cellular subtype expression and activation of CaMKII regulate the fate of atherosclerotic plaque.

scientific article published on 5 November 2016

Circulating miRNAs as intercellular messengers, potential biomarkers and therapeutic targets for Type 2 diabetes

scientific article published on June 2015

Comparison between fibroblast wound healing and cell random migration assays in vitro

scientific article published on 27 July 2016

Computational Analysis of Single Nucleotide Polymorphisms Associated with Altered Drug Responsiveness in Type 2 Diabetes

scientific article published on 25 June 2016

Cu,Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells.

scientific article

Decreased phosphorylation of mutant insulin receptor by protein kinase C and protein kinase A.

scientific article published in June 1995

Defective insulin action in fibroblasts from noninsulin-dependent diabetes mellitus patients with Gln1152 insulin receptor mutation

scientific article

Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor

scientific article published on January 1999

Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (HepG2) cells.

scientific article published on July 2002

Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells.

scientific article published in October 2006

Epicardial adipose tissue has an increased thickness and is a source of inflammatory mediators in patients with calcific aortic stenosis.

scientific article published on 18 March 2015

Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

scientific article published on July 1998

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

scientific article published on 16 June 2009

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.

scientific article

Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization.

scientific article published on 3 August 2007

Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells

scientific article

Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle

scientific article published on 9 October 2015

Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes

scientific article published in January 2008

Growth Hormone Deficiency Is Associated with Worse Cardiac Function, Physical Performance, and Outcome in Chronic Heart Failure: Insights from the T.O.S.CA. GHD Study

scientific article

Growth-promoting action and growth factor release by different platelet derivatives.

scientific article published on 15 July 2013

HCV and GBV-c/HGV infection in HIV positive patients in southern Italy.

scientific article published in January 2001

Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.

scientific article published on 16 April 2010

Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet

scientific article published on 16 March 2016

Human Peripheral Blood Mononuclear Cell Function and Dendritic Cell Differentiation Are Affected by Bisphenol-A Exposure.

scientific article

Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism

scientific article published on 11 September 2003

IGF-1 predicts survival in chronic heart failure. Insights from the T.O.S.CA. (Trattamento Ormonale Nello Scompenso CArdiaco) registry

scientific article published on 11 July 2014

In NIH-3T3 fibroblasts, insulin receptor interaction with specific protein kinase C isoforms controls receptor intracellular routing

scientific article published on May 1998

In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.

scientific article published on 27 October 2008

In skeletal muscle, glucose storage and oxidation are differentially impaired by the IR1152 mutant receptor.

scientific article published on March 1997

Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.

scientific article published on 18 May 2010

Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells

scientific article published on 31 July 2001

Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

scientific article

Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes

scientific article

Low-dose Bisphenol-A Promotes Epigenetic Changes at Pparγ Promoter in Adipose Precursor Cells

scientific article published on 13 November 2020

Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo.

scientific article

Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage.

scientific article published on 18 January 2017

Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.

scientific article published on 2 September 2008

Multifaceted Breast Cancer: The Molecular Connection With Obesity

scientific article published on July 2016

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

scientific article (publication date: 29 March 2002)

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

scientific article

Overexpression of the phosphoprotein enriched in diabetes gene product (Ped/pea-15) in women with polycystic ovary syndrome

scientific article published on 21 June 2007

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.

scientific article published on 30 September 2009

Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells

scientific article

PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms

scientific article published on May 2012

PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation

scientific article published on 27 January 2012

PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1

scientific article

PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.

scientific article published on July 2012

PED/PEA-15 modulates coxsackievirus-adenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells.

scientific article published on September 2010

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

scientific article

PKB Inhibition Prevents the Stimulatory Effect of Insulin on Glucose Transport and Protein Translocation but Not the Antilipolytic Effect in Rat Adipocytes

scientific article published on 01 February 2000

PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms.

scientific article published on 23 March 2014

PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.

scientific article

Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice

scientific article published on 18 July 2016

Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.

scientific article published on 29 February 2016

Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1

scientific article

Personalized medicine and type 2 diabetes: lesson from epigenetics.

scientific article published on April 2014

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

scientific article published on 16 January 2007

Platelet-Rich Plasma Increases Growth and Motility of Adipose Tissue-Derived Mesenchymal Stem Cells and Controls Adipocyte Secretory Function

scientific article

Platelet-rich plasma counteracts detrimental effect of high-glucose concentrations on mesenchymal stem cells from Bichat fat pad

scientific article published on 15 March 2020

Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

scientific article published on 11 August 2020

Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase ⬇️

scientific article published on September 23, 2010

Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.

scientific article published on 18 January 2018

Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

scientific article published on 21 July 2008

Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon

scientific article published on 10 October 2005

Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting

scientific article published on 6 January 2004

Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase.

scientific article published on May 2003

Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

scientific article

Residues 762-801 of PLD1 mediate the interaction with PED/PEA15.

scientific article

Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS

scientific article published on 23 November 2011

Substrate-zymography: a still worthwhile method for gelatinases analysis in biological samples.

scientific article published on 7 December 2015

Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.

scientific article published on 9 June 2008

The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.

scientific article published on 5 October 2006

The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret.

scientific article published on January 2001

Thyrotropin regulates autophosphorylation and kinase activity in both the insulin and the insulin-like growth factor-I receptors in FRTL5 cells

scientific article published on 01 March 1992

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling

scientific journal article

Understanding type 2 diabetes: from genetics to epigenetics

scientific article published on 05 April 2015

Paulina is supported by:

About Paulina

Help