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List of works by Alexander S Pym

A Novel Reporter Phage To Detect Tuberculosis and Rifampin Resistance in a High-HIV-Burden Population.

scientific article published on 29 April 2015

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

scientific article published on 19 September 2017

A new evolutionary scenario for the Mycobacterium tuberculosis complex

scientific article

Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling

scientific article

Assessing the utility of Xpert(®) MTB/RIF as a screening tool for patients admitted to medical wards in South Africa

scientific article published on 20 January 2016

Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis

scientific article

Biomarkers for Tuberculosis Based on Secreted, Species-Specific, Bacterial Small Molecules

scientific article

Challenges in estimating the total burden of drug-resistant tuberculosis.

scientific article published on 27 March 2008

Clofazimine protects against mycobacterium tuberculosis dissemination in the CNS following an aerosol challenge in a murine model.

scientific article

Comparative genomics uncovers large tandem chromosomal duplications in Mycobacterium bovis BCG Pasteur ⬇️

scientific article published in June 2000

Completeness and Reliability of the Republic of South Africa National Tuberculosis (TB) Surveillance System

scientific article published on 11 August 2015

Consensus standards for introductory e-learning courses in human participants research ethics

scientific article

Disease progression and survival in HIV-1-infected Africans in London.

scientific article published in July 1998

Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?

scientific article published on July 2005

Drug-Resistant tuberculosis, KwaZulu-Natal, South Africa, 2001-2007.

scientific article published in October 2011

Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum

scientific article

EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa

scientific article

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

scientific article

Effect of katG mutations on the virulence of Mycobacterium tuberculosis and the implication for transmission in humans.

scientific article

Effective anti-tuberculosis therapy correlates with plasma small RNA.

scientific article published on 5 March 2015

Efficiency and safety of the combination of moxifloxacin, pretomanid (PA-824), and pyrazinamide during the first 8 weeks of antituberculosis treatment: a phase 2b, open-label, partly randomised trial in patients with drug-susceptible or drug-resista

scientific article published on 18 March 2015

Evaluation of new antituberculosis drugs in mouse models

scientific article published on January 2007

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

scientific article published on 20 January 2005

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

scientific article (publication date: September 2015)

Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing

scientific article published on June 2015

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance

scientific article

Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance.

scientific article published on 11 April 2016

High rates of potentially infectious tuberculosis and multidrug-resistant tuberculosis (MDR-TB) among hospital inpatients in KwaZulu Natal, South Africa indicate risk of nosocomial transmission

scientific article (publication date: 2014)

High-throughput method for detecting genomic-deletion polymorphisms

scientific article published on July 2004

High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria

scientific article

Hyperlipidaemia following treatment with protease inhibitors in patients with HIV-1 infection

scientific article

Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis

scientific article

Inactivation of the Mycobacterium tuberculosis Nramp orthologue (mntH) does not affect virulence in a mouse model of tuberculosis

scientific article

International spread of MDR TB from Tugela Ferry, South Africa

scientific article published in November 2011

Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells.

scientific article

Isoniazid-monoresistant tuberculosis is associated with poor treatment outcomes in Durban, South Africa.

scientific article published on June 2017

Longitudinal assessment of health related quality of life of HIV infected patients treated for tuberculosis and HIV in a high burden setting.

scientific article published on 9 June 2016

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

scientific article published in November 2002

Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide ⬇️

scientific article published on August 27, 2012

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics

scientific article published on June 2016

Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs

scientific article

Post DOTS, post genomics: the next century of tuberculosis control

scientific article published in The Lancet

Proteome analysis of the plasma membrane of Mycobacterium tuberculosis

scientific article

Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam

scientific article (publication date: 2014)

Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy

scientific article

Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance.

scientific article

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for detection of pyrazinamide susceptibility

scientific article

Reasons for increased incidence of tuberculosis. Audit suggests that undernotification is common

scientific article published on August 1995

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

scientific article published on 14 April 2003

Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines

scientific article

Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis

scientific journal article

Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice

scientific article

Risk factors for tuberculosis in patients with AIDS in London: a case-control study

scientific article published in January 1999

Safety of nevirapine in pregnancy

Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX.

scientific article published on 09 May 2014

Spectrum of disease in Africans with AIDS in London.

scientific article published on November 1996

Systematic genetic nomenclature for type VII secretion systems.

scientific article

The Rabbit Study: Ritonavir and Saquinavir in Combination in Saquinavir-Experienced and Previously Untreated Patients

scientific article published on 01 September 1999

The diarylquinoline TMC207 for multidrug-resistant tuberculosis

scientific article (publication date: 4 June 2009)

The in Vivo Effects of Combination Antiretroviral Drug Therapy on Peripheral Blood CD34+ Cell Colony-Forming Units from HIV Type 1-Infected Patients

article

Tools for the population genomics of the tubercle bacilli.

scientific article

Treatment of drug-resistant tuberculosis with bedaquiline in a high HIV prevalence setting: an interim cohort analysis.

scientific article published on August 2015

Vancouver: optimism, but at a cost

scientific article published in October 1996

Whole transcriptome and genomic analysis of extensively drug-resistant Mycobacterium tuberculosis clinical isolates identifies downregulation of ethA as a mechanism of ethionamide resistance

scientific article published on 9 October 2017

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