List of works - Mikael Hedeland

A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry

scientific article published on 10 September 2014

A quantitative approach to analysing cortisol response in the horse

scientific article

Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension

scientific article

Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension

scientific article published on 5 August 2015

Animal botulism outcomes in the AniBioThreat project.

scientific article published in September 2013

Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase

scientific article published on 12 May 2006

Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension

scientific article published on 29 April 2015

Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing

scientific article published on June 2015

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

scientific article published on 5 January 2015

Clinical pharmacology of clemastine in healthy dogs

scientific article

Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS.

scientific article published on 12 May 2011

Detection of altrenogest and its metabolites in post administration horse urine using liquid chromatography tandem mass spectrometry--increased sensitivity by chemical derivatisation of the glucuronic acid conjugate

scientific article published on 7 March 2006

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.

scientific article published on 17 August 2009

Differentiation of estriol glucuronide isomers by chemical derivatization and electrospray tandem mass spectrometry

scientific article published on 01 January 2006

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

scientific article published on 27 September 2013

Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.

scientific article

First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model

scientific article published on 18 April 2006

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

scientific article

Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing.

scientific article published on 10 February 2016

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension

scientific article published on 26 June 2012

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

scientific article

Identification of finasteride metabolites in human bile and urine by high-performance liquid chromatography/tandem mass spectrometry.

scientific article published on 27 July 2009

Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry.

scientific article

Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry.

scientific article

Identification of transformation products from β-blocking agents formed in wetland microcosms using LC-Q-ToF.

scientific article

In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography-tandem mass spectrometry

scientific article published in May 2009

In vivo investigation in pigs of intestinal absorption, hepatobiliary disposition, and metabolism of the 5α-reductase inhibitor finasteride and the effects of coadministered ketoconazole

scientific article published on 11 February 2011

Investigation of hepatobiliary disposition of doxorubicin following intrahepatic delivery of different dosage forms

Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.

scientific article published in April 2016

Isolation and characterization of a β-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation

scientific article published on 09 May 2014

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer

scientific article published on 25 September 2018

Major signal suppression from metal ion clusters in SFC/ESI-MS - Cause and effects.

scientific article published on 19 March 2018

Management of animal botulism outbreaks: from clinical suspicion to practical countermeasures to prevent or minimize outbreaks.

scientific article published on September 2013

Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO.

scientific article

Mass spectrometric detection of protein-based toxins.

scientific article published on September 2013

Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

scientific article published on 29 October 2020

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

scientific article published in November 2003

Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations

scientific article

Non-aqueous capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion.

scientific article published in July 2001

Oxaliplatin degradation in the presence of chloride: identification and cytotoxicity of the monochloro monooxalato complex

scientific article

Pharmaceuticals are identified in insects in River Fyris – A study with both tandem quadrupole and quadrupole-time-of-flight mass spectrometry

scientific article published in 2022

Pharmacokinetics and pharmacodynamics of clemastine in healthy horses.

scientific article

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.

scientific article published on 3 November 2014

Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms

scientific article published on 21 July 2015

Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization.

scientific article published on 15 November 2015

Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

scientific article published in May 2004

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

scientific article published in April 2004

Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification

scientific article

Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry.

scientific article published on June 2012

Structural evaluation of the glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and liquid chromatography/ion trap mass spectrometry

scientific article

Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

scientific article published on 01 September 2021

Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing.

scientific article published on 23 July 2013

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men.

scientific article

The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo

scientific article published in August 2010

The effects of lipiodol and cyclosporin A on the hepatobiliary disposition of doxorubicin in pigs

scientific article published on 07 March 2014

The workshop on animal botulism in Europe

scientific article published in September 2013

Validation of a method for quantification of ketobemidone in human plasma with liquid chromatography-tandem mass spectrometry

scientific article published in June 2003

Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum

scientific article

List of works by Mikael Hedeland

A novel trapping system for the detection of reactive drug metabolites using the fungus Cunninghamella elegans and high resolution mass spectrometry

A quantitative approach to analysing cortisol response in the horse

Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension

Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension

Animal botulism outcomes in the AniBioThreat project.

Biliary secretion of rosuvastatin and bile acids in humans during the absorption phase

Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension

Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

Clinical pharmacology of clemastine in healthy dogs

Confirmation of botulism in birds and cattle by the mouse bioassay and Endopep-MS.

Detection of altrenogest and its metabolites in post administration horse urine using liquid chromatography tandem mass spectrometry--increased sensitivity by chemical derivatisation of the glucuronic acid conjugate

Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions.

Differentiation of estriol glucuronide isomers by chemical derivatization and electrospray tandem mass spectrometry

Effects of verapamil on the pharmacokinetics and hepatobiliary disposition of fexofenadine in pigs

Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.

First-pass effects of verapamil on the intestinal absorption and liver disposition of fexofenadine in the porcine model

Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.

Fully automated determination of nicotine and its major metabolites in whole blood by means of a DBS online-SPE LC-HR-MS/MS approach for sports drug testing.

High inter-individual variability of vardenafil pharmacokinetics in patients with pulmonary hypertension

High-resolution mass spectrometric investigation of the phase I and II metabolites of finasteride in pig plasma, urine and bile

Identification of finasteride metabolites in human bile and urine by high-performance liquid chromatography/tandem mass spectrometry.

Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry.

Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry.

Identification of transformation products from β-blocking agents formed in wetland microcosms using LC-Q-ToF.

In vitro formation of phase I and II metabolites of propranolol and determination of their structures using chemical derivatization and liquid chromatography-tandem mass spectrometry

In vivo investigation in pigs of intestinal absorption, hepatobiliary disposition, and metabolism of the 5α-reductase inhibitor finasteride and the effects of coadministered ketoconazole

Investigation of hepatobiliary disposition of doxorubicin following intrahepatic delivery of different dosage forms

Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.

Isolation and characterization of a β-glucuronide of hydroxylated SARM S1 produced using a combination of biotransformation and chemical oxidation

Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer

Major signal suppression from metal ion clusters in SFC/ESI-MS - Cause and effects.

Management of animal botulism outbreaks: from clinical suspicion to practical countermeasures to prevent or minimize outbreaks.

Mass spectrometric characterization of glucuronides formed by a new concept, combining Cunninghamella elegans with TEMPO.

Mass spectrometric detection of protein-based toxins.

Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks

Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

Nickel in equine sports drug testing - pilot study results on urinary nickel concentrations

Non-aqueous capillary electrophoretic separation of enantiomeric amines with (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid as chiral counter ion.

Oxaliplatin degradation in the presence of chloride: identification and cytotoxicity of the monochloro monooxalato complex

Pharmaceuticals are identified in insects in River Fyris – A study with both tandem quadrupole and quadrupole-time-of-flight mass spectrometry

Pharmacokinetics and pharmacodynamics of clemastine in healthy horses.

Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate.

Rapid chiral separation of atenolol, metoprolol, propranolol and the zwitterionic metoprolol acid using supercritical fluid chromatography-tandem mass spectrometry - Application to wetland microcosms

Seafood sold in Sweden contains BMAA: A study of free and total concentrations with UHPLC-MS/MS and dansyl chloride derivatization.

Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry

St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism

Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification

Structural elucidation of phase I and II metabolites of bupivacaine in horse urine and fungi of the Cunninghamella species using liquid chromatography/multi-stage mass spectrometry.

Structural evaluation of the glucuronides of morphine and formoterol using chemical derivatization with 1,2-dimethylimidazole-4-sulfonyl chloride and liquid chromatography/ion trap mass spectrometry

Survival and growth of saprotrophic and mycorrhizal fungi in recalcitrant amine, amide and ammonium containing media

Synthesis, characterization, and detection of new oxandrolone metabolites as long-term markers in sports drug testing.

The effect of St. John's wort on the pharmacokinetics, metabolism and biliary excretion of finasteride and its metabolites in healthy men.

The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo

The effects of lipiodol and cyclosporin A on the hepatobiliary disposition of doxorubicin in pigs

The workshop on animal botulism in Europe

Validation of a method for quantification of ketobemidone in human plasma with liquid chromatography-tandem mass spectrometry

Validation of the Endopep-MS method for qualitative detection of active botulinum neurotoxins in human and chicken serum