List of works - Ana L. Simplício

A methodology for detection and quantification of esterase activity

scientific article published in January 2013

A new amino-masking group capable of pH-triggered amino-drug release

scientific article published in March 2005

An Alternative Synthetic Route to (3R,5S,1′S)-5-{1′-[(tert-Butyloxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a Precursor of a Leu-Ala Hydroxyethylene Isostere

Carboxylesterase 2 production and characterization in human cells: new insights into enzyme oligomerization and activity

scientific article

Chiral separation and identification of beta-aminoketones of pharmacological interest by high performance liquid chromatography and capillary electrophoresis

scientific article published on 26 January 2006

Comparison of in vitro methods for carboxylesterase activity determination in immortalized cells representative of the intestine, liver and kidney.

scientific article published on 13 May 2015

Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease.

scientific article published in May 2009

Detection and Quantification of Carboxylesterase 2 Activity by Capillary Electrophoresis ⬇️

scientific article published on 05 January 2011

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

scientific article published on 27 March 2009

Electroosmotic flow modulation in capillary electrophoresis by organic cations from ionic liquids

scientific article published on 01 April 2012

Electrophoretically mediated microanalysis for the evaluation of interspecies variation in cholinesterase metabolism

scientific article published in July 2010

Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity.

scientific article published on 19 November 2015

Impregnation of an intraocular lens for ophthalmic drug delivery

scientific article published in April 2008

Improvement of Aroma and Shelf-Life of Non-alcoholic Beverages Through Cyclodextrins-Limonene Inclusion Complexes

Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis

scientific article published in August 2004

Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones

scientific article

Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs

scientific article published on 20 December 2005

Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation

scientific article published on 19 January 2006

Preparation of glyceryl monostearate-based particles by PGSS®—Application to caffeine

Prodrugs for amines.

scientific article published on 03 March 2008

Recovery of antioxidant and antiproliferative compounds from watercress using pressurized fluid extraction

scholarly article in RSC Advances, vol. 6 no. 37, 2016

Selective and mild oxidation of sulfides to sulfoxides or sulfones using H2O2 and Cp′Mo(CO)3Cl as catalysts

article published in 2008

Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis

scientific article published on 31 March 2010

Sodium dodecyl sulfate-capillary gel electrophoresis analysis of rotavirus-like particles

scientific article

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

Solubilization of fullerene C60 in micellar solutions of different solubilizers.

scientific article published on 14 August 2010

Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery

Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice

scientific article published in February 1999

β-Aminoketones as prodrugs with pH-controlled activation

scientific article published on 01 December 2006

List of works by Ana L. Simplício

A methodology for detection and quantification of esterase activity

A new amino-masking group capable of pH-triggered amino-drug release

An Alternative Synthetic Route to (3R,5S,1′S)-5-{1′-[(tert-Butyloxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a Precursor of a Leu-Ala Hydroxyethylene Isostere

Carboxylesterase 2 production and characterization in human cells: new insights into enzyme oligomerization and activity

Chiral separation and identification of beta-aminoketones of pharmacological interest by high performance liquid chromatography and capillary electrophoresis

Comparison of in vitro methods for carboxylesterase activity determination in immortalized cells representative of the intestine, liver and kidney.

Design, synthesis, and pharmacological effects of a cyclization-activated steroid prodrug for colon targeting in inflammatory bowel disease.

Detection and Quantification of Carboxylesterase 2 Activity by Capillary Electrophoresis ⬇️

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

Electroosmotic flow modulation in capillary electrophoresis by organic cations from ionic liquids

Electrophoretically mediated microanalysis for the evaluation of interspecies variation in cholinesterase metabolism

Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity.

Impregnation of an intraocular lens for ophthalmic drug delivery

Improvement of Aroma and Shelf-Life of Non-alcoholic Beverages Through Cyclodextrins-Limonene Inclusion Complexes

Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis

Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones

Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs

Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation

Preparation of glyceryl monostearate-based particles by PGSS®—Application to caffeine

Prodrugs for amines.

Recovery of antioxidant and antiproliferative compounds from watercress using pressurized fluid extraction

Selective and mild oxidation of sulfides to sulfoxides or sulfones using H2O2 and Cp′Mo(CO)3Cl as catalysts

Simultaneous determination of clopidogrel and its carboxylic acid metabolite by capillary electrophoresis

Sodium dodecyl sulfate-capillary gel electrophoresis analysis of rotavirus-like particles

Solubility enhancement of trans-chalcone using lipid carriers and supercritical CO2 processing

Solubilization of fullerene C60 in micellar solutions of different solubilizers.

Supercritical fluid polymerisation and impregnation of molecularly imprinted polymers for drug delivery

Validation of a solid-phase microextraction method for the determination of organophosphorus pesticides in fruits and fruit juice

β-Aminoketones as prodrugs with pH-controlled activation