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List of works by Darío Acuña-Castroviejo

1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence

scientific article published on 01 February 2012

4,5-dihydro-1H-pyrazole derivatives with inhibitory nNOS activity in rat brain: synthesis and structure-activity relationships

scientific article published in November 2004

5-Methoxytryptophol and melatonin in children: differences due to age and sex.

scientific article published in September 1996

5-methoxytryptophol preserves hepatic microsomal membrane fluidity during oxidative stress

scientific article published on 01 January 2000

A new guest playing with bone and fat

scientific article published on 15 March 2007

A review of the melatonin functions in zebrafish physiology

scientific article

Absence of plasma melatonin circadian rhythm during the first 72 hours of life in human infants

scientific article published on 01 September 1993

Accumulation of Exogenous Amyloid-BetaPeptide in Hippocampal Mitochondria Causes Their Dysfunction: A Protective Role for Melatonin ⬇️

scientific article published on May 13, 2012

Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: Effects of melatonin treatment

scientific article published on 17 October 2006

Age-related changes in mitochondrial function of mouse colonic smooth muscle: beneficial effects of melatonin.

scientific article published on 26 December 2013

Age-related changes in the rat brain mitochondrial antioxidative enzyme ratios: modulation by melatonin.

scientific article published on 11 July 2012

Age-related changes of neuronal responsiveness to melatonin in the striatum of sham-operated and pinealectomized rats

scientific article published on 01 September 1995

Agomelatine in depressive disorders: its novel mechanisms of action.

scientific article published on January 2012

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin ⬇️

scientific article published on November 23, 2011

Analysis of Plasma MicroRNAs as Predictors and Biomarkers of Aging and Frailty in Humans.

scientific article published on 18 July 2018

Analysis of the daily changes of melatonin receptors in the rat liver

scientific article published on 30 October 2012

Antioxidant defence and inflammatory response in professional road cyclists during a 4-day competition.

scientific article published on August 2010

Argan oil-contained antioxidants for human mitochondria.

scientific article published on January 2013

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

scientific article published on 20 March 2007

Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging

scientific article published on 3 August 2010

Calcium-dependent effects of melatonin inhibition of glutamatergic response in rat striatum

scientific article published in May 2001

Cardiometabolic impact of changing internal time during daylight saving time: a window for a deleterious role within sleep-related breathing disorders

scientific article published on 27 August 2018

Cartilage and serum levels of nitric oxide in patients with hip osteoarthritis

scientific article published on 01 September 1999

Cell protective role of melatonin in the brain

scientific article published on September 1995

Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture

scientific article published on 01 September 2007

Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures

scientific article

Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine

scientific article published in March 2004

Changes in the redox status and inflammatory response in handball players during one-year of competition and training

scientific article published on 7 March 2013

Characterization of high-affinity melatonin binding sites in purified cell nuclei of rat liver

scientific article published on 01 March 1994

Characterization of melatonin high-affinity binding sites in purified cell nuclei of the hamster (Mesocricetus auratus) harderian gland

scientific article

Characterization of nocturnal ultradian rhythms of melatonin in children with growth hormone-dependent and independent growth delay.

scientific article

Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

scientific article published in January 2007

Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice

scientific article published in April 2007

Circadian rhythms of dopamine and dihydroxyphenyl acetic acid in the mouse striatum: effects of pinealectomy and of melatonin treatment

scientific article published in March 2002

Clinical trial to test the efficacy of melatonin in COVID-19

scientific article published on 08 August 2020

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

scientific article

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

scientific article published on 16 December 2017

Comparative effects of melatonin, l-deprenyl, Trolox and ascorbate in the suppression of hydroxyl radical formation during dopamine autoxidation in vitro

scientific article published on 01 September 2000

Comparison between tryptophan methoxyindole and kynurenine metabolic pathways in normal and preterm neonates and in neonates with acute fetal distress

scientific article published on July 1998

Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice

scientific article published on 21 January 2017

Day-night variations in melatonin secretion by the pineal gland during febrile and epileptic convulsions in children

scientific article

Determination of Coenzyme Q10, Coenzyme Q9, and Melatonin Contents in Virgin Argan Oils: Comparison with Other Edible Vegetable Oils

scientific article published on 31 October 2011

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

scientific article published on 4 June 2015

Diurnal variations of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy

scientific article published in January 1986

Dysfunctional Coq9 protein causes predominant encephalomyopathy associated with CoQ deficiency

scientific journal article

Early gender differences in the redox status of the brain mitochondria with age: effects of melatonin therapy.

scientific article published in December 2013

Effect of Melatonin Supplementation on Antioxidant Status and DNA Damage in High Intensity Trained Athletes.

scientific article published on 17 November 2017

Effect of clonidine on plasma ACTH, cortisol and melatonin in children

scientific article published on 01 August 2000

Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay.

scientific article

Effects of febrile and epileptic convulsions on daily variations in plasma melatonin concentration in children

scientific article published on 01 January 1994

Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats

scientific article

Evaluation of plasma levels of melatonin after midazolam or sodium thiopental anesthesia in children

scientific article published in May 2002

Exercise and melatonin in humans: reciprocal benefits.

scientific article published on 16 August 2011

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

scientific article published on 2 September 2011

Extrapineal melatonin: sources, regulation, and potential functions.

scientific article published on 20 February 2014

Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation

scientific article published on 6 August 2009

Fluorination Effects on NOS Inhibitory Activity of Pyrazoles Related to Curcumin.

scientific article published on 28 August 2015

Genetic dissection of endothelial transcriptional activity of zebrafish aryl hydrocarbon receptors (AHRs).

scientific article published on 17 August 2017

Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM).

scientific article published on 19 September 2005

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

scientific article

Identification of mitochondrial deficits and melatonin targets in liver of septic mice by high-resolution respirometry.

scientific article published on 10 December 2014

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice.

scientific article published on 16 July 2016

Impact of Daylight Saving Time on circadian timing system: An expert statement

scientific article published on 05 January 2019

Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

scientific article published on 6 April 2008

In Vivo Determination of Mitochondrial Respiration in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Zebrafish Reveals the Efficacy of Melatonin in Restoring Mitochondrial Normalcy.

scientific article published on 29 November 2017

Influence of aging and growth hormone on different members of the NFkB family and IkB expression in the heart from a murine model of senescence-accelerated aging.

scientific article published on 12 November 2015

Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.

scientific article published in January 2002

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

scientific article published in September 2006

Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

scientific article published in April 2006

Intracerebroventricular injection of naloxone blocks melatonin-dependent brain [3H]flunitrazepam binding.

scientific article published in July 1993

Iron decreases the nuclear but not the cytosolic content of the neurohormone melatonin in several tissues in chicks

scientific article published in March 1996

Kynurenamines as neural nitric oxide synthase inhibitors

scientific article published in December 2005

Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin

scientific article published on 01 October 2019

Learning capabilities and CA1-prefrontal synaptic plasticity in a mice model of accelerated senescence.

scientific article published on 12 June 2011

Light deprivation increases plasma levels of melatonin during the first 72 h of life in human infants

scientific article published on 01 November 1993

Local application of melatonin into alveolar sockets of beagle dogs reduces tooth removal-induced oxidative stress

scientific article published in March 2007

Long-term melatonin administration protects brain mitochondria from aging.

scientific article published in July 2009

Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum

scientific article published in November 2004

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

scientific article published on 28 February 2019

Melatonin Treatment Reduces Oxidative Damage and Normalizes Plasma Pro-Inflammatory Cytokines in Patients Suffering from Charcot-Marie-Tooth Neuropathy: A Pilot Study in Three Children.

scientific article

Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice

scientific article published on 01 September 2007

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis.

scientific article published on 31 March 2017

Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome

scientific article published on 16 September 2020

Melatonin and beta-endorphin changes in children sensitized to olive and grass pollen after treatment with specific immunotherapy

scientific article published in September 2001

Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

scientific article published on October 2009

Melatonin and metabolic regulation: a review.

scientific article

Melatonin and mitochondrial function

scientific article published on July 2004

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

scientific article

Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress

scientific article published on 01 September 2000

Melatonin concentration in the umbilical artery and vein in human preterm and term neonates and neonates with acute fetal distress

scientific article published on 01 November 1992

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

scientific article published in January 2006

Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats

scientific article published on 28 March 2003

Melatonin counteracts pinealectomy-dependent decreases in rat brain [3H]flunitrazepam binding through an opioid mechanism

scientific article

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function.

scientific article

Melatonin expression in periodontal disease

scientific article published in December 2007

Melatonin improves deferoxamine antioxidant activity in protecting against lipid peroxidation caused by hydrogen peroxide in rat brain homogenates

scientific article published in April 2002

Melatonin in antinociception: its therapeutic applications.

scientific article

Melatonin in the oral cavity: physiological and pathological implications.

scientific article published on 25 March 2014

Melatonin increases following convulsive seizures may be related to its anticonvulsant properties at physiological concentrations.

scientific article published in June 2007

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

scientific article published in April 2002

Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats

scientific article published on 01 September 1999

Melatonin interaction with magnesium and zinc in the response of the striatum to sensorimotor cortical stimulation in the rat.

scientific article published in March 1998

Melatonin is protective against MPTP-induced striatal and hippocampal lesions

scientific article published in January 1997

Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

scientific article

Melatonin protects lung mitochondria from aging ⬇️

scientific article published on May 26, 2011

Melatonin protects rats from radiotherapy-induced small intestine toxicity

scientific article

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

scientific article published on 19 November 2008

Melatonin receptors in purified cell nuclei of liver

scientific article published on 01 November 1993

Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice.

scientific article

Melatonin reduces nitric oxide synthase activity in rat hypothalamus

scientific article published on 01 May 1996

Melatonin reduces oxidative stress because of tooth removal

scientific article published on 01 April 2007

Melatonin reduces oxidative stress in erythrocytes and plasma of senescence-accelerated mice

scientific article published on 01 September 2006

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

scientific article published on 11 April 2016

Melatonin restores the mitochondrial production of ATP in septic mice

scientific article published on 01 October 2006

Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks

scientific article published on 01 October 1995

Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy

scientific article published on 15 April 2011

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

scientific article published on 4 March 2010

Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence

scientific article published in October 1998

Melatonin, a potential therapeutic agent for smooth muscle-related pathological conditions and aging.

scientific article published on January 2010

Melatonin, clock genes and mitochondria in sepsis.

scientific article published on 07 August 2017

Melatonin, synthetic analogs, and the sleep/wake rhythm

scientific article published in March 2009

Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

scientific article published on 01 May 2000

Melatonin-mitochondria interplay in health and disease.

scientific article published on January 2011

Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

scientific article published on 27 November 2020

Melatonin: potential functions in the oral cavity.

scientific article published on June 2007

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes.

scientific article

Mitochondrial DNA and inflammatory diseases.

scientific article published on 07 July 2011

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

scientific article published on 11 August 2017

Mitochondrial regulation by melatonin and its metabolites.

scientific article published on January 2003

Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives

scientific article published in April 1998

Modulation of rat striatal glutamatergic response in search for new neuroprotective agents: evaluation of melatonin and some kynurenine derivatives

scientific article published on March 1998

N-acetylserotonin suppresses hepatic microsomal membrane rigidity associated with lipid peroxidation

scientific article published in October 2001

Oxidative damage in the livers of senescence-accelerated mice: a gender-related response.

scientific article published in February 2006

Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.

scientific article published on December 2010

Parameters of oxidative stress in saliva from diabetic and parenteral drug addict patients

scientific article published on 01 October 2006

Participation of ACTH1–10 and ACTH4–10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex

scientific article published on 01 March 1995

Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network

scientific article

Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.

scientific article

Pineal modulation of the rat caudate-putamen spontaneous neuronal activity: roles of melatonin and vasotocin

scientific article published on 01 October 1993

Pineal response after pyridoxine test in children

scientific article published on 01 January 1996

Pinealectomy increases ouabain high-affinity binding sites and dissociation constant in rat cerebral cortex

scientific article published in June 1991

Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memory

scientific journal article

Presence and effects of melatonin in Trypanosoma cruzi

article

Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation.

scientific article published on 7 August 2016

Prophylactic actions of melatonin in oxidative neurotoxicity

scientific article published on October 1997

Protective Effects of Melatonin on the Skin: Future Perspectives

scientific article published on 08 October 2019

Protective effect of beta-carbolines and other antioxidants on lipid peroxidation due to hydrogen peroxide in rat brain homogenates

scientific article published on 01 November 2000

Protective effects of melatonin against oxidative damage induced by Egyptian cobra (Naja haje) crude venom in rats

scientific article published on 24 December 2014

Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice

scientific article published on 17 March 2011

Protective role of melatonin against MPTP-induced mouse brain cell DNA fragmentation and apoptosis in vivo.

scientific article

Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).

scientific article published on 26 January 2008

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease

scientific article published on 18 March 2019

Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin.

scientific article

Redox status and antioxidant response in professional cyclists during training

scientific article published on 7 May 2014

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

scientific article published in Scientific Reports

Relationship between salivary melatonin and severity of periodontal disease

scientific article published on 01 September 2006

Relationship between salivary melatonin levels and periodontal status in diabetic patients

scientific article published in November 2003

Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures

scientific article published in December 1997

Retinoid-related orphan nuclear receptor alpha (RORα)-deficient mice display morphological testicular defects

scientific article published on 13 August 2019

Role of pinoline and melatonin in stabilizing hepatic microsomal membranes against oxidative stress

scientific article published on 01 December 1999

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

scientific article published on 17 December 2015

Scientists Against War: A Plea to World Leaders for Better Governance

scientific article published in 2022

Selective CCK-A but not CCK-B receptor antagonists inhibit HT-29 cell proliferation: synergism with pharmacological levels of melatonin

scientific article

Similarity between the effects of suprachiasmatic nuclei lesions and of pinealectomy on gonadotropin release in ovariectomized, sulpiride-treated and melatonin-replaced rats

scientific article published on 01 September 1993

Specific binding of melatonin to purified cell nuclei from mammary gland of swiss mice: day-night variations and effect of continuous light

scientific article published in May 2003

Structure-related inhibition of calmodulin-dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines

scientific article published on 01 November 2000

Suppressive effect of simultaneous injection of ACTH1-10 and beta-endorphin on brain [3H]flunitrazepam binding

scientific article published on 01 December 1993

Synergism between melatonin and atorvastatin against endothelial cell damage induced by lipopolysaccharide

scientific article published on 17 May 2011

Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion

scientific article published in May 2003

Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group

scientific article published on 17 May 2013

Synthesis and biological evaluation of indazole derivatives

scientific article published on 28 January 2011

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders

scientific article published on 01 December 2018

The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice.

scientific article published in March 2018

The Protective Effect of Melatonin Against Age-Associated Sarcopenia-Dependent Tubular Aggregates Formation, Lactate Depletion and Mitochondrial Changes.

scientific article published on 19 March 2018

The Role of Mitochondria in Brain Aging and the Effects of Melatonin ⬇️

scientific article published on September 1, 2010

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS.

scientific article

The benefit of a supplement with the antioxidant melatonin on redox status and muscle damage in resistance-trained athletes.

scientific article published on 13 February 2017

The benefits of four weeks of melatonin treatment on circadian patterns in resistance-trained athletes.

scientific article published on 11 September 2015

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene.

scientific article published on 23 March 2015

Time-dependent changes of serum gastrin and gastrin receptors in the rat oxyntic mucosa after proximal gastric vagotomy

scientific article published on 01 February 1997

Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency

scientific article published on 24 February 2014

Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience

scientific article published in September 1997

[The effect of melatonin as anti-convulsant and neuron protector]

scientific article published on 01 August 1997

β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in mice

scientific article published on 01 January 2019

β-globin gene cluster haplotypes in sickle cell patients from Panamá.

scientific article published on 8 March 2011

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