List of works - Bjørn Olav Brandsdal

A polarizable embedding DFT study of one-photon absorption in fluorescent proteins.

scientific article published in April 2013

A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption

scientific article

Albumin binding of short cationic antimicrobial micropeptides and its influence on the in vitro bactericidal effect

scientific article published on 15 June 2007

Altered activity and physicochemical properties of short cationic antimicrobial peptides by incorporation of arginine analogues.

scientific article

Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin.

scientific article published on April 2014

Antimicrobial peptides with stability toward tryptic degradation.

scientific article

Binding affinity prediction with different force fields: examination of the linear interaction energy method

scientific article published in July 2004

Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

scientific article

Catalytic Adaptation of Psychrophilic Elastase

scientific article published on 10 May 2018

Cold adaptation of enzyme reaction rates.

scientific article

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

scientific article published on 01 December 1999

Comparative unfolding studies of psychrophilic and mesophilic uracil DNA glycosylase: MD simulations show reduced thermal stability of the cold-adapted enzyme

scientific article published on 24 October 2006

Computational analysis of binding of P1 variants to trypsin.

scientific article published on August 2001

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase

scientific article

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

scientific article

Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae

scientific article

Electrostatic effects play a central role in cold adaptation of trypsin

scientific article published in June 2001

Electrostatic interactions play an essential role in DNA repair and cold-adaptation of uracil DNA glycosylase

scientific article published on 15 January 2008

Electrostatics of mesophilic and psychrophilic trypsin isoenzymes: qualitative evaluation of electrostatic differences at the substrate binding site

scientific article published in August 2000

Entropy and Enzyme Catalysis

scientific article

Evaluation of protein-protein association energies by free energy perturbation calculations

scientific article published in April 2000

Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)

scientific article published on 01 April 2010

Ferric uptake regulator protein: binding free energy calculations and per-residue free energy decomposition

scientific article

Free energy calculations and ligand binding

scientific article published on January 2003

Free energy calculations show that acidic P1 variants undergo large pKa shifts upon binding to trypsin

scientific article published on 01 August 2006

Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid.

scientific article published on 30 August 2012

Increased flexibility as a strategy for cold adaptation: a comparative molecular dynamics study of cold- and warm-active uracil DNA glycosylase

scientific article

Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

scientific article published in February 2006

Ion pairs and their role in modulating stability of cold- and warm-active uracil DNA glycosylase

article

Ligand binding affinities from MD simulations.

scientific article

Near Native-State Conformational Landscape of Psychrophilic and Mesophilic Enzymes: Probing the Folding Funnel Model

scientific article published on 01 June 2010

Optimization of electrostatics as a strategy for cold-adaptation: A case study of cold- and warm-active elastases

article

Predicting proteinase specificities from free energy calculations

scientific article published on 10 January 2006

Probing the effect of point mutations at protein-protein interfaces with free energy calculations

scientific article published on 4 November 2005

Protein surface softness is the origin of enzyme cold-adaptation of trypsin

scientific article

Qgui: A high-throughput interface for automated setup and analysis of free energy calculations and empirical valence bond simulations in biological systems

scientific article

QresFEP: An Automated Protocol for Free Energy Calculations of Protein Mutations in Q

scientific article published on 04 September 2019

Resolving the energy paradox of chaperone/usher-mediated fibre assembly

scientific article published on August 2005

Short cationic antimicrobial peptides bind to human alpha-1 acid glycoprotein with no implications for the in vitro bioactivity.

scientific article

Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division

scientific article published on 19 May 2015

Structural evidence for lack of inhibition of fish goose-type lysozymes by a bacterial inhibitor of lysozyme

scientific article published on 20 May 2008

Synthesis of anticancer heptapeptides containing a unique lipophilic β(2,2) -amino acid building block.

scientific article published on 16 January 2012

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

scientific article

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

scientific article published on 11 July 2012

The antibody site in Atlantic salmon; phage display and modeling of scFv with anti-hapten binding ability

scientific article

The primary structure and specificity determining residues displayed by recombinant salmon antibody domains.

scientific article published in April 2004

Thermodynamics and structure of a salmon cold active goose-type lysozyme

scientific article

Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations.

scientific article published on 15 December 2016

Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements

scientific article

Unnatural amino acid side chains as S1, S1', and S2' probes yield cationic antimicrobial peptides with stability toward chymotryptic degradation

scientific article published on August 2010

List of works by Bjørn Olav Brandsdal

A polarizable embedding DFT study of one-photon absorption in fluorescent proteins.

A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption

Albumin binding of short cationic antimicrobial micropeptides and its influence on the in vitro bactericidal effect

Altered activity and physicochemical properties of short cationic antimicrobial peptides by incorporation of arginine analogues.

Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin.

Antimicrobial peptides with stability toward tryptic degradation.

Binding affinity prediction with different force fields: examination of the linear interaction energy method

Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

Catalytic Adaptation of Psychrophilic Elastase

Cold adaptation of enzyme reaction rates.

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

Comparative unfolding studies of psychrophilic and mesophilic uracil DNA glycosylase: MD simulations show reduced thermal stability of the cold-adapted enzyme

Computational analysis of binding of P1 variants to trypsin.

Computer Simulations Reveal Substrate Specificity of Glycosidic Bond Cleavage in Native and Mutant Human Purine Nucleoside Phosphorylase

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae

Electrostatic effects play a central role in cold adaptation of trypsin

Electrostatic interactions play an essential role in DNA repair and cold-adaptation of uracil DNA glycosylase

Electrostatics of mesophilic and psychrophilic trypsin isoenzymes: qualitative evaluation of electrostatic differences at the substrate binding site

Entropy and Enzyme Catalysis

Evaluation of protein-protein association energies by free energy perturbation calculations

Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida)

Ferric uptake regulator protein: binding free energy calculations and per-residue free energy decomposition

Free energy calculations and ligand binding

Free energy calculations show that acidic P1 variants undergo large pKa shifts upon binding to trypsin

Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid.

Increased flexibility as a strategy for cold adaptation: a comparative molecular dynamics study of cold- and warm-active uracil DNA glycosylase

Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

Ion pairs and their role in modulating stability of cold- and warm-active uracil DNA glycosylase

Ligand binding affinities from MD simulations.

Near Native-State Conformational Landscape of Psychrophilic and Mesophilic Enzymes: Probing the Folding Funnel Model

Optimization of electrostatics as a strategy for cold-adaptation: A case study of cold- and warm-active elastases

Predicting proteinase specificities from free energy calculations

Probing the effect of point mutations at protein-protein interfaces with free energy calculations

Protein surface softness is the origin of enzyme cold-adaptation of trypsin

Qgui: A high-throughput interface for automated setup and analysis of free energy calculations and empirical valence bond simulations in biological systems

QresFEP: An Automated Protocol for Free Energy Calculations of Protein Mutations in Q

Resolving the energy paradox of chaperone/usher-mediated fibre assembly

Short cationic antimicrobial peptides bind to human alpha-1 acid glycoprotein with no implications for the in vitro bioactivity.

Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division

Structural evidence for lack of inhibition of fish goose-type lysozymes by a bacterial inhibitor of lysozyme

Synthesis of anticancer heptapeptides containing a unique lipophilic β(2,2) -amino acid building block.

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

The antibody site in Atlantic salmon; phage display and modeling of scFv with anti-hapten binding ability

The primary structure and specificity determining residues displayed by recombinant salmon antibody domains.

Thermodynamics and structure of a salmon cold active goose-type lysozyme

Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations.

Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements

Unnatural amino acid side chains as S1, S1', and S2' probes yield cationic antimicrobial peptides with stability toward chymotryptic degradation