List of works - Heikki Hyöty

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY

scientific article

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

scientific article

Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth

scientific article

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

scientific article

Amplifying control RNA for RT-PCR applications by nucleic acid sequence based amplification (NASBA).

scientific article

Antibiotic resistance in pathogens causing acute otitis media in Finnish children

scientific article

Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology

scientific article published on 23 June 2015

B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study

scientific article published on 29 September 2015

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes

scientific article

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

scientific article published on 29 April 2013

Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes

scientific article

Coxsackievirus B3-induced cellular protrusions: structural characteristics and functional competence

scientific article

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

scientific article published on 29 January 2017

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes

scientific article

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity

scientific article published on 9 January 2017

Developing a vaccine for Type 1 diabetes through targeting enteroviral infections

scientific article published on 26 June 2014

Diagnostic methods for and clinical pictures of polyomavirus primary infections in children, Finland

scientific article published on April 2014

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

scientific article published on 15 December 2008

Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin

scientific article

Enterovirus RNA in blood is linked to the development of type 1 diabetes ⬇️

scientific article

Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)

scientific article

Enterovirus infections and type 1 diabetes

scientific article

Enteroviruses in the pathogenesis of type 1 diabetes

scientific article published on 28 April 2010

Environmental causes: viral causes

scientific article published on March 2004

Environmental factors in the etiology of type 1 diabetes

scientific article

Environmental triggers and determinants of type 1 diabetes

scientific article

Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes

scientific article published on February 2004

Evaluation of immunohistochemistry and in situ hybridization methods for the detection of enteroviruses using infected cell culture samples

scientific article

Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life

scientific article

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes

scientific article

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study

scientific article

Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.

scientific article

Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes

scientific article

Is alcoholic pancreatitis associated with enteroviral infection?

scientific article published on June 2013

Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study

scientific article published on 2 September 2017

Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring

scientific article

Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.

scientific article published on January 2008

Microbial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort study

scientific article

Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children

scientific article published on 13 July 2016

Multiple consecutive norovirus infections in the first 2 years of life

scientific article

Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life

scientific article published on 31 August 2016

Next-Generation Sequencing Combined with Specific PCR Assays To Determine the Bacterial 16S rRNA Gene Profiles of Middle Ear Fluid Collected from Children with Acute Otitis Media

scientific article published on 22 March 2017

Onset of Type 1 diabetes mellitus in infancy after enterovirus infections ⬇️

scientific article published on May 1, 1998

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

scientific article

Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study

scientific article published on 2 August 2017

Role of viruses and other microbes in the pathogenesis of type 1 diabetes

scientific article

Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes

scientific article published on 22 December 2015

T cell epitopes in coxsackievirus B4 structural proteins concentrate in regions conserved between enteroviruses

scientific article published on February 2002

Temporal relationship between human parechovirus 1 infection and otitis media in young children

scientific article

The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland

scientific article

The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei

scientific article

Toward defining the autoimmune microbiome for type 1 diabetes

scientific article

Type 1 diabetes is associated with enterovirus infection in gut mucosa

scientific article published on 7 February 2012

Viruses in type 1 diabetes

scientific article

List of works by Heikki Hyöty

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

Age at development of type 1 diabetes- and celiac disease-associated antibodies and clinical disease in genetically susceptible children observed from birth

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes

Amplifying control RNA for RT-PCR applications by nucleic acid sequence based amplification (NASBA).

Antibiotic resistance in pathogens causing acute otitis media in Finnish children

Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology

B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes

Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes

Coxsackievirus B1 is associated with induction of β-cell autoimmunity that portends type 1 diabetes

Coxsackievirus B3-induced cellular protrusions: structural characteristics and functional competence

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity

Developing a vaccine for Type 1 diabetes through targeting enteroviral infections

Diagnostic methods for and clinical pictures of polyomavirus primary infections in children, Finland

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin

Enterovirus RNA in blood is linked to the development of type 1 diabetes ⬇️

Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)

Enterovirus infections and type 1 diabetes

Enteroviruses in the pathogenesis of type 1 diabetes

Environmental causes: viral causes

Environmental factors in the etiology of type 1 diabetes

Environmental triggers and determinants of type 1 diabetes

Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes

Evaluation of immunohistochemistry and in situ hybridization methods for the detection of enteroviruses using infected cell culture samples

Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study

Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.

Impact of intranasal insulin on insulin antibody affinity and isotypes in young children with HLA-conferred susceptibility to type 1 diabetes

Is alcoholic pancreatitis associated with enteroviral infection?

Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study

Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring

Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.

Microbial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort study

Moraxella catarrhalis Might Be More Common than Expected in Acute Otitis Media in Young Finnish Children

Multiple consecutive norovirus infections in the first 2 years of life

Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life

Next-Generation Sequencing Combined with Specific PCR Assays To Determine the Bacterial 16S rRNA Gene Profiles of Middle Ear Fluid Collected from Children with Acute Otitis Media

Onset of Type 1 diabetes mellitus in infancy after enterovirus infections ⬇️

Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells

Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study

Role of viruses and other microbes in the pathogenesis of type 1 diabetes

Serum 25-Hydroxyvitamin D Concentrations in Children Progressing to Autoimmunity and Clinical Type 1 Diabetes

T cell epitopes in coxsackievirus B4 structural proteins concentrate in regions conserved between enteroviruses

Temporal relationship between human parechovirus 1 infection and otitis media in young children

The 'Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland

The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei

Toward defining the autoimmune microbiome for type 1 diabetes

Type 1 diabetes is associated with enterovirus infection in gut mucosa

Viruses in type 1 diabetes