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List of works by Timothy B. Niewold

A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

scientific article

A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus

scholarly article by Zubin Patel published in April 2018

ABIN1 dysfunction as a genetic basis for lupus nephritis

scientific article published on 22 August 2013

Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

scientific article published on October 2013

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

scientific article

African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity

scientific article published on 7 May 2010

Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus.

scientific article published on 02 April 2009

Age- and sex-related patterns of serum interferon-alpha activity in lupus families

scientific article published on July 2008

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

scientific article

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus

scientific article published on 21 November 2011

Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis.

scientific article published on April 2007

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups

scientific article

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

scientific article

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility

scientific article

Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients

scientific article published on August 2008

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus

scientific article

Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds

scientific article published on 13 January 2018

Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept

scientific article published on December 2007

Autoimmune disease genetics

scientific article published on 24 December 2012

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients

scientific article published on 24 June 2011

B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels

scientific article published on December 2011

Bone health issues in sarcoidosis

scientific article published in June 2011

Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus

scientific article

CheB is required for behavioural responses to negative stimuli during chemotaxis in Bacillus subtilis

article

Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease

scientific article published on 4 February 2013

Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience

scientific article

Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

scientific article

Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

scientific article published on 9 June 2016

Concomitant interferon-alpha therapy and tumor necrosis factor alpha inhibition for rheumatoid arthritis and hepatitis C.

scientific article published in July 2006

Cytokines in systemic lupus erythematosus

scientific article published on January 2010

Cytokines in systemic lupus erythematosus 2011.

scientific article published on 29 December 2011

Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production

scientific article published on 18 January 2016

Defining biological subsets in systemic lupus erythematosus: progress toward personalized therapy.

scientific article

Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features.

scientific article published on 18 November 2016

Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange

article

Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab

scientific article published on 25 October 2010

Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy.

scientific article published on June 2009

End-stage renal disease in African Americans with lupus nephritis is associated with APOL1

scientific article published on February 2014

Evaluation of TRAF6 in a large multiancestral lupus cohort

scientific article

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

scientific article published on February 2012

Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade.

scientific article published on 14 July 2008

Familial aggregation of autoimmune disease in juvenile dermatomyositis

scientific article (publication date: May 2011)

Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus

scientific article published on 25 September 2013

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups

scientific article published on 17 August 2012

Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients

scientific article published on 17 August 2012

Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus

scientific article

Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis

scientific article

Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus

scientific article

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

scientific article

Genetic regulation of serum cytokines in systemic lupus erythematosus

scientific article

Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients

scientific article

Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis.

scientific article published on 22 August 2013

Genetics of the type I interferon pathway in systemic lupus erythematosus

scientific article published on December 2013

IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus

scientific article

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study

scientific article published on 29 March 2012

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study

scientific article

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

scientific article

Immunogenetics of systemic lupus erythematosus: A comprehensive review

scientific article

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations

scientific article

Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study

scientific article published on 29 November 2017

Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis

scientific article published on 6 November 2015

Increased serum type I interferon activity in organ-specific autoimmune disorders: clinical, imaging, and serological associations.

scientific article published on 19 August 2013

Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features

scientific article

Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins

scientific article published on October 2012

Interferon alpha as a primary pathogenic factor in human lupus ⬇️

scientific article published on September 16, 2011

Interferon alpha in systemic lupus erythematosus

scientific article

Interferon alpha-induced lupus: proof of principle

scientific article

Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus

scientific article

Interferon regulatory factors in human lupus pathogenesis

scientific article

Interferon regulatory factors: critical mediators of human lupus

scientific article

Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis

scientific article

Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus

scientific article

Lenalidomide for the treatment of cryoglobulinemia and undifferentiated spondyloarthropathy in a patient with multiple myeloma

scientific article published on March 2010

Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells

scientific article published in September 2010

Lessons from precision medicine in rheumatology

scientific article published on 22 January 2020

Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry

scientific article

MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus

scientific article

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

scientific article

Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies

scientific article published on 19 August 2020

Nucleic Acid sensors and type I interferon production in systemic lupus erythematosus

scientific article published in 2013

Ocrelizumab: a step forward in the evolution of B-cell therapy

scientific article (publication date: July 2009)

Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus

scientific article

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes

scientific article

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

scientific article published on 30 June 2011

Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus

scientific article published on 23 January 2013

Post-streptococcal reactive arthritis and glomerulonephritis in an adult

scientific article published on 01 October 2003

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

scientific article

Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression

scientific article

Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients

scientific article

Rheumatologic manifestations of sarcoidosis

scientific article

Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus

scientific article published on 30 April 2014

Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus

scientific article published on February 2008

Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations

scientific article

Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes

scientific article published in 2021

Sirukumab : a novel therapy for lupus nephritis?

scientific article published on 05 September 2014

Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman

scientific article published on 6 September 2013

Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C.

scientific article

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

scientific article

The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus

scientific article published on September 2008

The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes

scientific article published in November 2011

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis

scientific article published on 10 April 2012

The role of genetic variation near interferon-kappa in systemic lupus erythematosus

scientific article

The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies

scientific article

Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.

scientific article

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4.

scientific article

Transancestral mapping and genetic load in systemic lupus erythematosus

scientific article published on 17 July 2017

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription

scientific article published on April 2014

Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus

scientific article published on 19 August 2019

Type I interferon in human autoimmunity

scientific article published on 30 June 2014

Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis

scientific article

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry

scientific article

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

scientific article

Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus

scientific article

Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations

scientific article published on 24 April 2015

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