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List of works by Brendan J. Jenkins

A cell type-specific constitutive point mutant of the common beta-subunit of the human granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 receptors requires the GM-CSF receptor alpha-subunit for activation

scientific article published on March 1999

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

scientific article published on 01 April 2019

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis

scientific article

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

scientific article published on 20 January 2012

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis.

scientific article published on 14 April 2014

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.

scientific article

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis.

scientific article published on 3 June 2013

Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors.

scientific article published on 15 February 2017

Functional expression cloning reveals proapoptotic role for protein phosphatase 4

scientific article published on 01 September 2003

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

scientific article

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling

scientific article

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.

scientific article

Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. ⬇️

scientific article published on 8 February 2018

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

scientific article published on 10 December 2010

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation.

scientific article

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice.

scientific article published on 10 February 2014

IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.

scientific article published on 7 January 2016

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

scientific article published on 23 December 2014

In vivo evidence that RBM5 is a tumour suppressor in the lung

scientific article published on 24 November 2017

Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors.

scientific article

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice.

scientific article

Interacting residues in the extracellular region of the common beta subunit of the human granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptors involved in constitutive activation.

scientific article published on November 1996

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.

scientific article

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice.

scientific article published on 4 February 2011

Interleukin-6 signaling drives fibrosis in unresolved inflammation

scientific article published on 09 January 2014

Investigating the Role of Toll-Like Receptors in Mouse Models of Gastric Cancer

scientific article published on January 2016

Isolation and characterization of a sheep cysteine-rich cuticle keratin pseudogene

scientific article published on January 1, 1992

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling.

scientific article

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.

scientific article

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.

scientific article

Nucleotide oligomerization domain 1 enhances IFN-γ signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity.

scientific article published on 4 March 2013

Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer

scientific article published in 2021

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

scientific article published on 02 November 2006

Potential efficacy of interleukin-1β inhibition in lung cancer

scientific article

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

scientific article

STAT1 plays a role in TLR signal transduction and inflammatory responses.

scientific article published on 15 July 2014

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.

scientific article

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

scientific article published on May 2008

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation.

scientific article published in October 2012

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

scientific article

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.

scientific article published on 27 June 2011

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

scientific article published on 13 January 2005

Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

scientific article published on 07 January 2019

Transcriptional regulation of pattern recognition receptors by Jak/STAT signaling, and the implications for disease pathogenesis

scientific article

Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers.

scientific article published on 24 June 2013

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