List of works - Simon J. Williams

A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes

scientific article published on 15 March 2015

A rust‐fungus Nudix hydrolase effector decaps <scp>mRNA</scp><i>in vitro</i> and interferes with plant immune pathways

scientific article published in 2023

An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP.

scientific article published in August 2011

Animal NLRs provide structural insights into plant NLR function

scientific article

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1‐R immune receptor

scientific article published on 03 February 2019

Comparative Analysis of the Flax Immune Receptors L6 and L7 Suggests an Equilibrium-Based Switch Activation Model

scientific article published on 7 January 2016

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

scientific article published on 30 May 2017

Crystal Structure of Rice Importin- and Structural Basis of Its Interaction with Plant-Specific Nuclear Localization Signals

scientific article

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery

scientific article

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

scientific article published on 17 August 2017

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.

scientific article published on 26 November 2011

Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana

scientific article published on 30 October 2013

Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1.

scientific article published on 28 September 2013

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.

scientific article

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

scientific article

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans

scientific article published on 17 August 2016

Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α

scientific article

Emerging Insights into the Functions of Pathogenesis-Related Protein 1.

scientific article published on 22 July 2017

Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma.

scientific article

Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals

Fusion-protein-assisted protein crystallization

scientific article published on 27 June 2015

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

scientific article

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death

scientific article

Multiple functional self-association interfaces in plant TIR domains

scientific article

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

scientific article published on 01 August 2019

PR1-mediated defence via C-terminal peptide release is targeted by a fungal pathogen effector

scientific article published on 04 December 2020

Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies

scientific article

Purification of the M flax-rust resistance protein expressed in Pichia pastoris

scientific article published on 25 April 2007

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans

scientific article published on 21 August 2013

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

scientific article published on 13 October 2014

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

scientific article

Structural basis for assembly and function of a heterodimeric plant immune receptor

scientific article

Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-α

scientific article

Structural determinants of the IRF4/DNA homodimeric complex

scientific article published on 01 February 2021

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1.

scientific article published on 08 December 2016

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

scientific article

Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity

scientific article

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

scientific article published on 17 October 2016

The Plant "Resistosome": Structural Insights into Immune Signaling

scientific article published on 01 August 2019

The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site inplantnuclear import factor importin-α.

scientific article

The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana

scientific article

The stem rust effector protein AvrSr50 escapes Sr50 recognition by a substitution in a single surface‐exposed residue

scientific article published in 2022

Towards the structure of the TIR-domain signalosome

scientific article published on 13 January 2017

Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins

scientific article

List of works by Simon J. Williams

A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes

A rust‐fungus Nudix hydrolase effector decaps <scp>mRNA</scp><i>in vitro</i> and interferes with plant immune pathways

An autoactive mutant of the M flax rust resistance protein has a preference for binding ATP, whereas wild-type M protein binds ADP.

Animal NLRs provide structural insights into plant NLR function

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1‐R immune receptor

Comparative Analysis of the Flax Immune Receptors L6 and L7 Suggests an Equilibrium-Based Switch Activation Model

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Crystal Structure of Rice Importin- and Structural Basis of Its Interaction with Plant-Specific Nuclear Localization Signals

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.

Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana

Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1.

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans

Distinctive conformation of minor site-specific nuclear localization signals bound to importin-α

Emerging Insights into the Functions of Pathogenesis-Related Protein 1.

Engineering Saccharomyces cerevisiae to release 3-Mercaptohexan-1-ol during fermentation through overexpression of an S. cerevisiae Gene, STR3, for improvement of wine aroma.

Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals

Fusion-protein-assisted protein crystallization

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death

Multiple functional self-association interfaces in plant TIR domains

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

PR1-mediated defence via C-terminal peptide release is targeted by a fungal pathogen effector

Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies

Purification of the M flax-rust resistance protein expressed in Pichia pastoris

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

Structural basis for assembly and function of a heterodimeric plant immune receptor

Structural basis of interaction of bipartite nuclear localization signal from Agrobacterium VirD2 with rice importin-α

Structural determinants of the IRF4/DNA homodimeric complex

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1.

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

The Plant "Resistosome": Structural Insights into Immune Signaling

The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site inplantnuclear import factor importin-α.

The nuclear immune receptor RPS4 is required for RRS1SLH1-dependent constitutive defense activation in Arabidopsis thaliana

The stem rust effector protein AvrSr50 escapes Sr50 recognition by a substitution in a single surface‐exposed residue

Towards the structure of the TIR-domain signalosome

Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins