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List of works by Uwe Heinemann

5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices

scientific article

A LED-based method for monitoring NAD(P)H and FAD fluorescence in cell cultures and brain slices

scientific article

A neuronal lactate uptake inhibitor slows recovery of extracellular ion concentration changes in the hippocampal CA3 region by affecting energy metabolism

scientific article

A novel mechanism underlying drug resistance in chronic epilepsy

scientific article published on April 2003

A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats

scientific article published in January 2008

Accelerated hippocampal spreading depression and enhanced locomotory activity in mice with astrocyte-directed inactivation of connexin43.

scientific article published in February 2003

Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats

scientific article published in February 2008

Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network

scientific article published on March 2013

Acute and long-term effects of MK-801 on direct cortical input evoked homosynaptic and heterosynaptic plasticity in the CA1 region of the female rat.

scientific article published in November 2007

Acute neuronal injury after hypoxia is influenced by the reoxygenation mode in juvenile hippocampal slice cultures

scientific article

Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?

scientific article published on August 2009

Basic mechanisms of partial epilepsies

scientific article published on April 2004

Blood-Brain Barrier Dysfunction in Epileptogenesis of the Temporal Lobe ⬇️

scientific article published on June 7, 2011

Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy

scientific article published on 11 April 2009

Blood-brain barrier dysfunction can contribute to pharmacoresistance of seizures

scientific article published on 3 July 2014

Blood‐brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy ⬇️

scientific article published on February 29, 2012

C-Type natriuretic peptide modulates pre- and postsynaptic properties in hippocampal area CA1 in vitro

scientific article published on 24 October 2008

Ca2+-independent muscarinic excitation of rat medial entorhinal cortex layer V neurons

scientific article published in December 2003

Calcium currents in rat entorhinal cortex layer II stellate and layer III pyramidal neurons in acute brain slice

scientific article

Cell and gene therapies in epilepsy--promising avenues or blind alleys?

scientific article

Changes of neuronal activity in areas CA1 and CA3 during anoxia and normoxic or hyperoxic reoxygenation in juvenile rat organotypic hippocampal slice cultures

scientific article published on 27 December 2005

Characterization of the inhibitory glycine receptor on entorhinal cortex neurons

scientific article published in April 2004

Cholinergic dysfunction in temporal lobe epilepsy

scientific article published on January 2007

Co-existence of GABA and Glu in the hippocampal granule cells: implications for epilepsy

scientific article published on January 2006

Comment on "On the origin of interictal activity in human temporal lobe epilepsy in vitro".

scientific article published in July 2003

Contribution of Intrinsic Lactate to Maintenance of Seizure Activity in Neocortical Slices from Patients with Temporal Lobe Epilepsy and in Rat Entorhinal Cortex

scientific article published on 23 August 2017

Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells

scientific article published on 17 October 2012

Corticosterone and corticotropin-releasing factor acutely facilitate gamma oscillations in the hippocampus in vitro

scientific article published on 13 October 2014

Coupling of electrical and metabolic activity during epileptiform discharges

scientific article

Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1.

scientific article published in May 2002

Diagnostic strategies in spinal trauma

scientific article

Differential effects of blockade of ERG channels on gamma oscillations and excitability in rat hippocampal slices

scientific article published on 10 October 2012

Differential excitability and voltage-dependent Ca2+ signalling in two types of medial entorhinal cortex layer V neurons

scientific article published in October 2002

Differential participation of pyramidal cells in generation of spontaneous sharp wave-ripples in the mouse subiculum in vitro

scientific article published on 28 August 2015

Dopamine depresses cholinergic oscillatory network activity in rat hippocampus ⬇️

scientific article published on November 1, 2003

Drug refractoriness of epileptiform activity in organotypic hippocampal slice cultures depends on the mode of provocation

scientific article published on August 2010

Early adenosine release contributes to hypoxia-induced disruption of stimulus-induced sharp wave-ripple complexes in rat hippocampal area CA3.

scientific article published on 12 June 2015

Effects of 4-aminopyridine on sharp wave-ripples in rat hippocampal slices

scientific article

Effects of XE991, retigabine, losigamone and ZD7288 on kainate-induced theta-like and gamma network oscillations in the rat hippocampus in vitro

scientific article published on 20 August 2009

Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy

scientific article published in January 2002

Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats

scientific article

Effects of γ-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures

scientific article (publication date: October 2009)

Electrical and chemical long-term depression do not attenuate low-Mg2+-induced epileptiform activity in the entorhinal cortex

scientific article published in April 2005

Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?

scientific article

Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures

scientific article published in December 2002

Event-Associated Oxygen Consumption Rate Increases ca. Five-Fold When Interictal Activity Transforms into Seizure-Like Events In Vitro

scientific article published on 7 September 2017

Expression analysis of members of the neuronal calcium sensor protein family: combining bioinformatics and Western blot analysis.

scientific article published in October 2004

Far field effects of seizure like events induced by application of 4-AP in combined entorhinal cortex hippocampal slices

scientific article published in November 2002

First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5‐HT3 and D3 receptors ⬇️

scientific article published on December 1, 2012

Fluoxetine induces vasodilatation of cerebral arterioles by co‐modulating NO/muscarinic signalling ⬇️

scientific article published on November 1, 2012

Functional test of multidrug transporter activity in hippocampal-neocortical brain slices from epileptic patients

scientific article

GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments

scientific article

GABAB receptor dependent modulation of sharp wave-ripple complexes in the rat hippocampus in vitro

scientific article

Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat.

scientific article

Glutamate-induced gamma oscillations in the dentate gyrus of rat hippocampal slices

scientific article published in May 2002

Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro

scientific article published on 21 January 2009

Group III metabotropic glutamate receptor-mediated, chemically induced long-term depression differentially affects cell viability in the hippocampus

scientific article

Heterogeneous voltage dependence of interneuron resonance in the hippocampal stratum radiatum of adult rats

scientific article published on 31 August 2011

Hierarchical spike clustering analysis for investigation of interneuron heterogeneity

scientific article

High-frequency stimulation of the temporoammonic pathway induces input-specific long-term potentiation in subicular bursting cells

scientific article published on 31 October 2011

Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus ⬇️

scientific article published on August 3, 2011

Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures

scientific article

Hypoxia suppresses kainate-induced gamma-oscillations in rat hippocampal slices

scientific article

Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy

scholarly article

Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia

scientific article published on 22 July 2008

In search of models of pharmacoresistant epilepsy

scientific article published on July 2010

In vitro seizure like events and changes in ionic concentration

scientific article published on 20 August 2015

Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia

scientific article

Increased extracellular potassium concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression in human and rat brain slices

Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis

scientific article published on 12 December 2006

Increased susceptibility to acetylcholine in the entorhinal cortex of pilocarpine-treated rats involves alterations in KCNQ channels

scientific article published on 11 April 2013

Independent positioning of microelectrodes for multisite recordings in vitro

scientific article published on 6 September 2008

Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks

scientific article

Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO.

scientific article published on 18 May 2005

Kindling alters entorhinal cortex-hippocampal interaction by increased efficacy of presynaptic GABA(B) autoreceptors in layer III of the entorhinal cortex

scientific article published in August 2003

Kindling enhances kainate receptor-mediated depression of GABAergic inhibition in rat granule cells

scientific article published in September 2002

Long-lasting increase of corticosterone after fear memory reactivation: anxiolytic effects and network activity modulation in the ventral hippocampus

scientific article

Low-frequency stimulation of the direct cortical input to area CA1 induces homosynaptic LTD and heterosynaptic LTP in the rat hippocampal-entorhinal cortex slice preparation

scientific article

Low-frequency stimulation of the temporoammonic pathway induces heterosynaptic disinhibition in the subiculum

scientific article published on 13 April 2010

Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia

scientific article

Methodological standards for in vitro models of epilepsy and epileptic seizures. A TASK1-WG4 report of the AES/ILAE Translational Task Force of the ILAE.

scientific article published in November 2017

Monitoring stroke progression: in vivo imaging of cortical perfusion, blood-brain barrier permeability and cellular damage in the rat photothrombosis model

scientific article

Monoamines block kainate- and carbachol-induced gamma-oscillations but augment stimulus-induced gamma-oscillations in rat hippocampus in vitro

scientific article published in March 2009

Network activity in hippocampal slice cultures revealed by long-term in vitro recordings

scientific article published on 29 April 2013

Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience

scientific article published on 11 January 2017

Neuronal damage after moderate hypoxia and erythropoietin

scientific article published on 2 June 2005

New dangers of anesthesia: isoflurane induced opening of the blood-brain barrier (Commentary on Tétrault et al.).

scientific article published in October 2008

Nitric oxide modulates low-Mg2+-induced epileptiform activity in rat hippocampal-entorhinal cortex slices

scientific article published in October 2002

Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex

scientific article

Oxygen consumption and mitochondrial membrane potential indicate developmental adaptation in energy metabolism of rat cortical neurons

scientific article published on May 2005

Partial Disinhibition Is Required for Transition of Stimulus-Induced Sharp Wave–Ripple Complexes Into Recurrent Epileptiform Discharges in Rat Hippocampal Slices ⬇️

scientific article published on September 29, 2010

Persistent BBB disruption may underlie alpha interferon-induced seizures

scientific article published in January 2005

Pretreatment with β-adrenergic receptor agonists facilitates induction of LTP and sharp wave ripple complexes in rodent hippocampus

scientific article published on 3 October 2016

Primary afterdischarge in organotypic hippocampal slice cultures: Effects of standard antiepileptic drugs ⬇️

scientific article published on July 19, 2012

Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations ⬇️

scientific article published on October 8, 2011

RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats ⬇️

scientific article published on March 3, 2011

RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency

scientific article published on 15 May 2005

Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats ⬇️

scientific article published on July 20, 2011

Reduced ictogenic potential of 4-aminopyridine in the hippocampal region in the pilocarpine model of epilepsy ⬇️

scientific article published on February 9, 2012

Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats

scientific article published on 4 September 2007

Repetitive spreading depression-like events result in cell damage in juvenile hippocampal slice cultures maintained in normoxia

scientific article

Seizure forecasting using single robust linear feature as correlation vector of seizure-like events in brain slices preparation in vitro

scientific article published on 17 October 2018

Serotonin dependent masking of hippocampal sharp wave ripples

scientific article published on 24 September 2015

Shifts in excitatory/inhibitory balance by juvenile stress: A role for neuron-astrocyte interaction in the dentate gyrus

scientific article published on 15 February 2016

Should losartan be administered following brain injury?

scientific article

Slice cultures as a model to study neurovascular coupling and blood brain barrier in vitro

scientific article published on 16 February 2011

Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices

scientific article published in March 2002

State-dependencies of learning across brain scales

scientific article

Subthreshold resonance explains the frequency-dependent integration of periodic as well as random stimuli in the entorhinal cortex

scientific article published on 10 March 2004

Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin

scientific article published on 10 March 2016

Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy

scientific article published on 7 February 2007

TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

scientific article

TGFβ signaling is associated with changes in inflammatory gene expression and perineuronal net degradation around inhibitory neurons following various neurological insults

scientific article

The N-methyl-D-aspartate receptor (NMDAR) antagonist MK-801 does not block spreading ischemia in the rat

The blood-brain barrier-gatekeeper to neuronal homeostasis: clinical implications in the setting of stroke

scientific article

The combined use of non-radioactive in situ hybridization and real-time RT-PCR to assess gene expression in cryosections

scientific article published on 20 September 2006

The hippocampus influences assimilation and accommodation of schemata that are not hippocampus-dependent

scientific article published on 9 December 2016

The metabotropic glutamate receptor mGluR3 is critically required for hippocampal long-term depression and modulates long-term potentiation in the dentate gyrus of freely moving rats

scientific article published on 5 January 2005

The range of intrinsic frequencies represented by medial entorhinal cortex stellate cells extends with age.

scientific article published in March 2010

The subiculum: a potential site of ictogenesis in human temporal lobe epilepsy

scientific article published in January 2005

Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis

scientific article published on July 2009

Two-pore-domain potassium channels contribute to neuronal potassium release and glial potassium buffering in the rat hippocampus

scientific article published on 17 July 2007

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

scientific article

What is the clinical relevance of in vitro epileptiform activity?

scientific article published on January 2014

Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration

scientific article published on 31 May 2014

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