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List of works by Sandra K. Weller

A mutation in the C-terminal putative Zn2+ finger motif of UL52 severely affects the biochemical activities of the HSV-1 helicase-primase subcomplex.

scientific article

A mutation in the human herpes simplex virus type 1 UL52 zinc finger motif results in defective primase activity but can recruit viral polymerase and support viral replication efficiently.

scientific article

A putative leucine zipper within the herpes simplex virus type 1 UL6 protein is required for portal ring formation

scientific article

ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.

scientific article

An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates

scientific article published on August 2016

Beta interferon and gamma interferon synergize to block viral DNA and virion synthesis in herpes simplex virus-infected cells.

scientific article

Biochemical analyses of mutations in the HSV-1 helicase-primase that alter ATP hydrolysis, DNA unwinding, and coupling between hydrolysis and unwinding

scientific article published on February 1997

Catalysis of strand exchange by the HSV-1 UL12 and ICP8 proteins: potent ICP8 recombinase activity is revealed upon resection of dsDNA substrate by nuclease.

scientific article published on September 2004

DNA Damage Kills Bacterial Spores and Cells Exposed to 222-Nanometer UV Radiation

scientific article published on 01 April 2020

DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication ⬇️

scientific article published on September 28, 2011

DNA binding activity of the herpes simplex virus type 1 origin binding protein, UL9, can be modulated by sequences in the N terminus: correlation between transdominance and DNA binding.

scientific article

Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer.

scientific article

Disulfide Bond Formation in the Herpes Simplex Virus 1 UL6 Protein Is Required for Portal Ring Formation and Genome Encapsidation ⬇️

scientific article published on May 18, 2011

Disulfide bond formation contributes to herpes simplex virus capsid stability and retention of pentons.

scientific article

Efficient herpes simplex virus 1 replication requires cellular ATR pathway proteins

scientific article

Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein

scientific article

Functional Conservations of the Alkaline Nuclease of Herpes Simplex Type 1 and Human Cytomegalovirus

scientific article published on 01 September 1998

Genetic analysis of the UL 15 gene locus for the putative terminase of herpes simplex virus type 1.

scientific article published in March 1998

HSV cheats the executioner

scientific article published on February 2015

HSV-1 protein expression using recombinant baculoviruses

scientific article published on January 2014

HSV-I and the cellular DNA damage response.

scientific article published on April 2015

Herpes Simplex Viruses: Mechanisms of DNA Replication ⬇️

scientific article published on September 1, 2012

Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication

scientific article published on 31 December 2018

Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus

scientific article published in September 1993

Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation.

scientific article

Herpes simplex virus eliminates host mitochondrial DNA.

scientific article published on 22 December 2006

Herpes simplex virus reorganizes the cellular DNA repair and protein quality control machinery.

scientific article

Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus

scientific article published on August 2005

Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation

scientific article published on 10 November 2010

Herpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection

scientific article

Herpes simplex virus type 1 mutants for the origin-binding protein induce DNA amplification in the absence of viral replication

scientific article published on November 1990

Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling

scientific article

Herpes simplex virus type 1 single-strand DNA binding protein ICP8 enhances the nuclease activity of the UL12 alkaline nuclease by increasing its processivity

scientific article published on July 2005

Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection

scientific article published on 6 June 2006

Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments.

scientific article

Inhibition of the herpes simplex virus type 1 DNA polymerase induces hyperphosphorylation of replication protein A and its accumulation at S-phase-specific sites of DNA damage during infection.

scientific article

Interactions of herpes simplex virus type 1 with ND10 and recruitment of PML to replication compartments.

scientific article

Intracellular localization of the herpes simplex virus type-1 origin binding protein, UL9.

scientific article published in October 1996

Isolation of herpes simplex virus procapsids from cells infected with a protease-deficient mutant virus.

scientific article

Mutations in the putative zinc-binding motif of UL52 demonstrate a complex interdependence between the UL5 and UL52 subunits of the human herpes simplex virus type 1 helicase/primase complex.

scientific article

Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection

scientific article

Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex

scientific article published on 13 October 2010

Recombination promoted by DNA viruses: phage λ to herpes simplex virus.

scientific article

Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respo

scientific article published in May 2004

Recruitment of polymerase to herpes simplex virus type 1 replication foci in cells expressing mutant primase (UL52) proteins.

scientific article

Residues within the conserved helicase motifs of UL9, the origin-binding protein of herpes simplex virus-1, are essential for helicase activity but not for dimerization or origin binding activity

scientific article published on 2 November 2000

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

scientific article published on December 1985

Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1.

scientific article published on 29 July 2015

Structure of the herpes simplex virus 1 genome: manipulation of nicks and gaps can abrogate infectivity and alter the cellular DNA damage response.

scientific article

The DNA helicase-primase complex as a target for herpes viral infection

scientific article

The Exonuclease Activity of HSV-1 UL12 Is Required forin VivoFunction

scientific article published on 01 May 1998

The HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanism

scientific journal article

The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein

scientific article published on 31 January 2020

The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication

scientific article

The UL12.5 gene product of herpes simplex virus type 1 exhibits nuclease and strand exchange activities but does not localize to the nucleus

scientific article

The UL5 and UL52 subunits of the herpes simplex virus type 1 helicase-primase subcomplex exhibit a complex interdependence for DNA binding.

scientific article published on 25 January 2001

The UL6 gene product forms the portal for entry of DNA into the herpes simplex virus capsid.

scientific article

The exonuclease activity of HSV-1 UL12 is required for the production of viral DNA that can be packaged to produce infectious virus

scientific article published on 27 September 2017

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion

scientific article published on December 1996

The herpes simplex virus type 1 transactivator ICPO mediates aberrant intracellular localization of the viral helicase/primase complex subunits

scientific article published in June 1996

The product of a 1.9-kb mRNA which overlaps the HSV-1 alkaline nuclease gene (UL12) cannot relieve the growth defects of a null mutant

scientific article published on January 1996

The product of the UL12.5 gene of herpes simplex virus type 1 is not essential for lytic viral growth and is not specifically associated with capsids.

scientific article published on July 2002

The putative herpes simplex virus 1 chaperone protein UL32 modulates disulfide bond formation during infection

scientific article

The role of DNA recombination in herpes simplex virus DNA replication.

scientific article published on August 2003

The two helicases of herpes simplex virus type 1 (HSV-1).

scientific article

Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses

scientific article published on 25 January 2022

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