List of works - Paul A Kroon

4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: a randomised controlled trial.

scientific article published in February 2018

A Polyphenol‐Rich Diet Increases the Gut Microbiota Metabolite Indole 3‐Propionic Acid in Older Adults with Preserved Kidney Function

scientific article published in 2022

A Simple and Rapid LC-MS/MS Method for Quantification of Total Daidzein, Genistein, and Equol in Human Urine

scientific article published on 20 January 2020

A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids

scientific article published on 01 December 1999

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

scientific article published in July 2008

A family 11 xylanase from Penicillium funiculosum is strongly inhibited by three wheat xylanase inhibitors

scientific article

A modular cinnamoyl ester hydrolase from the anaerobic fungus Piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex

scientific article published in October 1999

A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module.

scientific article

AFM studies of water-soluble wheat arabinoxylans--effects of esterase treatment

scientific article published in August 2005

Absorption of hydroxycinnamates in humans after high-bran cereal consumption.

scientific article published in September 2003

Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans

scientific article

Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model

scientific article published on January 2009

Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.

scientific article

Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo

scientific article published in June 2003

Acute Consumption of Flavan-3-ol-Enriched Dark Chocolate Affects Human Endogenous Metabolism.

scientific article published on 06 June 2017

An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls.

scientific article

Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells

scientific article published on 20 March 2013

Antioxidant properties of ferulic acid dimers.

scientific article

Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress.

scientific article

Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells

scientific article published on 5 July 2013

Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebo-controlled, crossover trial

scientific article published on 23 April 2013

Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks.

scientific article published on 30 September 2009

Characterisation of heterogeneous arabinoxylans by direct imaging of individual molecules by atomic force microscopy

scientific article published in April 2003

Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells

scientific article published in December 2003

Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol

scientific article published on 22 September 2020

Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from models and a hum

scientific article published on 01 September 2018

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

scientific article published on 18 September 2007

Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives

article

Comparison of modular and non-modular xylanases as carrier proteins for the efficient secretion of heterologous proteins from Penicillium funiculosum

scientific article published on 21 December 2002

Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial ⬇️

scientific article published on 12 June 2014

Databases on food phytochemicals and their health-promoting effects

scientific article

Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils.

scientific article published on January 2010

Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

scientific article

Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. ⬇️

scientific article

Development of a food frequency questionnaire for the assessment of quercetin and naringenin intake

article

Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts.

scientific article

Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

scientific article published on 01 February 2000

Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells

scientific article published on 2 March 2018

Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells

scientific article published on 28 June 2018

Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study

scientific article published on 22 June 2016

Drinking your health? It's too early to say.

scientific article published in November 2003

Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial

scientific article published on 03 October 2018

Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation.

scientific article published on 4 September 2013

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

scientific article

Enzymic hydrolysis of diferulates from wheat bran cell walls

scientific article published in May 1998

Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals.

scientific article published in November 2001

EuroFIR eBASIS: application for health claims submissions and evaluations

scientific article published in November 2010

Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications

scientific article published on 28 May 2019

Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial

scientific article published on 08 November 2012

Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor

scientific article published on May 2002

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.

scientific article published on 14 August 2008

Hairy plant polysaccharides: a close shave with microbial esterases

scientific article published on 01 August 1998

High contents of nonextractable polyphenols in fruits suggest that polyphenol contents of plant foods have been underestimated.

scientific article

Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability.

scientific article

Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells

scientific article published on 28 August 2013

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study

scientific article published in May 2013

Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.

scientific article

Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors

scientific article published on 31 July 2019

Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

scientific article published on 5 December 2012

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells

scientific article published in September 2009

Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS

scientific article published on 01 July 2006

Impact of dietary polyphenols on human platelet function--a critical review of controlled dietary intervention studies.

scientific article published on January 2010

In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations

scientific article published on 05 September 2011

Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy

scientific article published in February 2004

Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

scientific article published on 21 October 2020

Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme

scientific article published on 31 May 2019

Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2)

scientific article published on 03 May 2007

Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme

scientific article published on 27 January 2017

Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved.

scientific article

Intestinal release and uptake of phenolic antioxidant diferulic acids.

scientific article

Isolation and Characterization of Wheat Derived Nonspecific Lipid Transfer Protein 2 (nsLTP2)

scientific article published on 22 May 2018

Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert).

scientific article published in August 2004

Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli.

scientific article

Lack of acute or chronic effects of epicatechin-rich and procyanidin-rich apple extracts on blood pressure and cardiometabolic biomarkers in adults with moderately elevated blood pressure: a randomized, placebo-controlled crossover trial

scientific article published on 01 November 2018

Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function

scientific article published on 12 June 2013

MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux.

scientific article published on 20 March 2015

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

scientific article published on 28 February 2018

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.

scientific article

Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples

scientific article published on 10 October 2014

Methyl phenylalkanoates as substrates to probe the active sites of esterases

scientific article published on 01 August 1997

Mixed pro- and anti-oxidative effects of pomegranate polyphenols in cultured cells

scientific article

Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity

scientific article published on 7 August 2015

Oligomeric procyanidins inhibit cell migration and modulate the expression of migration and proliferation associated genes in human umbilical vascular endothelial cells

scientific article

Ontogenic profiling of glucosinolates, flavonoids, and other secondary metabolites in Eruca sativa (salad rocket), Diplotaxis erucoides (wall rocket), Diplotaxis tenuifolia (wild rocket), and Bunias orientalis (Turkish rocket)

scientific article published on 01 May 2006

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells

scientific article published in May 2008

Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review

scientific article published on 28 October 2019

Polyphenols and Intestinal Permeability: Rationale and Future Perspectives

scientific article published on 02 July 2019

Polyphenols: dietary components with established benefits to health?

article

Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF: relevance to angiogenesis

scientific article published on 22 January 2015

Processing blackcurrants dramatically reduces the content and does not enhance the urinary yield of anthocyanins in human subjects

scientific article

Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerization

scientific article

Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae).

scientific article published on September 2004

Properties of ferulate dimers from plant cell walls

scientific article published on 01 May 1998

Purification of cytosolic beta-glucosidase from pig liver and its reactivity towards flavonoid glycosides

scientific article published on 01 November 1999

Quantitative Dietary Fingerprinting (QDF)-A Novel Tool for Comprehensive Dietary Assessment Based on Urinary Nutrimetabolomics

scientific article published on 01 March 2019

Quercetin and its in vivo metabolites inhibit neutrophil-mediated low-density lipoprotein oxidation

scientific article published on 3 May 2008

Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery

scientific article

Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery

scientific article published on April 2011

Quercetin solubilisation in bile salts: A comparison with sodium dodecyl sulphate.

scientific article published on 7 May 2016

Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products

scientific article published on 19 September 2012

Release of ferulic acid from sugar-beet pulp by using arabinanase, arabinofuranosidase and an esterase from Aspergillus niger.

scientific article

Screening crucifer seeds as sources of specific intact glucosinolates using ion-pair high-performance liquid chromatography negative ion electrospray mass spectrometry

scientific article published in February 2004

Solubilisation of ferulic acid from plant cell wall materials in a model human gut system

scientific article published on 01 August 1996

Special issue: Traditional foods: from culture, ecology and diversity, to human health and potential for exploitation

scientific article

Specificity of ferulic acid (feruloyl) esterases

scientific article published on 01 May 1998

Substrate (aglycone) specificity of human cytosolic beta-glucosidase

scientific article

Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Health-Promoting Polyphenol-Rich Dietary Pattern?

scientific article published on 16 June 2019

Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications

scientific article published on 22 October 2019

The Effects of Anthocyanins and Their Microbial Metabolites on the Expression and Enzyme Activities of Paraoxonase 1, an Important Marker of HDL Function

scientific article published on 24 November 2019

The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet

scientific article published on 09 November 2020

The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products.

scientific article

The biological responses to resveratrol and other polyphenols from alcoholic beverages.

scientific article published on 10 June 2009

The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential.

scientific article published on January 2010

The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase

scientific article

The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in degradation of complex cell wall polysaccharides

scientific article published in December 1997

The feruloyl esterase system of Talaromyces stipitatus: production of three discrete feruloyl esterases, including a novel enzyme, TsFaeC, with a broad substrate specificity

scientific article published in March 2004

The pharmacokinetics of anthocyanins and their metabolites in humans

scientific article

The substrate specificity and susceptibility to wheat inhibitor proteins ofPenicillium funiculosum xylanases from a commercial enzyme preparation

article published in 2005

Three distinct ferulic acid esterases produced by Aspergillus niger have specificities for different phenolic-sugar linkages in plant cell walls

scientific article published in May 1998

Towards an Understanding of the Low Bioavailability of Quercetin: A Study of Its Interaction with Intestinal Lipids

scientific article published on 5 February 2017

Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells

scientific article published on 7 October 2010

Urinary excretion of strawberry anthocyanins is dose dependent for physiological oral doses of fresh fruit

scientific article

Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts.

scientific article published on 17 July 2015

Validation of control genes and a standardised protocol for quantifying gene expression in the livers of C57BL/6 and ApoE-/- mice.

scientific article published on 24 May 2018

Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial

scientific article published on 3 April 2013

Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries.

scientific article published on 15 November 2017

List of works by Paul A Kroon

4-Week consumption of anthocyanin-rich blood orange juice does not affect LDL-cholesterol or other biomarkers of CVD risk and glycaemia compared with standard orange juice: a randomised controlled trial.

A Polyphenol‐Rich Diet Increases the Gut Microbiota Metabolite Indole 3‐Propionic Acid in Older Adults with Preserved Kidney Function

A Simple and Rapid LC-MS/MS Method for Quantification of Total Daidzein, Genistein, and Equol in Human Urine

A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

A family 11 xylanase from Penicillium funiculosum is strongly inhibited by three wheat xylanase inhibitors

A modular cinnamoyl ester hydrolase from the anaerobic fungus Piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex

A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module.

AFM studies of water-soluble wheat arabinoxylans--effects of esterase treatment

Absorption of hydroxycinnamates in humans after high-bran cereal consumption.

Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans

Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model

Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.

Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo

Acute Consumption of Flavan-3-ol-Enriched Dark Chocolate Affects Human Endogenous Metabolism.

An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls.

Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells

Antioxidant properties of ferulic acid dimers.

Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress.

Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells

Bioavailability of epicatechin and effects on nitric oxide metabolites of an apple flavanol-rich extract supplemented beverage compared to a whole apple puree: a randomized, placebo-controlled, crossover trial

Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks.

Characterisation of heterogeneous arabinoxylans by direct imaging of individual molecules by atomic force microscopy

Characterization of metabolites of hydroxycinnamates in the in vitro model of human small intestinal epithelium caco-2 cells

Citrus flavanone metabolites protect pancreatic-β cells under oxidative stress induced by cholesterol

Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from models and a hum

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

Comparison between single-cell cultures and tissue cultures as model systems for evaluating the modulation of gene expression by food bioactives

Comparison of modular and non-modular xylanases as carrier proteins for the efficient secretion of heterologous proteins from Penicillium funiculosum

Consumption of both low and high (-)-epicatechin apple puree attenuates platelet reactivity and increases plasma concentrations of nitric oxide metabolites: a randomized controlled trial ⬇️

Databases on food phytochemicals and their health-promoting effects

Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils.

Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies. ⬇️

Development of a food frequency questionnaire for the assessment of quercetin and naringenin intake

Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts.

Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase

Different antitumor effects of quercetin, quercetin-3'-sulfate and quercetin-3-glucuronide in human breast cancer MCF-7 cells

Differential Effects of Quercetin and Two of Its Derivatives, Isorhamnetin and Isorhamnetin-3-glucuronide, in Inhibiting the Proliferation of Human Breast-Cancer MCF-7 Cells

Does epicatechin contribute to the acute vascular function effects of dark chocolate? A randomized, crossover study

Drinking your health? It's too early to say.

Effect of an egg ovalbumin-derived protein hydrolysate on blood pressure and cardiovascular risk in adults with a mildly elevated blood pressure: a randomized placebo-controlled crossover trial

Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation.

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

Enzymic hydrolysis of diferulates from wheat bran cell walls

Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals.

EuroFIR eBASIS: application for health claims submissions and evaluations

Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications

Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial

Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.

Hairy plant polysaccharides: a close shave with microbial esterases

High contents of nonextractable polyphenols in fruits suggest that polyphenol contents of plant foods have been underestimated.

Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability.

Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells

Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study

Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.

Hydrophobic Interactions Drive Binding between Vascular Endothelial Growth Factor-A (VEGFA) and Polyphenolic Inhibitors

Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells

Identification of isomeric flavonoid glucuronides in urine and plasma by metal complexation and LC-ESI-MS/MS

Impact of dietary polyphenols on human platelet function--a critical review of controlled dietary intervention studies.

In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations

Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy

Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

Inhibitory Effects of Quercetin and Its Human and Microbial Metabolites on Xanthine Oxidase Enzyme

Interaction of Positional Isomers of Quercetin Glucuronides with the Transporter ABCC2 (cMOAT, MRP2)

Interaction of quercetin and its metabolites with warfarin: Displacement of warfarin from serum albumin and inhibition of CYP2C9 enzyme

Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved.

Intestinal release and uptake of phenolic antioxidant diferulic acids.

Isolation and Characterization of Wheat Derived Nonspecific Lipid Transfer Protein 2 (nsLTP2)

Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert).

Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli.

Lack of acute or chronic effects of epicatechin-rich and procyanidin-rich apple extracts on blood pressure and cardiometabolic biomarkers in adults with moderately elevated blood pressure: a randomized, placebo-controlled crossover trial

Lack of effect of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on platelet function

MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux.

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.

Methods for isolating, identifying, and quantifying anthocyanin metabolites in clinical samples