List of works - George E. Johnson

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens ⬇️

scientific article published on May 13, 2013

A Review: The Current In Vivo Models for the Discovery and Utility of New Anti-leishmanial Drugs Targeting Cutaneous Leishmaniasis

scientific article

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

scientific article published on 26 July 2016

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.

scientific article published on 6 November 2017

Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

scientific article published on 10 February 2020

Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.

scientific article

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

scientific article published on 2 December 2015

Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study

scientific article published on 5 October 2015

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.

scientific article published on 6 May 2014

Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.

scientific article

Do dose response thresholds exist for genotoxic alkylating agents?

scientific article

Dose-response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay.

scientific article published on 15 February 2017

Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation

scientific article published on 10 March 2009

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

scientific article published on 19 December 2015

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

scientific article

Estimating the carcinogenic potency of chemicals from the in vivo micronucleus test

scientific article published on 10 July 2015

Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

scientific article

Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment

scientific article

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

scientific article

Genotoxicity as a Toxicologically Relevant Endpoint to Inform Risk Assessment: A Case Study with Ethylene Oxide

scientific article published on 14 September 2020

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity

scientific article published on 6 October 2015

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).

scientific article published on 13 October 2014

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

scientific article published on 27 October 2014

Influence of DNA repair on nonlinear dose-responses for mutation

scientific article

Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning

scientific article published on 10 July 2021

Mammalian cell HPRT gene mutation assay: test methods.

scientific article

Measuring reproducibility of dose response data for the Pig-a assay using covariate benchmark dose analysis

scientific article

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens

scientific article published on April 2007

Mechanistic investigations of low dose exposures to the genotoxic compounds bisphenol-A and rotenone.

scientific article published on 12 November 2007

Metabolic influences for mutation induction curves after exposure to Sudan-1 and para red.

scientific article

MutAIT: an online genetic toxicology data portal and analysis tools.

scientific article published on 23 July 2015

Mutation as a Toxicological Endpoint for Regulatory Decision-Making

scientific article published on 23 October 2019

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

scientific article published on 11 November 2010

Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.

scientific article published on 21 September 2016

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

scientific article

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

scientific article

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy

scientific article published on 27 February 2019

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance

scientific article

Quantitative Interpretation of Genetic Toxicity Dose-Response Data for Risk Assessment and Regulatory Decision-Making: Current Status and Emerging Priorities

scientific article published on 19 December 2019

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

scientific article

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice

scientific article published on 17 February 2014

Radiation-induced transgenerational alterations in genome stability and DNA damage.

scientific article published on 05 June 2006

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

scientific article published on 4 April 2014

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

scientific article

Theoretical considerations for thresholds in chemical carcinogenesis.

scientific article published on 27 May 2015

Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions

scientific article published on 10 December 2018

Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

scientific article published on 27 November 2019

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.

scientific article published on 8 August 2009

List of works by George E. Johnson

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens ⬇️

A Review: The Current In Vivo Models for the Discovery and Utility of New Anti-leishmanial Drugs Targeting Cutaneous Leishmaniasis

A comparison of the genotoxicity of benzo[a]pyrene in four cell lines with differing metabolic capacity

A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells.

Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents

Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.

Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.

Do dose response thresholds exist for genotoxic alkylating agents?

Dose-response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay.

Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation

Empirical analysis of BMD metrics in genetic toxicology part I: in vitro analyses to provide robust potency rankings and support MOA determinations

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

Estimating the carcinogenic potency of chemicals from the in vivo micronucleus test

Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment

Genotoxic thresholds, DNA repair, and susceptibility in human populations.

Genotoxicity as a Toxicologically Relevant Endpoint to Inform Risk Assessment: A Case Study with Ethylene Oxide

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure-response relationships and points of departure (PoDs).

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk.

Influence of DNA repair on nonlinear dose-responses for mutation

Inter-laboratory automation of the in vitro micronucleus assay using imaging flow cytometry and deep learning

Mammalian cell HPRT gene mutation assay: test methods.

Measuring reproducibility of dose response data for the Pig-a assay using covariate benchmark dose analysis

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens

Mechanistic investigations of low dose exposures to the genotoxic compounds bisphenol-A and rotenone.

Metabolic influences for mutation induction curves after exposure to Sudan-1 and para red.

MutAIT: an online genetic toxicology data portal and analysis tools.

Mutation as a Toxicological Endpoint for Regulatory Decision-Making

N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage

Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations.

No-observed effect levels are associated with up-regulation of MGMT following MMS exposure.

Non-linear dose-response of DNA-reactive genotoxins: recommendations for data analysis

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance

Quantitative Interpretation of Genetic Toxicity Dose-Response Data for Risk Assessment and Regulatory Decision-Making: Current Status and Emerging Priorities

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice

Radiation-induced transgenerational alterations in genome stability and DNA damage.

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells

The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.

Theoretical considerations for thresholds in chemical carcinogenesis.

Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions

Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene

Vinblastine and diethylstilboestrol tested in the in vitro mammalian cell micronucleus test (MNvit) at Swansea University UK in support of OECD draft Test Guideline 487.