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List of works by Randall S. Johnson

A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase.

scientific article

A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium.

scientific article

A new notch in the HIF belt: how hypoxia impacts differentiation.

scientific article

A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection

scientific article published on 28 February 2012

A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function.

scientific article

A whiter shade of gray: HIF and coordination of angiogenesis with postnatal myelination

scientific article published on 01 July 2014

A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing

scientific article published on 25 November 2010

ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.

scientific article published on 18 December 2006

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.

scientific article published on 30 April 2012

Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy

scientific article published on 10 December 2013

Acute and chronic hypoxia differentially predispose lungs for metastases

scientific article published on 15 July 2019

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

scientific article published in November 1994

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.

scientific article published in November 2017

Angiogenesis: the role of the microenvironment in flipping the switch.

scientific article

Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina

scientific article published on August 2010

Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye

scientific article published on November 2011

Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature

scientific article (publication date: 29 July 2010)

Author Correction: Acute and chronic hypoxia differentially predispose lungs for metastases

scientific article published on 28 January 2020

Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.

scientific article published on 28 August 2006

Behavioral assessment of c-fos mutant mice

scientific article published in July 1994

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

scientific article

Can irradiated tumors take NO for an answer?

scientific article published on April 2007

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

scientific article

Cardiovascular adaptation to hypoxia and the role of peripheral resistance

scientific article published on 19 October 2017

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

scientific journal article

Constitutive Glycolytic Metabolism Supports CD8(+) T Cell Effector Memory Differentiation during Viral Infection.

scientific article published on 4 November 2016

Correction: HIF-2α is essential for carotid body development and function.

scientific article published on 4 June 2018

Critical role of HIF-1alpha in keratinocyte defense against bacterial infection

scientific article

Cutaneous control of blood pressure

scientific article

Cutaneous exposure to hypoxia does not affect skin perfusion in humans

scientific article

Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis

scientific article

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

scientific article published on 23 October 2020

DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation

scientific article

Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells ⬇️

scientific article published on May 1, 2003

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

scientific article published in May 2004

Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE)

scientific article published on 04 March 2020

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart.

scientific article

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice.

scientific article published on 22 October 2011

Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation.

scientific article published on 23 December 2015

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success ⬇️

scientific article published on January 17, 2012

Endothelial hypoxic metabolism in carcinogenesis and dissemination: HIF-A isoforms are a NO metastatic phenomenon

scientific article published on December 2013

Epidermal deletion of HIF-2α stimulates wound closure

scientific article published on 13 September 2013

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

scientific article published on October 2004

Evaluating the impact of multisensor data assimilation on a global aerosol particle transport model

article

Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.

scientific article

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

scientific article published on June 2000

Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1alpha null mouse embryonic fibroblasts

scientific article published on January 2003

Gene-environment interaction demonstrates the vulnerability of the embryonic heart.

scientific article published on 18 March 2014

Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun

scientific article published on May 2004

HIF isoforms in the skin differentially regulate systemic arterial pressure

scientific article published on 07 October 2013

HIF transcription factors, inflammation, and immunity

scientific article

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

scientific article

HIF-1 and hypoxic response: the plot thickens.

scientific article published on February 2004

HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite

scientific article published on 2 July 2007

HIF-1: an age-dependent regulator of lens cell proliferation.

scientific article published on 27 June 2008

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

scientific article published in May 2003

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

scientific article published on July 2005

HIF-1alpha in endurance training: suppression of oxidative metabolism

scientific article published on 12 September 2007

HIF-1alpha is necessary to support gluconeogenesis during liver regeneration.

scientific article published on 28 July 2009

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

scientific article published on 05 September 2011

HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination

scientific article published on 19 May 2013

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

scientific article published on 18 May 2016

HIF-2α is essential for carotid body development and function.

scientific article

HIF-mediated endothelial response during cancer progression.

scientific article published on 08 May 2012

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

scientific article published on March 2008

HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland

scientific journal article

HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis

scientific article published on 3 October 2007

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

scientific article published on 28 May 2015

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

scientific article

HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

scientific article published on 10 September 2013

HIF2α-arginase axis is essential for the development of pulmonary hypertension.

scientific article published on 18 July 2016

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

scientific article

Hypoxia and metastasis in breast cancer

scientific article published in January 2010

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival ⬇️

scientific article published on November 1, 2001

Hypoxia inducible factor (HIF) function in innate immunity and infection

scientific article

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

scientific article

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity

scientific article

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

scientific article

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

scientific article

Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis

scientific article

Hypoxia-inducible factor-1 is a determinant of lobular structure and oxygen consumption in the liver

scientific article published in July 2013

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

scientific article published in January 2007

Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

scientific article published on August 2000

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland

scientific article

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

scientific journal article

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

scientific article published on 19 May 2008

Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein

scientific article

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

scientific article

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.

scientific article published on 29 September 2013

Hypoxic induction of Ctgf is directly mediated by Hif-1.

scientific article

Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha

scientific article published in January 2005

In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage

scientific article published on 9 April 2007

In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.

scientific article

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice

scientific article

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

scientific article

Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration

scientific article

Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1

scientific article

Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia

scientific article published on March 2002

Interdependence of hypoxic and innate immune responses

scientific article published on September 2009

Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells.

scientific article published in March 2011

Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

scientific article

Kidney injury is independent of endothelial HIF-1α.

scientific article

Lorenz Poellinger

scientific article published in July 2017

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

scientific journal article

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

scientific article published in November 2004

Loss of PTEN facilitates HIF-1-mediated gene expression

scientific article (publication date: 15 February 2000)

Loss of fibroblast HIF-1α accelerates tumorigenesis.

scientific article

Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis

scientific article

Loss of skeletal muscle HIF-1alpha results in altered exercise endurance

scientific article

Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene.

scientific article published on 5 February 2007

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression ⬇️

scientific article published on September 14, 2010

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

scientific article published on 15 June 2020

Metabolic basis to Sherpa altitude adaptation

scientific article

Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

scientific article

Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

scientific article published on 19 December 2012

Myeloid hypoxia-inducible factor-1α is essential for skeletal muscle regeneration in mice.

scientific article published on 31 May 2013

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

scientific article published on 23 April 2008

Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism.

scientific article

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia

scientific article

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism

scientific article published on 22 December 2015

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

scientific article

Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy

scientific article published on 01 June 1996

O2 regulates stem cells through Wnt/β-catenin signalling.

scientific article

Oxygen regulation of TET enzymes

scientific article published on 06 January 2021

Oxygen sensing in the brain--invited article.

scientific article published on January 2009

Pharmacologic augmentation of hypoxia-inducible factor-1alpha with mimosine boosts the bactericidal capacity of phagocytes

scientific article published in January 2008

Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3

scientific article published on 14 January 2002

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

scientific article published on 01 November 1992

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting

scientific article published in May 2004

Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees.

scientific article

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

scientific article published on 7 February 2011

Putting the tissue and environmental ‘context’ into differentiation and gene regulation

article

RAG-1-deficient mice have no mature B and T lymphocytes

scientific journal article

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

scientific article published in July 2007

Response to Swenson and Bärtsch

scientific article published on 09 May 2020

Role of HIF-1alpha in skeletal development.

scientific article published on March 2010

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

scientific article published on 21 August 2015

Role of the hypoxia inducible factors HIF in iron metabolism.

scientific article published on January 2008

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

scientific article published on 26 October 2016

Suppression of erythropoiesis by dietary nitrate.

scientific article published on 24 November 2014

TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

scientific article published on 3 January 2006

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia

scientific article

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

scientific article

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

scientific article published on September 2004

The circadian system of c-fos deficient mice

scientific article published on 01 April 1996

The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts.

scientific article published on 20 August 2008

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

scientific article published on 05 October 2009

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

scientific article published on June 2007

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

scientific article published on May 2003

The hypoxic response of tumors is dependent on their microenvironment.

scientific article

The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent.

scientific article published on April 2002

Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress

scientific article published on 01 June 2015

Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

scientific article published on January 2000

To PFKFB3 or Not to PFKFB3, That Is the Question

scientific article

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

scientific article

Transgenic models to understand hypoxia-inducible factor function.

scientific article published on January 2007

Tumor vessels are Eph-ing complicated

scientific article published in June 2010

Tumour oxygenation: implications for breast cancer prognosis ⬇️

scientific article published on August 1, 2013

Two HIFs may be better than one.

scientific article published in April 2002

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

scientific article

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

scientific journal article

VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis

scientific article published on 25 June 2006

VEGFA is necessary for chondrocyte survival during bone development

scientific journal article

Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance

scientific article published on January 2002

Waiting to inhale: HIF-1 modulates aerobic respiration

scientific article

You don't need a PHD to grow a tumor

scientific article published on 01 June 2009

c-Jun is essential for organization of the epidermal leading edge

scientific journal article

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

scientific article

c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells

scientific article

microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation

scientific article

pVHL function is essential for endothelial extracellular matrix deposition.

scientific article

von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.

scientific article

von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

scientific article published on May 2010

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