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List of works by Józefa Wesierska-Gadek

5-FdUrd-araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2.

scientific article published in December 2006

A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy

scientific article published in May 2008

A new multiplex assay allowing simultaneous detection of the inhibition of cell proliferation and induction of cell death

scientific article published in September 2005

A new, unexpected action of olomoucine, a CDK inhibitor, on normal human cells: up-regulation of CLIMP-63, a cytoskeleton-linking membrane protein

scientific article published on December 2007

Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1.

scientific article published in August 2002

Action of resveratrol alone or in combination with roscovitine, a CDK inhibitor, on cell cycle progression in human HL-60 leukemia cells

scientific article published on 12 August 2008

Advantage of a baculovirus expression system for protein-protein interaction studies. Involvement of posttranslational phosphorylation in the interaction between wt p53 protein and poly(ADP-ribose) polymerase-1.

scientific article published on 4 August 2005

Anti-SLA seropositive autoimmune hepatitis sera recognize distinct subunits of glutathione S-transferase: high prevalence of the Ya autoantigen.

scientific article published in May 2002

Antinuclear antibodies in primary biliary cirrhosis

scientific article

Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment

scientific article

Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence

scientific article published on August 2007

Central and carboxy‐terminal regions of human p53 protein are essential for interaction and complex formation with PARP‐1 ⬇️

scientific article published on May 15, 2003

Characterization of autoantibodies against components of the nuclear pore complexes: high frequency of anti-p62 nucleoporin antibodies

scientific article published in August 2007

Characterization of the antibodies to p62 nucleoporin in primary biliary cirrhosis using human recombinant antigen

scientific article published on May 2008

Correlation of initial autoantibody profile and clinical outcome in primary biliary cirrhosis.

scientific article

Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells

scientific article published on 18 May 2015

Dual action of cyclin-dependent kinase inhibitors: induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin

scientific article published on September 2003

Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein

scientific article

Effect of anti-estrogen combined with roscovitine, a selective CDK inhibitor, on human breast cancer cells differing in expression of ER

scientific article published on 01 January 2011

Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells

scientific article published on January 2007

Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy

scientific article published on 01 September 2002

Functional p53 in cells contributes to the anticancer effect of the cyclin-dependent kinase inhibitor roscovitine

scientific article published on June 2009

Impact of roscovitine, a selective CDK inhibitor, on cancer cells: bi-functionality increases its therapeutic potential

scientific article

In vivo activated caspase-3 cleaves PARP-1 in rat liver after administration of the hepatocarcinogen N-nitrosomorpholine (NNM) generating the 85 kDa fragment

scientific article published in November 2004

Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints

scientific article published on 11 January 2010

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest

scientific article

Induction of cell cycle arrest and apoptosis in human cervix carcinoma cells during therapy by cisplatin

scientific article published on 01 January 2003

Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest

scientific article published on October 2007

Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells

scientific article published on June 2014

Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells

scientific article published on April 2011

Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors

scientific article published on August 2006

Is olomoucine, a weak CDK2 inhibitor, able to induce apoptosis in cancer cells?

scientific article published in August 2009

Major contribution of the multidrug transporter P-glycoprotein to reduced susceptibility of poly(ADP-ribose) polymerase-1 knock-out cells to doxorubicin action

Scientific article published in August 2005

Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose

scientific article published in August 2009

Non-apoptogenic killing of hela cervical carcinoma cells after short exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).

scientific article published in August 2003

Novel potent pharmacological cyclin-dependent kinase inhibitors

scientific article published on December 2009

Oncogenes do not Fully Override Cell-intrinsic Traits: Pronounced Impact of the Cellular Programme

scientific article published on 4 September 2009

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

scientific article published in April 2009

PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells ⬇️

scientific article published on August 14, 2012

Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine.

scientific article published on 19 January 2007

Phenol red reduces ROSC mediated cell cycle arrest and apoptosis in human MCF-7 cells

scientific article published on August 2006

Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1.

scientific article

Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS.

scientific article published in April 2004

Pleiotropic effects of selective CDK inhibitors on human normal and cancer cells

scientific article

Prevention of farnesylation of c-Ha-Ras protein enhances synergistically the cytotoxic action of doxorubicin in cycling but not in quiescent cells.

scientific article

Promotion of Apoptosis in Cancer Cells by Selective Purine-Derived Pharmacological CDK Inhibitors: One Outcome, Many Mechanisms ⬇️

scientific article published on January 1, 2011

R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis

scientific article published in January 2010

Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine-induced apoptosis of human MCF-7 breast cancer cells

scientific article published on 01 September 2003

Reconstitution of human MCF‐7 breast cancer cells with caspase‐3 does not sensitize them to action of CDK inhibitors ⬇️

scientific article published on January 1, 2011

Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells

scientific article

Role of PARP on iNOS pathway during endotoxin-induced acute lung injury

scientific article

Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment

scientific article published on 18 July 2003

Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells

scientific article published in August 2009

Roscovitine triggers apoptosis in B-cell chronic lymphocytic leukemia cells with similar efficiency as combinations of conventional purine analogs with cyclophosphamide

scientific article published in August 2009

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

scientific article published on December 2008

Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells

scientific article published on March 1, 2011

Roscovitine, a small molecule CDK inhibitor induces apoptosis in multidrug-resistant human multiple myeloma cells

scientific article published on January 1, 2011

Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells

scientific article published on March 2007

Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells

scientific article

Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?

scientific article published on August 2009

Signaling of DNA damage is not sufficient to induce p53 response: (re)activation of wt p53 protein strongly depends on cellular context

scientific article

Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM)

scientific journal article

Synergistic effects of erlotinib and everolimus on bronchial carcinoids and large-cell neuroendocrine carcinomas with activated EGFR/AKT/mTOR pathway

scientific article

Tamoxifen enhances the anti-proliferative effect of roscovitine, a selective cyclin-dependent kinase inhibitor, on human ER-positive human breast cancer cells

scientific article published on January 1, 2011

Targeting p53 as a promising therapeutic option for cancer by re-activating the wt or mutant p53's tumor suppression

scientific article published on 23 March 2018

The Impact Of CDK Inhibition In Human Malignancies Associated With Pronounced Defects In Apoptosis: Advantages Of Multi-Targeting Small Molecules ⬇️

scientific article published on March 1, 2012

The impact of multi-targeted cyclin-dependent kinase inhibition in breast cancer cells: clinical implications

scientific article published on 21 October 2011

The subcellular distribution of the p53 tumour suppressor, and organismal ageing.

scientific article

Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes

scientific article published on January 2012

Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle

scientific article published on 01 January 2011

Tubulohelical membrane arrays: From the initial observation to the elucidation of nanophysical properties and cellular function

scientific article published on 28 June 2010

Whether to target single or multiple CDKs for therapy? That is the question ⬇️

scientific article published on February 1, 2011

Why (multi)targeting of cyclin-dependent kinases is a promising therapeutic option for hormone-positive breast cancer and beyond

scientific article published on 21 December 2015

[Biological activity of poly(ADP-ribose)polymerase-1]

scientific article published on 30 July 2010

[New face of antiapoptotic proteins. I. Protein Mcl-1]

scientific article published on 01 January 2007

[New face of antiapoptotic proteins. II. Survivin]

scientific article published on 01 January 2007

mTOR and its link to the picture of Dorian Gray - re-activation of mTOR promotes aging ⬇️

scientific article published on December 1, 2010

p53-mediated regulation of cell cycle progression: pronounced impact of cellular microenvironment

scientific article

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