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List of works by David M Koelle

7th drug hypersensitivity meeting: part one.

scientific article

A Dual-Modality Herpes Simplex Virus 2 Vaccine for Preventing Genital Herpes by Using Glycoprotein C and D Subunit Antigens To Induce Potent Antibody Responses and Adenovirus Vectors Containing Capsid and Tegument Proteins as T Cell Immunogens

scientific article published on 3 June 2015

A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

scientific article

A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection

scientific article published on 01 August 2019

A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice

scientific article

A novel HSV-2 subunit vaccine induces GLA-dependent CD4 and CD8 T cell responses and protective immunity in mice and guinea pigs.

scientific article

APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding

scientific article published on 21 April 2010

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

scientific article published in Nature Communications

An Extremely Diverse CD4 Response to Vaccinia Virus in Humans Is Revealed by Proteome-Wide T-Cell Profiling

An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection

scientific article

An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling.

scientific article

Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection.

scientific article

Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions.

scientific article published on May 1994

Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes ⬇️

scientific article published on March 15, 1992

CD4 T-cell memory responses to viral infections of humans show pronounced immunodominance independent of duration or viral persistence.

scientific article published on 19 December 2012

CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins

scientific article

CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells.

scientific article

Cellular Immunity in Monozygotic Twins Discordant for Chronic Fatigue Syndrome

article

Chronic vulvar ulceration in an immunocompetent woman due to acyclovir-resistant, thymidine kinase-deficient herpes simplex virus

scientific article published in March 1998

Clinical, laboratory, and temporal predictors of neutralizing antibodies to SARS-CoV-2 after COVID-19

scientific article published on 08 October 2020

Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine

scientific article published on 3 January 2012

Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine.

scientific article published in August 2012

Current status and prospects for development of an HSV vaccine

scientific article published on 6 September 2013

Cytomegalovirus (CMV) Epitope-Specific CD4(+) T Cells Are Inflated in HIV(+) CMV(+) Subjects

scientific article published on 2 October 2017

DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge

scientific article published on 17 September 2010

Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens

scientific article

Development of a low-dose fast-dissolving tablet formulation of Newcastle disease vaccine for low-cost backyard poultry immunisation

scientific article published on 3 March 2014

Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions

scientific article published on May 1994

Diversity in CD8(+) T cell function and epitope breadth among persons with genital herpes

scientific article published on 16 July 2010

Diversity in the acute CD8 T cell response to vaccinia virus in humans

scientific article published in December 2005

Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes

scientific article

Doctor, Why Is My Herpes So Bad? The Search Continues

scientific article published on 01 February 2008

Dominance and diversity in the primary human CD4 T cell response to replication-competent vaccinia virus

scientific article

Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma

scientific article published on 12 August 2014

Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study.

scientific article published on 27 December 2017

Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons

scientific article

Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants.

scientific article published in August 2000

Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract.

scientific article

Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense

scientific article published on 29 March 2019

Erratum: Corrigendum: Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

scientific article published in Nature

Evasion of the mucosal innate immune system by herpes simplex virus type 2.

scientific article published on 30 September 2009

Expression cloning for the discovery of viral antigens and epitopes recognized by T cells ⬇️

scientific article published on March 1, 2003

Expression of cutaneous lymphocyte-associated antigen and E-selectin ligand by circulating human memory CD4+ T lymphocytes specific for herpes simplex virus type 2.

scientific article published on 15 December 2004

Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus

scientific article

Expression of cutaneous lymphocyte-associated antigen by CD8+ T cells specific for a skin-tropic virus

Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses

scientific article published on 25 January 2016

Famciclovir for the suppression of symptomatic and asymptomatic herpes simplex virus reactivation in HIV-infected persons. A double-blind, placebo-controlled trial

scientific article published in January 1998

Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates

scientific article published in July 1997

Fulminant, acyclovir-resistant, herpes simplex virus type 2 hepatitis in an immunocompetent woman.

scientific article published in April 2006

Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.

scientific article published on 27 May 2015

Genome-Wide Approach to the CD4 T-Cell Response to Human Herpesvirus 6B

scientific article published on 28 June 2019

Genome-wide association study (GWAS) of human host factors influencing viral severity of herpes simplex virus type 2 (HSV-2).

scientific article published on 28 February 2018

Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins

scientific article published on 27 May 2015

HHV-8 infection: a model for reactivation and transmission

scientific article published in January 2002

HLA-DQ tetramers identify epitope-specific T cells in peripheral blood of herpes simplex virus type 2-infected individuals: direct detection of immunodominant antigen-responsive cells

scientific article published in April 2000

HLA-DQB1 codon 57 is critical for peptide binding and recognition.

scientific article

HSV-2: in pursuit of a vaccine ⬇️

scientific article published on December 1, 2011

Herpes simplex virus infection of human dendritic cells induces apoptosis and allows cross-presentation via uninfected dendritic cells

scientific article

Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes.

scientific article

Herpes simplex virus lymphadenitis is associated with tumor reduction in a chronic lymphocytic leukemia patient

scientific article published on 21 July 2022

Herpes simplex virus shedding and plasma human immunodeficiency virus RNA levels in coinfected women

scientific article published on 10 August 2001

Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis.

scientific article published in January 1998

Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection

scientific article published on 04 March 2009

Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles

scientific article

High incidence of ganciclovir-resistant cytomegalovirus infection among lung transplant recipients receiving preemptive therapy

scientific article published on 14 December 2001

Highly conserved intragenic HSV-2 sequences: Results from next-generation sequencing of HSV-2 UL and US regions from genital swabs collected from 3 continents

scientific article

Homing in on the cellular immune response to HSV-2 in humans.

scientific article

Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain

scientific article published on 12 August 2019

Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens ⬇️

scientific article published on March 1, 1992

Human Herpesvirus 8 in the Prostate Glands of Men with Kaposi’s Sarcoma ⬇️

scientific article published on July 1, 1998

Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women.

scientific article

Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.

scientific article

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection

scientific article published on 8 May 2013

Immunobiology of herpes simplex virus and cytomegalovirus infections of the fetus and newborn

scientific article

Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor

scientific article published on 17 October 2003

Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses ⬇️

scientific article published on January 1, 2012

Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays

scientific article published on 17 September 2010

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors

scientific article (publication date: 15 February 2011)

In Situ Detection of Regulatory T Cells in Human Genital Herpes Simplex Virus Type 2 (HSV-2) Reactivation and Their Influence on Spontaneous HSV-2 Reactivation

scientific article published on 25 April 2016

Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes

scientific article published on March 2006

Latent Tuberculosis Infection Test Agreement in the National Health and Nutrition Examination Survey.

scientific article

Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia

scientific article

Longitudinal analysis of herpes simplex virus-specific CD4+ cell clonotypes in infected tissues and blood

scientific article

MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition

scientific article published on July 1999

Markers of viral infection in monozygotic twins discordant for chronic fatigue syndrome

scientific article (publication date: September 2002)

Merkel cell polyomavirus-specific CD8⁺ and CD4⁺ T-cell responses identified in Merkel cell carcinomas and blood.

scientific article published on 9 September 2011

Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers

scientific article published on 6 August 2013

Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes

scientific article

Mucosal shedding of human herpesvirus 8 in men.

scientific article

ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans

scientific article published on 9 June 2009

One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection

scientific article

Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition

scientific article published on July 1999

Peripheral blood CD4 T-cell and plasmacytoid dendritic cell (pDC) reactivity to herpes simplex virus 2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes

scientific article published on 3 July 2012

Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

scientific article published on 02 August 2009

Persistence of herpes simplex virus type 2 VP16-specific CD4+ T cells

scientific article

Phase I Dose-Escalation Study of a Monovalent Heat Shock Protein 70-Herpes Simplex Virus Type 2 (HSV-2) Peptide-Based Vaccine Designed To Prime or Boost CD8 T-Cell Responses in HSV-Naive and HSV-2-Infected Subjects

scientific article (publication date: May 2008)

Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system

scientific article published on 10 September 2008

Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection

scientific article

Polyomavirus-driven Merkel cell carcinoma: Prospects for therapeutic vaccine development

scientific article published on 27 March 2020

Preferential presentation of herpes simplex virus T-cell antigen by HLA DQA1*0501/DQB1*0201 in comparison to HLA DQA1*0201/DQB1*0201.

scientific article published on April 1997

Prevalence of human herpesvirus-8 salivary shedding in HIV increases with CD4 count

scientific article

Prevalent and diverse intratumoral oncoprotein-specific CD8+ T cells within polyoma virus-driven Merkel cell carcinomas

scientific article published on 16 March 2020

Primary and secondary syphilis lesions contain mRNA for Th1 cytokines

scientific article published in February 1996

Protective HIV-specific CD8+ T cells evade Treg cell suppression ⬇️

scientific article published on July 17, 2011

Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination

scientific article published on 04 August 2020

Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.

scientific article

Rapid epitope identification from complex class-II-restricted T-cell antigens.

scientific article published in November 2001

Reactivities of Human Sera with Human Herpesvirus-8-Infected BCBL-1 Cells and Identification of HHV-8-Specific Proteins and Glycoproteins and the Encoding cDNAs ⬇️

scientific article published on March 30, 1998

Recognition of Herpes Simplex Virus Type 2 Tegument Proteins by CD4 T Cells Infiltrating Human Genital Herpes Lesions ⬇️

scientific article published on September 1, 1998

Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma

scientific article

Reduction of herpes simplex virus type-2 replication in cell cultures and in rodent models with peptide-conjugated morpholino oligomers

scientific article published on January 2010

Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of re-inducing HLA class-I

scientific article published on January 2014

Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility

scientific article published on 27 January 2006

Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons

scientific article published on 21 September 2011

Selective Expression of CCR10 and CXCR3 by Circulating Human Herpes Simplex Virus-Specific CD8 T Cells

scientific article published on 12 July 2017

Sequence-based methods for identifying epidemiologically linked herpes simplex virus type 2 strains

scientific article published in July 2006

Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses

scientific article published on September 1997

Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results

scientific article published on 28 September 2019

Stability of live attenuated rotavirus vaccine with selected preservatives and primary containers.

scientific article published on 13 April 2016

Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials

scientific article

Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous interactions between the T cell receptor, peptide, and HLA-DR.

scientific article published on October 1998

T Cell Immunity to Herpes Simplex Viruses in Seronegative Subjects: Silent Infection or Acquired Immunity?

scientific article published on 01 April 2003

T Cell Immunity to Varicella-Zoster Virus in the Setting of Advanced HIV and Multiple Varicella-Zoster Virus Recurrences.

scientific article

T-cell Responses to HSV-1 in Persons Who Have Survived Childhood Herpes Simplex Encephalitis

scientific article published on 3 May 2017

T-cell immunity to human alphaherpesviruses

scientific article published on 08 May 2013

Tegument-specific, virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans.

scientific article

Tetramer-guided epitope mapping: rapid identification and characterization of immunodominant CD4+ T cell epitopes from complex antigens

scientific article published on June 2001

The Murine Intravaginal HSV-2 Challenge Model for Investigation of DNA Vaccines

scientific article published on 01 January 2020

The murine intravaginal HSV-2 challenge model for investigation of DNA vaccines.

scientific article

Tipping the scales of herpes simplex virus reactivation: the important responses are local

scientific article published on April 1998

Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.

scientific article

Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival

scientific article published on 16 January 2017

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

scientific article

Use of acyclovir for suppression of human immunodeficiency virus infection is not associated with genotypic evidence of herpes simplex virus type 2 resistance to acyclovir: analysis of specimens from three phase III trials

scientific article

Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8+ T cell effector function

scientific article published on 14 March 2019

Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection

scientific article published on 19 February 2014

Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation

scientific article published on 26 February 2007

Zoster Vaccination Increases the Breadth of CD4+ T Cells Responsive to Varicella Zoster Virus

scientific article published on 17 March 2015

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