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List of works by Christian J. Leumann

2'-Fluorination of tricyclo-DNA controls furanose conformation and increases RNA affinity

scientific article published on 02 April 2015

2'β-Fluoro-Tricyclo Nucleic Acids (2'F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation

scientific article

2-Phenanthrenyl-DNA: synthesis, pairing, and fluorescence properties

scientific article published in January 2009

2-Pyrenyl-DNA: synthesis, pairing, and fluorescence properties

scientific article published in 2012

3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair

scientific article published on 4 January 2016

6'-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

article

A 6′-fluoro-substituent in bicyclo-DNA increases affinity to complementary RNA presumably by CF–HC pseudohydrogen bonds

scientific article published on 01 February 2014

A parallel screen for the discovery of novel DNA base pairs

scientific article published on 21 January 2011

A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry

scientific article published in October 2003

A stable DNA duplex containing a non-hydrogen-bonding and non-shape-complementary base couple: interstrand stacking as the stability determining factor

scientific article published on 01 January 2001

Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications.

scientific article published on 22 March 2011

An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe

scientific article

Base pairing and miscoding properties of 1,N(6)-ethenoadenine- and 3,N(4)-ethenocytosine-containing RNA oligonucleotides

scientific article

Bicyclo

scientific article published on 01 July 2000

Bicyclo[3.2.1]amide-DNA: a chiral, nonchiroselective base-pairing system

scientific article published in December 2002

Bipyridyl- and biphenyl-DNA: a recognition motif based on interstrand aromatic stacking

scientific article

Comparative studies of tricyclo-DNA- and LNA-containing oligonucleotides as inhibitors of HIV-1 gene expression.

scientific article published on January 2007

Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers

scientific article published on 28 August 2019

Conformational diversity versus nucleic acid triplex stability, a combinatorial study

scientific article published on 5 July 2001

Corrigendum: Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates

scientific article published on 22 March 2017

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

scientific article published on 01 August 2006

DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides.

scientific article

DNA with hydrophobic base substitutes: a stable, zipperlike recognition motif based on interstrand-stacking interactions

scientific article published on 01 April 2003

Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model

scientific article published on 22 June 2017

Electron transfer through a stable phenanthrenyl pair in DNA.

scientific article

Electrospray tandem mass spectrometry of mixed-sequence RNA/DNA oligonucleotides

scientific article published on 01 August 2002

Enhancement of excess electron transfer efficiency in DNA containing a phenothiazine donor and multiple stable phenanthrenyl base pairs

scientific article published on 19 July 2013

Enzymatic Synthesis of 7',5'-Bicyclo-DNA Oligonucleotides

scientific article published on 31 March 2017

Exploring Hoogsteen and reversed-Hoogsteen duplex and triplex formation with tricyclo-DNA purine sequences

scientific article

Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA.

scholarly article

Fluorinated peptide nucleic acid.

scientific article published in May 2003

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.

scientific article published on 2 February 2015

Gas-phase dissociation of homo-DNA oligonucleotides.

scientific article

Highly beta-selective, N-iodosuccinimide-mediated nucleosidation to bicyclo- and tricyclo-nucleosides

scientific article

Homo-DNA templated chemistry and its application to nucleic acid sensing

scientific article published on 09 May 2011

Improving gene silencing of siRNAs via tricyclo-DNA modification ⬇️

scientific article published on July 1, 2010

Inhibition of DNA polymerase reactions by pyrimidine nucleotide analogues lacking the 2-keto group.

scientific article published on April 1998

Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease

scientific article published on 11 June 2019

Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates.

scientific article

Molecular beacons with a homo-DNA stem: improving target selectivity

scientific article

NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance

scientific article published on 01 May 2019

New nucleoside analogues for the recognition of pyrimidine-purine inversion sites

scientific article published in May 2003

Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA

scientific article published on 15 January 2004

Nucleic acid sensing by an orthogonal reporter system based on homo-DNA.

scientific article

Olefinic Peptide Nucleic Acids (OPAs): New Aspects of the Molecular Recognition of DNA by PNA The team at the University of Bern thanks the Swiss National Science Foundation and Novartis Pharma AG, Basel, for generous financial support

scientific article published on 01 April 2000

Olefinic peptide nucleic acid (OPA).

scientific article published in May 2003

Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center

scientific article published on 4 January 2018

Parallel synthesis and nucleic acid binding properties of C(6')-α-functionalized bicyclo-DNA.

scientific article

Photochemically induced RNA and DNA abasic sites.

scientific article published on January 2007

Polymerase incorporation of pyrene-nucleoside triphosphates.

scientific article published on 5 May 2012

Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes

scientific article

Probing the Backbone Topology of DNA: Synthesis and Properties of 7',5'-Bicyclo-DNA.

scientific article

Propagation of melting cooperativity along the phosphodiester backbone of DNA.

scientific article

Pyrrolidino-DNA.

scientific article published in May 2003

Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe

scientific article published on 30 May 2011

RNA abasic sites: preparation and trans-lesion synthesis by HIV-1 reverse transcriptase

scientific article published on 01 November 2005

RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes

scientific article published on 28 February 2005

Recognition properties of donor- and acceptor-modified biphenyl-DNA.

scientific article published in January 2008

Screening the structural and functional properties of bicyclo-DNA: bc(ox)-DNA.

scientific article

Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif

scientific article published on 01 September 1999

Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.

scientific article published on 15 June 2015

Solution structure of a DNA duplex containing a biphenyl pair

scientific article published in January 2008

Stability and kinetics of nucleic acid triplexes with chimaeric DNA/RNA third strands

scientific article published in October 2002

Stable cyclohexyl-phenyl recognition in the center of a DNA duplex.

scientific article published in January 2009

Strand invasion properties and serum stability of alpha-tricyclo-DNA

scientific article published on 01 January 2008

Structure/affinity studies in the bicyclo-DNA series: Synthesis and properties of oligonucleotides containing bc(en)-T and iso-tricyclo-T nucleosides

scientific article

Sugar modification as a means to increase the biological performance of oligonucleotides

scientific article published on 01 January 2006

Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs

scientific article published on 01 January 2019

Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP).

scientific article

Synthesis and electrochemical properties of TTF modified oligodeoxynucleotides

scientific article published on 26 August 2009

Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue

scientific article published on 01 November 2005

Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers

scientific article published on 01 May 2003

Synthesis and pairing properties of alpha-tricyclo-DNA

scientific article published on 01 October 2006

Synthesis and pairing properties of oligodeoxynucleotides containing bicyclo-RNA and bicyclo-ANA modifications.

scientific article published on 11 April 2012

Synthesis and properties of 6'-fluoro-tricyclo-DNA

scientific article published on 20 March 2015

Synthesis and properties of isobicyclo-DNA

scientific article published on 23 April 2013

Synthesis and structural analysis of [4.3.0]-bicyclothymidine

scientific article

Synthesis and triplex forming properties of pyrrolidino pseudoisocytidine containing oligodeoxynucleotides

scientific article published on 7 April 2005

Synthesis of a cyclopentane amide DNA analogue and its base pairing properties

scientific article published in May 2003

Synthesis of cyclopentane amide DNA (cpa-DNA) and its pairing properties

scientific article published in October 2003

Synthesis of functionalized biphenyl-C-nucleosides and their incorporation into oligodeoxynucleotides

scientific article published on 19 June 2006

Synthesis of pyrrolidine C-nucleosides via Heck reaction

scientific article published on 01 February 2001

Synthesis of the bicyclo-[4.3.0]-thymidyl-nucleoside via pd(II)-mediated ring expansion chemistry

scientific article published in January 2007

Synthesis, Pairing, and Cellular Uptake Properties of C(6′)-Functionalized Tricyclo-DNA ⬇️

scientific article published on 07 May 2012

Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine

scientific article published on 18 August 2011

Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA

Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA.

scientific article published in May 2003

Tc-DNA modified siRNA.

scientific article published in January 2008

The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes

scientific article published on 14 April 2016

The chemical stability of abasic RNA compared to abasic DNA.

scientific article published on 6 December 2006

The effect of RNA base lesions on mRNA translation.

scientific article published on 20 April 2015

Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides

scientific article (publication date: 27 May 2016)

Total synthesis of coraxeniolide-A

scientific article published on 01 December 2000

Transition metal ligands as novel DNA-base substitutes

scientific article published on 01 May 2003

TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.

scientific article

Watson-Crick base-pairing properties of tricyclo-DNA.

scientific article published in May 2002

What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?

scientific article

X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair

scientific article

pentafluorophenyl-phenyl interactions in biphenyl-DNA.

scientific article published in March 2005

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