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List of works by Joao Goncalves

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia

scientific article published on 16 May 2014

A novel reactive epitope-based antigen targeted by serum autoantibodies in oligoarticular and polyarticular juvenile idiopathic arthritis and development of an electrochemical biosensor.

scientific article published on 15 January 2016

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

scientific article published on 23 May 2017

Analysis of Immunogenicity Data in the Product Information of Biological Drugs: A Need to Report Immunogenicity Data Systematically

scientific article published on 01 December 2019

Anti-TNF biosimilars in psoriasis: from scientific evidence to real-world experience

scientific article published on 16 May 2019

Anti-type II collagen antibodies detection and avidity in patients with oligoarticular and polyarticular forms of juvenile idiopathic arthritis.

scientific article published on 20 March 2015

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

scientific article

Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

scientific article published on 05 June 2018

Assessing combinatorial strategies to multimerize libraries of single-domain antibodies

scientific article

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

scientific article

Biodistribution of a (67)Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag).

scientific article published on 17 January 2014

Biosimilar DMARDs: What Does the Future Hold?

scientific article published on 3 March 2016

Biosimilars in rheumatology

scientific article published on 27 September 2019

Biosimilars: An Opportunity to Update the Product Information of Biological Drugs Regarding their Immunogenicity

scientific article published on 01 December 2019

CIB1 and CIB2 are HIV-1 helper factors involved in viral entry.

scientific article published on 4 August 2016

Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

scientific article

Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies

scientific article

Characterization of plasma labile heme in hemolytic conditions

scientific article

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads.

scientific article published on 6 April 2018

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

scientific article

Editorial: antigenic response to CT-P13 and infliximab originator in IBD shows similar epitope recognition-evidence from basic science supports safe switching to biosimilars. Authors’ reply

scientific article published on 01 September 2018

Efficacy, immunogenicity and cost analysis of a systematic switch from originator infliximab to biosimilar CT-P13 of all patients with inflammatory arthritis from a single center

scientific article published on 22 November 2019

Establishment of a bioluminescent canine B-cell lymphoma xenograft model for monitoring tumor progression and treatment response in preclinical studies

scientific article published in PLoS ONE

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

scientific article

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

scientific article

HIV-1 Vif and APOBEC3G: multiple roads to one goal

scientific article

HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation

scientific article published on 20 December 2004

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay

scientific article published on 29 January 2011

HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action

scientific article

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches

scientific article published on 24 October 2013

Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

article

Identification of SOX3 as an XX male sex reversal gene in mice and humans

scientific article

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents

scientific article published on 01 February 2020

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

scientific article published on 23 June 2015

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody

scientific article published on 22 October 2019

Insights on the Formulation of Recombinant Proteins

scientific article published on 01 January 2020

Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

scientific article published on 21 December 2016

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

scientific article published on 9 August 2005

Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

scientific article

M13 bacteriophage purification using poly(ionic liquids) as alternative separation matrices.

scientific article published on 6 December 2017

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

scientific article published on 6 May 2014

Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates

scientific article

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

scientific article

Molecular construction of bionanoparticles: chimaeric SIV p17-HIV I p6 nanoparticles with minimal viral protein content.

scientific article published on September 2007

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

scientific article

Next-generation sequencing of hereditary hemochromatosis-related genes: Novel likely pathogenic variants found in the Portuguese population

scientific article published on 22 July 2016

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

scientific article published on 17 February 2010

Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ?-thalassaemia in the Portuguese population ⬇️

scientific article published on July 1, 1992

Nucleolin-based targeting strategies for cancer therapy: from targeted drug delivery to cytotoxic ligands

scientific article published on 02 July 2019

Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?

scientific article

Phosphorylation of Vif and its role in HIV-1 replication

scientific article

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

scientific article

Piezoelectric biosensors for biorecognition analysis: Application to the kinetic study of HIV-1 Vif protein binding to recombinant antibodies

scientific article published on 04 May 2007

Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies.

scientific article published on 11 November 2016

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

scientific article published on 30 March 2017

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure

scientific article published on 2 July 2015

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

scientific article

Recombinant antibodies as therapeutic agents: pathways for modeling new biodrugs

scientific article

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

scientific article

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor.

scientific article

SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis

scientific article published on 04 December 2019

Synthetic antibody discovery against native antigens by CRISPR/Cas9-library generation and endoplasmic reticulum screening

scientific article published on 04 February 2020

The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene.

scientific article published in December 2014

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

scientific article published on 19 June 2018

The mutational spectrum of WT1 in male infertility.

scientific article published on 11 November 2014

Therapeutic Antibody Engineering and Selection Strategies

scientific article published on 01 January 2020

Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?

scientific article published on 21 September 2010

Ultrastructure of HIV-1 genomic RNA

scientific article published on 01 July 1997

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

scientific article published on 19 December 2016

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