List of works - Joao Goncalves

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

scientific article

Identification of SOX3 as an XX male sex reversal gene in mice and humans

scientific article

Ultrastructure of HIV-1 genomic RNA

scientific article published on 01 July 1997

Phosphorylation of Vif and its role in HIV-1 replication

scientific article

HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation

scientific article published on 20 December 2004

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

scientific article

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

scientific article

Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

scientific article

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches

scientific article published on 24 October 2013

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

scientific article

Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies

scientific article

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

scientific article published on 17 February 2010

Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ?-thalassaemia in the Portuguese population

scientific article published on July 1, 1992

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

scientific article published on 6 May 2014

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

scientific article published on 9 August 2005

Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

article

Characterization of plasma labile heme in hemolytic conditions

scientific article

HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action

scientific article

HIV-1 Vif and APOBEC3G: multiple roads to one goal

scientific article

Recombinant antibodies as therapeutic agents: pathways for modeling new biodrugs

scientific article

Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?

scientific article

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

scientific article

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

scientific article

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

scientific article published on 19 December 2016

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

scientific article published on 19 June 2018

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor.

scientific article

Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

scientific article

Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates

scientific article

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

scientific article published on 23 May 2017

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay

scientific article published on 29 January 2011

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

scientific article

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

scientific article published on 23 June 2015

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

scientific article published on 30 March 2017

Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

scientific article published on 21 December 2016

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

scientific article

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure

scientific article published on 2 July 2015

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia

scientific article published on 16 May 2014

CIB1 and CIB2 are HIV-1 helper factors involved in viral entry.

scientific article published on 4 August 2016

The mutational spectrum of WT1 in male infertility.

scientific article published on 11 November 2014

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents

scientific article published on 01 February 2020

Molecular construction of bionanoparticles: chimaeric SIV p17-HIV I p6 nanoparticles with minimal viral protein content.

scientific article published on September 2007

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

scientific article

Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

scientific article published on 05 June 2018

SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis

scientific article published on 04 December 2019

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody

scientific article published on 22 October 2019

The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene

scientific article published in December 2014

Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies.

scientific article published on 11 November 2016

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

scientific article

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads.

scientific article published on 6 April 2018

Biosimilars in rheumatology

scientific article published on 27 September 2019

List of works by Joao Goncalves

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation

Identification of SOX3 as an XX male sex reversal gene in mice and humans

Ultrastructure of HIV-1 genomic RNA

Phosphorylation of Vif and its role in HIV-1 replication

HIV-1 Vif can directly inhibit apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G-mediated cytidine deamination by using a single amino acid interaction and without protein degradation

Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor.

Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

Camelized rabbit-derived VH single-domain intrabodies against Vif strongly neutralize HIV-1 infectivity

Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches

Functional analysis of Vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G.

Cell type-specific targeting with sindbis pseudotyped lentiviral vectors displaying anti-CCR5 single-chain antibodies

Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells

Novel promoter and splice junction defects add to the genetic, clinical or geographic heterogeneity of ?-thalassaemia in the Portuguese population

Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds

Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells.

Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

Characterization of plasma labile heme in hemolytic conditions

HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E. coli by a similar mechanism of action

HIV-1 Vif and APOBEC3G: multiple roads to one goal

Recombinant antibodies as therapeutic agents: pathways for modeling new biodrugs

Pharmacoeconomics of Biosimilars: What Is There to Gain from Them?

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Mutations selected in HIV-2-infected patients failing a regimen including atazanavir.

miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication.

The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma.

Recombinant single-chain variable fragment and single domain antibody piezoimmunosensors for detection of HIV1 virion infectivity factor.

Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates

Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins

HIV-1 Vif interaction with APOBEC3 deaminases and its characterization by a new sensitive assay

Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

Interactions Between Therapeutic Proteins and Small Molecules: The Shared Role of Perpetrators and Victims

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

Rare double sex and mab-3-related transcription factor 1 regulatory variants in severe spermatogenic failure

A novel Alu-mediated microdeletion at 11p13 removes WT1 in a patient with cryptorchidism and azoospermia

CIB1 and CIB2 are HIV-1 helper factors involved in viral entry.

The mutational spectrum of WT1 in male infertility.

Immunogenicity of Biosimilars for Rheumatic Diseases, Plaque Psoriasis, and Inflammatory Bowel Disease: A Review from Clinical Trials and Regulatory Documents

Molecular construction of bionanoparticles: chimaeric SIV p17-HIV I p6 nanoparticles with minimal viral protein content.

Modulation of translation factor's gene expression by histone deacetylase inhibitors in breast cancer cells.

Antigenic response to CT-P13 and infliximab originator in inflammatory bowel disease patients shows similar epitope recognition

SB5 shows cross-immunogenicity to adalimumab but not infliximab: results in patients with inflammatory bowel disease or rheumatoid arthritis

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody

The hepcidin gene promoter nc.-1010C > T; -582A > G haplotype modulates serum ferritin in individuals carrying the common H63D mutation in HFE gene

Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies.

Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.

Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic Payloads.

Biosimilars in rheumatology