List of works - Alexander Gray

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

scientific article (publication date: 16 September 2002)

A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

scientific article published on 15 March 2010

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

scientific article published on 26 May 2017

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.

scientific article

A screen for novel phosphoinositide 3-kinase effector proteins.

scientific article

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

scientific article published on 2 May 2016

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

scientific article

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

scientific article

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

scientific article

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

scientific article published in January 2018

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

scientific article published in October 2005

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

scientific article

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

scientific article published on 26 August 2013

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

scientific article

Differential transcription and expression of ornithine decarboxylase in embryos of replicated mouse lines divergently selected for lean body mass.

scientific article published on May 1995

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

scientific article published on January 2012

Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses

scientific article published on December 1999

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.

scientific article

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

scientific article

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

scientific article

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

scientific article published on 19 July 2017

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.

scientific article published on 13 November 2017

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

scientific article

Identification of an epidermal growth factor receptor homologue in trypanosomes

scientific article published on 01 August 1989

Impact of metal ions on PCR inhibition and RT-PCR efficiency

scientific article published on 03 July 2020

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

scientific article published on September 2004

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

scientific article published on 25 September 2018

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

scientific article published on 12 June 2009

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

scientific article published on December 2006

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

scientific article published on February 2003

PDK1 controls upstream PI3K expression and PIP3 generation.

scientific article published on 29 July 2013

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

scientific article published on 17 October 2017

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

scientific article

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

scientific article

Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth.

scientific article published on 8 January 2013

Probing phosphoinositide functions in signaling and membrane trafficking.

scientific article

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

scientific article

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation

scientific journal article

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

scientific article published on October 2000

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

scientific article published on March 2011

Significant increases in potato Starch-Synthase and Starch-Branching-Enzyme activities by dilution with buffer containing dithiothreitol and polyvinyl alcohol 50 K.

scientific article published on 7 December 2012

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

scientific article

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

scientific article

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphos

scientific article

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

scientific article published in December 2005

Trypanosoma brucei brucei: Uptake and Metabolism of Pyridoxine and Pyridoxal

scientific article published on 01 May 1995

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

scientific article

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

scientific article

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

scientific article published on 27 November 2006

List of works by Alexander Gray

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

A fluorescence lifetime-based assay for serine and threonine kinases that is suitable for high-throughput screening

A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.

A screen for novel phosphoinositide 3-kinase effector proteins.

AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor

Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK.

Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib.

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling

Defining the contribution of AMP-activated protein kinase (AMPK) and protein kinase C (PKC) in regulation of glucose uptake by metformin in skeletal muscle cells

Differential transcription and expression of ornithine decarboxylase in embryos of replicated mouse lines divergently selected for lean body mass.

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases.

Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A.

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.

IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold

Identification of an epidermal growth factor receptor homologue in trypanosomes

Impact of metal ions on PCR inhibition and RT-PCR efficiency

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

PDK1 controls upstream PI3K expression and PIP3 generation.

PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Phospholipase C-η2 is required for retinoic acid-stimulated neurite growth.

Probing phosphoinositide functions in signaling and membrane trafficking.

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation

Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

Significant increases in potato Starch-Synthase and Starch-Branching-Enzyme activities by dilution with buffer containing dithiothreitol and polyvinyl alcohol 50 K.

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphos

The regulation of membrane to cytosol partitioning of signalling proteins by phosphoinositides and their soluble headgroups

Trypanosoma brucei brucei: Uptake and Metabolism of Pyridoxine and Pyridoxal

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach