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List of works by Francisco Cruz

191 EFFECT OF BOTULINUM TOXIN TYPE A ON INTRAMURAL PARASYMPATHETIC GANGLIA OF THE GUINEA-PIG BLADDER

1952 URINARY NEUROTROPHINS – POTENTIAL BIOMARKERS OF OVERACTIVE BLADDER

article published in 2011

817 URINARY NEUROTROPHIC FACTORS IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS

A light- and electron-microscopic histopathological study of human bladder mucosa after intravesical resiniferatoxin application

scientific article

A review of detrusor overactivity and the overactive bladder after radical prostate cancer treatment

scientific article

Activation of the c-fosProto-Oncogene in the Spinal Cord Following Noxious Stimulation of the Urinary Bladder

scientific article published on 01 January 1994

Acute transient myopia with shallowing of the anterior chamber induced by sulfamethoxazole in a patient with pseudoxanthoma elasticum

scientific article published on 01 August 2014

Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.

scientific article published in December 2004

Are all metabolic syndrome components responsible for penile hemodynamics impairment in patients with erectile dysfunction? The role of body fat mass assessment

scientific article published on 22 November 2010

Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical study.

scientific article

Biomarkers in lower urinary tract symptoms/overactive bladder: a critical overview

scientific article published on July 2014

Biomarkers in overactive bladder: a new objective and noninvasive tool?

scientific article

Biomarkers in the Overactive Bladder Syndrome

article published in 2012

Biomarkers of fatigue related to adjuvant chemotherapy for breast cancer: evaluation of plasma and lymphocyte expression

scientific article

Biomarkers of spinal cord injury and ensuing bladder dysfunction

scientific article

Bladder C-fiber desensitization induces a long-lasting improvement of BPH-associated storage LUTS: a pilot study

scientific article

Bladder function after radical hysterectomy for cervical cancer

scientific article published on 12 February 2014

Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release

scientific article published on 2 July 2016

Bladder sensory desensitization decreases urinary urgency.

scientific article

Botulinum toxin in the management of lower urinary tract dysfunction: contemporary update.

scientific article

Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation

scientific article published on 8 January 2013

Can serum angiogenin be used to improve the diagnostic performance in prostate cancer screening?

scientific article published on May 2014

Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study

scientific article

Chapter 5: Clinical data in neurogenic detrusor overactivity (NDO) and overactive bladder (OAB).

scientific article

Characterization of VEGF and angiopoietins expression in human corpus cavernosum during aging

scientific article published on 06 January 2010

Co-administration of transient receptor potential vanilloid 4 (TRPV4) and TRPV1 antagonists potentiate the effect of each drug in a rat model of cystitis

scientific article published on 26 January 2015

Consensus Statement of the European Urology Association and the European Urogynaecological Association on the Use of Implanted Materials for Treating Pelvic Organ Prolapse and Stress Urinary Incontinence

scientific article published on 13 April 2017

Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies

scientific article published on 18 January 2014

Current medical treatment of lower urinary tract symptoms/BPH: do we have a standard?

scientific article

Cystitis is associated with TRPV1b-downregulation in rat dorsal root ganglia

scientific article

Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord

scientific article published on 01 March 1996

Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction

scientific article published on 01 February 1997

Desensitization of bladder sensory fibers by intravesical capsaicin or capsaicin analogs. A new strategy for treatment of urge incontinence in patients with spinal detrusor hyperreflexia or bladder hypersensitivity disorders

scientific article published on 01 January 1998

Distribution of the high-affinity binding site and intracellular target of botulinum toxin type A in the human bladder

scientific article published on 30 December 2009

Does baseline total testosterone improve the yielding of prostate cancer screening?

scientific article published on 16 February 2012

EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence.

scientific article published on 2 February 2018

EAU guidelines on surgical treatment of urinary incontinence.

scientific article published on 17 September 2012

Editorial comment on: Effect of thalamic deep brain stimulation on lower urinary tract function

scientific article published on 21 December 2007

Effect of onabotulinumtoxinA on intramural parasympathetic ganglia: an experimental study in the guinea pig bladder

scientific article published on 21 January 2012

Efficacy and Safety of OnabotulinumtoxinA in Patients with Urinary Incontinence Due to Neurogenic Detrusor Overactivity: Update of the Pivotal Randomised, Double-blind, Placebo-controlled Trials

scientific article published on 26 April 2016

Efficacy and safety of onabotulinumtoxinA in patients with urinary incontinence due to neurogenic detrusor overactivity: a randomised, double-blind, placebo-controlled trial

scientific article published on 13 July 2011

Erratum to: OnabotulinumtoxinA is Effective in Patients with Urinary Incontinence due to Neurogenic Detrusor Overactivity Regardless of Concomitant Anticholinergic Use or Neurologic Etiology.

scientific article published on 13 February 2014

Exploratory study assessing efficacy and complications of TVT-O, TVT-Secur, and Mini-Arc: results at 12-month follow-up

scientific article published on 21 January 2011

Expression of cleaved SNAP-25 after bladder wall injection of onabotulinumtoxina or abobotulinumtoxina: A comparative study in the mice

scientific article published on 16 October 2015

Extra-adrenal phechromocytoma and renal cell carcinoma--an unusual case of tumour synchronism

scientific article published on 01 April 1999

From bladder to systemic syndrome: concept and treatment evolution of interstitial cystitis

scientific article (publication date: 2015)

Functional transient receptor potential vanilloid 1 is expressed in human urothelial cells

scientific article published on 20 October 2009

Future direction in pharmacotherapy for non-neurogenic male lower urinary tract symptoms

scientific article published on 07 May 2013

GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models

scientific article

Has botulinum toxin therapy come of age: what do we know, what do we need to know, and should we use it?

scientific article published on July 2009

Impairment of sensory afferents by intrathecal administration of botulinum toxin A improves neurogenic detrusor overactivity in chronic spinal cord injured rats

scientific article

Increased spinal cord phosphorylation of extracellular signal-regulated kinases mediates micturition overactivity in rats with chronic bladder inflammation

scientific article published in February 2005

Insulin induces cobalt uptake in a subpopulation of rat cultured primary sensory neurons

scientific article published in November 2003

Intermediate-term results, up to 4 years, of a bone-anchored male perineal sling for treating male stress urinary incontinence after prostate surgery.

scientific article published on 8 September 2008

Intraprostatic Botulinum Toxin Type A injection in patients with benign prostatic enlargement: duration of the effect of a single treatment

scientific article published on 15 August 2009

Intraprostatic botulinum toxin type A administration: evaluation of the effects on sexual function.

scientific article published on 24 November 2010

Intrarenal artery pseudoaneurysm after blunt abdominal trauma: a case report of successful superselective angioembolization.

scientific article published on 02 April 2014

Intrathecal administration of botulinum toxin type A improves urinary bladder function and reduces pain in rats with cystitis.

scientific article

Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals

scientific article published on 12 September 2008

Intratrigonal Onabotulinum Toxin A Improves Bladder Symptoms and Quality of Life in Bladder Pain Syndrome/Interstitial Cystitis Patients: A Pilot, Single Center, Randomized, Double-Blind, Placebo Controlled Trial

scientific article

Intravesical resiniferatoxin decreases spinal c-fos expression and increases bladder volume to reflex micturition in rats with chronic inflamed urinary bladders

scientific article

Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation. A c-fos study

scientific article published on 01 July 1999

Is the adjustable transobturator system ATOMS® useful for the treatment of male urinary incontinence in low to medium volume urological centers?

scientific article published on 21 November 2017

Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies.

scientific article published on 11 December 2014

Lidocaine prevents noxious excitation of bladder afferents induced by intravesical capsaicin without interfering with the ensuing sensory desensitization: an experimental study in the rat.

scientific article published in February 1998

Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder Ischemia on Overactive Bladder Syndrome.

scientific article published on 15 October 2015

Mechanisms involved in new therapies for overactive bladder.

scientific article published on March 2004

Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat.

scientific article published on 15 July 2008

Mini-arc for the treatment of female stress urinary incontinence: long-term prospective evaluation by patient reported outcomes.

scientific article published on 20 January 2014

Modulation of urinary bladder innervation: TRPV1 and botulinum toxin A.

scientific article published on January 2011

N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.

scientific article

Nerve growth factor regulates galanin and c-jun overexpression occurring in dorsal root ganglion cells after intravesical resiniferatoxin application

scientific article published on October 2002

Neurochemical characterization of insulin receptor-expressing primary sensory neurons in wild-type and vanilloid type 1 transient receptor potential receptor knockout mice

scientific article published on 01 July 2007

Neurotrophins as regulators of urinary bladder function

scientific article published on 09 October 2012

Neurotrophins in the lower urinary tract: becoming of age

scientific article published on December 2011

OnabotulinumtoxinA is effective in patients with urinary incontinence due to neurogenic detrusor overactivity [corrected] regardless of concomitant anticholinergic use or neurologic etiology

scientific article published on 27 September 2013

Overactive bladder: pathophysiology, diagnostics, and therapies.

scientific article published on January 2011

Peptide immunoreactivity and ultrastructure of rat urinary bladder nerve fibers after topical desensitization by capsaicin or resiniferatoxin

scientific article published on 01 December 2000

Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis

scientific article published on 18 January 2006

Periterminal synaptic organization of primary afferents in laminae I and IIo of the rat spinal cord, as shown after anterograde HRP labelling

scientific article published on 01 March 1993

Persistent therapeutic effect of repeated injections of onabotulinum toxin a in refractory bladder pain syndrome/interstitial cystitis.

scientific article published on 14 December 2012

Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence

scientific article published on July 2009

Rat detrusor overactivity induced by chronic spinalization can be abolished by a transient receptor potential vanilloid 1 (TRPV1) antagonist

scientific article published on 28 October 2011

Re: Efficacy and Safety of Mirabegron Add-on Therapy to Solifenacin in Incontinent Overactive Bladder Patients with an Inadequate Response to Initial 4-week Solifenacin Monotherapy: A Randomised Double-blind Multicentre Phase 3B Study (BESIDE)

scientific article published on 25 August 2016

Reply from Authors re: Prokar Dasgupta. Volume Matters: Bladder Injections of Botulinum Toxin Type A. Eur Urol 2012;61:1185–6

Resiniferatoxin and botulinum toxin type A for treatment of lower urinary tract symptoms.

scientific article published on October 2007

Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis

scientific article published on 15 January 2010

Several morphological types of terminal arborizations of primary afferents in laminae I-II of the rat spinal cord, as shown after HRP labeling and Golgi impregnation.

scientific article published in July 1987

Short-term assessment of a tension-free vaginal tape for treating female stress urinary incontinence.

scientific article published on 19 January 2009

Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia

scientific article published on 28 August 2012

Single-incision sling system as primary treatment of female stress urinary incontinence: prospective 12 months data from a single institution.

scientific article

Sites of renal pain processing in the rat spinal cord. A c-fos study using a percutaneous method to perform ureteral obstruction

scientific article published on 01 December 1997

Spinal cord injury and bladder dysfunction: new ideas about an old problem.

scientific article

Spread of onabotulinumtoxinA after bladder injection. Experimental study using the distribution of cleaved SNAP-25 as the marker of the toxin action

Suburethral single incision slings in the treatment of female stress urinary incontinence: what is the evidence for using them in 2010?

scientific article published on May 2011

Sympathetic nervous system and chronic bladder pain: a new tune for an old song

scientific article

TRPV1 (vanilloid receptor) in the urinary tract: expression, function and clinical applications.

scientific article

TRPV1: a therapeutic target for novel analgesic drugs?

scientific article

Technical aspects of botulinum toxin type A injection in the bladder to treat urinary incontinence: reviewing the procedure.

scientific article published on 29 January 2014

The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction

scientific article published on December 2007

The Motion: Antimuscarinics are the Mainstay of Therapy for Overactive Bladder

scientific article published on 16 April 2008

The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate

scientific article published on 27 January 2005

The effect of intravesical resiniferatoxin in patients with idiopathic detrusor instability suggests that involuntary detrusor contractions are triggered by C-fiber input

scientific article

The future of pharmacologic treatment for bladder pain syndrome/interstitial cystitis: lessons from a meta-analysis.

scientific article published on 28 September 2011

The medical treatment of overactive bladder, including current and future treatments.

scientific article published on 08 February 2011

The role of brain-derived neurotrophic factor (BDNF) in the development of neurogenic detrusor overactivity (NDO).

scientific article

The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation.

scientific article published on 31 May 2017

Transient receptor potential channel: a reality that still requires many years of scientific efforts

scientific article published on 01 May 2015

Transient receptor potential channels in bladder function

scientific article

Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input

scientific article published on 30 April 2012

Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis

scientific article published in April 2007

Treatment of male stress urinary incontinence with the adjustable transobturator male system: Outcomes of a multi-center Iberian study

scientific article published on 9 January 2018

Treatment of priapism

scientific article published on 01 December 1984

Trigonal injection of botulinum toxin A in patients with refractory bladder pain syndrome/interstitial cystitis

scientific article published on 6 March 2010

Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A.

scientific article

Urinary Neurotrophin Levels Increase in Women With Stress Urinary Incontinence After a Midurethral Sling Procedure

scientific article published on 30 September 2016

Urinary bladder inflammation induces changes in urothelial nerve growth factor and TRPV1 channels

scientific article

Urinary neurotrophic factors in healthy individuals and patients with overactive bladder

scientific article published on 19 November 2012

Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: results of a double-blind randomized placebo-controlled trial

scientific article published in October 2005

Use of botulinum toxin for genitourinary conditions: What is the evidence?

scientific article published on 30 July 2015

VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG

scientific article

Vanilloid receptor and detrusor instability.

scientific article

Words of Wisdom. Re: Combination Treatment with Mirabegron and Solifenacin in Patients with Overactive Bladder: Efficacy and Safety Results from a Randomised, Double-blind, Dose-ranging, Phase 2 Study (Symphony)

scientific article published on 01 June 2015

[European Association of Urology guidelines on assessment and nonsurgical management of urinary incontinence]

scientific article published on 27 February 2013

[New treatment strategies for male lower urinary tract symptoms]

scientific article published on 01 December 2012

α1-Blockers in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction: Is Silodosin Different?

scientific article

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