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List of works by Javier Ortego

A Vaccine Based on a Modified Vaccinia Virus Ankara Vector Expressing Zika Virus Structural Proteins Controls Zika Virus Replication in Mice

scientific article published in Scientific Reports

A modified vaccinia Ankara virus (MVA) vaccine expressing African horse sickness virus (AHSV) VP2 protects against AHSV challenge in an IFNAR -/- mouse model.

scientific article

A protective bivalent vaccine against Rift Valley fever and bluetongue

scientific article published on 30 July 2020

A single dose of African horse sickness virus (AHSV) VP2 based vaccines provides complete clinical protection in a mouse model

scientific article published on 08 October 2018

Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway.

scientific article published on 10 August 2007

An experimental subunit vaccine based on Bluetongue virus 4 VP2 protein fused to an antigen-presenting cells single chain antibody elicits cellular and humoral immune responses in cattle, guinea pigs and IFNAR(-/-) mice.

scientific article published on 6 April 2015

Antiserum from mice vaccinated with modified vaccinia Ankara virus expressing African horse sickness virus (AHSV) VP2 provides protection when it is administered 48h before, or 48h after challenge.

scientific article published on 30 January 2015

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR Mice

article

CRALBP transcriptional regulation in ciliary epithelial, retinal Müller and retinal pigment epithelial cells

scientific article

Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.

scientific article published on August 1997

Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.

scientific article

Coronavirus derived expression systems.

scientific article

Cross-protective immune responses against African horse sickness virus after vaccination with protein NS1 delivered by avian reovirus muNS microspheres and modified vaccinia virus Ankara

scientific article published on 07 November 2019

Current strategies for subunit and genetic viral veterinary vaccine development.

scientific article published on 21 February 2011

Differential regulation of gene expression of neurotensin and prohormone convertases PC1 and PC2 in the bovine ocular ciliary epithelium: possible implications on neurotensin processing

scientific article published on November 2002

Efficacy of different DNA and MVA prime-boost vaccination regimens against a Rift Valley fever virus (RVFV) challenge in sheep 12 weeks following vaccination

scientific article published on 21 February 2018

Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor

scientific article

Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice

scientific article published on 18 August 2010

Functional expression of components of the natriuretic peptide system in human ocular nonpigmented ciliary epithelial cells

scientific article published on April 1999

Gene Expression of Proteases and Protease Inhibitors in the Human Ciliary Epithelium and ODM-2 Cells ⬇️

scientific article published on August 1, 1997

Generation of Recombinant Modified Vaccinia Virus Ankara Encoding VP2, NS1, and VP7 Proteins of Bluetongue Virus.

scientific article published on January 2016

Heterologous Combination of ChAdOx1 and MVA Vectors Expressing Protein NS1 as Vaccination Strategy to Induce Durable and Cross-Protective CD8+ T Cell Immunity to Bluetongue Virus

scientific article published on 29 June 2020

Identification of CD8 T cell epitopes in VP2 and NS1 proteins of African horse sickness virus in IFNAR(-/-) mice.

scientific article published on 10 August 2015

Immunization of knock-out α/β interferon receptor mice against lethal bluetongue infection with a BoHV-4-based vector expressing BTV-8 VP2 antigen.

scientific article published on 12 February 2011

Increasing the Safety Profile of the Master Donor Live Attenuated Influenza Vaccine

scientific article published on 29 January 2020

Inhibition of Orbivirus Replication by Aurintricarboxylic Acid

scientific article published on 02 October 2020

Interferon α/β receptor knockout mice as a model to study bluetongue virus infection

scientific article published on 04 October 2013

Isolation and characterization of cell-specific cDNA clones from a subtractive library of the ocular ciliary body of a single normal human donor: transcription and synthesis of plasma proteins

scientific article

Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells

scientific article

MVA Vectored Vaccines Encoding Rift Valley Fever Virus Glycoproteins Protect Mice against Lethal Challenge in the Absence of Neutralizing Antibody Responses

scientific article published on 12 February 2020

Microspheres-prime/rMVA-boost vaccination enhances humoral and cellular immune response in IFNAR(-/-) mice conferring protection against serotypes 1 and 4 of bluetongue virus.

scientific article published on 16 March 2017

Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor

scientific article published on 08 January 2019

Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus

scientific article

Ns1 is a key protein in the vaccine composition to protect Ifnar(-/-) mice against infection with multiple serotypes of African horse sickness virus.

scientific article

Organization of Two Transmissible Gastroenteritis Coronavirus Membrane Protein Topologies within the Virion and Core ⬇️

scientific article published on December 1, 2001

Pathological Characterization Of IFNAR(-/-) Mice Infected With Bluetongue Virus Serotype 4

scientific article

Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge

scientific article published on 04 December 2020

Recombinant vaccines against bluetongue virus

scientific article

Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium.

scientific article

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

scientific article published on 17 April 2018

The membrane M protein carboxy terminus binds to transmissible gastroenteritis coronavirus core and contributes to core stability

scientific article published on February 2001

Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence.

scientific article published on March 2003

Transmissible gastroenteritis virus (TGEV)-based vectors with engineered murine tropism express the rotavirus VP7 protein and immunize mice against rotavirus

scientific article published on 21 November 2010

VP2, VP7, and NS1 proteins of bluetongue virus targeted in avian reovirus muNS-Mi microspheres elicit a protective immune response in IFNAR(-/-) mice.

scientific article

Vaccination of mice with a modified Vaccinia Ankara (MVA) virus expressing the African horse sickness virus (AHSV) capsid protein VP2 induces virus neutralising antibodies that confer protection against AHSV upon passive immunisation

scientific article published on 12 December 2013

Viral Vector Vaccines against Bluetongue Virus

scientific article published on 25 December 2020

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