List of works - Riccardo Fodde

A 10-Mb paracentric inversion of chromosome arm 2p inactivatesMSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred

scientific article published on 01 September 2002

A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States

scientific article published in February 2004

A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor

article

A new conditional Apc-mutant mouse model for colorectal cancer

scientific article published on 22 February 2010

A novel ?� arising from a frameshift insertion, detected by direct sequencing of enzymatically amplified DNA

scientific article published on 01 August 1989

A novel frameshift mutation [FSC 47 (+A)] causing beta-thalassemia in a Surinam patient.

scientific article

A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis

scientific article

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

scientific article

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis

scientific article published on 3 July 2009

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

scientific article published in May 2001

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

scientific article published on 16 August 2006

APC dosage effects in tumorigenesis and stem cell differentiation

scientific article published in January 2004

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis.

scientific article

AT repeat polymorphism at the D5S122 locus tightly linked to adenomatous polyposis coli (APC) ⬇️

scientific article published on December 11, 1991

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

scientific article

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression

scientific article published on 14 March 2013

Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

scientific article published in 2022

American founder mutation for Lynch syndrome. Prevalence estimates and implications

scientific article published in January 2006

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

scientific journal article

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

scientific article published on 11 November 2002

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

scientific journal article

Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers

scientific article published on August 2010

CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC) ⬇️

scientific article published on October 25, 1991

CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC).

scientific article

CA repeat polymorphism from YAC JW25 at the D5S318 locus, distal to adenomatous polyposis coli (APC).

scientific article published on December 1991

CA repeat polymorphism within the MCC (mutated in colorectal cancer) gene

scientific article published on October 1991

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations

scientific article published on October 2013

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

scientific article published on 24 June 2013

CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models

scientific article

Cancer biology. A matter of dosage

scientific article

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.

scientific article

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance

scientific article

Cancer stem cells and metastasis

scientific article published on June 2012

Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective

scientific article published on January 2014

Cancer stemness and metastasis: therapeutic consequences and perspectives

scientific article published on 18 March 2010

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis

scientific article (publication date: 2013)

Cancer stemness in Wnt-driven mammary tumorigenesis

scientific article published on 16 August 2013

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

scientific article published on 22 March 2018

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion

scientific article

Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer

scientific article published on 14 September 2019

Chromosomal instability in MYH- and APC-mutant adenomatous polyps

scientific article published in March 2006

Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer

article by Juul T. Wijnen et al published 20 August 1998 in The New England Journal of Medicine

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability

scientific article published on 01 August 2010

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes

article

Concepts of metastasis in flux: the stromal progression model

scientific article published on 21 February 2012

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis

scientific article

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).

scientific article published in January 2001

DGGE polymorphism in intron 10 of MSH2, the HNPCC gene

article

Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach

article

Dinucleotide repeat polymorphism proximal to the spinal muscular atrophy region at the D5S524 locus

scientific article published in June 1993

Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures

scientific journal article

Early morbidity encountered in the dietary-related mouse model of Barrett's esophagus: a question of zinc?

scientific article

Ectopic activation of WNT signaling in human embryonal carcinoma cells and its effects in short- and long-term in vitro culture

scientific article published on 15 August 2019

Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis

scientific article published on August 1992

Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors

scientific article published in January 2011

Expression and genomic profiling of colorectal cancer

scientific article published on 22 August 2006

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer

scientific article

Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids

scientific article

Familial endometrial cancer in female carriers of MSH6 germline mutations

scientific article (publication date: October 1999)

Generation and characterization of an inducible transgenic model for studying mouse esophageal biology

scientific article

Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

scientific article published in January 2009

Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).

scientific article

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis

scientific article published on July 1992

Germline APC mutation familial adenomatous polyposis in Indian family.

scientific article published in October 1992

Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.

scientific article

Hb J-Anatolia [alpha 61(E10)Lys----Thr]: structural characterization and gene localization of a new alpha chain variant

scientific article published in January 1990

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells

scientific article published on May 2016

Homology of a 130-kb region enclosing the ?-globin gene cluster, the ?-locus controlling region, and two non-globin genes in human and mouse

article

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden

scientific article

Identification of quiescent, stem-like cells in the distal female reproductive tract

scientific article

Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays

scientific article published in November 1997

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

scientific article

Junk DNA and the long non-coding RNA twist in cancer genetics.

scientific article

Leiden Open Variation Database of the MUTYH gene

scientific article

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

scientific article published on 27 October 2011

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

article

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice

scientific article

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

scientific article

MSH2 genomic deletions are a frequent cause of HNPCC

article

Mapping of two new markers within the smallest interval harboring the spinal muscular atrophy locus by family and radiation hybrid analysis

scientific article published on May 1994

Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association?

scientific article published on 01 July 1999

Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.

scientific article published in August 2004

Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene

scientific article

Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis

scientific article published on 01 January 1997

Molecular characterization of the spectrum of genomic deletions in the mismatch repair genesMSH2,MLH1,MSH6, andPMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)

article

Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5; I0)(q22; q25) responsible for familial adenomatous polyposis in a Dutch pedigree ⬇️

scientific article published on 01 July 1995

Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour

article

Multiple Primary Cancer, Including Transitional Cell Carcinoma of the Upper Uroepithelial Tract in a Multigeneration Hnpcc Family: Molecular Genetic, Diagnostic, and Management Implications

Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications

scientific article published on 01 March 2003

Mutations in the APC tumour suppressor gene cause chromosomal instability

scientific article published in April 2001

Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma

scientific article

Nucleotide sequence of the Belgian G gamma+(A gamma delta beta)0-thalassemia deletion breakpoint suggests a common mechanism for a number of such recombination events

scientific article published in December 1990

Paneth cells in intestinal homeostasis and tissue injury

scientific article

Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications

scientific article

Prediction of the outcome of genetic testing in HNPCC kindreds using the revised Amsterdam criteria and immunohistochemistry

scientific article published on 01 January 2001

Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers

scientific article published on October 2003

Prevalence and molecular heterogeneity of alfa+ thalassemia in two tribal populations from Andhra Pradesh, India

scientific article published in October 1988

Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2.

scientific article published on July 2008

Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer

scientific article published on 8 September 2009

Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer.

scientific article

Quiescent stem cells in intestinal homeostasis and cancer

Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma.

scientific article published on 16 December 2004

Rapid detection of polymorphism near gene for adult polycystic kidney disease

article

Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test.

scientific article

Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds.

scientific article published on June 2003

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility

scientific article

SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice

scientific article published on 14 June 2007

Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene

scientific article published on March 2003

Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors

scientific article published on 20 June 2011

Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice

scientific article published on April 1997

Smad4 haploinsufficiency in mouse models for intestinal cancer

scientific article published on 01 March 2006

Somatic acquisition and signaling of TGFBR1*6A in cancer

scientific article

Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.

scientific article published in June 2012

Stem cells and metastatic cancer: fatal attraction?

scientific article

TGFBR1*6A may contribute to hereditary colorectal cancer

scientific article published in May 2005

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia

scientific article

The APC gene in colorectal cancer

scientific article (publication date: May 2002)

The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function

scientific article

The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype

scientific article

The Stem of Cancer

scientific article published on 01 February 2009

The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties

scientific article published on 25 February 2019

The involvement of Alu repeats in recombination events at the alpha-globin gene cluster: characterization of two alphazero-thalassaemia deletion breakpoints

scientific article published in April 1997

The multiple functions of tumour suppressors: it's all in APC

scientific article published on 01 March 2003

The nature of intestinal stem cells' nurture

scientific article

Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness

scientific article published on 27 May 2008

Use of aspirin postdiagnosis improves survival for colon cancer patients

scientific article published on 27 March 2012

Wnt Signaling in Adult Stem Cells

Wnt pathway-related gene expression during malignant progression in ulcerative colitis

article

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation

scientific article

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

scientific article published on 16 February 2007

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo

scholarly article

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis

scientific article published on 9 February 2011

List of works by Riccardo Fodde

A 10-Mb paracentric inversion of chromosome arm 2p inactivatesMSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred

A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States

A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor

A new conditional Apc-mutant mouse model for colorectal cancer

A novel ?� arising from a frameshift insertion, detected by direct sequencing of enzymatically amplified DNA

A novel frameshift mutation [FSC 47 (+A)] causing beta-thalassemia in a Surinam patient.

A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage

APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression

APC dosage effects in tumorigenesis and stem cell differentiation

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis.

AT repeat polymorphism at the D5S122 locus tightly linked to adenomatous polyposis coli (APC) ⬇️

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression

Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

American founder mutation for Lynch syndrome. Prevalence estimates and implications

Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts

Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers

CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC) ⬇️

CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC).

CA repeat polymorphism from YAC JW25 at the D5S318 locus, distal to adenomatous polyposis coli (APC).

CA repeat polymorphism within the MCC (mutated in colorectal cancer) gene

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models

Cancer biology. A matter of dosage

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.

Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance

Cancer stem cells and metastasis

Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective

Cancer stemness and metastasis: therapeutic consequences and perspectives

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis

Cancer stemness in Wnt-driven mammary tumorigenesis

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion

Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer

Chromosomal instability in MYH- and APC-mutant adenomatous polyps

Clinical Findings with Implications for Genetic Testing in Families with Clustering of Colorectal Cancer

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes

Concepts of metastasis in flux: the stromal progression model

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis

Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).

DGGE polymorphism in intron 10 of MSH2, the HNPCC gene

Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach

Dinucleotide repeat polymorphism proximal to the spinal muscular atrophy region at the D5S524 locus

Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures

Early morbidity encountered in the dietary-related mouse model of Barrett's esophagus: a question of zinc?

Ectopic activation of WNT signaling in human embryonal carcinoma cells and its effects in short- and long-term in vitro culture

Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis

Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors

Expression and genomic profiling of colorectal cancer

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer

Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids

Familial endometrial cancer in female carriers of MSH6 germline mutations

Generation and characterization of an inducible transgenic model for studying mouse esophageal biology

Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology

Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor).

Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis

Germline APC mutation familial adenomatous polyposis in Indian family.

Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.

Hb J-Anatolia [alpha 61(E10)Lys----Thr]: structural characterization and gene localization of a new alpha chain variant

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells

Homology of a 130-kb region enclosing the ?-globin gene cluster, the ?-locus controlling region, and two non-globin genes in human and mouse

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden

Identification of quiescent, stem-like cells in the distal female reproductive tract

Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

Junk DNA and the long non-coding RNA twist in cancer genetics.

Leiden Open Variation Database of the MUTYH gene

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice

Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.

MSH2 genomic deletions are a frequent cause of HNPCC