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List of works by Juan José Lasarte

A Combined PD-1/C5a Blockade Synergistically Protects against Lung Cancer Growth and Metastasis.

scientific article published on 13 March 2017

A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C.

scientific article published on 4 March 2013

A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo.

scientific article published on 05 September 2013

A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice.

scientific article

A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage

scientific article published in February 2003

A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury

scientific article published in April 2003

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats

scientific article published on 19 November 2008

Abnormal priming of CD4(+) T cells by dendritic cells expressing hepatitis C virus core and E1 proteins.

scientific article

Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors

article

Anaphylatoxin C5a creates a favorable microenvironment for lung cancer progression.

scientific article

Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL).

scientific article published on December 1998

B cell epitopes of HIV type 1 p24 capsid protein: a reassessment

scientific article published on 01 April 1996

Bivalent therapeutic vaccine against HPV16/18 genotypes consisting of a fusion protein between the extra domain A from human fibronectin and HPV16/18 E7 viral antigens

scientific article published on 01 June 2020

Blockage of FOXP3 transcription factor dimerization and FOXP3/AML1 interaction inhibits T regulatory cell activity: sequence optimization of a peptide inhibitor.

scientific article published on 13 May 2017

CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination.

scientific article published on December 2003

CD4-modified synthetic peptides containing phenylalanine inhibit HIV-1 infection in vitro.

scientific article published on February 1994

Carcinoembryonic antigen as a target to induce anti-tumor immune responses.

scientific article published in August 2004

Cellular immunity to hepatitis C virus core protein and the response to interferon in patients with chronic hepatitis C.

scientific article published on September 1998

Characterization of T-cell responses against immunodominant epitopes from hepatitis C virus E2 and NS4a proteins.

scientific article published in January 2006

Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes

scientific article published on February 2001

Clinical testing of a dendritic cell targeted therapeutic vaccine in patients with chronic hepatitis C virus infection.

scientific article published on 11 March 2015

Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

scientific article

Combined immunization with adjuvant molecules poly(I:C) and anti-CD40 plus a tumor antigen has potent prophylactic and therapeutic antitumor effects

scientific article published on 13 June 2007

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy

scientific article

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

Different doses of adenoviral vector expressing IL-12 enhance or depress the immune response to a coadministered antigen: the role of nitric oxide

scientific article published in May 1999

Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies

scientific article

Dynamic of nasal colonization by methicillin-resistant Staphylococcus aureus ST398 and ST1 after mupirocin treatment in a family in close contact with pigs

scientific article published on 01 January 2011

Emergency visits for childhood poisoning: a 2-year prospective multicenter survey in Spain

scientific article published on 01 May 2006

Engineered promiscuous T helper peptides for the induction of immune responses

scientific article published on 8 December 2006

Engineering Anti-myeloma Responses Using Affinity-Enhanced TCR-Engineered T Cells.

scientific article published on September 2015

Engineering Th determinants for efficient priming of humoral and cytotoxic T cell responses

scientific article published on 01 June 2003

Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells

scientific article published on 14 May 2011

Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model

scientific article published on 13 December 2018

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus

scientific article published in May 2005

Enhancement of peptide immunogenicity by insertion of a cathepsin B cleavage site between determinants recognized by B and T cells

scientific article published on 01 May 1993

Enhancing immunogenicity of a CTL epitope from carcinoembryonic antigen by selective amino acid replacements.

scientific article

Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin

scientific article published on 05 October 2011

Evaluation of a Salmonella Strain Lacking the Secondary Messenger C-di-GMP and RpoS as a Live Oral Vaccine

scientific article

Expansion of Tumor-Infiltrating CD8+ T cells Expressing PD-1 Improves the Efficacy of Adoptive T-cell Therapy.

scientific article published on 18 May 2017

FOXP3 Inhibitory Peptide P60 Increases Efficacy of Cytokine-induced Killer Cells Against Renal and Pancreatic Cancer Cells

scientific article published on 01 October 2019

Fine analysis of immunoreactivity of V3 peptides: antibodies specific for V3 domain of laboratory HIV type 1 strains recognize multiple V3 sequences synthesized from field HIV type 1 isolates

scientific article published in December 1996

Further insights on the inhibition of HIV type 1 infection in vitro by CD4-modified synthetic peptides containing phenylalanine

scientific article published on July 1996

Gene expression analysis during acute hepatitis C virus infection associates dendritic cell activation with viral clearance.

scientific article published on 8 October 2015

Genetic basis for clinical response to CTLA-4 blockade

scientific article published on 01 February 2015

Helper cell-independent antitumor activity of potent CD8(+) T cell epitope peptide vaccines is dependent upon CD40L.

scientific article published on 05 December 2013

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

scientific article

Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.

scientific article published on 26 September 2010

IL-10 expression defines an immunosuppressive dendritic cell population induced by antitumor therapeutic vaccination.

scientific article published on December 2016

Id1 and PD-1 Combined Blockade Impairs Tumor Growth and Survival of KRAS-mutant Lung Cancer by Stimulating PD-L1 Expression and Tumor Infiltrating CD8+ T Cells

scientific article published on 28 October 2020

Identification and characterization of a T-helper peptide from carcinoembryonic antigen.

scientific article published on April 2004

Identification of CD4+ and CD8+ T cell epitopes of woodchuck hepatitis virus core and surface antigens in BALB/c mice.

scientific article published on July 2010

Identification of HLA-B27-restricted cytotoxic T lymphocyte epitope from carcinoembryonic antigen

scientific article

Identification of LAG3 high affinity aptamers by HT-SELEX and Conserved Motif Accumulation (CMA).

scientific article published on 21 September 2017

Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen

scientific article published in October 2002

Identification of peptide inhibitors of transforming growth factor beta 1 using a phage-displayed peptide library

scientific article published in August 2007

Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.

scientific article published on 23 June 2015

Immune monitoring of immunosuppression withdrawal of liver transplant recipients

scientific article published on 27 July 2015

Immunization with a tumor-associated CTL epitope plus a tumor-related or unrelated Th1 helper peptide elicits protective CTL immunity

scientific article published on 01 June 2001

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

scientific article published on 25 January 2018

Immunostimulatory Monoclonal Antibodies and Immunomodulation: Harvesting the Crop

scientific article published on 2 May 2016

In vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-beta1.

scientific article published in July 2008

In vivo cytotoxic T-lymphocyte induction may take place via CD8 T helper lymphocytes

scientific article published on 01 January 1995

Induction of antibodies against a peptide hapten does not require covalent linkage between the hapten and a class II presentable T helper peptide

scientific article published on 01 June 1991

Induction of cytotoxic T lymphocytes in mice against the principal neutralizing domain of HIV-1 by immunization with an engineered T-cytotoxic-T-helper synthetic peptide construct

scientific article published on 01 April 1992

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus

scientific article published on February 1997

Induction of gp120-specific protective immune responses by genetic vaccination with linear polyethylenimine-plasmid complex

scientific article published in February 2005

Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer

scientific article published in October 2007

Induction of multiepitopic and long-lasting immune responses against tumour antigens by immunization with peptides, DNA and recombinant adenoviruses expressing minigenes

scientific article published on 10 December 2008

Induction of neutralizing antibodies against human immunodeficiency virus type 1 using synthetic peptide constructs containing an immunodominant T-helper cell determinant from vpr.

scientific article published on July 1994

Induction of potent and long-lasting CD4 and CD8 T-cell responses against hepatitis C virus by immunization with viral antigens plus poly(I:C) and anti-CD40.

scientific article published on 22 January 2007

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation.

scientific article

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

scientific article published on 03 July 2019

Inhibitory effect against polymerase and ribonuclease activities of HIV-reverse transcriptase of the aqueous leaf extract of Terminalia triflora.

scientific article published on December 2002

Insights on the amino acid side-chain interactions of a synthetic T-cell determinant

scientific article published on July 1991

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

scientific article

Liver expression of proteins controlling interferon-mediated signalling as predictive factors in the response to therapy in patients with hepatitis C virus infection.

scientific article

MRP1-CD28 bi-specific oligonucleotide aptamers: target costimulation to drug-resistant melanoma cancer stem cells

scientific article published on 15 March 2016

Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting

scientific article published in August 2005

Overcoming class II-linked non-responsiveness to hepatitis B vaccine

scientific article published on 01 August 1994

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

scientific article published on 11 April 2019

Peptide inhibitors of hepatitis C virus NS3 protease

scientific article published in September 2003

Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.

scientific article

Polarity of immunogens: implications for vaccine design

scientific article published in October 1990

Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation

scientific article published on 14 July 2010

Poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as innate immune system activators

scientific article published on 07 June 2011

Production of interleukin-2 in response to synthetic peptides from hepatitis C virus E1 protein in patients with chronic hepatitis C: relationship with the response to interferon treatment

scientific article published on July 1996

Protection against liver damage by cardiotrophin-1: a hepatocyte survival factor up-regulated in the regenerating liver in rats

scientific article

Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.

scientific article

Protective vaccination with hepatitis C virus NS3 but not core antigen in a novel mouse challenge model

scientific article published on February 2008

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12.

scientific article

Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance

scientific article published on 30 May 2017

Reversal of Diabetes in NOD Mice by Clinical-Grade Proinsulin and IL-10-Secreting Lactococcus lactis in Combination With Low-Dose Anti-CD3 Depends on the Induction of Foxp3-Positive T Cells.

scientific article published on 8 November 2016

SRC family kinase (SFK) inhibitor dasatinib improves the antitumor activity of anti-PD-1 in NSCLC models by inhibiting Treg cell conversion and proliferation

scientific article published in March 2021

Searching for the Achilles Heel of FOXP3

scientific article published on 03 December 2013

Short-Term Local Expression of a PD-L1 Blocking Antibody from a Self-Replicating RNA Vector Induces Potent Antitumor Responses

scientific article published on 16 September 2019

Simple strategy to induce antibodies of distinct specificity: Application to the mapping of gp120 and inhibition of HIV-1 infectivity

article

Skin lesion caused by ST398 and ST1 MRSA, Spain

scientific article published on January 2010

Specific and general HLA-DR binding motifs: comparison of algorithms

scientific article published in March 2000

Synthesis and evaluation of new Reissert analogs as HIV-1 RT inhibitors. 2. Benzo[f]quinoline and pyridine derivatives.

scientific article published on April 1997

Synthesis and evaluation of new Reissert analogs as HIV-1 reverse transcriptase inhibitors. 1. Quinoline and quinoxaline derivatives

scientific article published on April 1997

T(h)1 but not T(h)0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides

scientific article published on 01 December 1999

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

scientific article published on 14 July 2016

T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine

scientific article published in July 2001

Targeting inhibition of Foxp3 by a CD28 2'-Fluro oligonucleotide aptamer conjugated to P60-peptide enhances active cancer immunotherapy

scientific article published on 8 March 2016

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms.

scientific article published on 30 November 2017

The Toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer

scientific article published on 21 December 2017

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.

scientific article published on September 2007

The extra domain A from fibronectin targets antigens to TLR4-expressing cells and induces cytotoxic T cell responses in vivo

scientific article published on 01 January 2007

The extradomain A of fibronectin (EDA) combined with poly(I:C) enhances the immune response to HIV-1 p24 protein and the protection against recombinant Listeria monocytogenes-Gag infection in the mouse model

article

The extradomain a of fibronectin enhances the efficacy of lipopolysaccharide defective Salmonella bacterins as vaccines in mice

scientific article

The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases

scientific article

The involvement of ADAM10 in acantholysis in mucocutaneous pemphigus vulgaris depends on the autoantibody profile of each patient

scientific article published on 01 August 2019

The vaccine adjuvant extra domain A from fibronectin retains its proinflammatory properties when expressed in tobacco chloroplasts

scientific article published on 28 January 2010

Therapeutic Effect of Irreversible Electroporation in Combination with Poly-ICLC Adjuvant in Preclinical Models of Hepatocellular Carcinoma

scientific article published on 14 May 2019

Therapeutic blockade of Foxp3 in experimental breast cancer models.

scientific article published on 29 July 2017

Therapeutic effect of a peptide inhibitor of TGF-β on pulmonary fibrosis ⬇️

scientific article published on December 23, 2010

Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection.

scientific article published in October 1997

Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis

scientific article published on 01 September 2005

Transmission of hepatitis C virus infection to tree shrews

scientific article published on May 1998

Treatment of Experimental Autoimmune Encephalomyelitis by Sustained Delivery of Low-Dose IFN-α

scientific article published on 17 June 2019

Trial of complete weaning from immunosuppression for liver transplant recipients: factors predictive of tolerance

scientific article published on 26 July 2013

Tumor therapy in mice by using a tumor antigen linked to modulin peptides from Staphylococcus epidermidis

scientific article published on 15 September 2010

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection

scientific article published on 17 January 2007

Vaccination against hepatitis C virus with dendritic cells transduced with an adenovirus encoding NS3 protein.

scientific article

Vaccination with an adenoviral vector encoding hepatitis C virus (HCV) NS3 protein protects against infection with HCV-recombinant vaccinia virus

scientific article published on December 2002

Vaccine-induced but not tumor-derived Interleukin-10 dictates the efficacy of Interleukin-10 blockade in therapeutic vaccination.

scientific article published on 12 August 2015

Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity

scientific article published in March 2007

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