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List of works by Thibault Mesplède

A high-throughput assay for HIV-1 integrase 3'-processing activity using time-resolved fluorescence.

scientific article

A resveratrol analog termed 3,3',4,4',5,5'-hexahydroxy-trans-stilbene is a potent HIV-1 inhibitor

scientific article published on 18 May 2015

Addition of E138K to R263K in HIV integrase increases resistance to dolutegravir, but fails to restore activity of the HIV integrase enzyme and viral replication capacity.

scientific article

Antimalarial drugs and their metabolites are potent Zika virus inhibitors

scientific article published on 04 March 2019

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

scientific article published on 18 September 2017

Automethylation of protein arginine methyltransferase 6 (PRMT6) regulates its stability and its anti-HIV-1 activity.

scientific article published on 17 July 2013

Bictegravir in a fixed-dose tablet with emtricitabine and tenofovir alafenamide for the treatment of HIV infection: pharmacology and clinical implications

scientific article published on 30 January 2019

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in January 2014

Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase.

scientific article published in June 2014

Biochemical analysis of the role of G118R-linked dolutegravir drug resistance substitutions in HIV-1 integrase

scientific article published on 30 September 2013

Cenicriviroc blocks HIV entry but does not lead to redistribution of HIV into extracellular space like maraviroc

scientific article published on 2 November 2014

Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239.

scientific article

Characterization of the R263K mutation in HIV-1 integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir

scientific article

Combination of the R263K and M184I/V resistance substitutions against dolutegravir and lamivudine decreases HIV replicative capacity.

scientific article published on 9 February 2015

Combination therapies currently under investigation in phase I and phase II clinical trials for HIV-1

scientific article published on 05 February 2020

Correction for Anstett et al., "HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity"

article

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

scientific article published on 29 March 2016

Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.

scientific article

Differences among HIV-1 subtypes in drug resistance against integrase inhibitors

scientific article published on 25 June 2016

Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase

scientific article

Diverse Types of Diterpenoids with an Aromatized C Ring from the Twigs of Podocarpus imbricatus

scientific article published on 03 August 2020

Does antiretroviral treatment change HIV-1 codon usage patterns in its genes: a preliminary bioinformatics study

scientific article

Dolutegravir inhibits HIV-1 Env evolution in primary human cells

scientific article published on March 2015

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

scientific article

Dolutegravir monotherapy of simian immunodeficiency virus-infected macaques selects for several patterns of resistance mutations with variable virological outcomes

scientific article published on 04 January 2019

Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs.

scientific article published on 13 December 2017

Dolutegravir resistance mutation R263K cannot coexist in combination with many classical integrase inhibitor resistance substitutions

scientific article published on 4 February 2015

Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity.

scientific article published on 5 August 2015

Durable suppression of HIV-1 with resistance mutations to integrase inhibitors by dolutegravir following drug washout

article

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors

scientific article

Effect on HIV-1 viral replication capacity of DTG-resistance mutations in NRTI/NNRTI resistant viruses

scientific article published on 30 April 2016

Erratum for Mesplède et al., "The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration"

article

Evolution of HIV integrase resistance mutations.

scientific article published on February 2013

Exploring an alternative explanation for the second phase of viral decay: Infection of short-lived cells in a drug-limited compartment during HAART

scientific article published in PLoS ONE

Exposure to entry inhibitors alters HIV infectiousness and sensitivity to broadly neutralizing monoclonal antibodies.

scientific article

Fitness impaired drug resistant HIV-1 is not compromised in cell-to-cell transmission or establishment of and reactivation from latency

scientific article

HIV Drug Resistance and the Advent of Integrase Inhibitors.

scientific article published on February 2013

HIV drug resistance against strand transfer integrase inhibitors

scientific article published on 5 June 2017

HIV gp120 H375 is unique to HIV-1 subtype CRF01_AE and confers strong resistance to the entry inhibitor BMS-599793, a candidate microbicide drug.

scientific article published on 21 May 2012

HIV-1 Group O Resistance Against Integrase Inhibitors

scientific article published on 21 May 2015

HIV-1 group O integrase displays lower enzymatic efficiency and higher susceptibility to raltegravir than HIV-1 group M subtype B integrase

scientific article

HIV-1 group O integrase displays lower susceptibility to raltegravir and has a different mutational pathway for resistance than HIV-1 group M.

scientific article published on 2 November 2014

HIV-1 resistance dynamics in patients failing dolutegravir maintenance monotherapy.

scientific article published on 29 March 2018

HIV-1 resistance to dolutegravir is affected by cellular histone acetyltransferase activity

scientific article published on 23 August 2017

Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor

scientific article published on February 2015

Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay

scientific article published on 10 August 2016

Implications for the future of the HIV epidemic if drug resistance against dolutegravir cannot occur in first-line therapy

scientific article

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

scientific article published on 21 February 2018

Insertion as a Resistance Mechanism Against Integrase Inhibitors in Several Retroviruses

scientific article published on 01 September 2019

Integrase Strand Transfer Inhibitors in HIV Therapy.

scientific article

Integrase strand transfer inhibitors in the management of HIV-positive individuals

scientific article published on 03 March 2014

Investigational HIV integrase inhibitors in phase I and phase II clinical trials

scientific article published on 28 September 2017

Investigational drugs for the treatment of Zika virus infection: a preclinical and clinical update

scientific article published on 01 December 2018

Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.

scientific article published in February 2007

Is resistance to dolutegravir possible when this drug is used in first-line therapy?

scientific article

IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis

scientific article

JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1.

scientific article published on 15 February 2017

Lamivudine-resistant HIVM184V is durably suppressed with dolutegravir plus lamivudine dual therapy in humanised mice

scientific article published on 13 February 2020

M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA.

scientific article published on 22 August 2017

Might dolutegravir be part of a functional cure for HIV?

scientific article

Nonhuman Primates and Humanized Mice for Studies of HIV-1 Integrase Inhibitors: A Review

scientific article published on 31 May 2016

Pharmaceutical, clinical, and resistance information on doravirine, a novel non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1 infection

scientific article published on 03 March 2020

Polymorphic substitution E157Q in HIV-1 integrase increases R263K-mediated dolutegravir resistance and decreases DNA binding activity

scientific article

Positive and negative control of virus-induced interferon-A gene expression

scientific article published on December 2003

Proceedings of the Frontiers of Retrovirology Conference 2016.

scientific article published on 26 September 2016

Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis

scientific article published on 15 May 2013

Progressive emergence of an S153F plus R263K combination of integrase mutations in the proviral DNA of one individual successfully treated with dolutegravir

scientific article published on 13 November 2020

Reply to Achieng and Riedel

scientific article published on 01 January 2019

Reply to Darcis and Berkhout

scientific article published on 01 November 2018

Repression by homeoprotein pitx1 of virus-induced interferon a promoters is mediated by physical interaction and trans repression of IRF3 and IRF7

scientific article

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence

scientific article (publication date: July 2015)

Resistance mutations against dolutegravir in HIV integrase impair the emergence of resistance against reverse transcriptase inhibitors

scientific article published on March 2014

Resistance to HIV integrase inhibitors.

scientific article published on September 2012

Simian-tropic HIV as a model to study drug resistance against integrase inhibitors.

scientific article

Structural Studies of the HIV-1 Integrase Protein: Compound Screening and Characterization of a DNA-Binding Inhibitor

scientific article

The Combination of the R263K and T66I Resistance Substitutions in HIV-1 Integrase Is Incompatible with High-Level Viral Replication and the Development of High-Level Drug Resistance.

scientific article published on 26 August 2015

The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation

scientific article

The M184I/V and K65R nucleoside resistance mutations in HIV-1 prevent the emergence of resistance mutations against dolutegravir

scientific article published on 29 June 2016

The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness

scientific article published on 17 January 2014

The POU transcription factor Oct-1 represses virus-induced interferon A gene expression

scientific article

The R262K substitution combined with H51Y in HIV-1 subtype B integrase confers low-level resistance against dolutegravir

scientific article published on 27 October 2014

The R263K Dolutegravir Resistance-Associated Substitution Progressively Decreases HIV-1 Integration

scientific article published on 4 April 2017

The R263K mutation in HIV integrase that is selected by dolutegravir may actually prevent clinically relevant resistance to this compound

scientific article

The R263K substitution in HIV-1 subtype C is more deleterious for integrase enzymatic function and viral replication than in subtype B.

scientific article published on July 2015

The S230R Integrase Substitution Associated with Viral Rebound during DTG Monotherapy Confers Low Levels INSTI Drug Resistance.

scientific article published on 29 March 2018

The antimalarial drug amodiaquine possesses anti-ZIKA virus activities.

scientific article published on 9 January 2018

The development of novel HIV integrase inhibitors and the problem of drug resistance.

scientific article published on 16 September 2012

The dolutegravir R263K resistance mutation in HIV-1 integrase is incompatible with the emergence of resistance against raltegravir

scientific article published on 13 September 2015

The dual CCR5 and CCR2 inhibitor cenicriviroc does not redistribute HIV into extracellular space: implications for plasma viral load and intracellular DNA decline.

scientific article

The latest evidence for possible HIV-1 curative strategies

scientific article published on 21 February 2018

Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.

scientific article published on February 2009

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation

scientific article published on 16 April 2008

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

scientific article published on 22 February 2013

What if HIV were unable to develop resistance against a new therapeutic agent?

scientific article

Where are we with injectables against HIV infection and what are the remaining challenges?

scientific article published on 19 January 2018

Will LEDGIN molecules be able to play a role in a cure for HIV infection?

scientific article published on 7 May 2016

p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes

scientific article published on 19 October 2011

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