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List of works by Donald M. Bers

A cardiac dihydropyridine receptor II-III loop peptide inhibits resting Ca(2+) sparks in ferret ventricular myocytes

scientific article

A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function

scientific article (publication date: 8 July 2011)

A method to estimate mitochondrial Ca2+ uptake in intact cardiac myocytes

scientific article published on 01 December 1996

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

scientific article published on 13 January 2014

A novel computational model of the human ventricular action potential and Ca transient

scientific article published on 14 October 2009

A practical guide to the preparation of Ca(2+) buffers

scientific article published on January 2010

A practical guide to the preparation of Ca2+ buffers

scientific article

A simple device to illustrate the Einthoven triangle

scientific article published on December 2012

A simple method for the accurate determination of free [Ca] in Ca-EGTA solutions

scientific article published on 01 May 1982

AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.

scientific article published on 09 December 2013

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells

scientific article

Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytes

scientific article published on 8 July 2004

Acute β-adrenergic activation triggers nuclear import of histone deacetylase 5 and delays G(q)-induced transcriptional activation

scientific article published on 16 November 2012

Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA function

article

Adrenergic Fight-or-Flight: S-NO Falls on PKA Targets

scientific article

Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.

scientific article published on March 2009

Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability.

scientific article

Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes.

scientific article

Altered cardiac myocyte Ca regulation in heart failure.

scientific article published on December 2006

Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart

scientific article published in August 2004

Analysis of the mechanisms of mitochondrial NADH regulation in cardiac trabeculae.

scientific article

Ankyrin-B reduction enhances Ca spark-mediated SR Ca release promoting cardiac myocyte arrhythmic activity.

scientific article

Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness

scientific article published in June 2001

Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load.

scientific article published on 08 May 2008

Arrhythmogenic transient dynamics in cardiac myocytes.

scientific article published on March 2014

Assessing GPCR and G protein signaling to the nucleus in live cells using fluorescent biosensors

scientific article

Assessment of intra-SR free [Ca] and buffering in rat heart

scientific article published on September 1997

Atherosclerosis exacerbates arrhythmia following myocardial infarction: Role of myocardial inflammation

scientific article

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

scientific article published on August 2015

BAY K 8644 depresses excitation-contraction coupling in cardiac muscle

scientific article published on 01 March 1996

Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects.

scientific article

BayK 8644 increases resting calcium spark frequency in ferret ventricular myocytes.

scientific article

Beat-to-beat dynamic regulation of intracellular pH in cardiomyocytes

scientific article published on 13 December 2021

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase

scientific article published on 18 January 2007

Beyond beta blockers

scientific article published on 01 April 2005

Binding of Ca2+ and Na+ to sarcolemmal membranes: relation to control of myocardial contractility

scientific article published on 01 March 1980

Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution

scientific article

Biphasic contractions induced by milrinone at low temperature in ferret ventricular muscle: role of the sarcoplasmic reticulum and transmembrane calcium influx

scientific article published on 01 August 1986

Ca current facilitation during postrest recovery depends on Ca entry

scientific article

Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes

scientific article published on 01 April 1998

Ca influx and sarcoplasmic reticulum Ca release in cardiac muscle activation during postrest recovery

scientific article published on March 1985

Ca regulation in cardiac muscle

scientific article published on October 1, 1991

Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes

scientific article

Ca transport during contraction and relaxation in mammalian ventricular muscle

scientific article published on January 1997

Ca(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequences

scientific article

Ca(2+) influx through Ca(2+) channels in rabbit ventricular myocytes during action potential clamp: influence of temperature

scientific article published on 01 September 1999

Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase

scientific article published on 01 September 1994

Ca/calmodulin kinase II differentially modulates potassium currents

scientific article published on 17 April 2009

Ca2+ cycling between sarcoplasmic reticulum and mitochondria in rabbit cardiac myocytes

scientific article published in January 1993

Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes.

scientific article published on October 1996

Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium

scientific article published in July 1999

Ca2+ influx via the L-type Ca2+ channel during tail current and above current reversal potential in ferret ventricular myocytes

scientific article published on 01 February 2000

Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve

scientific article

Ca2+ sparks. Jumping the gap from the cell to cardiac muscle ⬇️

scientific article published on 01 October 1997

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes

scientific article published on 13 July 2006

Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites

scientific article

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

scientific article

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure

scientific article published on 3 November 2005

CaMKII Inhibition in Heart Failure Makes Jump to Human ⬇️

scientific article published on October 29, 2010

CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure

scientific article published on 13 April 2015

CaMKII comes of age in cardiac health and disease.

scientific article

CaMKII in myocardial hypertrophy and heart failure

scientific article published on 27 January 2011

CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation.

scientific article published on 17 October 2006

CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes

scientific article published on 01 February 1995

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy

scientific article published on 08 January 2019

CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses

scientific article published on 8 October 2007

CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.

scientific article published on 14 June 2015

Calcium and cardiac rhythms: physiological and pathophysiological

scientific article (publication date: 11 January 2002)

Calcium and cardiomyopathies.

scientific article published on January 2007

Calcium at the surface of cardiac plasma membrane vesicles: cation binding, surface charge screening, and Na-Ca exchange

scientific article

Calcium binding to cardiac sarcolemmal vesicles: potential role as a modifier of contraction

scientific article published on 01 December 1986

Calcium channels are ganging up in the sarcolemma

scientific article published on March 2010

Calcium cycling and signaling in cardiac myocytes.

scientific article published on January 2008

Calcium influx via I(NCX) is favored in failing human ventricular myocytes

scientific article published on 01 November 2002

Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes ⬇️

scientific article published on January 13, 2013

Calcium signaling in cardiac ventricular myocytes.

scientific article

Calcium signaling in heart: Multiscale, diverse, rapid, local, and remarkable

scientific article published on 13 March 2013

Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond.

scientific article

Calcium-sensitive mini- and microelectrodes.

scientific article

Calibration of indo-1 and resting intracellular [Ca]i in intact rabbit cardiac myocytes

scientific article published on April 1995

Calmodulin and Ca2+/calmodulin kinases in the heart - physiology and pathophysiology

scientific article published on 12 January 2007

Calmodulin and S100A1 fine tune skeletal muscle E-C coupling. Focus on “Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1” ⬇️

scientific article published on February 23, 2011

Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes ⬇️

scientific article published on June 12, 2011

Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes

scientific article

Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?

scientific article published in May 1988

Can the sodium-calcium exchanger initiate or suppress calcium sparks in cardiac myocytes?

scientific article published on April 2012

Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets

scientific article published on 12 October 2018

Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes

scientific article published on 11 February 2013

Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference?

scientific article published on 01 April 2002

Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations

scientific article published on 31 August 2006

Cardiac contractility and sarcolemmal calcium binding in several cardiac muscle preparations

scientific article published on 01 April 1981

Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling

scientific article published on December 2010

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

scientific article published on November 2013

Cardiac myocyte alternans in intact heart: Influence of cell-cell coupling and β-adrenergic stimulation.

scientific article published on 28 March 2015

Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects

scientific article published on 01 April 1998

Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.

scientific article

Cardiac pacemaking: I(f) vs. Ca(2+), is it really that simple?

scientific article published in August 2003

Cardiac ryanodine receptor phosphorylation: target sites and functional consequences

scientific article

Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction.

scientific article

Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current

scientific article published on 17 April 2003

Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II.

scientific article published on 13 February 2005

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure

scientific article published in Scientific Reports

Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes

scientific article published on 20 October 2010

Cellular basis of abnormal calcium transients of failing human ventricular myocytes

scientific article published on 20 February 2003

Chasing cardiac physiology and pathology down the CaMKII cascade

scientific article published on 6 March 2015

Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport

scientific article published on 13 March 2003

Citrate alters Ca channel gating and selectivity in rabbit ventricular myocytes

scientific article

Citrate decreases Ca current and changes selectivity of cardiac Ca channels.

scientific article published in January 1992

Citrate decreases contraction and Ca current in cardiac muscle independent of its buffering action

scientific article published in May 1991

Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes

scientific article published on 01 June 1996

Competition and redistribution among calcium transport systems in rabbit cardiac myocytes

scientific article published on 01 October 1993

Confocal imaging of CICR events from isolated and immobilized SR vesicles.

scientific article published in November 2005

Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation.

scientific article

Contractile activity modulates atrial natriuretic factor gene expression in neonatal rat ventricular myocytes

scientific article published on 01 January 1998

Contractile arrest increases sarcoplasmic reticulum calcium uptake and SERCA2 gene expression in cultured neonatal rat heart cells

scientific article published on 01 May 1994

Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress

scientific article published on 17 December 2014

Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol

scientific article

Coordinated feet and the dance of ryanodine receptors

scientific article published on 01 August 1998

Correction

Correction of proton and Ca association constants of EGTA for temperature and ionic strength

scientific article

Cumulative depletions of extracellular calcium in rabbit ventricular muscle monitored with calcium-selective microelectrodes

scientific article published on 01 June 1986

Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes

scientific article published on 01 November 1998

Cytosolic and mitochondrial Ca2+ signals in patch clamped mammalian ventricular myocytes

scientific article published on March 1998

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice

scientific article published on December 2011

Decreased inward rectifying K+ current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart

Deranged sodium to sudden death.

scientific article published on March 2015

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

scientific article published on 29 September 2013

Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes

scientific article published on 01 August 1997

Differences in Ca(2+)-handling and sarcoplasmic reticulum Ca(2+)-content in isolated rat and rabbit myocardium

scientific article published in December 2000

Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts

scientific article published on 11 July 2019

Differential distribution and regulation of mouse cardiac Na+/K+-ATPase alpha1 and alpha2 subunits in T-tubule and surface sarcolemmal membranes.

scientific article

Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets.

scientific article

Digitalis and Na/Ca exchange: old dog learns new mitochondrial tricks

scientific article published on 11 August 2010

Dihydropyridine receptors are primarily functional L-type calcium channels in rabbit ventricular myocytes

scientific article

Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity

scientific article published on 10 October 2019

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

scientific article published on 21 February 2014

Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy

scientific article published on 01 May 1997

Dual role of inorganic polyphosphate in cardiac myocytes: The importance of polyP chain length for energy metabolism and mPTP activation

scientific article published on 17 December 2018

Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release

scientific article published on 10 February 2011

Dynamic changes in free Ca-calmodulin levels in adult cardiac myocytes.

scientific article published on September 2006

Dynamic imaging in living cells: windows into local signaling.

scientific article

Dynamic regulation of sodium/calcium exchange function in human heart failure

scientific article published on 13 October 2003

Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans.

scientific article

Early remodeling of perinuclear Ca2+ stores and nucleoplasmic Ca2+ signaling during the development of hypertrophy and heart failure.

scientific article

Early transient depletion of extracellular Ca during individual cardiac muscle contractions

scientific article published on 01 March 1983

Effect of acetylstrophanthidin on twitches, microscopic tension fluctuations and cooling contractures in rabbit ventricle

scientific article published in October 1988

Effect of extracellular calcium on myocardial mechanical function in the neonatal rabbit.

scientific article

Effect of intracellular Ca2+ and action potential duration on L-type Ca2+ channel inactivation and recovery from inactivation in rabbit cardiac myocytes

scientific article published on 30 March 2007

Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes

scientific article published on 01 December 1996

Effects of [Ca2+]i, SR Ca2+ load, and rest on Ca2+ spark frequency in ventricular myocytes

scientific article published on 01 February 1997

Effects of left ventricular hypertrophy on force and Ca2+ handling in isolated rat myocardium

scientific article published on 01 April 1998

Effects of rest duration and ryanodine on changes of extracellular [Ca] in cardiac muscle from rabbits

scientific article published on 01 September 1987

Effects of thapsigargin and cyclopiazonic acid on twitch force and sarcoplasmic reticulum Ca2+ content of rabbit ventricular muscle

scientific article published on 01 November 1993

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure

scientific article published on 28 August 2003

Epac enhances excitation-transcription coupling in cardiac myocytes

scientific journal article

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

scientific article

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

scientific article

Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening

scientific article published on 25 October 2004

Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum

scientific article published in January 1990

Expression and phosphorylation of the na-pump regulatory subunit phospholemman in heart failure

scientific article published on 11 August 2005

Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes

scientific article published in December 2001

Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman.

scientific article

FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel

scientific journal article

FRET-based trilateration of probes bound within functional ryanodine receptors.

scientific article

Factors that control sarcoplasmic reticulum calcium release in intact ventricular myocytes

scientific article published on 01 September 1998

Fluorescence resonance energy transfer-based sensor Camui provides new insight into mechanisms of calcium/calmodulin-dependent protein kinase II activation in intact cardiomyocytes

scientific article published on 11 August 2011

Formation of spatially discordant alternans due to fluctuations and diffusion of calcium

scientific article

Free and bound intracellular calmodulin measurements in cardiac myocytes

scientific article published on 26 September 2006

Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholamban

scientific article published on 01 August 2002

Frequency-dependent changes in contribution of SR Ca2+ to Ca2+ transients in failing human myocardium assessed with ryanodine

scientific article published on 01 July 1998

Functional analysis of Na+/K+-ATPase isoform distribution in rat ventricular myocytes

scientific article published on 28 March 2007

Functional interconversion of rest decay and ryanodine effects in rabbit and rat ventricle depends on Na/Ca exchange

scientific article published in June 1990

Going to cAMP just got more complicated

scientific article

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

scientific article

Histidine-rich Ca binding protein: a regulator of sarcoplasmic reticulum calcium sequestration and cardiac function

scientific journal article

How Does Stochastic Ryanodine Receptor-Mediated Ca Leak Fail to Initiate a Ca Spark? ⬇️

scientific article published on November 15, 2011

How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?

scientific article published on March 2014

How to make and use calcium-specific mini- and microelectrodes.

scientific article

How to make calcium-sensitive microelectrodes

scientific article published in April 2013

How to make calcium-sensitive minielectrodes

scientific article

Human Atrial Fibrillation: Insights From Computational Electrophysiological Models ⬇️

scientific article published on July 1, 2011

Human Biological Pacemakers

scientific article published on 18 January 2012

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation

scientific article published on 15 September 2011

Hyperamylinemia contributes to cardiac dysfunction in obesity and diabetes: a study in humans and rats

scientific article published on 24 January 2012

Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury

scientific article published on 5 January 2006

Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways

scientific article published on 25 November 2020

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice

scientific article

Impaired relaxation in transgenic mice overexpressing junctin.

scientific article published in August 2003

Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection

scientific article published on 09 January 2007

In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding

scientific article

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes

scientific article published on 22 December 2005

Increased work in cardiac trabeculae causes decreased mitochondrial NADH fluorescence followed by slow recovery.

scientific article

Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings

scientific article published on 28 December 2015

Indo-1 binding to protein in permeabilized ventricular myocytes alters its spectral and Ca binding properties

scientific article published on July 1992

Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes

scientific article

Inotropic response to hypothermia and the temperature-dependence of ryanodine action in isolated rabbit and rat ventricular muscle: implications for excitation-contraction coupling

scientific article

Interplay of voltage and Ca-dependent inactivation of L-type Ca current.

scientific article

Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart

scientific article published on 17 August 2007

Intracellular Ca transients in rat cardiac myocytes: role of Na-Ca exchange in excitation-contraction coupling

scientific article published on 01 May 1990

Intracellular Ca2+ increases the mitochondrial NADH concentration during elevated work in intact cardiac muscle

scientific article published on 01 January 1997

Intracellular Ca2+ transients during rapid cooling contractures in guinea-pig ventricular myocytes

scientific article published in October 1989

Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis

scientific article

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged

scientific article published in May 2002

Intracellular Na+ regulation in cardiac myocytes.

scientific article

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes

scientific article published on 01 February 2002

Intracellular calcium and sodium activity in sheep heart Purkinje fibres. Effect of changes of external sodium and intracellular pH

scientific article published on 01 April 1982

Intracellular signalling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes.

scientific article published on 25 November 2013

Intrafibrillar and perinuclear mitochondrial heterogeneity in adult cardiac myocytes

scientific article published on 03 September 2019

Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure

scientific article

Isolation and characterization of cardiac sarcolemma ⬇️

scientific article published on July 19, 1979

Isoproterenol does not enhance Ca-dependent Na/Ca exchange current in intact rabbit ventricular myocytes

scientific article published on 19 October 2005

Junctional cleft [Ca²⁺]i measurements using novel cleft-targeted Ca²⁺ sensors

scientific article

K+ channels and cardiac electrophysiology.

scientific article published in April 2017

KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes

scientific article published on 01 March 2000

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

scientific article

Kinetics of [Ca]i decline in cardiac myocytes depend on peak [Ca]i

scientific article published on 01 January 1995

Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization

scientific article

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

scientific article published on March 2006

Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia

scientific article published on 26 April 2012

Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes

scientific journal article

Macromolecular complexes regulating cardiac ryanodine receptor function.

scientific article published in August 2004

Making and using calcium-selective mini- and microelectrodes.

scientific article published on January 2010

Measurement of calcium transport in heart using modern approaches.

scientific article published on February 1996

Measuring intranuclear and nuclear envelope [Ca(2+)] vs. cytosolic [Ca (2+)].

scientific article published in January 2015

Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.

scientific article published on 14 December 2012

Mechanics and energetics in cardiac arrhythmias and heart failure

scientific article published on 01 April 2020

Mechano-electric and mechano-chemo-transduction in cardiomyocytes

scientific article published on 03 February 2020

Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling.

scientific article

Membrane receptor neighborhoods: snuggling up to the nucleus

scientific article published in January 2013

Minding the store of Ca2+ during ischaemia/reperfusion

scientific article published on 07 January 2010

Mitochondria: from basic biology to cardiovascular disease

scientific article published on 14 March 2009

Mitochondrial and sarcolemmal Ca2+ transport reduce [Ca2+]i during caffeine contractures in rabbit cardiac myocytes

scientific article published in January 1992

Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes.

scientific article

Modification of temperature dependence of myofilament Ca sensitivity by troponin C replacement

scientific article

Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: effects of CASQ2 mutations linked to sudden cardiac death.

scientific article published on 9 May 2008

Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange.

scientific article

Modulation of excitation-contraction coupling by isoproterenol in cardiomyocytes with controlled SR Ca2+ load and Ca2+ current trigger

scientific article published on 14 January 2004

Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients

scientific article published on 22 March 2004

Myosin heavy chain gene expression in neonatal rat heart cells: effects of [Ca2+]i and contractile activity

scientific article published on 01 August 1997

Na(+) channel I-II loop mediates parallel genetic and phosphorylation-dependent gating changes

scientific article published on October 2012

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential

scientific article published on February 2002

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes

scientific article

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling.

scientific article published on March 2009

Na+/Ca2+ exchange and Na+/K+-ATPase in the heart

scientific article

Na-Ca exchange and Ca fluxes during contraction and relaxation in mammalian ventricular muscle

scientific article published on April 1996

Na-Ca exchange is required for rest-decay but not for rest-potentiation of twitches in rabbit and rat ventricular myocytes

scientific article published on 01 October 1994

Na/Ca exchange function in intact ventricular myocytes.

scientific article published in November 2002

Na/Ca exchange in heart failure: contractile dysfunction and arrhythmogenesis

scientific article published on 01 November 2002

Na/K pump current and [Na](i) in rabbit ventricular myocytes: local [Na](i) depletion and Na buffering

scientific article

Na/K-ATPase--an integral player in the adrenergic fight-or-flight response.

scientific article published on May 2009

Na⁺/K⁺-ATPase E960 and phospholemman F28 are critical for their functional interaction

scientific article

Nitric oxide regulates cardiac intracellular Na⁺ and Ca²⁺ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism

scientific article

Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation

scientific article

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling

scientific article

Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

scientific article

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.

scientific article

Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy.

scientific article published on 26 June 2013

Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment

scientific article

Nuclear calcium in cardiac myocytes

scientific article

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process

scientific article

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability

scientific article published on 25 October 2012

Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation

scientific article published on 25 February 2014

Overexpression of the Na+/K+ ATPase α2 but not α1 isoform attenuates pathological cardiac hypertrophy and remodeling

scientific article

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

scientific article

Oxygen-bridged Dinuclear Ruthenium Amine Complex Specifically Inhibits Ca2+ Uptake into Mitochondria in Vitroand in Situ in Single Cardiac Myocytes ⬇️

scientific article published on April 24, 1998

Paradoxical twitch potentiation after rest in cardiac muscle: increased fractional release of SR calcium

scientific article published on 01 September 1993

Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release

scientific article

Passive Ca buffering and SR Ca uptake in permeabilized rabbit ventricular myocytes ⬇️

scientific article published on March 1, 1993

Passive Ca2+ binding in ventricular myocardium of neonatal and adult rats

scientific article published on 01 June 1998

Pentameric assembly of phospholamban facilitates inhibition of cardiac function in vivo

scientific article published on 01 December 1998

Phorbol 12-myristate 13-acetate alters SR Ca(2+)-ATPase gene expression in cultured neonatal rat heart cells

scientific article published on 01 September 1996

Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes

scientific article

Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice

scientific article

Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump

scientific article published on 21 November 2000

Phospholamban is required for CaMKII-dependent recovery of Ca transients and SR Ca reuptake during acidosis in cardiac myocytes

scientific article

Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells

scientific article published on 19 February 2008

Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport

scientific article published on 26 December 2008

Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump

scientific article published on 30 August 2006

Phospholemman phosphorylation mediates the protein kinase C-dependent effects on Na+/K+ pump function in cardiac myocytes

scientific journal article

Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during beta-adrenergic stimulation in mouse ventricular myocytes

scientific article

Phospholemman-phosphorylation mediates the beta-adrenergic effects on Na/K pump function in cardiac myocytes

scientific article published on 7 July 2005

Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase.

scientific article

Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation

scientific article published on 01 March 2000

Point/counterpoint: a new feature in the JMCC.

scientific article published in June 2008

Positive and negative effects of nitric oxide on Ca(2+) sparks: influence of beta-adrenergic stimulation

scientific article published in December 2001

Possible functional linkage between the cardiac dihydropyridine and ryanodine receptor: acceleration of rest decay by Bay K 8644

scientific article published on 01 January 1996

Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias

scientific article

Postrest inotropy in rabbit ventricle: Na+-Ca2+ exchange determines sarcoplasmic reticulum Ca2+ content

scientific article published on 01 April 1986

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes

scientific article published in February 2002

Protein kinase inhibitor H-89 reverses forskolin stimulation of cardiac L-type calcium current

scientific article published on March 1995

Protein kinase inhibitors reduce SR Ca transport in permeabilized cardiac myocytes

scientific article published on 01 August 1994

Pulmonary arterial hypertension

scientific article published on 01 January 2007

Quantitative analysis of regional variability in the distribution of transverse tubules in rabbit myocardium

scientific article published in May 1991

Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes

scientific article published on 23 December 2016

Quantitative assessment of the SR Ca2+ leak-load relationship

scientific article published in October 2002

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

scientific article published on 29 July 2013

Rapid cooling contractures as an index of sarcoplasmic reticulum calcium content in rabbit ventricular myocytes

scientific article published in November 1989

Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes.

scientific article published in April 1989

Ratio of ryanodine to dihydropyridine receptors in cardiac and skeletal muscle and implications for E-C coupling

scientific article published in June 1993

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

scientific article published on 20 January 2011

Reduced Arrhythmia Inducibility With Calcium/Calmodulin-dependent Protein Kinase II Inhibition in Heart Failure Rabbits

scientific article published on 21 November 2015

Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model.

scientific article

Regulation of mitochondrial [NADH] by cytosolic [Ca2+] and work in trabeculae from hypertrophic and normal rat hearts

scientific article published on 01 June 1998

Regulation of the cloned L-type cardiac calcium channel by cyclic-AMP-dependent protein kinase

scientific article published on April 1994

Regulatory Role of Phospholamban in the Efficiency of Cardiac Sarcoplasmic Reticulum Ca2+Transport†

scientific article published in November 2000

Relaxation in ferret ventricular myocytes: role of the sarcolemmal Ca ATPase

scientific article published on 01 August 1995

Relaxation in ferret ventricular myocytes: unusual interplay among calcium transport systems

scientific article published on 01 April 1994

Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms

scientific article published on 01 April 1994

Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum calcium pump. Ryanodine and voltage sensitivity

scientific article published in August 1989

Requirement for Ca/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

scientific article published on 20 April 2009

Reverse mode of the sarcoplasmic reticulum Ca pump limits sarcoplasmic reticulum Ca uptake in permeabilized and voltage-clamped myocytes

scientific article published on 01 September 1998

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart

scientific article

Role of phospholemman phosphorylation sites in mediating kinase-dependent regulation of the Na+-K+-ATPase

scientific article

Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death

scientific article

Role of the sarcoplasmic reticulum in contraction and relaxation of immature rabbit ventricular myocytes

scientific article published on 01 October 1997

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

scientific article published on 04 February 2020

Ryanodine and the calcium content of cardiac SR assessed by caffeine and rapid cooling contractures

scientific article published on 01 September 1987

Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring

scientific article published in March 2012

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.

scientific article published on 26 August 2008

S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ.

scientific article

SR Ca loading in cardiac muscle preparations based on rapid-cooling contractures.

scientific article published in January 1989

SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.

scientific article

Sarcoplasmic Reticulum Ca2+ Release Causes Myocyte Depolarization : Underlying Mechanism and Threshold for Triggered Action Potentials

scientific article published on 01 October 2000

Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks

scientific article published in January 2016

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport

scientific article published in September 2003

Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes

scientific article

Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte

scientific article published on 22 June 2006

Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity

scientific article published on 15 January 2007

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays

scientific article

Sex differences in repolarization and slow delayed rectifier potassium current and their regulation by sympathetic stimulation in rabbits ⬇️

scientific article published on December 15, 2012

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials

scientific article

Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes

scientific article published on 01 November 2002

Simultaneous measurements of mitochondrial NADH and Ca(2+) during increased work in intact rat heart trabeculae

scientific article

Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

scientific article

Sodium and calcium regulation in cardiac myocytes: from molecules to heart failure and arrhythmia

scientific article

Sodium and the heart: a hidden key factor in cardiac regulation

scientific article published on 01 March 2003

Sodium-calcium exchange and sidedness of isolated cardiac sarcolemmal vesicles

scientific article published on 01 September 1980

Some just can't say enough in the new JMCC Point-Counterpoint feature

scientific article published on 01 February 2009

SparkMaster: automated calcium spark analysis with ImageJ

scientific article

Spatiotemporal characteristics of SR Ca(2+) uptake and release in detubulated rat ventricular myocytes

scientific article

Spatiotemporally Distinct Protein Kinase D Activation in Adult Cardiomyocytes in Response to Phenylephrine and Endothelin ⬇️

scientific article published on July 27, 2011

Species Differences and the Role of Sodium-Calcium Exchange in Cardiac Muscle Relaxation ⬇️

scientific article published on January 1, 1991

Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II.

scientific article published on 29 March 2010

Steady-state twitch Ca2+ fluxes and cytosolic Ca2+ buffering in rabbit ventricular myocytes

scientific article published on 01 January 1996

Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent

scientific article published in March 2003

Subcellular [Ca2+]i gradients during excitation-contraction coupling in newborn rabbit ventricular myocytes.

scientific article

Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes

scientific article published on 3 June 2017

Subcellular properties of [Ca2+]i transients in phospholamban-deficient mouse ventricular cells.

scientific article published in May 1998

Sudden unexpected death

scientific article published in January 2005

Surface:volume relationship in cardiac myocytes studied with confocal microscopy and membrane capacitance measurements: species-dependence and developmental effects.

scientific article

Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

scientific article

Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility

scientific article published on 2 September 2005

Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2.

scientific article

Targets for therapy in sarcomeric cardiomyopathies

scientific article

Temperature and relative contributions of Ca transport systems in cardiac myocyte relaxation

scientific article published on 01 May 1996

Temperature dependence of myofilament Ca sensitivity of rat, guinea pig, and frog ventricular muscle.

scientific article published in February 1990

Temperature-dependent activation of neurons by continuous near-infrared laser

scientific article

Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.

scientific article published on 21 December 2006

Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion

scientific article published on 11 September 2008

The IP3 receptor regulates cardiac hypertrophy in response to select stimuli

scientific article

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

scientific article published on 25 June 2015

The beat goes on: diastolic noise that just won't quit

scientific article published on 01 October 2006

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure

scientific article

The effect of Ca(2+)-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes

scientific article published on 01 May 1997

The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA

scientific article published on 01 August 1987

The force-frequency relationship: insights from mathematical modeling.

scientific article published on March 2013

The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase

scientific article

The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function

scientific article

The mechanism of ryanodine action in rabbit ventricular muscle evaluated with Ca-selective microelectrodes and rapid cooling contractures

scientific article published on 01 April 1987

The real estate of NOS signaling: location, location, location

scientific article published on 01 June 2003

The role of Ca influx in cardiac muscle excitation-contraction coupling. Assessment by extracellular Ca microelectrodes

scientific article published in January 1985

The role of phospholipids in the Ca2+ binding of isolated cardiac sarcolemma

scientific article published on 01 November 1980

Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations

scientific article

Time course of action of antagonists of mitochondrial Ca uptake in intact ventricular myocytes

scientific article published in August 2002

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release

scientific article

Translational medicine: to the rescue of the failing heart

scientific article published in May 2011

Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks

scientific article published on 01 July 2000

Twitch-dependent SR Ca accumulation and release in rabbit ventricular myocytes

scientific article published on 01 August 1993

Two different electrophysiological responses to ryanodine: evidence for two populations of muscles isolated from the rabbit right ventricle.

scientific article published in August 1987

Uncoupling cation effects on cardiac contractility and sarcolemmal Ca2+ binding

scientific article published on 01 September 1979

Upregulated Na/Ca exchange is involved in both contractile dysfunction and arrhythmogenesis in heart failure.

scientific article

Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure

scientific article published on 01 November 1999

Voltage dependence of cardiac excitation-contraction coupling: unitary Ca2+ current amplitude and open channel probability

scientific article published on 19 July 2007

When is cAMP not cAMP? Effects of compartmentalization.

scientific article

While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice

scientific article published on 06 March 2013

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

scientific article published on 01 July 2019

β-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.

scientific article published on 2 May 2017

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

scientific article published on 25 February 2015

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