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List of works by Yibin Wang

"Good enough solutions" and the genetics of complex diseases

scientific article

A H(a)rd Way to Adapt in Cardiac Hypertrophy

scientific article

A Path to Implement Precision Child Health Cardiovascular Medicine

scientific article

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

scientific article published in March 2017

A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord

scientific article

A new (heat) shocking player in cardiac hypertrophy

scientific article published on November 2008

A new branch connecting thermogenesis and diabetes

scientific article published on 01 September 2019

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development

scientific article

A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response

scientific article published on 24 February 2017

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin

scientific article

Adenovirus technology for gene manipulation and functional studies.

scientific article

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

scientific article

Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts

scientific article published on 27 October 2011

Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.

scientific article

BCVS Scientific Conference 2012 Meeting Report

Blind dates in sciences: dealing with rejection in peer review

scientific article

Branched chain amino acid metabolic reprogramming in heart failure

scientific article published on 14 September 2016

Branched-Chain Amino Acid Negatively Regulates KLF15 Expression via PI3K-AKT Pathway

scientific article published on 25 October 2017

Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?

scientific article

Calmodulin Regulation of Excitation-Contraction Coupling in Cardiac Myocytes

Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification.

scientific article published on 15 November 2016

Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells

scientific article

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

scientific article

Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart

scientific article published on 21 June 2017

Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy

scientific article published on 31 May 2012

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

scientific article published on 08 April 2016

Catabolism of branched-chain amino acids in heart failure: insights from genetic models.

scientific article

Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells

scientific article published on 23 December 2011

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

scientific article

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

scientific article published on 23 January 2005

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

scientific journal article

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

scientific article

Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice

scientific article

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

scientific article published on 01 January 2019

Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium

scientific article

Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.

scientific article published on 27 December 2011

Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity

scientific article published on October 2013

DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States

scientific article published on 11 January 2016

Dawn of the Epi-LncRNAs: new path from Myheart

scientific article published in January 2015

Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery

scientific article

Decoding the noncoding transcripts in human heart failure

scientific article published on 15 January 2014

Deconvolution of the Human Endothelial Transcriptome

scientific article published on September 2016

Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation

scientific article

Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy

scientific article

Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling

scientific article published on 08 February 2019

Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation

article

Divergent mitochondrial biogenesis responses in human cardiomyopathy

scientific article

Effect of p38 MAP kinases on contractility and ischemic injury in intact heart

scientific article

Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study

scientific article published on 01 June 2019

Electrochemical properties and myocyte interaction of carbon nanotube microelectrodes.

scientific article published on 18 October 2010

Embryonic and neonatal cardiac gene transfer in vivo

article

Embryonic expression patterns of the neural cell adhesion molecule gene are regulated by homeodomain binding sites

scientific article published on March 1996

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

scientific article

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

scientific article

Epigenetics in dilated cardiomyopathy.

scientific article

Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture ⬇️

scientific article published on 29 October 2018

Extracellular Signal-regulated Kinase Plays an Essential Role in Hypertrophic Agonists, Endothelin-1 and Phenylephrine-induced Cardiomyocyte Hypertrophy

scientific article published in Journal of Biological Chemistry

Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart

scientific article published in August 2003

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

scientific article published on 2 January 2009

Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation

scientific article published on January 2009

Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family

scientific article published on February 2008

Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model

scientific article

Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis

scientific article published on 01 September 2018

Genetics of common forms of heart failure: challenges and potential solutions

scientific article published on May 2015

Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy

scientific article

Gi-biased β2AR signaling links GRK2 upregulation to heart failure

scientific article published on 15 December 2011

Global impact of RNA splicing on transcriptome remodeling in the heart

scientific article

Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure

scientific article published on 13 March 2019

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

scientific article published on 02 January 2020

Heart hypertrophy during pregnancy: a better functioning heart?

scientific article published on November 2006

High Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure

scientific article

High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping

scientific article

Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits

scientific article

Hypertrophic preconditioning: short-term tricks for long-term gain

scientific article published on 27 March 2015

IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland

scientific article

Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury

scientific article published on 7 November 2008

Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy

scientific article published on 21 November 2014

Induction of apoptosis in vascular smooth muscle cells by mechanical stretch

scientific article

Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction

scientific article

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor

scientific article published on 19 April 2007

Interferon regulatory factors in heart: stress response beyond inflammation

scientific article published on 6 January 2014

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

scientific article

JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes

scientific article

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

scientific article

Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury

scientific article published on 7 November 2016

Klf15 orchestrates circadian nitrogen homeostasis

scientific article published in March 2012

Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death

scientific article published on 16 March 2004

Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution

scientific article

Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy

scientific article published on 6 November 2008

MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart

scientific article

Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice

scientific article published on 16 March 2009

Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice

scientific article

Mechanism-based engineering against anthracycline cardiotoxicity

scientific article published on 11 June 2013

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models

scientific article

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

scientific article published on 04 September 2020

Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

scientific article

Mitogen-activated protein kinases in heart development and diseases

scientific article published on September 2007

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene

scientific article

Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.

scientific article published on 29 January 2004

Molecular and functional signature of heart hypertrophy during pregnancy

scientific article published on 19 May 2005

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

scientific article

Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

scientific article published on 21 October 2010

Myocardin induces cardiomyocyte hypertrophy

scientific article published on 23 March 2006

Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition

scientific article published on 4 November 2004

Novel Ser/Thr Protein Phosphatases in Cell Death Regulation ⬇️

scientific article published on February 1, 2012

Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator)

scientific article (publication date: February 2003)

Nuclear phosphatase PPM1G in cellular survival and neural development.

scientific article published on 26 July 2013

Operationalizing Precision Cardiovascular Medicine: Three Innovations

scientific article published on October 2016

Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth

scientific journal article

Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load

PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response

scientific article published on 3 August 2013

Phosphoproteome analysis reveals regulatory sites in major pathways of cardiac mitochondria

scientific article

Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy

scientific article published on 28 March 2016

Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy

scientific article

Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.

scientific article

Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition

scientific article published on 22 August 2006

Prostaglandin E2 in Remote Control of Myocardial Remodeling ⬇️

scientific article published on May 15, 2012

Protective role of transient pore openings in calcium handling by cardiac mitochondria

scientific article

Protein kinetic signatures of the remodeling heart following isoproterenol stimulation

scientific article published on 10 March 2014

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells

scientific article published on June 2009

Proteomic insights into cardiac cell death and survival

scientific article published on June 2008

Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth

scientific article

RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure

scientific article

RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure

scientific article published on 13 March 2019

Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION.

scientific article published on 16 May 2016

Recombinant adenoviral expression of dominant negative IkappaBalpha protects brain from cerebral ischemic injury

scientific article published in November 2002

RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts

scientific article

Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation

scientific article published on 10 June 2016

Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells

scientific article

Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy

scientific article published on 22 January 2016

Restriction of Big Hearts by a Small RNA ⬇️

scientific article published on February 4, 2011

Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies

scholarly article

Robust Adenoviral and Adeno-Associated Viral Gene Transfer to the In Vivo Murine Heart

article

Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival

scientific article published on 30 October 2003

Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase

scientific article

Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction

scientific article

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart

scientific article published on 11 September 2003

Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach

scientific journal article

Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte

scientific article

Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies

scientific article published on February 2004

Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells

scientific article published on 12 March 2003

Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis

scientific article published on December 1999

Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice

scientific article

Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes

scientific article

Systems-based approaches to cardiovascular disease

scientific article published on 10 January 2012

TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling

scientific journal article

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

scientific article published on April 1996

Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects

scientific article published on 23 January 2004

Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility

scientific article

The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets

scientific article

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

scientific article

The chromatin-binding protein Smyd1 restricts adult mammalian heart growth

scientific article published on 23 September 2016

The elusive philosopher's stone in young blood

scientific article

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

scientific journal article

The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy

scientific article published on 12 September 2016

The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase

scientific article published in March 1998

The p38 mitogen-activated protein kinase pathway--a potential target for intervention in infarction, hypertrophy, and heart failure

scientific article

The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

scientific article

The role of the Grb2–p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

article published in 2003

The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.

scientific article

Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm).

scientific article

Transcriptome Complexity in Cardiac Development and Diseases

article

Untangle a Broken Heart via Janus Kinase 1.

scientific article published in September 2017

Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus

scientific article

WIPI1 is a conserved mediator of right ventricular failure

scientific article published on 25 April 2019

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure

scientific article published on 24 June 2019

Wnt11 regulates cardiac chamber development and disease during perinatal maturation

scientific article published on 7 September 2017

Zebrafish as a model for cardiovascular development and disease

scientific article published on January 2008

c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes

scientific article published in October 2002

p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart

article by Manxiang Li et al published 17 May 2005 in Circulation

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

scientific article

p38 MAP kinases in the heart

scientific article

p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes

scientific article published on February 2002

p38-MAPK Induced Dephosphorylation of α-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity

article

p38α MAPK Regulates Lineage Commitment and OPG Synthesis of Bone Marrow Stromal Cells to Prevent Bone Loss under Physiological and Pathological Conditions

scientific article published on 12 February 2016

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner

scientific article published on 06 April 2017

p38γ activity is required for maintenance of slow skeletal muscle size

scientific article published on February 2012

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