List of works - Linda Z Penn

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

scientific article

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

scientific article

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

scientific article

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

scientific article published on 10 April 2019

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

scientific article

Apoptosis modulators as cancer therapeutics.

scientific article

Association between depression, glycaemic control and the prevalence of diabetic retinopathy in a diabetic population in Cameroon

scientific article published on 01 June 2017

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

scientific article

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

scientific article

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

scientific article published on June 1999

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

scientific article

BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors

scientific article published on 14 October 2014

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

scientific article

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

scientific article published in September 2001

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

scientific article

CUL7 is a novel antiapoptotic oncogene

scientific article

Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation

scientific article

Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

scientific article published in July 2001

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

scientific article

ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data

scientific article

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

scientific article

Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death

scientific article published on 04 August 2020

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

scientific article published on 01 June 2007

Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents

scientific article published on December 2010

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

scientific article published in 2021

Dysregulation of the mevalonate pathway promotes transformation

scientific article

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

scientific article published in April 2001

Erratum: Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

scholarly article published in Laboratory Investigation

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

scientific article published on April 2010

Functional analysis of the N-terminal domain of the Myc oncoprotein

scientific article published on April 2003

Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity

scientific article published on October 2006

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

scientific article

Guiding principles for a successful multidisciplinary research collaboration

scientific article published on November 2015

Identification of c-MYC SUMOylation by mass spectrometry

scientific article published on 18 December 2014

Identifying Myc interactors.

scientific article published in January 2013

Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP.

scientific article published on April 2013

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

scientific article published on 17 December 2013

Image-Based Analysis of Protein Stability

scientific article published on 27 November 2019

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

scientific article

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

scientific article published on 01 February 1999

Induction of apoptosis in fibroblasts by c-myc protein

scientific article (publication date: 3 April 1992)

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

scientific article

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

scientific article

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung

scientific article published on 21 January 2015

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

scientific article

Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation

scientific article

Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

scientific article

Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

scientific article

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

scientific article

Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

scientific article

MYC Deregulation in Primary Human Cancers.

scientific article

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

article

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

scientific article published on 08 November 2018

MYC activity is negatively regulated by a C-terminal lysine cluster

scientific article published on 25 February 2013

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

scientific article published in Nature Communications

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

scientific article published on 07 June 2016

MYC phosphorylation at novel regulatory regions suppresses transforming activity

scientific article published on 12 September 2013

Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor

scientific article (publication date: April 2001)

Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

scientific article published in July 2002

Modelling the MYC-driven normal-to-tumour switch in breast cancer

scientific article published on 26 July 2019

More than MAX: Discovering the Myc interactome

scientific article published on 01 February 2011

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

scientific article published on May 2013

Multiple direct interactions of TBP with the MYC oncoprotein

scientific article published on 04 November 2019

Myc and its interactors take shape.

scientific article

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

scientific article

Myc represses the growth arrest gene gadd45

article

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

scientific journal article

Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells

scientific article published on 01 May 2000

OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.

scientific article

Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies

scientific article published on 21 October 2008

Oxygen regulation of arterial smooth muscle cell proliferation and survival

scientific article published on 30 November 2007

Prognostic gene signatures for non-small-cell lung cancer

scientific article

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

scientific article published on August 2000

Quantitation of enteroviral RNA by competitive polymerase chain reaction.

scientific article published on October 1993

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

scientific article published on 22 February 2021

Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein

scientific article published in May 2004

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

scientific article

Role of Pirh2 in mediating the regulation of p53 and c-Myc

scientific article

Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins

scientific article published on 11 December 2017

Statins as anti-cancer agents in the era of precision medicine

scientific article published on 04 September 2020

TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.

scientific article published on 23 November 2005

Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

scientific article published on 01 June 2021

Targeting tumor cell metabolism via the mevalonate pathway: Two hits are better than one

scientific article published on October 2014

Targeting tumor cell metabolism with statins.

scientific article published on 06 February 2012

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

scientific article published on 01 April 2022

The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis

scientific article (publication date: 15 May 2006)

The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53

scientific article

The interplay between cell signalling and the mevalonate pathway in cancer

scientific article

The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma

scientific article published on 14 July 2020

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

scientific article published in June 1998

The role of ligand density and size in mediating quantum dot nuclear transport

scientific article published on 2 July 2014

Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer

article

Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding

scientific article published on 28 March 2012

Tumor cell kill by c-MYC depletion: role of MYC-regulated genes that control DNA double-strand break repair.

scientific article published on 12 October 2010

c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

scientific article published on April 2004

List of works by Linda Z Penn

A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

Apoptosis modulators as cancer therapeutics.

Association between depression, glycaemic control and the prevalence of diabetic retinopathy in a diabetic population in Cameroon

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

BioID data of c-MYC interacting protein partners in cultured cells and xenograft tumors

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors

Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis

CUL7 is a novel antiapoptotic oncogene

Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation

Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.

Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

ChromNet: Learning the human chromatin network from all ENCODE ChIP-seq data

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome

Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death

Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma

Differential interactions between statins and P-glycoprotein: implications for exploiting statins as anticancer agents

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Dysregulation of the mevalonate pathway promotes transformation

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

Erratum: Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma

Functional analysis of the N-terminal domain of the Myc oncoprotein

Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Guiding principles for a successful multidisciplinary research collaboration

Identification of c-MYC SUMOylation by mass spectrometry

Identifying Myc interactors.

Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP.

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

Image-Based Analysis of Protein Stability

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach

Induction of apoptosis in fibroblasts by c-myc protein

Inhibiting MYC binding to the E-box DNA motif by ME47 decreases tumour xenograft growth

Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function

Integrating RAS status into prognostic signatures for adenocarcinomas of the lung

Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells

Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation

Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

MYC Deregulation in Primary Human Cancers.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

MYC activity is negatively regulated by a C-terminal lysine cluster

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability

MYC interaction with the tumor suppressive SWI/SNF complex member INI1 regulates transcription and cellular transformation

MYC phosphorylation at novel regulatory regions suppresses transforming activity

Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor

Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas

Modelling the MYC-driven normal-to-tumour switch in breast cancer

More than MAX: Discovering the Myc interactome

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Multiple direct interactions of TBP with the MYC oncoprotein

Myc and its interactors take shape.

Myc is an essential negative regulator of platelet-derived growth factor beta receptor expression.

Myc represses the growth arrest gene gadd45

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells

OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner.

Optimization of experimental design parameters for high-throughput chromatin immunoprecipitation studies

Oxygen regulation of arterial smooth muscle cell proliferation and survival

Prognostic gene signatures for non-small-cell lung cancer

Promotion of growth and apoptosis in c-myc nullizygous fibroblasts by other members of the myc oncoprotein family

Quantitation of enteroviral RNA by competitive polymerase chain reaction.

Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning

Repression of the human immunodeficiency virus type-1 long terminal repeat by the c-Myc oncoprotein

Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues

Role of Pirh2 in mediating the regulation of p53 and c-Myc

Statin-induced cancer cell death can be mechanistically uncoupled from prenylation of RAS family proteins