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List of works by J Javier Meana

5-HT2A receptor-mediated Gαq/11 activation in psychiatric disorders: A postmortem study

scientific article published on 21 October 2020

A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia.

scientific article published on 03 September 2012

A follow-up investigation on the quality of medical documents from examinations of Basque incommunicado detainees: the role of the medical doctors and national and international authorities in the prevention of ill-treatment and torture.

scientific article published on 7 November 2008

Acute and chronic effects of desipramine and clorgyline on alpha(2)-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study

scientific article

Acute ethanol intoxication may not alter alpha 2-adrenoceptors in the human brain

scientific article published in January 1992

Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain

scientific article published on 3 April 2013

Adenosine A1( )receptors are selectively coupled to Gα(i-3) in postmortem human brain cortex: Guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS) binding/immunoprecipitation study.

scientific article published on 23 July 2015

Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia

scientific article

Alpha 2-adrenoceptors in human forebrain: autoradiographic visualization and biochemical parameters using the agonist [3H]UK-14304

scientific article published on 01 December 1988

Alpha 2-adrenoceptors in the brain of depressed suicide victims

scientific article published on January 1, 1992

Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression

scientific article published in March 1992

Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence

scientific article

Altered CB1 receptor coupling to G-proteins in the post-mortem caudate nucleus and cerebellum of alcoholic subjects.

scientific article published on 7 August 2015

Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia

scientific article published on 25 May 2016

Aminopeptidase activity in the postmortem brain of human heroin addicts.

scientific article published on 8 December 2004

Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: a pilot study of relationship to negative symptoms.

scientific article published on 27 March 2013

Antidepressant-like properties of three new α2-adrenoceptor antagonists

scientific article published on 11 September 2012

Autoradiography of receptor-activated G-proteins in post mortem human brain

scientific article published on January 2000

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

scientific article

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex.

scientific article published on 4 November 2016

Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.

scientific article published on 24 October 2012

CCK in cerebral cortex and at the spinal level

scientific article published on March 1994

Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons

scientific article published on 17 January 2019

Characterization and regional distribution of alpha 2-adrenoceptors in postmortem human brain using the full agonist [3H]UK 14304

scientific article published on 01 April 1989

Characterization of CB1 cannabinoid receptor immunoreactivity in postmortem human brain homogenates.

scientific article published on 23 March 2006

Characterization of receptor-mediated [35S]GTPgammaS binding to cortical membranes from postmortem human brain

scientific article published on 01 February 2000

Chronic cannabis promotes pro-hallucinogenic signaling of 5-HT2A receptors through Akt/mTOR pathway

scientific article published on 27 April 2018

Chronic nicotine treatment counteracts the decrease in extracellular neostriatal dopamine induced by a unilateral transection at the mesodiencephalic junction in rats: a microdialysis study

scientific article published on December 1991

Chronic pain leads to concomitant noradrenergic impairment and mood disorders.

scientific article published on 31 July 2012

Correction to α2-Adrenoceptor Antagonists: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of Pyridinoguanidine, Pyridino-2-aminoimidazoline and Their Derivatives

scientific article published on 14 April 2015

Cyclin-dependent kinase-5 and p35/p25 activators in schizophrenia and major depression prefrontal cortex: basal contents and effects of psychotropic medications

scientific article published on 11 September 2012

Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease

scientific article published on May 1, 1992

Densities of I2-imidazoline receptors, imidazoline receptor proteins, and MAO-B sites in human gliomas and pituitary adenomas

scientific article

Description of a bivalent cannabinoid ligand with hypophagic properties

scientific article

Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo

scientific article

Differential [(3)H]idazoxan and [(3)H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) binding to imidazoline I(2) receptors in human postmortem frontal cortex.

scientific article published in July 2001

Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment

scientific article published on 01 January 1999

Differential postmortem delay effect on agonist-mediated phospholipase Cbeta activity in human cortical crude and synaptosomal brain membranes.

scientific article published in July 2004

Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers.

scientific article published on 31 October 2011

Dissociation between I2-imidazoline receptors and MAO-B activity in platelets of patients with Alzheimer's type dementia.

scientific article

Distribution of prolyl endopeptidase activities in rat and human brain

scientific journal article

Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics

scientific article published on 18 November 2019

Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects

scientific article published on 21 November 2012

Effect of subchronic corticosterone administration on α2-adrenoceptor functionality in rat brain: an in vivo and in vitro study.

scientific article published on 4 September 2016

Effect of the neurotoxin AF64A on intrinsic and extrinsic neuronal systems of rat neostriatum measured by in vivo microdialysis

scientific article published on November 1992

Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain.

scientific article

Endocannabinoid system imbalance in the postmortem prefrontal cortex of subjects with schizophrenia

scientific article published on 25 June 2019

Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.

scientific article published on 20 August 2014

FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments

scientific article published on 27 July 2014

Fentanyl derivatives bearing aliphatic alkaneguanidinium moieties: a new series of hybrid molecules with significant binding affinity for mu-opioid receptors and I2-imidazoline binding sites.

scientific article

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

scientific article published on 13 May 2010

Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs

scientific article

Guanidine and 2-Aminoimidazoline Aromatic Derivatives as α2-Adrenoceptor Antagonists, 1: Toward New Antidepressants with Heteroatomic Linkers

scientific article published on 10 August 2007

Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.

scientific article published on 7 May 2008

Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships

scientific article published in February 2009

Guanidinium and aminoimidazolinium derivatives of N-(4-piperidyl)propanamides as potential ligands for mu opioid and I2-imidazoline receptors: synthesis and pharmacological screening.

scientific article published on April 2002

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.

scientific article

Heterotrimeric g proteins: insights into the neurobiology of mood disorders.

scientific article published on April 2006

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

scientific article

I(2)-imidazoline binding site affinity of a structurally different type of ligands.

scientific article published in May 2002

I2-Imidazoline receptors and monoamine oxidase B enzyme sites in human brain: covariation with age

scientific article published on 01 July 2000

I2-imidazoline receptors in the healthy and pathologic human brain.

scientific article

Identification of a serotonin/glutamate receptor complex implicated in psychosis

scientific article

Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function

scientific article

Imidazoline I(2) receptor density increases with the malignancy of human gliomas

scientific article published on May 2004

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

scientific article published on 4 August 2009

Immunohistochemical evidence for a crossed cholecystokinin corticostriatal pathway in the rat.

scientific article published in December 1992

In vivo modulation of norepinephrine and glutamate release through imidazoline receptors in the rat central nervous system

scientific article published on 01 July 1995

In vivo potentiation of reboxetine and citalopram effect on extracellular noradrenaline in rat brain by α2-adrenoceptor antagonism.

scientific article published on November 2010

In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha(2)-adrenoceptors.

scientific article

Increased [3H] raclopride binding sites in postmortem brains from schizophrenic violent suicide victims

scientific article published in January 1992

Increased alpha 2-adrenoceptor density in the frontal cortex of depressed suicide victims

scientific article published on 01 January 1987

Increased density of mu-opioid receptors in the postmortem brain of suicide victims

scientific article published in June 1995

Increased α2- and β1-adrenoceptor densities in postmortem brain of subjects with depression: differential effect of antidepressant treatment

scientific article published on 18 June 2014

Inhibition of 5-hydroxytryptamine reuptake by the antidepressant citalopram in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo

scientific article published in October 2000

Involvement of serotonin 5-HT3 receptors in the modulation of noradrenergic transmission by serotonin reuptake inhibitors: a microdialysis study in rat brain

scientific article

Levels of G-protein alpha q/11 subunits and of phospholipase C-beta(1-4), -gamma, and -delta1 isoforms in postmortem human brain caudate and cortical membranes: potential functional implications.

scientific article published on 14 February 2006

Levels of Gsα(short and long), Gα(olf) and Gβ(common) subunits, and calcium-sensitive adenylyl cyclase isoforms (1, 5/6, 8) in post-mortem human brain caudate and cortical membranes: comparison with rat brain membranes and potential stoichiometric r

scientific article published on 27 November 2010

Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus

scientific article published on 4 January 2012

Long-acting fentanyl analogues: synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides.

scientific article published in March 2002

Low-affinity conditions for agonists increase the binding of the antagonist [3H]RX821002 to the alpha(2B/C)-adrenoceptor subtypes in human brain and rat kidney

scientific article published in July 1997

Modulation of catecholamine release by alpha 2-adrenoceptors and I1-imidazoline receptors in rat brain

scientific article published on 01 January 1997

Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats

scientific journal article

Monoamine oxidase B activity is increased in human gliomas.

scientific article

Neuronal dependence of extracellular dopamine, acetylcholine, glutamate, aspartate and gamma-aminobutyric acid (GABA) measured simultaneously from rat neostriatum using in vivo microdialysis: reciprocal interactions

scientific article published on 01 February 1992

Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of alpha(2A)-adrenoceptors.

scientific article published in January 2002

Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome

scientific article published in 2024

Non-adrenoceptor [3H]idazoxan binding sites (I2-imidazoline sites) are increased in postmortem brain from patients with Alzheimer's disease.

scientific article published in September 1993

Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts

scientific article

On the release of glutamate and aspartate in the basal ganglia of the rat: interactions with monoamines and neuropeptides.

scientific article published on July 1997

On the search of new I2-IBS aliphatic ligands: Bis-guanidino carbonyl derivatives

scientific article published on 23 August 2007

Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas.

scientific article

Opposite changes in imidazoline I2 receptors and alpha2-adrenoceptors density in rat frontal cortex after induced gliosis

scientific article published on 16 August 2005

Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain

scientific article

Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pat

scientific article published on 20 March 2009

Quantification of endocannabinoids in postmortem brain of schizophrenic subjects

scientific article published on 22 June 2013

Quantitative stoichiometry of G-proteins activated by mu-opioid receptors in postmortem human brain

scientific article published in September 2002

Recent cocaine use is a significant risk factor for sudden cardiovascular death in 15-49-year-old subjects: a forensic case-control study.

scientific article published on 27 August 2014

Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients

scientific article published on 21 May 2010

Regulation of central noradrenergic activity by 5-HT(3) receptors located in the locus coeruleus of the rat.

scientific article published in March 2012

Regulation of munc18-1 and syntaxin-1A interactive partners in schizophrenia prefrontal cortex: down-regulation of munc18-1a isoform and 75 kDa SNARE complex after antipsychotic treatment

scientific article published on 14 June 2011

Regulation of phospholipase Cbeta activity by muscarinic acetylcholine and 5-HT(2) receptors in crude and synaptosomal membranes from human cerebral cortex.

scientific article published in April 2001

Relationship between non-functional masticatory activity and central dopamine in stressed rats.

scientific article published on November 2010

Release of endogenous excitatory amino acids in the neostriatum of the rat under physiological and pharmacologically-induced conditions.

scientific article

Screening and quantification of antipsychotic drugs in human brain tissue by liquid chromatography-tandem mass spectrometry: application to postmortem diagnostics of forensic interest

scientific article published on 20 January 2012

Semaphorin and plexin gene expression is altered in the prefrontal cortex of schizophrenia patients with and without auditory hallucinations

article

Serotonin 5-HT2A receptors in schizophrenia: Reflexions on an unfinished story

scientific article published in 2023

Simultaneous determination of cholecystokinin, dopamine, glutamate and aspartate in cortex and striatum of the rat using in vivo microdialysis

scientific article published on 01 October 1991

Specific binding of [3H]Ro 19-6327 (lazabemide) to monoamine oxidase B is increased in frontal cortex of suicide victims after controlling for age at death.

scientific article published on 13 June 2007

Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions.

scientific article

Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites

scientific article published on 23 June 2006

The N251K functional polymorphism in the alpha(2A)-adrenoceptor gene is not associated with depression: a study in suicide completers

scientific article published on 7 December 2005

The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects

scientific article published on 8 July 2014

The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain

scientific article published on 29 October 2011

The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain

scientific article published on 07 November 2011

The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain

scientific article published in October 1996

Transcription factor SP4 phosphorylation is altered in the postmortem cerebellum of bipolar disorder and schizophrenia subjects

scientific article

Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning.

scientific article

Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment

scientific article

[3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney

scientific article published on 01 December 1996

mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts

scientific article

mu-opioid receptor and alpha2-adrenoceptor agonist stimulation of [35S]GTPgammaS binding to G-proteins in postmortem brains of opioid addicts

scientific article published in May 2000

α2-Adrenoceptor Functionality in Postmortem Frontal Cortex of Depressed Suicide Victims ⬇️

scientific article published on September 22, 2010

α2-adrenoceptor antagonists: synthesis, pharmacological evaluation, and molecular modeling investigation of pyridinoguanidine, pyridino-2-aminoimidazoline and their derivatives

scientific article published on 2 January 2015

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