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List of works by David R Greaves

5' structural motifs and Xenopus beta globin gene activation

scientific article published in February 1988

A novel protein derived from the MUC1 gene by alternative splicing and frameshifting.

scientific article

A novel real time imaging platform to quantify macrophage phagocytosis

scientific article published on 27 July 2016

A real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages

scientific article

Absence of the Non-Signalling Chemerin Receptor CCRL2 Exacerbates Acute Inflammatory Responses In Vivo.

scientific article published on 21 November 2017

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages.

scientific article

Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.

scientific article published on 25 July 2007

Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

scientific article published on 30 August 2016

Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice

scientific article published in December 2003

Adenoviral-mediated delivery of a viral chemokine binding protein blocks CC-chemokine activity in vitro and in vivo

scientific article published on January 2003

Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin

scientific article published on 31 August 2009

Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms

scientific article

Atherosclerosis: role of chemokines and macrophages ⬇️

scientific article published on November 5, 2001

Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice

scientific article published on 11 October 2004

CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges

scientific article published on 08 January 2013

CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression.

scientific article

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis

scientific article published in September 2008

CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells

scientific article

Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia.

scientific article published on 09 August 2017

Chapter 17 Zymosan‐Induced Peritonitis as a Simple Experimental System for the Study of Inflammation

scientific article published on 01 January 2009

Chemerin contributes to inflammation by promoting macrophage adhesion to VCAM-1 and fibronectin through clustering of VLA-4 and VLA-5.

scientific article published on 18 August 2010

Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner

scientific article

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

scientific article published in May 2002

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis

scientific article

Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb

scientific article published on 24 March 2008

Efferocytosis perpetuates substance accumulation inside macrophage populations

scientific article published in 2019

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.

scientific article published on 7 September 2017

Evaluation of macrophage-specific promoters using lentiviral delivery in mice ⬇️

scientific article published on December 1, 2011

Facile cruciform formation by an (A-T)34 sequence from a Xenopus globin gene

scientific article published on 01 October 1985

Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling

scientific article

Fractalkine promotes human monocyte survival via a reduction in oxidative stress

scientific article

Fractalkine: a survivor's guide: chemokines as antiapoptotic mediators.

scientific article published on 12 January 2012

Fractalkine: one chemokine, many functions

scientific article published on 01 January 2009

Functional analysis of the murine Emr1 promoter identifies a novel purine-rich regulatory motif required for high-level gene expression in macrophages

scientific article published in December 2004

Functional comparison of the murine macrosialin and human CD68 promoters in macrophage and nonmacrophage cell lines.

scientific article

Galectin-3 Is an Amplifier of Inflammation in Atherosclerotic Plaque Progression Through Macrophage Activation And Monocyte Chemoattraction

scientific article published on 20 December 2007

Gene transfer of a broad spectrum CC-chemokine inhibitor reduces vein graft atherosclerosis in apolipoprotein E-knockout mice

scientific article published in August 2005

Generation of a novel mouse model for the inducible depletion of macrophages in vivo

scientific article published on 20 September 2012

Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β

scientific article published on 06 September 2011

Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences

scientific article published on 4 January 2013

Glucocorticoids Suppress CCR9-Mediated Chemotaxis, Calcium Flux, and Adhesion to MAdCAM-1 in Human T Cells.

scientific article published on 25 March 2016

Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice.

scientific article published on 26 April 2015

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis

scientific article

How Have Leukocyte In Vitro Chemotaxis Assays Shaped Our Ideas about Macrophage Migration?

scientific article published on 02 December 2020

Human CD2 3'-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

scientific article published on 01 March 1989

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.

scientific article

Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo

scientific article

Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation

scientific article

Immune modulation in gastrointestinal disorders: new opportunities for therapeutic peptides?

scientific article

Immunity, atherosclerosis and cardiovascular disease

scientific article published on 01 April 2001

Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease

scientific article published on April 1998

Immunology on the Internet Web alert ⬇️

scientific article published on August 1, 1997

Immunophenotyping of macrophages in human pulmonary tuberculosis and sarcoidosis

scientific article published in December 2003

Impaired Mitochondrial Microbicidal Responses in Chronic Obstructive Pulmonary Disease Macrophages

scientific article published on 30 May 2017

In Vitro Migration Assays

scientific article published on 01 January 2018

Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting

scientific article published on 4 January 2007

Inflammation and immune responses in atherosclerosis

scientific article

Inflammation-a Critical Appreciation of the Role of Myeloid Cells

scientific article

Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications

scientific article

Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter

scientific article

Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition.

scientific article

Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists

scientific article published on 8 November 2014

Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis.

scientific article published on 04 September 2015

Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?

scientific article published on 27 April 2012

Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology

scientific article

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice.

scientific article published on 02 February 2009

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

scientific article published on 30 January 2020

MafB is essential for renal development and F4/80 expression in macrophages

scientific article published on August 2006

Magnetic resonance imaging of endothelial adhesion molecules in mouse atherosclerosis using dual-targeted microparticles of iron oxide

scientific article published on 25 October 2007

Molecular immunobiology of macrophages: recent progress.

scientific article published on February 1995

Monocyte recruitment in venous thrombus resolution

scientific article published in March 2006

NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance

scientific article published on 4 March 2012

Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a.

scientific article

Novel candidate genes in unstable areas of human atherosclerotic plaques

scientific article published in June 2006

Organization of the mouse macrophage C-type lectin (Mcl) gene and identification of a subgroup of related lectin molecules

scientific article published in February 2002

Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo.

scientific article published on December 2009

PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization

scientific article published on 16 December 2009

Polymorphism in the innate immune receptor SIRPα controls CD47 binding and autoimmunity in the nonobese diabetic mouse

scientific article published on 10 October 2014

Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor.

scientific article published on 2 June 2015

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

scientific article

Ratiometric analysis of fura red by flow cytometry: a technique for monitoring intracellular calcium flux in primary cell subsets

scientific article

Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence

scientific article published on 01 October 1998

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

scientific article

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

scientific article published in Nature Communications

Site-directed mutagenesis of the CC chemokine binding protein 35K-Fc reveals residues essential for activity and mutations that increase the potency of CC chemokine blockade

scientific article published on 17 May 2011

Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1)

scientific article published on 27 October 2003

Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11 ⬇️

scientific article published on October 8, 2010

Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation

scientific article

Synthetic chemerin-derived peptides suppress inflammation through ChemR23

scientific article

TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function

scientific article published on 27 May 2011

TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

scientific article

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration

scientific article published on September 2013

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

scientific article

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

scientific article

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

scientific article

The Role of Metabolite-sensing G Protein-Coupled Receptors in inflammation and metabolic disease.

scientific article published on 8 November 2017

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

scientific article published on 01 March 1989

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction

scientific article published on 09 July 2018

The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization.

scientific article

The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines

scientific article (publication date: 15 December 1999)

The human lysozyme promoter directs reporter gene expression to activated myelomonocytic cells in transgenic mice.

scientific article published on February 1996

The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13

scientific article

The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics

scientific article published on April 2004

The use of human CD68 transcriptional regulatory sequences to direct high-level expression of class A scavenger receptor in macrophages in vitro and in vivo

scientific article

Tissue-specific targeting of cytokine unresponsiveness in transgenic mice

scientific article published on 01 November 1995

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE-/- Reporter Mouse-Brief Report

scientific article published on December 2016

Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice.

scientific article

Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2.

scientific article published on 7 May 2009

Web alert Immunity to infection Genetic effects on immunity HIV ⬇️

scientific article published on 01 August 1997

c-Maf is essential for the F4/80 expression in macrophages in vivo.

scientific article published on 17 June 2009

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