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List of works by Erik B. Pedersen

1-, 2-, and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids: structure, thermal stability, and fluorescence relationship

scientific article published in January 2008

2,3-Dideoxy-3-Phthalimidopentoses in the Synthesis of 3'-Amino-2',3'-Dideoxynucleosides

5'-Azido and 5'-fluoro alpha-nucleosides as analogues of AZT and FLT.

scientific article published on March 1994

A Novel Route to N6-Alkylated 2'-Deoxyadenosine Using Benzotriazole as a Synthetic Auxiliary

A Simple Synthetic Route to Silylated Methyl 3-Azido-2,3-dideoxy-alpha,beta-D-erythro-pentofuranoside

A novel FRET pair for detection of parallel DNA triplexes by the LightCycler

scientific article

A novel synthetic route for the anti-HIV drug MC-1220 and its analogues.

scientific article published in November 2010

Anomalously Coupled Nucleosides

Anti-HIV Active Naphthyl Analogues of HEPT and DABO

article

Anti-parallel triplexes: Synthesis of 8-aza-7-deazaadenine nucleosides with a 3-aminopropynyl side-chain and its corresponding LNA analog

scientific article published on 27 March 2015

Bis-intercalation of homodimeric thiazole orange dye derivatives in DNA.

scientific article

Bisintercalation of homodimeric thiazole orange dyes in DNA: effect of modifying the linker.

scientific article published in November 1997

Cationic modified nucleic acids for use in DNA hairpins and parallel triplexes

scientific article published on 27 April 2011

Chemical Maturation of a Bivalent Aptamer by Single Domain Variation

scientific article published on 13 February 2012

Conjugation of a 3-(1H-phenanthro[9,10-d]imidazol-2-yl)-1H-indole intercalator to a triplex oligonucleotide and to a three-way junction

scientific article published on 13 November 2011

Convergent synthesis of 2′,3′-dideoxy-3′-methylthio and 2′,3′-dideoxy-3′-mercapto nucleosides and their disulfide analogues — Potential anti-HIV agents

article

DNA Conjugated Phenoxyaniline Intercalators: Synthesis of Diethanolaminoacetamide-type Linkers

DNA glue: 1-, 2- and 4-ethynylpyrenes in the structure of twisted intercalating nucleic acids (TINAs), DNA duplexes/triplexes and interstrand excimer formation

scientific article

DNA-Conjugated Organic Chromophores in DNA Stacking Interactions

article

Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates.

scientific article

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA.

scientific article published on 23 January 2013

Easily denaturing nucleic acids derived from intercalating nucleic acids: thermal stability studies, dual duplex invasion and inhibition of transcription start

scientific article

Enhanced Inhibition of Transcription Start by Targeting with 2′-OMe Pentaribonucleotides Comprising Locked Nucleic Acids and Intercalating Nucleic Acids

scientific article published on 01 July 2005

Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids

scientific article

Evaluation of Oligonucleotides with Novel Modifications

Facile route for the synthesis of the iminosugar nucleoside (3R,4R)-1-(pyren-1-yl)-4-(hydroxymethyl)pyrrolidin-3-ol

scientific article

Facile synthesis of the NNRTI microbicide MC-1220 and synthesis of its phosphoramidate prodrugs.

scientific article published on 26 November 2015

G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy

scientific article

GC-elements controlling HRAS transcription form i-motif structures unfolded by heterogeneous ribonucleoprotein particle A1

scientific article

Hexofuranosyl thymidines inserted into oligodeoxynucleotides via their two exocyclic hydroxy groups. Oligo synthesis and RNase H activity

scientific article

High Thermal Stability of 5′-5′-Linked Alternate Hoogsteen Triplexes at Physiological pH

scientific article published on 01 August 2006

High physiological thermal triplex stability optimization of twisted intercalating nucleic acids (TINA).

scientific article

Highly Efficient Synthesis of Allopurinol Locked Nucleic Acid Monomer by C6 Deamination of 8-Aza-7-bromo-7-deazaadenine Locked Nucleic Acid Monomer

Hydantoin analogs of thymidine

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells

scientific article

Improved DNA Clamps by Stacking to Adjacent Nucleobases

Increasing the analytical sensitivity by oligonucleotides modified with para- and ortho-twisted intercalating nucleic acids--TINA

scientific article (publication date: 2011)

Insertion of 5-methyl-N4-(1-pyrenylmethyl)cytidine into DNA. Duplex, three-way junction and triplex stabilities

Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

scientific article published on 01 January 2004

Intercalating nucleic acids (INAs) containing insertions of 6H-indolo[2,3-b]quinoxaline

Intercalating nucleic acids (INAs) with insertion of N-(pyren-1-ylmethyl)-(3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. DNA (RNA) duplex and DNA three-way junction stabilities

scientific article published in January 2003

Intercalating nucleic acids: The inversion of the stereocenter in 1-O-(pyren-1-ylmethyl)glycerol from R to S. Thermal stability towards ssDNA, ssRNA and its own type of oligodeoxynucleotides

Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells.

scientific article published on 08 December 2016

Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies

scientific article published in December 2004

MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice

scientific article published on 6 March 2013

Multiple pathways in the synthesis of new annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (emivirine).

scientific article published on August 2003

NMR structure determination of a modified DNA oligonucleotide containing a new intercalating nucleic acid

scientific article published in March 2004

New Emivirine (MKC-442) Analogues Containing a Tetrahydronaphthalene at C-6 and their Anti-HIV Activity

article

New Strategies in the Synthesis of 3′-Azido-2′,3′-dideoxy-nucleosides with Furanose Configuration

New acylated flavone and cyanogenic glycosides from Linum grandiflorum

scientific article

New route for the synthesis of 2-thiouracil analogues of 3?-azido-2?,3?-dideoxy nucleosides

New synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides

scientific article (publication date: November 1991)

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes

scientific article

Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (Aryl S-DABOs)

article

Nucleic Acid Targeted Therapy: G4 Oligonucleotides Downregulate HRAS in Bladder Cancer Cells through a Decoy Mechanism.

scientific article

Nucleic acid component analogues: synthesis of 2'-deoxynucleosides from 5-substituted-4-hydroxy-6(1H)-pyrimidinones

scientific article published in January 2003

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.

scientific article

PYRENE INTERCALATING NUCLEIC ACIDS WITH A CARBON LINKER

scientific article published on 01 March 2011

Phosphoramides, XIX [1] Phosphorus Pentoxide Amine Hydrochloride Reagents in the Synthesis of 3-Amino-1,2-benzisothiazole-1,1-dioxides and 3-Aminothieno [3,4-d] isothiazole-1,1-dioxides

Phosphoramides. IV. A New Synthesis of Biologically Important Formamidines

Phosphoramides. Part 9. An attempt to describe the mechanism in the reaction of benzyl alcohols with hexamethylphosphoric triamide

article by Erik B. Pedersen & Jens Peter Jacobsen published 1979 in Perkin transactions II RSC

Phosphoramides. VII. Phenyl N,N'-Dimethylphosphorodiamidate as a Reagent for Synthesis of 3-Methylthieno[2,3-d]pyrimidin-4(3H)-ones

Phosphoramides. X. Phosphorus Pentaoxide Amine Mixtures and HMPT as Reagents in the Synthesis of 4-Amino- and 4-Dimethylamino-2,3-polymethylenequinolines

Phosphoramides. XI. Phosphoramides as Reagents in the Synthesis of Benzamidines from Benzophenone Oxime

Phosphoramides. XII. Diphosphorus Pentoxide Amine Mixtures as Reagents in a New Synthesis of Formamidines with Potential Pesticidal Activity

Phosphoramides. XIII. Phosphorus Pentaoxide--Amine Hydrochloride Mixtures as Reagents in the Synthesis of 4(3H)-Quinazolinones and 4-Quinazolinamines

Phosphorus Pentoxide in Organic Synthesis. XXX. New Synthesis of 4(3H)-Quinazolinones

Phosphorus Pentoxide in Organic Synthesis. XXXV. Synthesis of Thiazolo[5,4-d]pyrimidin-7-amines and Purine-6-thiones from 5-Acylamino-4-thiazolecarboxamides

Phosphorus Pentoxide in Organic Synthesis. XXXVII. Synthesis of 2-Amino-6-arylaminopurines

Potential anti-HIV active pyranoid analogs of AZT

scientific article

Preparation of oligodeoxynucleotides containing 5-(N-methylpiperazinyl) and 5-benzyloxymethyl uracils

scientific article published in January 2001

Prevention of mouse-rat brain xenograft rejection by a combination therapy of cyclosporin A, prednisolone and azathioprine

scientific article published on 01 January 1995

Prompt Lithiation of 1-Dimethylsulfamoylthymine Used for the Synthesis of 1-Allyloxymethyl-6-(α,2,6-trifluorobenzyl)thymine

Purine twisted-intercalating nucleic acids: a new class of anti-gene molecules resistant to potassium-induced aggregation

scientific article published on 2 May 2008

Stabilization of Parallel Triplexes by Twisted Intercalating Nucleic Acids (TINAs) Incorporating 1,2,3-Triazole Units and Prepared by Microwave-Accelerated Click Chemistry

scientific article published on 01 January 2007

Stabilizing a DNA Three-Way Junction by Insertion of N4-Aryl-2-deoxy-5-methylcytidines

Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) prepared via postsynthetic Sonogashira solid-phase coupling reactions

scientific article

Stereoselective 1,4-Addition of Thiols to (2E)-4,6-Di-O-acetyl-2,3-dideoxy-aldehydo-D-erythro-hex-2-enose

Studying the Influence of the Pyrene Intercalator TINA on the Stability of DNA i-Motifs

scientific article published on 01 January 2012

Synthesis and Anti-HIV-1 Activity of Novel MKC-442 Analogues Containing Alkenyl Chains or Reactive Functionalities in the 6-Benzyl Group

article

Synthesis and Anti-HIV-1 Evaluation of Some Novel MC-1220 Analogs as Non-Nucleoside Reverse Transcriptase Inhibitors.

scientific article published on 21 March 2016

Synthesis and DNA binding properties of a new benzo[f]imidazo[1,5b]-isoquinoline-butan-1,2-diol derivative

scientific article published on January 2006

Synthesis and anti-HIV-1 activity of 1-substiuted 6-(3-cyanobenzoyl) and [(3-cyanophenyl)fluoromethyl]-5-ethyl-uracils.

scientific article

Synthesis and anti-HIV-1 activity of new MKC-442 analogues with an alkynyl-substituted 6-benzyl group

scientific article published on May 2007

Synthesis and anti-HIV-1 activity of new fluoro-HEPT analogues: an investigation on fluoro versus hydroxy substituents.

scientific article published on April 2011

Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones

scientific article

Synthesis and anti-HIV-1 evaluation of 1,5-disubstituted pyrimidine-2,4-diones

Synthesis and antiviral activity of new dimeric inhibitors against HIV-1.

scientific article published on 14 September 2007

Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186.

scientific article published on January 2008

Synthesis and antiviral evaluation of hydantoin analogues of AZT.

scientific article published on October 1994

Synthesis and evaluation of antiviral activity of L-acosamine and L-ristosamine nucleosides of furanose configuration

scientific article (publication date: July 1991)

Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.

scientific article published on February 2005

Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position

scientific article published on October 2003

Synthesis and evaluation of novel 6-(3,5-dimethylbenzyl)uracil analogs as potential anti-HIV-1 agents

article

Synthesis and evaluation of thalidomide and phthalimide esters as antitumor agents.

scientific article

Synthesis and incorporation of an alpha-hexofuranosyl thymidine into oligodeoxynucleotides via its two exocyclic OH-groups

scientific article published on February 2004

Synthesis and potent anti-HIV-1 activity of novel 6-benzyluracil analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

scientific article published on June 1996

Synthesis of 1-(3-(1,2,4-triazol-1-yl)-2,3,6-trideoxy-L-arabino-hexofuranosyl)uracils via an ?,?-unsaturated aldehydrohexose

Synthesis of 1-(3-Alkyl-2,3-dideoxy-D-pentofuranosyl)uracils with Potential Anti-HIV Activity

article

Synthesis of 1′-aza-C-nucleosides from (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol

article published in 2001

Synthesis of 2-(aminocarbonylmethylthio)-1H-imidazoles as novel Capravirine analogues

scientific article published in July 2005

Synthesis of 2-methylsulfanyl-1H-imidazoles as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs).

scientific article

Synthesis of 2?,3?-dideoxynucleosides from 5-alkoxymethyluracils

Synthesis of 3'-(4-nitroimidazol-1-yl)-2',3'-dideoxynucleosides of pyrimidine analogues and their biological evaluation against HIV

scientific article

Synthesis of 3'-C-Phosphono Nucleosides from α,β-Unsaturated Lactone

Synthesis of 3'-Dialkylamino-2',3'-dideoxynucleosides from a 2,3'-Anhydrothymidine or an alpha,beta-Unsaturated Aldehyde

Synthesis of 3'-O-(2-Aminoethyl)-2'-deoxyuridines

scientific article published on 01 August 1995

Synthesis of 3'-azolyl-2',3'-dideoxyhexose nucleosides

scientific article published on July 1998

Synthesis of 4-Arylamino-1H-pyrazolo[3,4-d]pyrimidines

Synthesis of 4-methylthio analogues of FLT and AZT and their evaluation against HIV.

scientific article published on January 1995

Synthesis of 5-(4-Nitroimidazol-1-yl)-2'-deoxyuridines

Synthesis of 5-Homologous AZT and D4T Derivatives

scientific article published on 01 October 1992

Synthesis of 5-alkoxymethyl derivatives of 3'-amino-2',3'-dideoxyuridine and evaluation of their activity against HIV and cancer

scientific article (publication date: 1992)

Synthesis of 5-dialkylaminomethyl-3′-azido and 3′-fluoro-2′,3′-dideoxyuridines for evaluation as anti-HIV agents

article

Synthesis of 6-(3,5-dichlorobenzyl) derivatives as isosteric analogues of the HIV drug 6-(3,5-dimethylbenzyl)-1-(ethoxymethyl)-5-isopropyluracil (GCA-186).

scientific article published on July 2005

Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine

scientific article published on March 2004

Synthesis of N,N'-Dialkylamidines from Heterocyclic Carboxylic Acids

Synthesis of N-1-(Indanyloxymethyl) and N-1-(4-Hydroxybut-2-enyloxymethyl) Analogues of the HIV Drugs Emivirine and GCA-186

article

Synthesis of N6-Aryl-2-methyladenosines

Synthesis of New Acyclic Nucleosides

Synthesis of New DNA G-Quadruplex Constructs with Anthraquinone Insertions and Their Anticoagulant Activity

Synthesis of New MKC-442 Analogues Containing Alkenyl Chains or Reactive Functionalities at C-5

Synthesis of Trifluoromethylisoxazoloazines

Synthesis of a Carboxamide Linked T∗T Dimer with an Acyclic Nucleoside Unit and Its Incorporation in Oligodeoxynucleotides

Synthesis of a Carboxamide Linked UBr∗UBrDimer–Duplex and Triplex Stabilities of the Corresponding Oligodeoxynucleotides

Synthesis of a New Furanoid Glycal Auxiliary

article published in 2005

Synthesis of a new intercalating nucleic acid 6H-INDOLO[2,3-b] quinoxaline oligonucleotides to improve thermal stability of Hoogsteen-type triplexes

scientific article published in January 2013

Synthesis of a new intercalating nucleic acid analogue with pyrenol insertions and the thermal stability of the resulting oligonucleotides towards DNA over RNA

Synthesis of an AZT-HEPT Hybrid and Homologous AzddU Derivatives

scientific article published on 01 May 1996

Synthesis of an aza analogue of 2-deoxy-D-ribofuranose and its homologues.

scientific article published in July 2001

Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H )-diones as key intermediates

Synthesis of carboxamide linked dimers, αT*αT and αUCl*αT. — duplex and triplex stabilities of the corresponding α oligodeoxynucleotides

Synthesis of furoannelated analogues of Emivirine (MKC-442).

scientific article published on March 2004

Synthesis of locked pyranosyl nucleic acid (LpNA)

scientific article published on 08 October 2011

Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants

scientific article published on December 2002

Synthesis of novel fluoro analogues of MKC442 as microbicides.

scientific article published on 3 June 2014

Synthesis of novel uracil non-nucleoside derivatives as potential reverse transcriptase inhibitors of HIV-1.

scientific article published in November 2009

Synthesis of twisted intercalating nucleic acids possessing acridine derivatives. Thermal stability studies

scientific article

Syntiiesis of New 3'-Amino-2',3'-Dideoxynucleosides in Five Steps Starting from Peracetylated Clycals

Targeting Chimeric alpha,beta-Oligonucleotides to the Flanks of a Stem in DNA. The Enhanced Effect of an Intercalator

The Potential of Aspirin in Prodrug Synthesis: A New Potential Delivery System of AZT and FLT

scientific article published on 01 August 1996

The effect of INA [(R)-1-O-(1-pyrenylmethyl)glycerol] insertions on the structure and biological activity of a G-quadruplex from a critical KRAS G-rich sequence.

scientific article published on January 2007

Thermal Stability of Modified i-Motif Oligonucleotides with Naphthalimide Intercalating Nucleic Acids

Thermal stability of G-rich anti-parallel DNA triplexes upon insertion of LNA and α-l-LNA

scientific article published on 01 May 2015

Thio Nucleoside Derivatives as Intermediates or Target Compounds in the Attempt of Finding New Agents Against HIV

article

Triplex formation by pyrene-labelled probes for nucleic acid detection in fluorescence assays

scientific article

Twisted Intercalating Nucleic Acids – Intercalator Influence on Parallel Triplex Stabilities

Unexpected Hydration of a Triple Bond During DNA Synthesis: Conjugating 3-(Pyren-1-ylethynyl)indole to DNA for Triplex Studies

Unexpected Isolation of 4‐Isothiocyanatomethylene‐4H‐pyridine‐1‐carboxylic Acid Ethyl Ester as Potential Template in Organic Synthesis

Unlocked Nucleic Acids with a Pyrene-Modified Uracil: Synthesis, Hybridization Studies, Fluorescent Properties and i-Motif Stability

scientific article published on 01 January 2014

Using an aryl phenanthroimidazole moiety as a conjugated flexible intercalator to improve the hybridization efficiency of a triplex-forming oligonucleotide

scientific article

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