List of works - Juan Anguita

A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity

scientific article (publication date: March 2009)

A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi.

scientific article published on 7 March 2018

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

scientific article published on 18 December 2020

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

scientific article published on 21 February 2014

Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice ⬇️

scientific article published on October 1, 1997

Adaptation of Borrelia burgdorferi in the tick and the mammalian host

scientific article published on October 2003

Adult peripheral blood and umbilical cord blood NK cells are good sources for effective CAR therapy against CD19 positive leukemic cells

scientific article published on 10 December 2019

Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent

scientific article

Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A

scientific article published on August 2000

B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis ⬇️

scientific article published on August 1, 1997

Bacterial tannases: classification and biochemical properties

scientific article published on 20 November 2018

Binding of full-length HIV-1 gp120 to CD4 induces structural reorientation around the gp120 core

scientific article

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector

scientific article published on January 2013

Borrelia burgdorferi erpT expression in the arthropod vector and murine host.

scientific article

Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity

scientific article

Borrelia burgdorferi induces inflammatory mediator production by murine microglia

scientific article published on September 2002

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

scientific article published on 04 January 2021

Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety

scientific article published on 05 August 2008

Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination

scientific article

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

article

Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro

scientific article published on 17 March 2021

CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi

scientific article

CD14 targets complement receptor 3 to lipid rafts during phagocytosis of Borrelia burgdorferi

scientific article published on 20 August 2013

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR Mice

article

Cell-attached patch clamping of the intact rabbit ciliary epithelium

scientific article published on February 1996

Characterization of a Chikungunya virus strain isolated from banked patients' sera

scientific article

Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1.

scientific article

Cloning and expression in Escherichia coli of tryptophan genes from Streptomyces griseus IMRU 3570

article

Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis

scientific article

Conformational Rearrangement within the Soluble Domains of the CD4 Receptor Is Ligand-specific

scientific article published on 28 November 2007

Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity

scientific article

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

article

Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector

scientific article published on 29 June 2016

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

scientific article

Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox

scientific article

Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis

scientific article

Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis

scholarly article by Juan Anguita published 15 November 2002 in FEMS Immunology and Medical Microbiology

Delivery of the immunosuppressive antigen Salp15 to antigen-presenting cells by Salmonella enterica serovar Typhimurium aroA mutants

scientific article

Dissociation of infectivity and pathogenicity in Borrelia burgdorferi

scientific article

Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad.

scientific article

Effect of anti-interleukin 12 treatment on murine lyme borreliosis

scientific article published on February 1996

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

scientific article

Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor

scientific article

Evidence that Escherichia coli isolated from the intestine of healthy pigs hybridize with LT-II, ST-Ib and SLT-II DNA probes.

scientific article

Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis

scientific article

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

scientific article published on 01 January 2020

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis

scientific article

Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi

scientific article

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

scientific article published on 23 May 2016

Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2)

scientific article published on 07 November 2020

Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase

scientific article

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

scientific article published on 18 July 2019

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

scientific article

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

scientific journal article

IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program

scientific article

Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp. polymorphum

scientific article published on 26 February 2018

Identification of synthetic host defense peptide mimics that exert dual antimicrobial and anti-inflammatory activities

scientific article published on 5 September 2012

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

scientific article

Impact of local traffic exclusion on near-road air quality: findings from the New York City "Summer Streets" campaign

scientific article published on 22 March 2011

Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

scientific article

Influence of growth temperature on the production of extracellular virulence factors and pathogenicity of environmental and human strains of Aeromonas hydrophila

scientific article published on 01 February 1993

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

scientific article published on 01 December 2000

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

scientific article

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

scientific article published on 03 January 2020

Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development

scientific article published on 16 September 2020

Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis

scientific article published on March 2009

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

scientific journal article

Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection

scientific article

Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes

scientific article

Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis

scientific article published on 16 December 2020

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

scientific article published on 26 January 2017

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

scientific article published on 20 September 2018

Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans.

scientific article

Molecular cloning and characterization of an extracellular protease gene from Aeromonas hydrophila.

scientific article

Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium

scientific article (publication date: 8 March 1995)

Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus

scientific article

Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity

scientific article

Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection.

scientific article published on 7 June 2019

Notch signaling regulates mouse and human Th17 differentiation

scientific article

Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model

scientific article published on 12 August 2021

Passage through Ixodes scapularis ticks enhances the virulence of a weakly pathogenic isolate of Borrelia burgdorferi

scientific article

Phagocytosis Assays for Borrelia burgdorferi

scientific article published in January 2018

Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells

scientific article

Plasticity in early immune evasion strategies of a bacterial pathogen

scientific article published on 2 April 2018

Preliminary Evaluation of Tick Protein Extracts and Recombinant Ferritin 2 as Anti-tick Vaccines Targeting in Cattle

scientific article published on 05 December 2018

Quantum DNA Sequencing: A Peek Into a Dystopic Future?

scientific article published on 29 January 2018

RFLP-PCR analysis of the aroA gene as a taxonomic tool for the genus Aeromonas

article

RFLP-PCR analysis of the aroA gene as a taxonomic tool for the genus Aeromonas

scientific article published on 01 November 1997

Regulation of macrophage activity by surface receptors contained within Borrelia burgdorferi-enriched phagosomal fractions

scientific article published on 18 November 2019

Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults

scientific article

Replacing the rhamnose-xylose moiety of QS-21 with simpler terminal disaccharide units attenuates adjuvant activity in truncated saponin variants

scientific article published on 25 November 2020

Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

scientific article published on 01 September 2018

Role of Aramchol in steatohepatitis and fibrosis in mice.

scientific article published on 4 October 2017

Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation

scientific article published in June 2002

Selective anti-inflammatory action of interleukin-11 in murine Lyme disease: arthritis decreases while carditis persists

scientific article published in March 1999

Serum C3 Enhances Complement Receptor 3-Mediated Phagocytosis of Borrelia burgdorferi

scientific article published on 11 September 2015

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

scientific article published on 03 July 2020

Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts

scientific article

Stratification and therapeutic potential of PML in metastatic breast cancer

scientific article

Structural Analysis of the Black-Legged Tick Saliva Protein Salp15

scientific article published in 2022

Substance P augments Borrelia burgdorferi-induced prostaglandin E2 production by murine microglia

scientific article published in May 2004

Synthetic mimics of antimicrobial peptides with immunomodulatory responses

scientific article

T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15

scientific article published on 02 March 2007

TRAIL expression is induced in both osteoblasts containing intracellular Staphylococcus aureus and uninfected osteoblasts in infected cultures

scientific article published on 7 December 2007

The Ixodes scapularis salivary protein, salp15, prevents the association of HIV-1 gp120 and CD4

scientific article

The Lyme disease agent exploits a tick protein to infect the mammalian host

scientific article

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis

scientific article published on 18 July 2019

The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes

scientific article published on 01 January 2021

The immunosuppresive tick salivary protein, Salp15.

scientific article published on January 2009

The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant

scientific article published on 6 September 2017

The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.

scientific article

The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

scientific article published on 17 January 2020

The tick saliva immunosuppressor, Salp15, contributes to Th17-induced pathology during Experimental Autoimmune Encephalomyelitis

scientific article

The tick salivary protein, Salp15, inhibits the development of experimental asthma

scientific article

c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages.

scientific article

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.

scientific article published on 28 June 2017

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

scientific article published on 16 August 2019

p38 mitogen-activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi

scientific article

List of works by Juan Anguita

A chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity

A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi.

A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

Ablation of interleukin-12 exacerbates Lyme arthritis in SCID mice ⬇️

Adaptation of Borrelia burgdorferi in the tick and the mammalian host

Adult peripheral blood and umbilical cord blood NK cells are good sources for effective CAR therapy against CD19 positive leukemic cells

Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent

Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A

B7-1 and B7-2 monoclonal antibodies modulate the severity of murine Lyme arthritis ⬇️

Bacterial tannases: classification and biochemical properties

Binding of full-length HIV-1 gp120 to CD4 induces structural reorientation around the gp120 core

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector

Borrelia burgdorferi erpT expression in the arthropod vector and murine host.

Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity

Borrelia burgdorferi induces inflammatory mediator production by murine microglia

Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety

Borrelia burgdorferi-induced inflammation facilitates spirochete adaptation and variable major protein-like sequence locus recombination

Borrelia burgdorferi–Infected, Interleukin‐6–Deficient Mice Have Decreased Th2 Responses and Increased Lyme Arthritis

Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> clearance <i>In Vitro</i>

CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi

CD14 targets complement receptor 3 to lipid rafts during phagocytosis of Borrelia burgdorferi

CD8 T Cell Responses to an Immunodominant Epitope within the Nonstructural Protein NS1 Provide Wide Immunoprotection against Bluetongue Virus in IFNAR Mice

Cell-attached patch clamping of the intact rabbit ciliary epithelium

Characterization of a Chikungunya virus strain isolated from banked patients' sera

Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1.

Cloning and expression in Escherichia coli of tryptophan genes from Streptomyces griseus IMRU 3570

Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis alters murine immune responses, pathogen burden, and severity of Lyme arthritis

Conformational Rearrangement within the Soluble Domains of the CD4 Receptor Is Ligand-specific

Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector

Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15

Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox

Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis

Cyclooxygenase 2 activity modulates the severity of murine Lyme arthritis

Delivery of the immunosuppressive antigen Salp15 to antigen-presenting cells by Salmonella enterica serovar Typhimurium aroA mutants

Dissociation of infectivity and pathogenicity in Borrelia burgdorferi

Distinct bacterial dissemination and disease outcome in mice subcutaneously infected with Borrelia burgdorferi in the midline of the back and the footpad.

Effect of anti-interleukin 12 treatment on murine lyme borreliosis

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Establishment of a Bluetongue Virus Infection Model in Mice that Are Deficient in the Alpha/Beta Interferon Receptor

Evidence that Escherichia coli isolated from the intestine of healthy pigs hybridize with LT-II, ST-Ib and SLT-II DNA probes.

Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis

Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis

Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2)

Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase

Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program

Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp. polymorphum

Identification of synthetic host defense peptide mimics that exert dual antimicrobial and anti-inflammatory activities

Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

Impact of local traffic exclusion on near-road air quality: findings from the New York City "Summer Streets" campaign

Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation

Influence of growth temperature on the production of extracellular virulence factors and pathogenicity of environmental and human strains of Aeromonas hydrophila

Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells

Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

Lessons from Bacillus Calmette-Guérin: Harnessing Trained Immunity for Vaccine Development

Local production of IFN-gamma by invariant NKT cells modulates acute Lyme carditis

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection

Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes

Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis

Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis.

MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans.

Molecular cloning and characterization of an extracellular protease gene from Aeromonas hydrophila.

Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium

Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus

Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity

Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection.

Notch signaling regulates mouse and human Th17 differentiation