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List of works by Kazuhiro Aoki

A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction

scientific article published on 21 December 2020

A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro

scientific article published on 06 December 2021

A quantitative model of ERK MAP kinase phosphorylation in crowded media

scientific article published on January 2013

An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells

scientific journal article

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death

scientific article published on 01 September 2018

Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.

scientific article

Control cell migration by engineering integrin ligand assembly

scientific article published in 2022

Development of a FRET biosensor with high specificity for Akt.

scientific article

Development of an optimized backbone of FRET biosensors for kinases and GTPases

scientific article published on 5 October 2011

Distinct predictive performance of Rac1 and Cdc42 in cell migration

scientific article

Dynamics of the Ras/ERK MAPK Cascade as Monitored by Fluorescent Probes

scientific article published in Journal of Biological Chemistry

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

scientific article published on 27 May 2020

Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling

scientific article

Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells

scientific article published on 20 March 2020

FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells.

scientific article

FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain

scientific article published on 01 October 2005

Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

scientific article published on 9 June 2014

Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: basis of biosensor construction, live imaging, and image processing

scientific article published on 07 February 2013

GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.

scientific article

Improved secretion of glycoproteins using an N-glycan-restricted passport sequence tag recognized by cargo receptor

scientific article published on 13 March 2020

Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics

scientific article published on 09 November 2020

Improvement of the bioluminescence reporter system for real-time monitoring of circadian rhythms in the cyanobacterium Synechocystis sp. strain PCC 6803.

scientific article

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin.

scientific article

Inverse tissue mechanics of cell monolayer expansion

scientific article published in March 2018

Live-cell Imaging with Genetically Encoded Protein Kinase Activity Reporters.

scientific article published on 17 March 2018

Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells.

scientific article

Monitoring spatio-temporal regulation of Ras and Rho GTPase with GFP-based FRET probes.

scientific article published in October 2005

Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK.

scientific article published on 19 August 2010

Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression.

scientific article

On the Synchrony of Morphological and Molecular Signaling Events in Cell Migration

Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF.

scientific article published on 24 July 2008

Processive phosphorylation of ERK MAP kinase in mammalian cells

scientific article

Propagating Wave of ERK Activation Orients Collective Cell Migration.

scientific article published in November 2017

Quantification of dissociation constant in living cells by fluorescence cross-correlation spectroscopy

scientific article published on 01 February 2016

Quantification of local morphodynamics and local GTPase activity by edge evolution tracking

scientific article

Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer.

scientific article published on 20 August 2015

Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactions

scientific article

Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein

scientific article

Regulation of RalA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes

scientific article published on 01 November 2006

SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility

scientific article

Single-cell quantification of the concentrations and dissociation constants of endogenous proteins

scientific article published on 09 February 2019

Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells

scientific article published on 21 October 2003

Spatiotemporal regulation of small GTPases as revealed by probes based on the principle of Förster Resonance Energy Transfer (FRET): Implications for signaling and pharmacology

scientific article published on January 2011

Stable expression of FRET biosensors: a new light in cancer research

scientific article

Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

scientific article published on 17 October 2013

Synergistic antitumor effects of combination PI3K/mTOR and MEK inhibition (SAR245409 and pimasertib) in mucinous ovarian carcinoma cells by fluorescence resonance energy transfer imaging

scientific article published on 18 April 2016

The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.

scientific article

Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules

scientific article

Variegated RHOA mutations in adult T-cell leukemia/lymphoma.

scientific article

Visualization of Neuregulin 1 ectodomain shedding reveals its local processing in vitro and in vivo.

scientific article

Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer

scientific article published on June 2008

Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

scientific article published on 15 October 2009

[Dynamics of Rho-family G proteins as visualized with FRET-based probes]

scientific article published on 01 August 2005

mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells.

scientific article

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