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List of works by Klaus H Metzeler

A 17-gene stemness score for rapid determination of risk in acute leukaemia

scientific article published on 7 December 2016

A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.

scientific article published on 14 December 2017

A fluorescence in situ hybridization-based screen allows rapid detection of adverse cytogenetic alterations in patients with acute myeloid leukemia.

scientific article published on 18 April 2017

ASXL genes and RUNX1: an intimate connection?

scientific article

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

scientific article

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

scientific article published on 17 January 2013

Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome

scientific article published on 28 December 2009

Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.

scientific article published on 16 September 2016

Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

scientific article published on 25 August 2016

Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia

scientific article

Age-specific differences in oncogenic pathway dysregulation and anthracycline sensitivity in patients with acute myeloid leukemia

scientific article published on 26 October 2009

Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia

scientific article published on 13 August 2019

An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia

scientific article

An Immune Risk Score Predicts Survival of Patients with Acute Myeloid Leukemia Receiving Chemotherapy

scientific article published on 01 December 2020

An Intrinsic gamma-aminobutyric acid (GABA)ergic system in the adrenal cortex: findings from human and rat adrenal glands and the NCI-H295R cell line

scientific article published on 15 January 2004

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

scientific article

An eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia

scientific article published on 31 May 2011

Applications and data analysis of next-generation sequencing

Association between a prognostic gene signature and functional gene sets

scientific article published on 22 September 2008

BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Bifunctional PD-1 x αCD3 x αCD33 fusion protein reverses adaptive immune escape in acute myeloid leukemia

scientific article published on 01 October 2018

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

scientific article published on 4 August 2015

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.

scientific article published on 3 December 2013

Characterization of a Novel FLT3 BiTE® Antibody Construct for the Treatment of Acute Myeloid Leukemia

scientific article published on 09 June 2020

Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome

scientific article published on 18 February 2009

Clinical Relevance of RUNX1 and CBFB Alterations in Acute Myeloid Leukemia and Other Hematological Disorders

scientific article

Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia

scientific article published on 01 August 2019

Clinical manifestations and diagnosis

Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients

scientific article published on 06 May 2013

Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications

scientific article published on 16 April 2019

Clonal hematopoiesis of indeterminate potential in older patients having received an allogeneic stem cell transplantation from young donors

scientific article published on 30 May 2019

Clonal heterogeneity of -ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia

scientific article published on 10 July 2018

Close correlation of copy number aberrations detected by next-generation sequencing with results from routine cytogenetics in acute myeloid leukemia

scientific article

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML

scientific article published on 26 June 2018

Combined molecular and clinical prognostic index for relapse and survival in cytogenetically normal acute myeloid leukemia

scientific article published on 07 April 2014

Diagnose und Therapie der akuten myeloischen Leukämie

scientific article published on 01 October 2006

Diagnostic applications of next generation sequencing: working towards quality standards/Diagnostische Anwendung von Next Generation Sequencing: Auf dem Weg zu Qualitätsstandards

Diagnostic criteria, classification, and prognosis of acute leukemias

Die akute myeloische Leukämie - Auf dem Weg zu einer Pathogenese-orientierten Therapie

scientific article published on 01 June 2006

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesis

scientific article published on 01 December 2018

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.

scientific article published on 17 October 2014

ERG expression is an independent prognostic factor and allows refined risk stratification in cytogenetically normal acute myeloid leukemia: a comprehensive analysis of ERG, MN1, and BAALC transcript levels using oligonucleotide microarrays

scientific article published on 14 September 2009

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score

scientific article published on 30 December 2013

Evolution of cytogenetically normal acute myeloid leukemia during therapy and relapse: An exome sequencing study of 50 patients

scientific article published on 12 January 2018

FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Fortuitous finding: thrombocytopenia and thrombocytosis

scientific article

GAS6 expression identifies high-risk adult AML patients: potential implications for therapy

scientific article

Gene mutations and clonal architecture in myelodysplastic syndromes and changes upon progression to acute myeloid leukaemia and under treatment

article

Genetic heterogeneity of cytogenetically normal AML with mutations of

scientific article published on 01 October 2018

Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged ≥ 75 years

article

Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia

scientific article

High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature

scientific article published on 27 December 2012

High expression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in cytogenetically normal acute myeloid leukemia

scientific article

IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Idiopathic hyperammonemia (IHA) after dose-dense induction chemotherapy for acute myeloid leukemia: Case report and review of the literature

scientific article published on 23 February 2009

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline

scientific article published on 10 June 2013

Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis

scientific article published on 12 June 2014

Loss of KDM6A confers drug resistance in acute myeloid leukemia

scientific article published on 14 June 2019

Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia

scientific article published on 9 August 2011

Mediation analysis reveals common mechanisms of RUNX1 point mutations and RUNX1/RUNX1T1 fusions influencing survival of patients with acute myeloid leukemia

scientific article published on 26 July 2018

Molecular Genetic Characterization of Individual Cancer Cells Isolated via Single-Cell Printing

scientific article

Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia

scientific article published on 12 September 2007

Patients with spontaneous remission of high-risk MDS and AML show persistent preleukemic clonal hematopoiesis

scientific article published on 01 September 2019

Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia

scientific article published on 23 February 2018

Precision Oncology and "Molecular Tumor Boards" - Concepts, Chances and Challenges

scientific article published on 27 October 2017

Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.

scientific article

Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

scientific article

Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8.

scientific article

Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia

scientific article

Präzisionsonkologie und molekulare Tumorboards – Konzepte, Chancen und Herausforderungen

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures

scientific article

RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes

scientific article published on 11 June 2012

Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of WT1 alterations and high mutation load

scientific article published on 28 June 2018

Response assessment in acute myeloid leukemia by flow cytometry supersedes cytomorphology at time of aplasia, amends cases without molecular residual disease marker and serves as an independent prognostic marker at time of aplasia and post-induction

scientific article published on 04 April 2019

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome

scientific article published on 03 March 2014

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.

scientific article

Stem cell gene expression programs influence clinical outcome in human leukemia.

scientific article published on 28 August 2011

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

scientific article

Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission

scholarly article published 10 July 2018

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

scientific article published on 01 November 2019

The clinical mutatome of core binding factor leukemia

scientific article published on 02 January 2020

The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia

scientific article published on 10 June 2019

The new and recurrent FLT3 juxtamembrane deletion mutation shows a dominant negative effect on the wild-type FLT3 receptor.

scientific article published on 27 June 2016

The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.

scientific article published on 21 December 2015

Therapeutic management of neuro-oncologic patients - potential relevance of CSF liquid biopsy

scientific article published on 01 January 2020

Therapy of older persons with acute myeloid leukaemia

scientific article published on June 2017

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

scientific article published on 14 August 2017

Universal Genomic Testing: The next step in oncological decision-making or a dead end street?

scientific article

Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia

scientific article published on 30 March 2020

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

scientific article published on 2 June 2016

inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations

scientific article published on 16 November 2012

miR-3151 Interplays With its Host Gene BAALC and Independently Impacts on Outcome of Older Patients With Cytogenetically Normal Acute Myeloid Leukemia by Direct Deregulation of TP53

article

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia

scientific article

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