List of works - Knut R Steffensen

ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes

scientific article

Accumulation of foam cells in liver X receptor-deficient mice

scientific article published in August 2002

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

scientific article published on April 2004

Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma

scientific article published on 29 August 2003

Activation of liver X receptor regulates substrate oxidation in white adipocytes

scientific article published on 25 June 2009

Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes

scientific article published on 16 May 2008

Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden

scientific article published on 14 July 2005

Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.

scientific article published in August 2005

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

scientific article

CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells

scientific journal article

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

scientific article published in May 2011

Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins

scientific article

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose

scientific article published in November 2008

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

scientific article published on 27 March 2014

Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors

scientific article published on 17 October 2005

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study

scientific article

Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue

scientific article

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

scientific article

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

scientific article

Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively

scientific article published in October 2003

Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

scientific article

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

scientific article

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

scientific article published on 12 December 2011

Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene

scientific article published on December 2003

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

scientific article (publication date: 20 December 2002)

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice

scientific article

Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator

scientific article

Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden

scientific article published in February 2005

Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content

scientific article published on 14 June 2012

LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

scientific article published on 27 October 2013

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

scientific article published on 13 April 2005

LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

scientific article published on 26 March 2012

Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer

scientific article

Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages

scientific article

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

scientific article published on 27 April 2012

Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture

scientific article published on 04 August 2011

Liver X receptors alpha and beta regulate renin expression in vivo

scientific article

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells

scientific article

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

scientific article

Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback

scientific article published on 14 September 2006

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice

scientific article published on 26 April 2011

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

scientific article

Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXRalpha promoter

scientific article

Metabolic nuclear receptor signaling and the inflammatory acute phase response

scientific article published on 07 June 2011

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors

scientific article

Myelin-derived lipids modulate macrophage activity by liver X receptor activation

scientific article

Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease.

scientific article published in June 2010

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

scientific article

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

scientific article published on 12 July 2007

Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP.

scientific article published on 13 January 2006

Putative metabolic effects of the liver X receptor (LXR).

scientific article published on February 2004

RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.

scientific article

Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes

scientific article published on 8 August 2006

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice

scientific article published on 18 August 2009

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis

scientific article published on 24 December 2013

Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice.

scientific article

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta

scientific article published in February 2000

TACC3 expression is tightly regulated during early differentiation

scientific article

Targeting liver X receptors in inflammation.

scientific article published on 06 June 2013

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

scientific article

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells

scientific article published on 23 January 2009

The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.

scientific article published on 18 May 2012

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

scientific article

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

scientific article

List of works by Knut R Steffensen

ADD1/SREBP1c activates the PGC1-alpha promoter in brown adipocytes

Accumulation of foam cells in liver X receptor-deficient mice

Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression

Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma

Activation of liver X receptor regulates substrate oxidation in white adipocytes

Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes

Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden

Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.

Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells

Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins

Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose

Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study

Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue

GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively

Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

Glucocorticoid response and promoter occupancy of the mouse LXRalpha gene

Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP

Hepatic ACAT2 knock down increases ABCA1 and modifies HDL metabolism in mice

Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator

Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden

Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content

LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-alpha nuclear receptor heterodimer

Liver X receptor agonist GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture

Liver X receptors alpha and beta regulate renin expression in vivo

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells

Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback

Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXRalpha promoter

Metabolic nuclear receptor signaling and the inflammatory acute phase response

Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors

Myelin-derived lipids modulate macrophage activity by liver X receptor activation

Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease.

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride (GW3965).

Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP.

Putative metabolic effects of the liver X receptor (LXR).

RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.

Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes

Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice

Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis

Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice.

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta

TACC3 expression is tightly regulated during early differentiation

Targeting liver X receptors in inflammation.

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells

The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.

The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses