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List of works by Robert E. Chapin

A different approach to validating screening assays for developmental toxicity

scientific article published in December 2010

Analytic evaluation of a human ELISA kit for measurement of inhibin B in rat samples

scientific article published on 24 January 2013

Are mouse strains differentially susceptible to the reproductive toxicity of ethylene glycol monomethyl ether? A study of three strains

scientific article published in July 1993

Assessment of circulating hormones in regulatory toxicity studies II. Male reproductive hormones.

scientific article published on 02 May 2012

Assessment of the Embryonic Stem Cell Test and application and use in the pharmaceutical industry

scientific article published on April 2008

Assessment of the reproductive and developmental toxicity of pesticide/fertilizer mixtures based on confirmed pesticide contamination in California and Iowa groundwater.

scientific article published in May 1994

Assessment of the reproductive toxicity of a complex mixture of 25 groundwater contaminants in mice and rats

scientific article published on 01 April 1995

Boron supplementation inhibits the growth and local expression of IGF-1 in human prostate adenocarcinoma (LNCaP) tumors in nude mice

scientific article published on January 2004

Cadmium at a non-toxic dose alters gene expression in mouse testes

scientific article published in December 2004

Calcium channel blockers protect against ethylene glycol monomethyl ether (2-methoxyethanol)-induced testicular toxicity

scientific article published in June 1990

Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig

scientific article

Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning

scientific article

Comparison of the testicular effects of 2-methoxyethanol (ME) in rats and guinea pigs

scientific article published on October 1994

Cyclophilin A is present in rat germ cells and is associated with spermatocyte apoptosis. Reproductive Toxicology Group

scientific article published on 01 February 1997

Determination of the di-(2-ethylhexyl) phthalate NOAEL for reproductive development in the rat: importance of the retention of extra animals to adulthood.

scientific article

Development of testicular lesions in F344 rats after treatment with boric acid

scientific article published on February 1991

Developmental toxicology evaluations--issues with including neurotoxicology and immunotoxicology assessments in reproductive toxicology studies

scientific article published on 24 August 2005

Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells

scientific article published in October 2000

Effects of boric acid supplementation on bone histomorphometry, metabolism, and biomechanical properties in aged female F-344 rats

scientific article published in January 2003

Effects of feed restriction during organogenesis on embryo-fetal development in rabbit

scientific article published in October 2005

Effects of feed restriction on fertility in female rats

scientific article published in October 2005

Endless possibilities: stem cells and the vision for toxicology testing in the 21st century

scientific article

Endocrine modulation of reproduction

scientific article

Histologic and cytologic detection of endocrine and reproductive tract effects of exemestane in female rats treated for up to twenty-eight days

scientific article published on 2 May 2011

Impaired reproduction in adult male, but not female, rats following juvenile treatment with the aromatase inhibitor, exemestane.

scientific article published on 15 June 2011

In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México

scientific article

In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques

journal article published in 2013

Incidence and nature of testicular toxicity findings in pharmaceutical development.

scientific article published on December 2011

Inhibition of the enzymatic activity of prostate-specific antigen by boric acid and 3-nitrophenyl boronic acid

scientific article published in January 2003

Inter-laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test.

scientific article

Introduction to the HESI-sponsored inhibin consortium.

scientific article published on 24 January 2013

Isoflurane reduces motile sperm counts in the Sprague-Dawley rat.

scientific article published on 21 July 2011

Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans

scientific article published on January 1997

Light and electron microscopic evidence of tri-o-cresyl phosphate (TOCP)-mediated testicular toxicity in Fischer 344 rats

journal article published in 1991

Male reproductive effects of lead, including species extrapolation for the rabbit model

journal article published in 1998

Maternal-placental insulin-like growth factor (IGF) signaling and its importance to normal embryo-fetal development.

scientific article published on August 2010

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of butyl benzyl phthalate

scientific article

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isodecyl phthalate

scientific article

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate

scientific article

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-butyl phthalate

scientific article

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-hexyl phthalate

scientific article

NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate

scientific article

NTP-CERHR expert panel report on the reproductive and developmental toxicity of acrylamide.

scientific article

Nature is complex: our orchestra seats at the most wonderful show on earth

scientific article published in July 2004

Neurotoxicological outcomes of perinatal heptachlor exposure in the rat.

scientific article published in April 2001

Normative reproductive indices for male and female adult Sprague-Dawley rats

scientific article published on March 1999

Not a walk in the park: the ECVAM whole embryo culture model challenged with pharmaceuticals and attempted improvements with random forest design

scientific article published on 2 March 2011

Primary cell cultures for understanding rat epididymal inflammation

scientific article published on 10 July 2014

Prioritization of NTP reproductive toxicants for field studies

journal article published in 2000

Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid

scientific article published in November 2001

Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis

scientific article published on 01 March 2000

Reproductive endpoints in general toxicity studies: are they predictive?

scientific article published on 01 July 1998

Reproductive toxicity assessment by continuous breeding in Sprague-Dawley rats: a comparison of two study designs

scientific article

Six high-priority organochlorine pesticides, either singly or in combination, are nonestrogenic in transfected HeLa cells.

scientific article

Spermatocyte toxicity of 2-methoxyethanol (ME) in rats and guinea pigs: evidence for the induction of apoptosis

scientific article published on September 1995

Spermatocyte toxicity of 2-methoxyethanol in vivo and in vitro: Requirement for an intact seminiferous tubule structure for germ cell degeneration ⬇️

scientific article published on December 1, 1994

State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish

scientific article published in August 2008

Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006.

scientific article published on 17 October 2006

Summary of the HESI consortium studies exploring circulating inhibin B as a potential biomarker of testis damage in the rat.

scientific article published on 30 January 2013

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches ⬇️

scientific article published on March 16, 2012

The effects of dietary boron on bone strength in rats

scientific article published in February 1997

The effects of feed restriction during organogenesis on embryo-fetal development in the rat.

scientific article published in October 2005

The effects of feed restriction on reproductive function in Sprague-Dawley rats

scientific article published in January 1993

The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats

scientific article published in August 2001

The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats

scientific article published in May 2001

The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function

scientific article published on November 1997

The effects of tri-o-cresyl phosphate and metabolites on rat Sertoli cell function in primary culture

scientific article published in April 1991

The hidden effect of estrogenic/antiandrogenic methoxychlor on spermatogenesis

scientific article published in April 2002

The inhibin B response in male rats treated with two drug candidates

scientific article published on 24 January 2013

The interaction of Sertoli and Leydig cells in the testicular toxicity of tri-o-cresyl phosphate

scientific article published in July 1990

The relationships among reproductive endpoints in Swiss mice, using the reproductive assessment by Continuous Breeding database

scientific article published in August 1997

The reproductive and developmental toxicity of indium in the Swiss mouse

scientific article published in August 1995

The reproductive and neural toxicities of acrylamide and three analogues in Swiss mice, evaluated using the continuous breeding protocol

scientific article published on 01 August 1995

The use of the rat in developmental immunotoxicology studies

scientific article published in September 2002

Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology.

scientific article published on February 2004

Tissue disposition of boron in male Fischer rats

scientific article published in October 1991

Toxicity of 3,3',4,4'-tetrachloroazobenzene in rats and mice

scientific article published on 01 April 1999

Toxicity of 3,3',4,4'-tetrachloroazoxybenzene in rats and mice

scientific article published on 01 May 1999

Toxicity studies of acetone administered in the drinking water of rodents

scientific article published in August 1991

Toxicological highlights

scientific article published in August 2007

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