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List of works by Scott H Kaufmann

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.

scientific article published on 25 February 2016

6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin ⬇️

scientific article published on January 1, 1998

A One-Step Method for Protein Estimation in Biological Samples: Nitration of Tyrosine in Nitric Acid

scientific article published on 01 February 1999

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia

scientific article published on 8 August 2016

A Phase I Multicenter Study of Continuous Oral Administration of Lonafarnib (SCH 66336) and Intravenous Gemcitabine in Patients With Advanced Cancer ⬇️

scientific article published on November 1, 2011

A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia

scientific article published on 22 August 2016

A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer

scientific article

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

scientific article

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

scientific article (publication date: 26 February 2004)

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

scientific article published on 5 January 2016

A multistep model for paclitaxel-induced apoptosis in human breast cancer cell lines

scientific article

A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia

scientific article published on 2 November 2006

A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer

scientific article published in August 2002

A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer

scientific article

A phase I and pharmacological study of topotecan infused over 30 minutes for five days in patients with refractory acute leukemia.

scientific article published on December 1996

A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin

scientific article published in October 2002

A phase I study of the farnesyltransferase inhibitor Tipifarnib in combination with the epidermal growth factor tyrosine kinase inhibitor Erlotinib in patients with advanced solid tumors

scientific article published on 31 August 2018

A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662, in combination with paclitaxel and carboplatin in patients with advanced cancer.

scientific article

A phase II "window" study of topotecan in untreated patients with high risk adult acute lymphoblastic leukemia

scientific article published on 01 November 1998

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

scientific article published on November 2011

A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation

scientific article

A subset of non-histone nuclear proteins reversibly stabilized by the sulfhydryl cross-linking reagent tetrathionate

scientific article published on 01 December 1984

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.

scientific article published on 23 October 2013

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

scientific article

ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.

scientific article published on 02 April 2013

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

scientific article published in Journal of Biological Chemistry

Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.

scientific article

Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide

scientific article published on 24 December 2008

Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes

scientific article published in January 2006

Adaphostin-induced apoptosis in CLL B cells is associated with induction of oxidative stress and exhibits synergy with fludarabine

scientific article published on 23 September 2004

Addition of etoposide to initial therapy of adult acute lymphoblastic leukemia: a combined clinical and laboratory study

scientific article published on September 1996

Additional members of the rat liver lamin polypeptide family. Structural and immunological characterization

scientific article published in Journal of Biological Chemistry

Alteration of the nucleolar localization of poly(ADP-ribose) polymerase upon treatment with transcription inhibitors

scientific article published on August 1996

Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes ⬇️

scientific article

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance ⬇️

scientific article published on October 20, 2003

Altered formation of topotecan-stabilized topoisomerase I-DNA adducts in human leukemia cells

scientific article published on 01 March 1997

An Alternative Approach to the Quantitation of Glucocorticoid-Receptor Complexes in the Nuclei of Lymphoid Cells*

scientific article published on 01 March 1982

Analysis of Caspase Activation During Apoptosis

article

Analysis of the internal nuclear matrix

article

Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor α

scientific article published on 25 February 2020

Antagonism between camptothecin and topoisomerase II-directed chemotherapeutic agents in a human leukemia cell line

scientific article published on February 1991

Anticancer therapy: boosting the bang of Bim.

scientific article published on 23 October 2008

Apoptosis and the response to anticancer therapy.

scientific article

Apoptosis in the treatment of cancer: a promise kept?

scientific article published on 16 October 2006

Apoptosis-associated caspase activation assays

scientific article published on March 2008

Apoptosis: an optimization approach

scientific article

Apparent cleavage of poly(ADP-ribose) polymerase in non-apoptotic mouse LTA cells: an artifact of cross-reactive secondary antibody

scientific article published on January 1998

Assessment of aldehyde dehydrogenase in viable cells.

scientific article published on May 1995

Association of poly(ADP-ribose) polymerase with the nuclear matrix: the role of intermolecular disulfide bond formation, RNA retention, and cell type

scientific article published on February 1991

Association of topoisomerase II with the hepatoma cell nuclear matrix: the role of intermolecular disulfide bond formation

scientific article

Ataxia telangiectasia and rad3-related kinase contributes to cell cycle arrest and survival after cisplatin but not oxaliplatin

scientific article published on April 2009

Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: a cell suicide module

scientific article

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma

scientific article

BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis

scientific article

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

scientific article published on 16 October 2019

Bcl-2 Prevents CD95 (Fas/APO-1)-induced Degradation of Lamin B and Poly(ADP-ribose) Polymerase and Restores the NF-κB Signaling Pathway

scientific article published in Journal of Biological Chemistry

Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line

scientific article published on April 2002

Bile acids inhibit Mcl-1 protein turnover via an epidermal growth factor receptor/Raf-1-dependent mechanism

scientific article published in November 2002

Bim regulation miRrors microRNA 17∼92 cluster expression in endothelial cells in vivo

scientific article published on November 2014

Binding of dexamethasone to rat liver nuclei in vivo and in vitro: Evidence for two distinct binding sites

article

Binding of the glucocorticoid receptor to the rat liver nuclear matrix. The role of disulfide bond formation

scientific article published in Journal of Biological Chemistry

CDK2-mediated upregulation of TNFa as a mechanism of selective cytotoxicity in acute leukemia

scientific article published on 07 January 2021

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.

scientific article published on 31 October 2013

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

scientific article

Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia

scientific article

Camptothecin analogues: studies from the Johns Hopkins Oncology Center.

scientific article

Cancer. Targeting bacteria to improve cancer therapy

scientific article published on November 2010

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

scientific article

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation.

scientific article

Caspase-7 gene disruption reveals an involvement of the enzyme during the early stages of apoptosis

scientific article published on 28 October 2003

Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

scientific article

Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons.

scientific article published in September 2001

Caspases and caspase inhibitors

scientific article published on October 1997

Caspases mediate tumor necrosis factor-alpha-induced neutrophil apoptosis and downregulation of reactive oxygen production

article

Cell death induced by topoisomerase-targeted drugs: more questions than answers

scientific article published on 01 October 1998

Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro

scientific article published on 8 September 2003

Changes in topoisomerase I levels and localization during myeloid maturation in vitro and in vivo

scientific article published on 01 March 1995

Characterization of Caspase Processing and Activation in HL-60 Cell Cytosol Under Cell-free Conditions

scientific article published in Journal of Biological Chemistry

Characterization of a <i>RAD51C</i>-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance

scientific article published on 09 July 2021

Characterization of an alternative BAK-binding site for BH3 peptides

scientific article published on 03 July 2020

Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol.

scientific article

Characterization of the major polypeptides of the rat liver nuclear envelope

scientific article published in Journal of Biological Chemistry

Chemotherapy-induced apoptosis

scientific article published on January 1997

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis

scientific article

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

scientific article (publication date: 22 September 1994)

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

scientific article published in June 2001

Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions ⬇️

scientific article published on August 1, 1997

Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis.

scientific article

Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis

scientific article published on May 1999

Comparison of potential markers of farnesyltransferase inhibition

scientific article published on 01 June 2000

Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel.

scientific article

Considerations in the isolation of rat liver nuclear matrix, nuclear envelope, and pore complex lamina

scientific article published on 01 March 1981

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.

scientific article

Context-dependent Bcl-2/Bak interactions regulate lymphoid cell apoptosis.

scientific article published on 07 April 2009

Context-dependent antagonism between Akt inhibitors and topoisomerase poisons

scientific article published on 25 February 2014

Contribution of Bcl-2 phosphorylation to Bak binding and drug resistance.

scientific article published on 4 October 2013

Correction: Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

scientific article

Current status of clinical trials of farnesyltransferase inhibitors.

scientific article

Cyclophosphamide resistance in medulloblastoma.

scientific article published on October 1992

Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines

scientific article published on June 1996

Cytotoxic synergy between flavopiridol (NSC 649890, L86-8275) and various antineoplastic agents: the importance of sequence of administration ⬇️

scientific article published on August 15, 1997

Cytotoxic synergy between pyrazoloacridine (NSC 366140) and cisplatin in vitro: inhibition of platinum-DNA adduct removal.

scientific article published in May 1997

Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation.

scientific article published on 14 June 2011

DNA topoisomerases in chemotherapy

scientific article published on January 1, 1991

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis ⬇️

scientific article published on September 22, 2011

Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.

scientific article published on 9 March 2009

Decreased drug accumulation in a mitoxantrone-resistant gastric carcinoma cell line in the absence of P-glycoprotein.

scientific article published on May 1997

Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.

scientific article published on 17 August 2009

Detection of DNA Cleavage in Apoptotic Cells

article

Detection of Poly(ADP-Ribose) Polymerase and Its Apoptosis-Specific Fragment by a Nonisotopic Activity–Western Blot Technique

scientific article published on 01 December 1995

Development and validation of the gene-expression Predictor of high-grade-serous Ovarian carcinoma molecular subTYPE (PrOTYPE)

scientific article published on 17 June 2020

Development of PARP inhibitors: an unfinished story.

scientific article published on January 2010

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

scientific article published on 27 March 2014

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

scientific article

Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines

scientific article published on January 1991

Distribution of nucleolar proteins B23 and nucleolin during mouse spermatogenesis

scientific article published on 01 March 1991

Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

scientific article

Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies

scientific article published on 11 November 2011

Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia

scientific article published in June 2005

Dynamics of granzyme B-induced apoptosis: mathematical modeling

scientific article published on 23 December 2007

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

scientific article published on 05 March 2019

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

scientific article

Effect of P-glycoprotein on flavopiridol sensitivity

scientific article

Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity

scientific article published on 01 January 1998

Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II

article

Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide, and camptothecin

scientific article published on 01 December 1995

Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro ⬇️

scientific article published on August 6, 2012

Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro

scientific article published in January 2002

Effects of the MEK inhibitor CI-1040 (PD 184352) on progenitor growth from normal and myelodysplastic marrow.

scientific article published in September 2003

Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro

scientific article published on 01 January 2000

Efficient method to optimize antibodies using avian leukosis virus display and eukaryotic cells

scientific article

Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse.

scientific article

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.

scientific article published on 27 March 2015

Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT(388)-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF.

scientific article

Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.

scientific article published on 12 December 2011

Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells

scientific article published on 01 October 1994

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

scientific article

Erasable Western Blots

scientific article published on 01 January 1992

Erasure of Western blots after autoradiography or chemiluminescent detection

scientific article published on 01 March 1993

Erasure of western blots after autoradiographic or chemiluminescent detection

scientific article

Evaluation of 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl) hexanamide (NPC 15437), a protein kinase C inhibitor, as a modulator of P-glycoprotein-mediated resistancein vitro

scientific article published on 01 January 1996

Evaluation of Apaf-1 and procaspases-2, -3, -7, -8, and -9 as potential prognostic markers in acute leukemia

scientific article published on 01 December 2000

Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data

scientific article

Evaluation of the BH3-only protein Puma as a direct Bak activator

scientific article

Evaluation of the role of caspase-6 in anticancer drug-induced apoptosis

scientific article

Evidence that rodent epididymal sperm contain the Mr approximately 94,000 glucocorticoid receptor but lack the Mr approximately 90,000 heat shock protein

scientific article published on 01 May 1992

Expression of nuclear envelope lamins A and C in human myeloid leukemias ⬇️

scientific article published on May 15, 1992

Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias

scientific article published on 01 February 1996

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

scientific article published on 12 March 2020

Factors affecting topotecan sensitivity in human leukemia samples

scientific article

Failure of Iniparib to Inhibit Poly(ADP-Ribose) Polymerase In Vitro ⬇️

scientific article published on January 30, 2012

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells

scientific article published on 30 August 2013

Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma

scientific article (publication date: May 2004)

Fine-structural cytochemical and immunocytochemical observations on nuclear bodies in the bovine 2-cell embryo

scientific article published in November 2000

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

scientific article published in January 2006

Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells

scientific article published in November 1996

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

scientific article published on 8 January 2018

Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

scientific article published on 26 August 2005

Gene expression profiles predict early relapse in ovarian cancer after platinum-paclitaxel chemotherapy

article

Genes associated with bowel metastases in ovarian cancer

scientific article published on 14 June 2019

Genetic analysis of the short splice variant of the inhibitor of caspase-activated DNase (ICAD-S) in chicken DT40 cells.

scientific article

HIC1 hypermethylation is a late event in hematopoietic neoplasms

scientific article published on 01 May 1997

Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.

scientific article

Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines

scientific article published on December 2003

High cell surface death receptor expression determines type I versus type II signaling

scientific article

Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts

scientific article

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

scientific article

How does doxorubicin work?

scientific article published on 18 December 2012

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

scientific article (publication date: May 2001)

Imatinib spells BAD news for Bcr/abl-positive leukemias

scholarly article

Immunodetection of human topoisomerase I-DNA covalent complexes

scientific article

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

scientific article published on January 2006

In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia ⬇️

scientific article published on May 1, 2003

In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma.

scientific article published on 07 September 2016

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

article

Increased phosphorylation rate of intermediate filaments during mitotic arrest

scientific article published on 01 June 1981

Induction of apoptosis by cancer chemotherapy.

scientific article

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

scientific article published in November 1989

Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells☆☆☆

article

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

scientific article

Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

scientific article published on 9 January 2007

Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.

scientific article published on July 2006

Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells

scientific article published in June 2005

Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells

scientific article published on 14 August 2003

Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group

scientific article published on May 2003

Isolation of a TRAIL antagonist from the serum of HIV-infected patients.

scientific article

JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained

scientific article published on 01 June 2006

Janus kinase 2 (V617F) mutation status, signal transducer and activator of transcription-3 phosphorylation and impaired neutrophil apoptosis in myelofibrosis with myeloid metaplasia.

scientific article

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

scientific article published on 2 April 2018

Lack of correlation between caspase activation and caspase activity assays in paclitaxel-treated MCF-7 breast cancer cells

scientific article

Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy

scientific article published in May 2002

Loss of HSulf-1 expression enhances tumorigenicity by inhibiting Bim expression in ovarian cancer.

scientific article

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.

scientific article

Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer.

scientific article published on May 2001

Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group

scientific article

MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.

scientific article published on 5 June 2015

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

scientific article (publication date: June 1999)

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

scientific article published on 13 August 2007

Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

scientific article published on May 2004

Methods utilized in the study of apoptosis

scientific article published on January 1997

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

scientific article published in Nature Communications

Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I

scientific article published on 11 April 2008

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

scientific article

Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia

scientific article published on 14 October 2011

Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas ⬇️

scientific article published on November 3, 2011

Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent

scientific article

Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

scientific article

Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition.

scientific article

Noxa/Bcl-2 Protein Interactions Contribute to Bortezomib Resistance in Human Lymphoid Cells ⬇️

scientific article published on March 22, 2011

On the TRAIL of a new therapy for leukemia.

scientific article

On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents

scientific article

Osteoblasts protect AML cells from SDF-1-induced apoptosis.

scientific article

Overcoming S-phase checkpoint-mediated resistance: sequence-dependent synergy of gemcitabine and 7-ethyl-10-hydroxycamptothecin (SN-38) in human carcinoma cell lines

scientific article published on 28 May 2008

Paclitaxel induces programmed cell death in MDA-MB-468 human breast cancer cells

scientific article published on 01 May 1996

Phase 1 study of sorafenib in combination with bortezomib in patients with advanced malignancies.

scientific article published on 26 July 2013

Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.

scientific article published on August 2005

Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia

scientific article published in May 2002

Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemia

scientific article published in October 1994

Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias

scientific article published in December 2005

Phase I and pharmacokinetic study of lonafarnib, SCH 66336, using a 2-week on, 2-week off schedule in patients with advanced solid tumors

article

Phase I and pharmacologic studies of pyrazoloacridine, a novel DNA intercalating agent, on single-dosing and multiple-dosing schedules.

scientific article

Phase I and pharmacologic study of high doses of the topoisomerase I inhibitor topotecan with granulocyte colony-stimulating factor in patients with solid tumors.

scientific article

Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia

scientific article

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor ⬇️

scientific article published on April 1, 1992

Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias.

scientific article published on 23 October 2012

Phase I trial of autologous hematopoietic SCT with escalating doses of topotecan combined with CY and carboplatin in patients with relapsed or persistent ovarian or primary peritoneal carcinoma.

scientific article

Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer

scientific article published on May 2003

Phorbol 12-myristate 13-acetate inhibits death receptor-mediated apoptosis in Jurkat cells by disrupting recruitment of Fas-associated polypeptide with death domain

scientific article

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm.

scientific article

Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis

scientific article published on 01 November 1998

Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.

scientific article

Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

scientific article

Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.

scientific article published on 16 March 2015

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.

scientific article

Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.

scientific article

Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes

scientific article published on 9 March 2017

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

scientific article published on 3 February 2016

Programmed cell death: alive and well in the new millennium ⬇️

scientific article published on December 1, 2001

Prospects for the Use of ATR Inhibitors to Treat Cancer.

scientific article

Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy.

scientific article

Proteolytic cleavage during chemotherapy-induced apoptosis

scientific article published on July 1996

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

scientific article published on 18 May 2021

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I

scientific article published on 01 April 1996

Rad9 protects cells from topoisomerase poison-induced cell death

scientific article published on 25 February 2004

Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer

scientific article published on 10 December 2019

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

scientific article published on 19 October 2020

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

scientific article published on 28 July 2020

Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling

scientific article published in February 2006

Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release

scientific article published in January 2002

Resistance to topoisomerase II poisons: Is the answer in the promoter?

scientific article published on 01 November 1997

Reutilization of Immunoblots after Chemiluminescent Detection

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Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

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Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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S-peptide epitope tagging for protein purification, expression monitoring, and localization in mammalian cells.

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Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

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Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

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Serine 64 phosphorylation enhances the antiapoptotic function of Mcl-1.

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Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

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Severe graft-versus-host disease in a liver-transplant recipient

scientific article published in March 1988

Simultaneous immunoelectron microscopic visualization of protein B23 and C23 distribution in the HeLa cell nucleolus

scientific article published on 01 September 1989

Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.

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Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

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Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution

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Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads

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Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines.

scientific article published on May 2001

Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes.

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Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo

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Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

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TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

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Temporal changes in chromatin, intracellular calcium, and poly(ADP-ribose) polymerase during Sindbis virus-induced apoptosis of neuroblastoma cells

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The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer

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The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells.

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The current status of camptothecin analogues as antitumor agents

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The erasable Western blot

scientific article published on 01 February 1987

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

scientific article published on March 1996

The molecular origin and taxonomy of mucinous ovarian carcinoma

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The relationship of the nuclear matrix to cellular structure and function ⬇️

scientific article published on January 1, 1978

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

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The role of proteases during apoptosis.

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The saintly side of Smac/DIABLO: giving anticancer drug-induced apoptosis a boost

scientific article published on 01 October 2003

Therapy‐related acute promyelocytic leukemia: observations relating to APL pathogenesis and therapy* ⬇️

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Topoisomerase II and the response to antileukemic therapy.

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Topoisomerase II as a target for anticancer chemotherapy

scientific article published on January 1995

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

scientific article published on January 1994

Topoisomerase II levels during granulocytic maturation in vitro and in vivo

scientific article published on July 1991

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions

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Topoisomerases in human leukemia.

scientific article published on January 1994

Topotecan in combination chemotherapy.

scientific article published on December 1997

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

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Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution.

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Tumorgrafts as in vivo surrogates for women with ovarian cancer.

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Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

scientific article published on 30 August 2018

ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer

scientific article published on 11 October 2019

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