List of works - Jae-Kyung Jung

(E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3.

scientific article

4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease

scientific article published in January 2011

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase

scientific article

4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity.

scientific article

4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity.

scientific article

ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment

scientific article published on 21 January 2014

An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate

scientific article published on 24 February 2018

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

scientific article published on 27 March 2020

Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro and in vivo models.

scientific article published on January 2012

Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6

scientific article (publication date: 2014)

Anti-platelet activity of diacetylated obovatol through regulating cyclooxygenase and lipoxygenase activities

scientific article published on 21 December 2012

Antioxidant and Anti-inflammatory Activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-Induced BV2 Microglial Cells.

scientific article published on January 2015

Asymmetric total synthesis of bacillariolide III, a marine oxylipin

scientific article published on 01 February 2004

Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process.

scientific article published on February 2017

Characterization of fimasartan metabolites in human liver microsomes and human plasma.

scientific article published on 11 June 2015

Concise Synthesis of Broussonone A

scientific article published on 02 September 2015

Concise synthesis of Obovatol: Chemoselective ortho-bromination of phenol and survey of Cu-catalyzed diaryl ether couplings

scientific article

Design and synthesis of 2,3-dihydro- and 5-chloro-2,3-dihydro-naphtho-[1,2-b]furan-2-carboxylic acid N-(substitutedphenyl)amide analogs and their biological activities as inhibitors of NF-κB activity and anticancer agents.

scientific article published on 28 March 2016

Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors

scientific article published on 20 April 2014

Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f][1,7]naphthyrdines.

scientific article published on 22 August 2017

Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB.

scientific article published on 23 April 2015

Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors

scientific article published on 18 September 2018

Expedient synthesis of chiral homoallylamines via N,O-acetal TMS ethers and its application

scientific article

Functional divergency oriented synthesis of azoninones as the key intermediates for bioactive indolizidine alkaloids analogs.

scientific article

IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid

scientific article published on 29 December 2014

Inhibitory effects of OD 78 [3-(4-bromo-phenoxy)-4,5-dihydroxybenzoic acid-methyl ester] on the proliferation and migration of TNF-α-induced rat aortic smooth muscle cells.

scientific article published in July 2011

JJK694, a synthesized obovatol derivative, inhibits platelet activation by suppressing cyclooxygenase and lipoxygenase activities

scientific article published on 07 November 2012

JY0691, a newly synthesized obovatol derivative, inhibits cell cycle progression of rat aortic smooth muscle cells through up-regulation of p21(cip1).

scientific article published on 9 October 2009

Neuroprotective and antioxidant effects of novel benzofuran-2-carboxamide derivatives.

scientific article published on May 2015

Novel NF-κB inhibitors: a patent review (2011 - 2014).

scientific article published on 02 January 2015

Nuclear factor-kappa B inhibitors; a patent review (2006-2010).

scientific article published on December 2011

Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

scientific article published on 17 November 2011

Obovatol improves cognitive functions in animal models for Alzheimer's disease.

scientific article

Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats

scientific article published on 3 July 2013

Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway

scientific article

Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

scientific article published on 27 November 2020

Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method

scientific article

Stereoselective formation of N-acyliminium ion via chiral N,O-acetal TMS ether and its application to the synthesis of beta-amino acids

scientific article published on 01 October 2003

Stereoselective synthesis of (E)- and (Z)-enol ethers from beta-amino aldehydes

scientific article published on 01 June 2007

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives.

scientific article published on 8 June 2010

Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation.

scientific article published on October 2007

Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol

scientific article published on 09 November 2018

Synthesis and anti-platelet activity of obovatol derivatives

scientific article published on 01 July 2011

Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.

scientific article

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

scientific article published on 20 October 2017

Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5,10-diones.

scientific article published on August 2008

Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants

scientific article published in June 2005

Synthesis and evaluation of antitumor activity of novel 1,4-naphthoquinone derivatives (IV).

scientific article published on February 2006

Synthesis and in Vitro cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones

scientific article

Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

scientific article published on March 2004

Synthesis of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid N-alkyl amides and their antioxidant activity

scientific article published in March 2006

Synthesis of 7-hydroxy-4-oxo-4H-chromene- and 7-hydroxychroman-2-carboxylic acid N-alkyl amides and their antioxidant activities.

scientific article published in September 2006

Synthesis of N-arylindazole-3-carboxamide and N-benzoylindazole derivatives and their evaluation against α-MSH-stimulated melanogenesis

scientific article published on 01 August 2019

Synthesis of chroman-2-carboxylic acid N-(substituted)phenylamides and their inhibitory effect on nuclear factor-kappaB (NF-kappaB) activation.

scientific article

Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.

scientific article published on 25 March 2014

Synthesis, biological evaluation, and metabolic stability of chlorogenic acid derivatives possessing thiazole as potent inhibitors of α-MSH-stimulated melanogenesis

scientific article

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

scientific article

The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation.

scientific article

The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.

scientific article

The versatile conversion of acyclic amides to alpha-alkylated amines

scientific article published on 01 May 2002

Total synthesis of (+)-Brefeldin A.

scientific article published in June 2002

Total synthesis of anti-HIV agent chloropeptin I.

scientific article published in July 2003

Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon

scientific article published on 27 August 2019

Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models

scientific article published on 31 July 2014

List of works by Jae-Kyung Jung

(E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3.

4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase

4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity.

4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity.

ALK inhibitors of bis-ortho-alkoxy-para-piperazinesubstituted-pyrimidines and -triazines for cancer treatment

An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway

Anti-amyloidogenic effect of thiacremonone through anti-inflamation in vitro and in vivo models.

Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6

Anti-platelet activity of diacetylated obovatol through regulating cyclooxygenase and lipoxygenase activities

Antioxidant and Anti-inflammatory Activities of N-((3,4-Dihydro-2H-benzo[h]chromene-2-yl)methyl)-4-methoxyaniline in LPS-Induced BV2 Microglial Cells.

Asymmetric total synthesis of bacillariolide III, a marine oxylipin

Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process.

Characterization of fimasartan metabolites in human liver microsomes and human plasma.

Concise Synthesis of Broussonone A

Concise synthesis of Obovatol: Chemoselective ortho-bromination of phenol and survey of Cu-catalyzed diaryl ether couplings

Design and synthesis of 2,3-dihydro- and 5-chloro-2,3-dihydro-naphtho-[1,2-b]furan-2-carboxylic acid N-(substitutedphenyl)amide analogs and their biological activities as inhibitors of NF-κB activity and anticancer agents.

Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-κB inhibitors

Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f][1,7]naphthyrdines.

Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB.

Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors

Expedient synthesis of chiral homoallylamines via N,O-acetal TMS ethers and its application

Functional divergency oriented synthesis of azoninones as the key intermediates for bioactive indolizidine alkaloids analogs.

IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid

Inhibitory effects of OD 78 [3-(4-bromo-phenoxy)-4,5-dihydroxybenzoic acid-methyl ester] on the proliferation and migration of TNF-α-induced rat aortic smooth muscle cells.

JJK694, a synthesized obovatol derivative, inhibits platelet activation by suppressing cyclooxygenase and lipoxygenase activities

JY0691, a newly synthesized obovatol derivative, inhibits cell cycle progression of rat aortic smooth muscle cells through up-regulation of p21(cip1).

Neuroprotective and antioxidant effects of novel benzofuran-2-carboxamide derivatives.

Novel NF-κB inhibitors: a patent review (2011 - 2014).

Nuclear factor-kappa B inhibitors; a patent review (2006-2010).

Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

Obovatol improves cognitive functions in animal models for Alzheimer's disease.

Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats

Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway

Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles

Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method

Stereoselective formation of N-acyliminium ion via chiral N,O-acetal TMS ether and its application to the synthesis of beta-amino acids

Stereoselective synthesis of (E)- and (Z)-enol ethers from beta-amino aldehydes

Structure-activity relationship of indoline-2-carboxylic acid N-(substituted)phenylamide derivatives.

Structure-activity relationships of 6-hydroxy-7-methoxychroman-2-carboxylic acid N-(substituted)phenylamides as inhibitors of nuclear factor-kappaB activation.

Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol

Synthesis and anti-platelet activity of obovatol derivatives

Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of α-MSH-stimulated melanogenesis.

Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

Synthesis and cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6,9-triazacyclopenta[b]anthracene-5,10-diones.

Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants

Synthesis and evaluation of antitumor activity of novel 1,4-naphthoquinone derivatives (IV).

Synthesis and in Vitro cytotoxic activities of 2-alkyl-2,3-dihydro-1H-2,6-diazacyclopenta[b]anthracene-5,10-diones

Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

Synthesis of 6-hydroxy-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid N-alkyl amides and their antioxidant activity

Synthesis of 7-hydroxy-4-oxo-4H-chromene- and 7-hydroxychroman-2-carboxylic acid N-alkyl amides and their antioxidant activities.

Synthesis of N-arylindazole-3-carboxamide and N-benzoylindazole derivatives and their evaluation against α-MSH-stimulated melanogenesis

Synthesis of chroman-2-carboxylic acid N-(substituted)phenylamides and their inhibitory effect on nuclear factor-kappaB (NF-kappaB) activation.

Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents.

Synthesis, biological evaluation, and metabolic stability of chlorogenic acid derivatives possessing thiazole as potent inhibitors of α-MSH-stimulated melanogenesis

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation.

The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.

The versatile conversion of acyclic amides to alpha-alkylated amines

Total synthesis of (+)-Brefeldin A.

Total synthesis of anti-HIV agent chloropeptin I.

Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon

Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models