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List of works by Angela Risch

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

scientific article published on 10 June 2011

A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer

scientific article published on 07 October 2016

A common coding variant in CASP8 is associated with breast cancer risk

article

A comprehensive study of polymorphisms inABCB1, ABCC2andABCG2and lung cancer chemotherapy response and prognosis

article

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

scientific article

A multiplex real-time PCR method for detection of GSTM1 and GSTT1 copy numbers

scientific article published on 30 December 2008

A network-based kernel machine test for the identification of risk pathways in genome-wide association studies

scientific article

Arylarnine N-acetyltransferase as a potential biornarker in bladder cancer: fluorescent in situ hybridization and irnmunohistochernistry studies

scientific article published in January 1996

Association analysis of driver-gene related genetic variants identified novel lung cancer susceptibility loci with 20,871 lung cancer cases and 15,971 controls

scientific article published on 10 April 2020

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

scientific article

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

scientific article published in June 2004

Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs

scientific article published on 17 March 2017

CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis

scientific article published in May 2015

CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences

scientific article

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification.

scientific article

Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking

scientific article

Comparison of pathway analysis approaches using lung cancer GWAS data sets

scientific article

Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy

scientific article published on 29 May 2012

Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer

scientific article

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations

scientific article

Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: a pooled analysis of genotype-based studies ⬇️

scientific article published on 01 December 2001

DNA Damage from Endogenous Processes, Workshop

scientific article published on 01 January 1997

DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.

scientific article

DNA methylation changes measured in pre-diagnostic peripheral blood samples are associated with smoking and lung cancer risk

scientific article published on 15 September 2016

Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer

scientific article

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

scientific article published on December 2009

Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene

scientific article

Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption

scientific article published in January 2006

Elevated platelet count appears to be causally associated with increased risk of lung cancer: A Mendelian randomization analysis

scientific article published on 30 January 2019

Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles of the TP53 Arg72Pro and p21 Ser31Arg polymorphisms

scientific article published on 23 October 2006

Empirical hierarchical bayes approach to gene-environment interactions: development and application to genome-wide association studies of lung cancer in TRICL.

scientific article published on 26 July 2013

Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4

scientific article published on 03 September 2012

Erratum to: Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls

scientific article

Erratum: Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk

scholarly article published in Nature Genetics

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scholarly article published in Nature Genetics

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

scientific article published in Nature Communications

Functional variants in DCAF4 associated with lung cancer risk in European populations

scientific article published on 5 April 2017

GPC5 rs2352028 variant and risk of lung cancer in never smokers

scientific article published in August 2010

Gene-set meta-analysis of lung cancer identifies pathway related to systemic lupus erythematosus

scientific article

Genes for human arylamine N-acetyltransferases in relation to loss of the short arm of chromosome 8 in bladder cancer

article

Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy

scientific article published on 4 November 2009

Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis

scientific article published on 10 August 2016

Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium

scientific article published on 23 January 2017

Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study

scientific article

Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners

journal article published in 2018

Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy

scientific article published in January 2010

Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer

scientific article published in October 2010

Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium

scientific article

Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population

scientific article published on 20 October 2017

Genome-wide prediction of splice-modifying SNPs in human genes using a new analysis pipeline called AASsites

scientific article

Genotype relationships in the CYP3A locus in Caucasians

scientific article published in April 2004

Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants

scientific article

Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas

scientific article published in December 2001

Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls

scientific article published on February 2013

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

scientific article

Identification of HERC5 and its potential role in NSCLC progression

scientific article

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

scientific article

Identification of shared and unique susceptibility pathways among cancers of the lung, breast, and prostate from genome-wide association studies and tissue-specific protein interactions

scientific article

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

scientific article published in Nature Communications

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

scientific article

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

scientific article

Informed conditioning on clinical covariates increases power in case-control association studies

scientific article published on 8 November 2012

Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer

scientific article

Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia

scientific article published on 12 July 2017

Insulin-like growth factor 1 pathway mutations and protein expression in resected non-small cell lung cancer

scientific article

International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants

scientific article

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways

scientific article

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

scientific article published on 12 June 2017

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

scientific article

Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region

scientific article published on 19 April 2019

Lung cancer epigenetics and genetics

scientific article published on July 2008

META-GSA: Combining Findings from Gene-Set Analyses across Several Genome-Wide Association Studies

scientific article

Mapping AAC1 AAC2 and AACP, the genes for arylamine N-acetyltransferases, carcinogen metabolising enzymes on human chromosome 8p22, a region frequently deleted in tumours

article

Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer

scientific article published in May 2008

Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review

scientific article published on 24 February 2009

Metabolic gene polymorphism frequencies in control populations

scientific article published in December 2001

Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study

scientific article published on 11 July 2005

Methylome analysis and epigenetic changes associated with menarcheal age

scientific article

Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2.

scientific article published in July 2001

Myeloperoxidase (MPO) genotype and lung cancer histologic types: the MPO -463 A allele is associated with reduced risk for small cell lung cancer in smokers

scientific article published on December 2002

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk

scientific article

Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer

scientific article published on 26 October 2017

Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study

scientific article published on 8 June 2017

Occupation, exposure to polycyclic aromatic hydrocarbons and laryngeal cancer risk

scientific article

Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies

scientific article published on 13 July 2017

Pathway-analysis of published genome-wide association studies of lung cancer: A potential role for the CYP4F3 locus

scientific article

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides

scientific article

Pleiotropic associations of risk variants identified for other cancers with lung cancer risk: the PAGE and TRICL consortia

scientific article

Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients

scientific article

Polymorphisms in the Apoptotic Pathway Gene BCL-2 and Survival in Small Cell Lung Cancer

article

Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups

scientific article published on 18 January 2008

Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls

scientific article published on 10 February 2016

Principles for the post-GWAS functional characterization of cancer risk loci

scientific article published in June 2011

Progressive lung cancer determined by expression profiling and transcriptional regulation

scientific article published on 28 March 2012

Protein-altering germline mutations implicate novel genes related to lung cancer development

scientific article published on 11 May 2020

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

scientific article published on 23 September 2019

Rapid screening assay for mutagen sensitivity and DNA repair capacity in human peripheral blood lymphocytes

scientific article published on 01 January 2001

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility.

scientific article

Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

scientific article

SULT1A1 genotype and susceptibility to colorectal cancer

scientific article published in January 2007

SULT1A1 genotype, active and passive smoking, and breast cancer risk by age 50 years in a German case-control study

scientific article

Shared heritability and functional enrichment across six solid cancers

scientific article published in Nature Communications

Shared heritability and functional enrichment across six solid cancers

Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?

scientific article published in November 2000

Single nucleotide polymorphisms in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis

article

Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer

scientific article published in February 1995

Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer

scientific article

Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk - a re-analysis of eight GWASs

scientific article (publication date: 15 November 2016)

Synergistic cross-talk of hedgehog and interleukin-6 signaling drives growth of basal cell carcinoma

scientific article published on 01 October 2018

Telomere structure and maintenance gene variants and risk of five cancer types

scientific article published on 15 December 2016

The CYP3A4*1B allele increases risk for small cell lung cancer: effect of gender and smoking dose

scientific article published on 01 October 2003

The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers

scientific article published on 03 October 2016

The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

scientific article published on 31 March 2017

Xenogenetics in multifactorial disease susceptibility

scientific article published on December 1995

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