List of works - Javier S. Castresana

ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.

scientific article

Absence of mutation at the GAP-related domain of the neurofibromatosis type 1 gene in sporadic neurofibrosarcomas and other bone and soft tissue sarcomas

scientific article published on 01 June 1995

Amplification of c-myc oncogene and absence of c-Ha-ras point mutation in human bone sarcoma

scientific article published on 01 July 1993

Amplification of the c-myc proto-oncogene in soft tissue sarcomas

scientific article published on 01 January 1994

CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast

scientific article published on 01 September 2002

Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment

scientific article

Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination.

scientific article published on 25 December 2013

Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q.

scientific article published in January 2003

Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors

scientific article published on 21 May 2013

Correction: Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

scientific article published on 9 June 2016

DNA copy gains of tumor-related genes in vestibular schwannoma.

scientific article

Detection of TP53 gene mutations in human sarcomas

scientific article published on 01 January 1995

Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR.

scientific article

Determination of genomic damage in neuroblastic tumors by arbitrarily primed PCR: MYCN amplification as a marker for genomic instability in neuroblastomas

scientific article published in June 2006

Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells

scientific article

Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples

scientific article

Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas

scientific article published on 2 October 2012

Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.

scientific article published on 10 September 2010

Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma

scientific article

Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas.

scientific article

Gene expression analysis of aberrant signaling pathways in meningiomas

scientific article

Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system.

scientific article published in December 2005

Genome-wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster

scientific article published on 23 December 2014

Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells.

scientific article

Genomic deletions at 1p and 14q are associated with an abnormal cDNA microarray gene expression pattern in meningiomas but not in schwannomas

article

Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

scientific article

Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32.

scientific article

Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines

scientific article published on May 2004

Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component.

scientific article published on 6 January 2014

Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples

scientific article published on 19 September 2010

Identification of p53 mutations by means of single strand conformation polymorphism analysis in gynaecological tumours: comparison with the results of immunohistochemistry

scientific article published on 01 January 1994

Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells.

scientific article

KIT expression and methylation in medulloblastoma and PNET cell lines and tumors.

scientific article published on 19 September 2010

Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma

scientific article published on 01 October 1993

Laminin-adherent versus suspension-non-adherent cell culture conditions for the isolation of cancer stem cells in the DAOY medulloblastoma cell line.

scientific article published on 15 June 2016

Loss of heterozygosity and microsatellite instability on chromosome arm 10q in neuroblastoma.

scientific article

Molecular classification defines 4 prognostically distinct glioma groups irrespective of diagnosis and grade.

scientific article published in March 2015

NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications

scientific article published in September 2013

No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis

scientific article published on 01 June 1994

No association between c-myc amplification and TP53 mutation in sarcoma tumorigenesis.

scientific article published in August 1994

On habit and the mind-body problem. The view of Felix Ravaisson

scientific article published on 9 September 2014

Overexpression of alpha-synuclein promotes both cell proliferation and cell toxicity in human SH-SY5Y neuroblastoma cells

scientific article published on 22 January 2020

P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors

scientific article

P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines

scientific article published on 26 July 2016

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance.

scientific article published on 23 September 2016

Quantitative method for in vitro matrigel invasiveness measurement through image analysis software.

scientific article

RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system.

scientific article

RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.

scientific article

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma.

scientific article

Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines

scientific article published on September 2003

The sonic hedgehog-GLI1 signaling pathway in brain tumor development.

scientific article published on 19 September 2012

Whole exome sequencing in a case of sporadic multiple meningioma reveals shared NF2, FAM109B, and TPRXL mutations, together with unique SMARCB1 alterations in a subset of tumor nodules.

scientific article published on 11 April 2015

c-myc oncogene amplification and cytometric DNA ploidy pattern as prognostic factors in musculoskeletal neoplasms.

scientific article published in September 1994

List of works by Javier S. Castresana

ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem-like properties.

Absence of mutation at the GAP-related domain of the neurofibromatosis type 1 gene in sporadic neurofibrosarcomas and other bone and soft tissue sarcomas

Amplification of c-myc oncogene and absence of c-Ha-ras point mutation in human bone sarcoma

Amplification of the c-myc proto-oncogene in soft tissue sarcomas

CCND1- and ERBB2-gene deregulation and PTEN mutation analyses in invasive lobular carcinoma of the breast

Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment

Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination.

Chromosomal abnormalities in human glioblastomas: gain in chromosome 7p correlating with loss in chromosome 10q.

Codeletion of 1p and 19q determines distinct gene methylation and expression profiles in IDH-mutated oligodendroglial tumors

Correction: Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

DNA copy gains of tumor-related genes in vestibular schwannoma.

Detection of TP53 gene mutations in human sarcomas

Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR.

Determination of genomic damage in neuroblastic tumors by arbitrarily primed PCR: MYCN amplification as a marker for genomic instability in neuroblastomas

Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells

Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples

Expression analysis of tumor-related genes involved in critical regulatory pathways in schwannomas

Expression and epigenetic modulation of sonic hedgehog-GLI1 pathway genes in neuroblastoma cell lines and tumors.

Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma

Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas.

Gene expression analysis of aberrant signaling pathways in meningiomas

Genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumours of the central nervous system.

Genome-wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster

Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells.

Genomic deletions at 1p and 14q are associated with an abnormal cDNA microarray gene expression pattern in meningiomas but not in schwannomas

Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32.

Homozygous deletion and expression of PTEN and DMBT1 in human primary neuroblastoma and cell lines

Homozygous deletion of TNFRSF4, TP73, PPAP2B and DPYD at 1p and PDCD5 at 19q identified by multiplex ligation-dependent probe amplification (MLPA) analysis in pediatric anaplastic glioma with questionable oligodendroglial component.

Human hedgehog interacting protein expression and promoter methylation in medulloblastoma cell lines and primary tumor samples

Identification of p53 mutations by means of single strand conformation polymorphism analysis in gynaecological tumours: comparison with the results of immunohistochemistry

Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells.

KIT expression and methylation in medulloblastoma and PNET cell lines and tumors.

Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma

Laminin-adherent versus suspension-non-adherent cell culture conditions for the isolation of cancer stem cells in the DAOY medulloblastoma cell line.

Loss of heterozygosity and microsatellite instability on chromosome arm 10q in neuroblastoma.

Molecular classification defines 4 prognostically distinct glioma groups irrespective of diagnosis and grade.

NF2 genetic alterations in sporadic vestibular schwannomas: clinical implications

No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis

No association between c-myc amplification and TP53 mutation in sarcoma tumorigenesis.

On habit and the mind-body problem. The view of Felix Ravaisson

Overexpression of alpha-synuclein promotes both cell proliferation and cell toxicity in human SH-SY5Y neuroblastoma cells

P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumors

P144, a Transforming Growth Factor beta inhibitor peptide, generates antitumoral effects and modifies SMAD7 and SKI levels in human glioblastoma cell lines

Potential role of Shh-Gli1-BMI1 signaling pathway nexus in glioma chemoresistance.

Quantitative method for in vitro matrigel invasiveness measurement through image analysis software.

RASSF1A promoter is highly methylated in primitive neuroectodermal tumors of the central nervous system.

RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma.

Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines

The sonic hedgehog-GLI1 signaling pathway in brain tumor development.

Whole exome sequencing in a case of sporadic multiple meningioma reveals shared NF2, FAM109B, and TPRXL mutations, together with unique SMARCB1 alterations in a subset of tumor nodules.

c-myc oncogene amplification and cytometric DNA ploidy pattern as prognostic factors in musculoskeletal neoplasms.