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List of works by David A. Dougan

A folding machine for many but a master of none

scientific article

AAA+ Machines of Protein Destruction in Mycobacteria

scientific article published on 19 July 2017

AAA+ proteins and substrate recognition, it all depends on their partner in crime

scientific article

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

scientific article published on August 2009

Adaptor protein controlled oligomerization activates the AAA+ protein ClpC

scientific article

Anti-adaptors use distinct modes of binding to inhibit the RssB-dependent turnover of RpoS (σ(S)) by ClpXP.

scientific article published on 23 April 2015

Broad yet high substrate specificity: the challenge of AAA+ proteins

scientific article published on April 2004

Chemical Activators of ClpP: Turning Jekyll into Hyde

article

ClpS is an essential component of the N-end rule pathway in Escherichia coli.

scientific article published in February 2006

ClpS, a substrate modulator of the ClpAP machine

scientific article

Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding

scientific article

Control of protein function through regulated protein degradation: biotechnological and biomedical applications

scientific article published on 05 August 2013

Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE.

scientific article published on 7 March 2018

Crystallization and preliminary X-ray analysis of the Escherichia coli adaptor protein ClpS, free and in complex with the N-terminal domain of ClpA.

scientific article

Diverse functions of mitochondrial AAA+ proteins: protein activation, disaggregation, and degradation

scientific article published on February 2010

Dysregulating ClpP: From Antibiotics to Anticancer?

scientific article published on 01 August 2018

Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome

scientific article published on 17 June 2020

Heat shock proteins of barley mitochondria and chloroplasts Identification of organellar hsp 10 and 12: putative chaperonin 10 homologues

scientific article published on 01 June 1992

Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane

scientific article

Insight into the RssB-Mediated Recognition and Delivery of σs to the AAA+ Protease, ClpXP

scientific article published on 16 April 2020

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

scientific article published on 2 December 2015

Machines of destruction - AAA+ proteases and the adaptors that control them.

scientific article published on January 2013

MecA, an adaptor protein necessary for ClpC chaperone activity

scholarly article

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA.

scientific article published on 10 January 2014

Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli

scientific article published on 14 May 2009

Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis

scientific article published on 02 December 2019

N-degron specificity of chloroplast ClpS1 in plants

scientific article published on 20 April 2019

Perrault syndrome type 3 caused by diverse molecular defects in CLPP

scientific article published in Scientific Reports

Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP

scientific article published on 06 November 2020

Preface

Pro(moting) the Turnover of Gluconeogenic Enzymes by a New Branch of the N-end Rule Pathway

scientific article published on 4 April 2017

Protein folding and degradation in bacteria: to degrade or not to degrade? That is the question.

scientific article

Proteolytic regulation of stress response pathways in Escherichia coli.

scientific article published on January 2013

Pupylation of PafA or Pup inhibits components of the Pup-Proteasome System

scientific article published on 2 December 2017

Single-chain Fv of anti-idiotype 11-1G10 antibody interacts with antibody NC41 single-chain Fv with a higher affinity than the affinity for the interaction of the parent Fab fragments

article

Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA

scientific article

Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS

scientific article

Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX

scientific article

Targeted Delivery of an ssrA-Tagged Substrate by the Adaptor Protein SspB to Its Cognate AAA+ Protein ClpX ⬇️

scientific article published on August 1, 2003

The Direct Molecular Target for Imipridone ONC201 Is Finally Established

scientific article published on 01 May 2019

The N-end rule adaptor protein ClpS from Plasmodium falciparum exhibits broad substrate specificity

scientific article published on 2 September 2016

The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.

scientific article published on 12 July 2011

The tyrosine kinase McsB is a regulated adaptor protein for ClpCP

scientific article published on 22 March 2007

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

scientific article

Understanding the Pro/N-end rule pathway

scientific article published on 01 May 2018

Unfolded protein responses in bacteria and mitochondria: a central role for the ClpXP machine

scientific article

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