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List of works by Elizabeth Gardiner

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

scientific article published on 27 September 2016

A GPIb-IX-V complex signaling environment

scientific article published on 27 June 2009

A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway

scientific article published in June 2007

A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3.

scientific article published on April 2004

A mitogenic action for fibrinogen mediated through intercellular adhesion molecule-1

scientific article

A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI.

scientific article published on 8 May 2001

A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets

scientific article published on 3 February 2016

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase.

scientific article

Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events

scientific article published on 26 May 2019

All-Trans Retinoic Acid Impairs Platelet Function and Thrombus Formation and Inhibits Protein Kinase CßI/δ Phosphorylation

scientific article published on 01 August 2019

An absence of platelet activation following thalidomide treatment in vitro or in vivo

scientific article

An acquired defect associated with abnormal signaling of the platelet collagen receptor glycoprotein VI.

scientific article

An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets.

scientific article

An exit strategy for new platelets

scientific article published in March 2018

Anti-glycoprotein VI mediated immune thrombocytopenia: An under-recognized and significant entity?

scientific article published on 24 August 2017

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding

scientific article published in March 2009

Antihemostatic Activity of Human Granzyme B Mediated by Cleavage of von Willebrand Factor

scientific article published in Journal of Biological Chemistry

Arterial thrombosis: going, gone!

scientific article published on 01 September 2010

Autoregulation of von Willebrand factor function by a disulfide bond switch.

scientific article published on 28 February 2018

Basic mechanisms of platelet receptor shedding

scientific article

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

scientific article

Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL.

scientific article

CLEC-2 expression is maintained on activated platelets and on platelet microparticles.

scientific article

Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets

scientific article published on 01 February 2019

Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma.

scientific article

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.

scientific article published on 06 January 2017

Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

scientific article published on 20 January 2011

Colocalization of neutrophils, extracellular DNA and coagulation factors during NETosis: Development and utility of an immunofluorescence-based microscopy platform

scientific article published on 7 June 2016

Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura.

scientific article

Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood

scientific article

Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.

scientific article published on 18 April 2007

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 30 August 2017

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.

scientific article published on 16 November 2016

DiagnoSTic assays for heparin-induced thrombocytopenia

scientific article

Diesel exhaust particles impair platelet response to collagen and are associated with GPIbα shedding

scientific article published on 20 April 2012

Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability

scientific article published on 29 October 2020

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia

scientific article published on 20 November 2018

Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa

scientific article

Editorial: ADAMs control inflammation from afar

scientific article published on March 2015

Effects of abacavir administration on structural and functional markers of platelet activation.

scientific article

Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of Type 1 diabetes

scientific article published on 06 June 2013

Extracorporeal membrane oxygenation-hemostatic complications.

scientific article

Focusing on plasma glycoprotein VI.

scientific article

Fractionation of snake venom metalloproteinases by metal ion affinity: A purified cobra metalloproteinase, Nk, from Naja kaouthia binds Ni2+-agarose

article

Functional analysis of the C-terminal flanking sequence of platelet glycoprotein Ib alpha using canine-human chimeras

scientific article published in January 2002

GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events

scientific article published in January 2010

GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors

scientific article

Glycoprotein Ib-IX-V.

scientific article

Glycoprotein VI is associated with GPIb-IX-V on the membrane of resting and activated platelets

scientific article published on 01 April 2005

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm

scientific article

High contrast imaging and flexible photomanipulation for quantitative in vivo multiphoton imaging with polygon scanning microscope.

scientific article published on 28 February 2018

Histone deacetylase inhibitors reduce glycoprotein VI expression and platelet responses to collagen related peptide

scientific article published on 2 May 2013

ITAM receptor-mediated generation of reactive oxygen species in human platelets occurs via Syk-dependent and Syk-independent pathways.

scientific article

Identification of an Active Sequence within the First Immunoglobulin Domain of Intercellular Cell Adhesion Molecule-1 (ICAM-1) That Interacts with Fibrinogen

scientific article published in Journal of Biological Chemistry

In vitro flow based systems to study platelet function and thrombus formation: Recommendations for standardization: Communication from the SSC on Biorheology of the ISTH

scientific article published on 01 March 2020

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

scientific article published on 15 February 2016

Inside platelets..

scientific article published on 01 January 2012

Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

scientific article published on 22 September 2014

Ligand Binding Rapidly Induces Disulfide-dependent Dimerization of Glycoprotein VI on the Platelet Plasma Membrane

scientific article published in Journal of Biological Chemistry

Longitudinal changes in hemostatic parameters and reduced pulsatility contribute to non-surgical bleeding in patients with centrifugal continuous-flow left ventricular assist devices

scientific article published on 7 January 2016

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

scientific article published in February 2013

Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibβ in a patient with Bernard-Soulier syndrome

scientific article published on 16 August 2015

Lymphomania

scientific article published on 01 May 2014

M1761K mutation in the von Willebrand factor A3 domain associated with impaired collagen binding and without platelet dysfunction

scientific article published on 28 June 2016

Matrix metalloproteinase-13 unlucky for the forming thrombus

Measuring soluble platelet glycoprotein VI in human plasma by ELISA.

scientific article

Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI.

scientific article published on 7 September 2016

Mechanisms of Platelet Dysfunction in Patients with Implantable Devices

scientific article published on 12 September 2017

Mechanisms of receptor shedding in platelets

article

Metalloproteolytic receptor shedding…platelets "acting their age".

scientific article

Methods papers in Platelets Journal

scientific article published on 22 October 2018

Methods to Determine the Lagrangian Shear Experienced by Platelets during Thrombus Growth

scientific article published on 14 December 2015

Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function

scientific journal article

Modified inverted selective plane illumination microscopy for sub-micrometer imaging resolution in polydimethylsiloxane soft lithography devices

scientific article published on 17 September 2020

Monitoring the pulse of thrombus formation

scientific article published on 24 July 2018

NLRP3 regulates platelet integrin αIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

article

Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI

scientific article

Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction ⬇️

scientific article published on September 26, 2012

Neutrophil extracellular traps (NETs) and the role of platelets in infection

article

Novel Stenotic Microchannels to Study Thrombus Formation in Shear Gradients: Influence of Shear Forces and Human Platelet-Related Factors

scientific article published on 18 June 2019

Novel scientific approaches and future research directions in understanding ITP

scientific article published on 13 February 2020

Parkin the bus to manage stress

scientific article published on 17 July 2019

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

scientific article published on 19 March 2012

Phase I pilot clinical trial of antenatal maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by pre-eclampsia (PAMPR): study protocol

scientific article published on 20 September 2013

Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators

scientific article

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

scientific article published on 04 August 2019

Plasma sGPVI: Changing levels in human disease.

scientific article published on 22 December 2013

Platelet Ubiquitylation-It's Everywhere

scientific article published on 31 December 2018

Platelet adhesion receptors and (patho)physiological thrombus formation.

scientific article

Platelet interactions in thrombosis

scientific article published on January 2004

Platelet receptor expression and shedding: glycoprotein Ib-IX-V and glycoprotein VI.

scientific article

Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity

scientific article published on 26 April 2007

Platelet receptor redox regulation

scientific article published on February 2008

Platelet receptor shedding

scientific article published on January 2012

Platelets: Envoys at the Infection Frontline ⬇️

scientific article published on July 11, 2013

Polymorphisms and interspecies differences of the activating and inhibitory FcγRII of Macaca nemestrina influence the binding of human IgG subclasses

scientific article

Polymorphonuclear neutrophils release 35S-labelled proteoglycans into cartilage during frustrated phagocytosis

scientific article published on 01 April 1994

Programmed autologous cleavage of platelet receptors.

scientific article published on July 2007

Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation

scientific article published in 2022

Proteolysis of platelet receptors in humans and other species

scientific article

Proteolytic processing of platelet receptors

Rabbit polymorphonuclear neutrophils form 35S-labeled S-sulfo-calgranulin C when incubated with inorganic [35S]sulfate.

scientific article

Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G.

scientific article published in September 2001

Regulation of platelet activation and thrombus formation by reactive oxygen species

scientific article published on 7 September 2017

Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase

scientific article

Remote ischemic preconditioning inhibits platelet αIIb β3 activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial

scientific article published on 13 February 2020

Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura

article

Role of calmodulin in platelet receptor function

scientific article

Sequences within fibrinogen and intercellular adhesion molecule-1 (ICAM-1) modulate signals required for mitogenesis

scientific article published on April 1999

SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation

scientific article published on 02 November 2018

Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.

scientific article

Snake Venom Toxins Affecting Platelet Function

article

Snake venom metalloproteinases, crotarhagin and alborhagin, induce ectodomain shedding of the platelet collagen receptor, glycoprotein VI.

scientific article published in December 2007

Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI

article

Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke

article

Soluble glycoprotein VI, a specific marker of platelet activation is increased in the plasma of subjects with seropositive rheumatoid arthritis

scientific article published on 15 November 2017

Structure and function of platelet receptors initiating blood clotting

scientific article

Structure-activity relationships of snake toxins targeting platelet receptors, glycoprotein Ib-IX-V and glycoprotein VI.

scientific article published in June 2003

Successful Renal Denervation Decreases the Platelet Activation Status in Hypertensive Patients

scientific article published on 04 February 2019

Synthesis of 35S-labelled macromolecules by polymorphonuclear neutrophils. Evidence for the production of [35S]sulphite which can modify both endogenous and exogenous proteins

scientific article published on December 1992

TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets.

scientific article

Targeting GPVI as a novel antithrombotic strategy

scientific article

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: comment.

scientific article published on 20 October 2017

The NET effect of clot formation

scientific article published on 01 January 2012

The cut of the clot(h): snake venom fibrinogenases as therapeutic agents

scientific article published on 28 June 2008

The cutting edge of platelets

scientific article published in June 2017

The influence of platelet membranes on tumour cell behaviour.

scientific article

The platelet Fc receptor, FcγRIIa

scientific article

The vascular biology of the glycoprotein Ib-IX-V complex

scientific article published on 01 July 2001

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα.

scientific article published on 28 October 2015

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