List of works - Hans Törmä

13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?

scientific article

A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis

scientific article

A Single-Nucleotide Deletion in the POMP 5′ UTR Causes a Transcriptional Switch and Altered Epidermal Proteasome Distribution in KLICK Genodermatosis

scientific article published in April 2010

A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis

scientific article

Age-related variations in acyl-CoA:retinol acyltransferase activity and vitamin A concentration in the liver and epidermis of hairless mice

scientific article published on 01 September 1987

Biologic activities of retinoic acid and 3,4-didehydroretinoic acid in human keratinocytes are similar and correlate with receptor affinities and transactivation properties

scientific article published on 01 January 1994

Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells

scientific article

Biosynthesis of 3,4-didehydroretinol and fatty acyl esters of retinol and 3,4-didehydroretinol by organ-cultured human skin

scientific article

Biosynthesis of 3-dehydroretinol (vitamin A2) from all-trans-retinol (vitamin A1) in human epidermis.

scientific article

Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis

scientific article published on 18 March 2009

CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells

scientific article published on 17 May 2007

CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells

scientific article published on 6 July 2010

Cellular retinoic acid-binding protein type II is expressed in adult human osteoblasts and in adult liver

scientific article

Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial.

scientific article

Characterization of AT-1 cardiomyocytes as a model for studies of T3 effects on cardiac cells

scientific article published on August 1997

Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

scientific article

Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases

scientific article published on 14 April 2011

Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells

scientific article

Decreased mRNA levels of retinoic acid receptor alpha, retinoid X receptor alpha and thyroid hormone receptor alpha in lesional psoriatic skin

scientific article published on 01 January 2000

Decreased retinyl ester concentrations in UV-induced murine squamous cell carcinomas

scientific article published on 01 January 1989

Detection of mRNA transcripts for retinoic acid, vitamin D3, and thyroid hormone (c-erb-A) nuclear receptors in human skin using reverse transcription and polymerase chain reaction

scientific article published on 01 April 1993

Detergents with different chemical properties induce variable degree of cytotoxicity and mRNA expression of lipid-metabolizing enzymes and differentiation markers in cultured keratinocytes

scientific article published on 29 June 2006

Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells

scientific article published on 06 July 2006

Different pathways in irritant contact eczema? Early differences in the epidermal elemental content and expression of cytokines after application of 2 different irritants

scientific article published on 01 December 1996

Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes

scientific article published on October 2003

Either chick embryo dermis or retinoid-treated mouse dermis can initiate glandular morphogenesis from mammalian epidermal tissue

scientific article

Epidermolysis bullosa simplex due to KRT5 mutations: mutation-related differences in cellular fragility and the protective effects of trimethylamine N-oxide in cultured primary keratinocytes

scientific article

Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions

scientific article (publication date: 2003)

Expression of cytosolic retinoid-binding protein genes in human skin biopsies and cultured keratinocytes and fibroblasts

scientific article published on August 1994

Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole

scientific article published in January 2009

Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris

scientific article

High-performance liquid chromatography of natural and synthetic retinoids in human skin samples

scientific article published in January 1990

Identification of 3-dehydroretinol (vitamin A2) in mouse liver

scientific article published on 01 July 1988

Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments

scientific article published on February 2011

Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin

scientific article

Increased concentrations of 3,4-didehydroretinol and retinoic acid-binding protein (CRABPII) in human squamous cell carcinoma and keratoacanthoma but not in basal cell carcinoma of the skin

scientific article

Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes

scientific article published in April 1996

Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha

scientific article published on 01 February 1995

Increased retinoid signaling in vascular smooth muscle cells by proinflammatory cytokines

scientific article

Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis.

scientific article published on May 2001

Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial

scientific article

Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment

scientific article published on 16 August 2017

Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis

Keratin 4 upregulation by retinoic acid in vivo: a sensitive marker for retinoid bioactivity in human epidermis.

scientific article

Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways

scientific article published on 15 January 2010

Keratinocyte-based cell assays: their potential pitfalls.

scientific article

Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha

scientific article published on 20 April 2010

Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation.

scientific article

Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids.

scientific article published on 23 May 2009

Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype.

scientific article

Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome

scientific article published on 23 July 2009

Novel point mutation in the STS gene in a patient with X-linked recessive ichthyosis.

scientific article published on 7 April 2011

On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens

scientific article (publication date: 2005)

Patients with Congenital Ichthyosis and TGM1 Mutations Overexpress Other ARCI Genes in the Skin: Part of a Barrier Repair Response?

article

Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes

scientific article

Quantitative image analysis of protein expression and colocalisation in skin sections.

scientific article published in November 2017

Regulation of keratin expression by retinoids.

scientific article published on July 2011

Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha

scientific article published on 01 April 2000

Retinoid receptor expression and its correlation to retinoid sensitivity in non-M3 acute myeloid leukemia blast cells

scientific article

Retinoids can be classified according to their effects on vitamin A metabolism in HeLa cells

scientific article published on 01 January 1996

Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*.

scientific article

Retinol esterification by mouse epidermal microsomes: evidence for acyl-CoA:retinol acyltransferase activity

scientific article published on 01 April 1987

Retinol uptake by human keratinocytes--receptor-mediated or not?

scientific article published on 01 October 1992

Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts

scientific article published on May 1993

Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26.

scientific article

Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo

scientific article published on 15 November 2007

Sodium lauryl sulphate alters the mRNA expression of lipid-metabolizing enzymes and PPAR signalling in normal human skin in vivo

scientific article

Synthetic Retinoids Affect Differently the Epidermal Synthesis of 3,4-Didehydroretinol ⬇️

scientific article published on 01 January 1991

The effect of two endogenous retinoids on the mRNA expression profile in human primary keratinocytes, focusing on genes causing autosomal recessive congenital ichthyosis

scientific article

The expression of cellular retinoid binding proteins in non-APL leukemic cells and its association with retinoid sensitivity

scientific article

The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis

scientific article

The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes

scientific article published on 24 December 2008

The metabolism of vitamin A to 3,4-didehydroretinol can be demonstrated in human keratinocytes, melanoma cells and HeLa cells, and is correlated to cellular retinoid-binding protein expression

scientific article published on 01 December 1994

The vitamin A metabolism and expression of retinoid-binding proteins differ in HaCaT cells and normal human keratinocytes

scientific article published on June 1999

Topical retinoic acid alters the expression of cellular retinoic acid-binding protein-I and cellular retinoic acid-binding protein-II in non-lesional but not lesional psoriatic skin

scientific article

Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis

scientific article published on 21 October 2008

UV irradiation and topical vitamin A modulate retinol esterification in hairless mouse epidermis.

scientific article

Ultraviolet irradiation depletes cellular retinol and alters the metabolism of retinoic acid in cultured human keratinocytes and melanocytes

scientific article published on 01 August 1999

Uptake of vitamin A and retinol-binding protein by human placenta in vitro

scientific article published on 01 July 1986

Variations in the mRNA expression of inflammatory mediators, markers of differentiation and lipid-metabolizing enzymes caused by sodium lauryl sulphate in cultured human keratinocytes

scientific article published on 7 November 2005

Vitamin A esterification in human epidermis: a relation to keratinocyte differentiation

scientific article

Vitamin A metabolism and mRNA expression of retinoid-binding protein and receptor genes in human epidermal melanocytes and melanoma cells.

scientific article published on August 1997

Vitamin A transporting proteins in human epidermis and blister fluids

scientific article published on 01 January 1983

Vitamin A uptake by human skin in vitro

scientific article published on 01 January 1984

Vitamin D induces the antimicrobial protein hCAP18 in human skin

scientific article published on 01 May 2005

X-linked recessive ichthyosis: an impaired barrier function evokes limited gene responses before and after moisturizing treatments.

scientific article published on 10 August 2012

siRNA silencing of proteasome maturation protein (POMP) activates the unfolded protein response and constitutes a model for KLICK genodermatosis

scientific article

List of works by Hans Törmä

13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?

A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis

A Single-Nucleotide Deletion in the POMP 5′ UTR Causes a Transcriptional Switch and Altered Epidermal Proteasome Distribution in KLICK Genodermatosis

A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis

Age-related variations in acyl-CoA:retinol acyltransferase activity and vitamin A concentration in the liver and epidermis of hairless mice

Biologic activities of retinoic acid and 3,4-didehydroretinoic acid in human keratinocytes are similar and correlate with receptor affinities and transactivation properties

Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells

Biosynthesis of 3,4-didehydroretinol and fatty acyl esters of retinol and 3,4-didehydroretinol by organ-cultured human skin

Biosynthesis of 3-dehydroretinol (vitamin A2) from all-trans-retinol (vitamin A1) in human epidermis.

Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis

CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells

CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells

Cellular retinoic acid-binding protein type II is expressed in adult human osteoblasts and in adult liver

Changes in skin barrier function following long-term treatment with moisturizers, a randomized controlled trial.

Characterization of AT-1 cardiomyocytes as a model for studies of T3 effects on cardiac cells

Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases

Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells

Decreased mRNA levels of retinoic acid receptor alpha, retinoid X receptor alpha and thyroid hormone receptor alpha in lesional psoriatic skin

Decreased retinyl ester concentrations in UV-induced murine squamous cell carcinomas

Detection of mRNA transcripts for retinoic acid, vitamin D3, and thyroid hormone (c-erb-A) nuclear receptors in human skin using reverse transcription and polymerase chain reaction

Detergents with different chemical properties induce variable degree of cytotoxicity and mRNA expression of lipid-metabolizing enzymes and differentiation markers in cultured keratinocytes

Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells

Different pathways in irritant contact eczema? Early differences in the epidermal elemental content and expression of cytokines after application of 2 different irritants

Differential effects of UV irradiation on nuclear retinoid receptor levels in cultured keratinocytes and melanocytes

Either chick embryo dermis or retinoid-treated mouse dermis can initiate glandular morphogenesis from mammalian epidermal tissue

Epidermolysis bullosa simplex due to KRT5 mutations: mutation-related differences in cellular fragility and the protective effects of trimethylamine N-oxide in cultured primary keratinocytes

Expression of CYP4F8 (prostaglandin H 19-hydroxylase) in human epithelia and prominent induction in epidermis of psoriatic lesions

Expression of cytosolic retinoid-binding protein genes in human skin biopsies and cultured keratinocytes and fibroblasts

Expression of retinoid-regulated genes in lamellar ichthyosis vs. healthy control epidermis: changes after oral treatment with liarozole

Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris

High-performance liquid chromatography of natural and synthetic retinoids in human skin samples

Identification of 3-dehydroretinol (vitamin A2) in mouse liver

Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments

Immunofluorescence localization of nuclear retinoid receptors in psoriasis versus normal human skin

Increased concentrations of 3,4-didehydroretinol and retinoic acid-binding protein (CRABPII) in human squamous cell carcinoma and keratoacanthoma but not in basal cell carcinoma of the skin

Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes

Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha

Increased retinoid signaling in vascular smooth muscle cells by proinflammatory cytokines

Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis.

Inefficacy of topical thyroid hormone analogue TriAc in plaque psoriasis: results of a double-blind placebo-controlled trial

Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment

Interactions between FATP4 and ichthyin in epidermal lipid processing may provide clues to the pathogenesis of autosomal recessive congenital ichthyosis

Keratin 4 upregulation by retinoic acid in vivo: a sensitive marker for retinoid bioactivity in human epidermis.

Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways

Keratinocyte-based cell assays: their potential pitfalls.

Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha

Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation.

Moisturizers change the mRNA expression of enzymes synthesizing skin barrier lipids.

Moisturizing treatment of patients with atopic dermatitis and ichthyosis vulgaris improves dry skin, but has a modest effect on gene expression regardless of FLG genotype.

Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome

Novel point mutation in the STS gene in a patient with X-linked recessive ichthyosis.

On the mechanism of biosynthesis of 19-hydroxyprostaglandins of human seminal fluid and expression of cyclooxygenase-2, PGH 19-hydroxylase (CYP4F8) and microsomal PGE synthase-1 in seminal vesicles and vas deferens

Patients with Congenital Ichthyosis and TGM1 Mutations Overexpress Other ARCI Genes in the Skin: Part of a Barrier Repair Response?

Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes

Quantitative image analysis of protein expression and colocalisation in skin sections.

Regulation of keratin expression by retinoids.

Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha

Retinoid receptor expression and its correlation to retinoid sensitivity in non-M3 acute myeloid leukemia blast cells

Retinoids can be classified according to their effects on vitamin A metabolism in HeLa cells

Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*.

Retinol esterification by mouse epidermal microsomes: evidence for acyl-CoA:retinol acyltransferase activity

Retinol uptake by human keratinocytes--receptor-mediated or not?

Reverse transcription-polymerase chain reaction assay demonstrates that the 9-cis retinoic acid receptor alpha is expressed in human osteoblasts

Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26.

Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo

Sodium lauryl sulphate alters the mRNA expression of lipid-metabolizing enzymes and PPAR signalling in normal human skin in vivo

Synthetic Retinoids Affect Differently the Epidermal Synthesis of 3,4-Didehydroretinol ⬇️

The effect of two endogenous retinoids on the mRNA expression profile in human primary keratinocytes, focusing on genes causing autosomal recessive congenital ichthyosis

The expression of cellular retinoid binding proteins in non-APL leukemic cells and its association with retinoid sensitivity

The expression of epidermal lipoxygenases and transglutaminase-1 is perturbed by NIPAL4 mutations: indications of a common metabolic pathway essential for skin barrier homeostasis

The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes

The metabolism of vitamin A to 3,4-didehydroretinol can be demonstrated in human keratinocytes, melanoma cells and HeLa cells, and is correlated to cellular retinoid-binding protein expression

The vitamin A metabolism and expression of retinoid-binding proteins differ in HaCaT cells and normal human keratinocytes

Topical retinoic acid alters the expression of cellular retinoic acid-binding protein-I and cellular retinoic acid-binding protein-II in non-lesional but not lesional psoriatic skin

Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis

UV irradiation and topical vitamin A modulate retinol esterification in hairless mouse epidermis.

Ultraviolet irradiation depletes cellular retinol and alters the metabolism of retinoic acid in cultured human keratinocytes and melanocytes

Uptake of vitamin A and retinol-binding protein by human placenta in vitro